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公开(公告)号：US5827826A
公开(公告)日：1998-10-27
申请号：US743261
申请日：1996-11-04
申请人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
发明人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
CPC分类号： C07K14/501 , A61K38/00 , Y10S930/12
摘要： The present invention is directed to compositions comprising endothelial cell growth factor, an acceptable carrier and, optionally, an extracellular matrix protein, a glycosaminoglycan or serum albumin. The compositions are useful for wound repair.
摘要翻译： 本发明涉及包含内皮细胞生长因子，可接受的载体和任选的细胞外基质蛋白，糖胺聚糖或血清白蛋白的组合物。 组合物可用于伤口修复。
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公开(公告)号：US20110091353A1
公开(公告)日：2011-04-21
申请号：US12959106
申请日：2010-12-02
IPC分类号： A61L2/00
CPC分类号： A61L2/0035 , A61L2/0088
摘要： Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.
摘要翻译： 公开了用于灭菌组织以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，脲酶原，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用照射对一个或多个组织进行灭菌。
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13.发明授权公开(公告)号：US07848487B2
公开(公告)日：2010-12-07
申请号：US12264106
申请日：2008-11-03
IPC分类号： G21K5/00
CPC分类号： C07K16/26 , A61K39/39591 , A61L2/0011 , A61L2/0035 , A61L2/0082 , A61L2/10 , A61L2/16
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.
摘要翻译： 公开了用于灭菌生物材料以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用辐射对含有一种或多种非水溶剂的生物材料进行灭菌。
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公开(公告)号：US20050047958A1
公开(公告)日：2005-03-03
申请号：US10840425
申请日：2004-05-07
申请人： David Mann , Wilson Burgess , William Drohan , Yuri Griko , Martin MacPhee
发明人： David Mann , Wilson Burgess , William Drohan , Yuri Griko , Martin MacPhee
IPC分类号： A61L2/08 , A61K9/08 , A61K9/19 , A61K38/46 , A61K38/48 , A61K41/00 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/36 , A61K47/42 , A61L2/00 , A61L2/10 , A61L2/12 , A61P1/06 , A61P1/12 , A61P1/14 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/08 , A61P7/00 , A61P7/06 , A61P9/00 , A61P11/00 , A61P13/12 , A61P17/00 , A61P17/16 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/04 , A61P25/28 , A61P27/02 , A61P27/16 , A61P43/00 , C12N13/00
CPC分类号： A61L2/007 , A61L2/0011 , A61L2/0029 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0082 , C12N13/00
摘要： Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations of digestive enzymes, such as trypsin, α-galactosidase and iduronate-2-sulfatase, with irradiation.
摘要翻译： 公开了用于对消化酶的制备物进行消毒以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素酶，纳米细菌，衣原体，立克次体）， 对TSE和/或单细胞或多细胞寄生虫单独或组合负责的酵母，霉菌，真菌，朊病毒或类似物质。 这些方法包括消化酶的消毒，如胰蛋白酶，α-半乳糖苷酶和艾杜糖醛酸-2-硫酸酯酶的照射。
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公开(公告)号：US06749851B2
公开(公告)日：2004-06-15
申请号：US09942938
申请日：2001-08-31
IPC分类号： A61K3846
CPC分类号： A61L2/007 , A61L2/0011 , A61L2/0029 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0082 , C12N13/00
摘要： Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations of digestive enzymes, such as trypsin, &agr;-galactosidase and iduronate-2-sulfatase, with irradiation.
摘要翻译： 公开了用于对消化酶的制备物进行消毒以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素酶，纳米细菌，衣原体，立克次体）， 对TSE和/或单细胞或多细胞寄生虫单独或组合负责的酵母，霉菌，真菌，朊病毒或类似物质。 这些方法包括消化酶的消毒，如胰蛋白酶，α-半乳糖苷酶和艾杜糖醛酸-2-硫酸酯酶的照射。
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公开(公告)号：US5571790A
公开(公告)日：1996-11-05
申请号：US472964
申请日：1995-06-07
申请人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
发明人： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
CPC分类号： C07K14/501 , A61K38/00 , Y10S930/12
摘要： Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human origin. The product is useful for, among other purposes, diagnostic applications and as potential in the treatment of damaged blood vessels or other endothelial cell-lined structures.
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公开(公告)号：US20080080998A1
公开(公告)日：2008-04-03
申请号：US11826513
申请日：2007-07-16
申请人： Wilson Burgess , William Drohan , Martin MacPhee , David Mann
发明人： Wilson Burgess , William Drohan , Martin MacPhee , David Mann
CPC分类号： A61L2/0047 , A01N1/02 , A01N1/0294 , A61K35/12 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0052 , A61L2/0058 , A61L2/0064 , A61L2/007 , A61L2/0082 , A61L2/0088 , C12M37/00
摘要： Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.
摘要翻译： 公开了用于灭菌组织以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，脲酶原，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用照射对一个或多个组织进行消毒。
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公开(公告)号：US20060182652A1
公开(公告)日：2006-08-17
申请号：US11399385
申请日：2006-04-07
申请人： Wilson Burgess , William Drohan , Martin MacPhee , David Mann , Ewa Maddox
发明人： Wilson Burgess , William Drohan , Martin MacPhee , David Mann , Ewa Maddox
IPC分类号： A61L2/08
CPC分类号： A61M1/3681 , A61L2/0011 , A61L2/0035 , A61M1/3683
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of active biological contaminants or pathogens such as viruses, bacteria, nanobacteria, yeasts, molds, mycoplasmas, ureaplasmas, prions and parasites. These methods involve the use of dipeptide stabilizers in methods of sterilizing biological materials with irradiation.
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公开(公告)号：US06783968B2
公开(公告)日：2004-08-31
申请号：US09960704
申请日：2001-09-24
IPC分类号： A01N6300
CPC分类号： C12N13/00 , C12N9/2465 , C12Y302/01022
摘要： Methods are disclosed for sterilizing preparations of glycosidases to reduce the level therein of one or more active biological contaminants or pathogens, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, prions or similar agents responsible, alone or in combination, for TSEs. These methods involve sterilizing preparations of glycosidases, such as alpha-glucosidase or alpha-galactosidase, with irradiation.
摘要翻译： 公开了消除糖苷酶制剂的方法以降低其中一种或多种活性生物污染物或病原体如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原，尿细菌，衣原体，立克次体），酵母中的水平 ，霉菌，单细胞或多细胞寄生虫，朊病毒或类似物质，单独或组合负责TSE。 这些方法包括用照射消毒糖苷酶（例如α-葡糖苷酶或α-半乳糖苷酶）的制剂。
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20.再颁专利DNA encoding human endothelial cell growth factors and plasmids comprising said DNA 失效编码人内皮细胞生长因子的DNA和包含所述DNA的质粒公开(公告)号：USRE38240E1
公开(公告)日：2003-08-26
申请号：US09538305
申请日：2000-03-28
IPC分类号： C12P2104
CPC分类号： C07K14/501 , A61K38/00 , Y02A50/473 , Y10S930/12
摘要： The present invention is directed to DNA encoding human endothelial cell growth factors, and to plasmids comprising said DNA. In particular, the invention relates to DNA encoding a cleavable signal peptide and an endothelial cell growth factor, wherein removal of said signal peptide yields a mature form of the growth factor.
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