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公开(公告)号：US20140377853A1
公开(公告)日：2014-12-25
申请号：US14484384
申请日：2014-09-12
Applicant: Hitachi High-Technologies Corporation
Inventor： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
IPC: G01N21/51
CPC classification number: G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
Abstract: To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
Abstract translation: 适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。 为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。 为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。
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公开(公告)号：US11366132B2
公开(公告)日：2022-06-21
申请号：US16642934
申请日：2018-10-05
Applicant: Hitachi High-Technologies Corporation
Inventor： Takamichi Mori , Akihiro Nojima , Isao Yamazaki
Abstract: Since a detergent is a consumption article, it is desirable that a use amount of the detergent be as small as possible in a limit that the washing effect is not substantially reduced. Provided is an automatic analyzer which includes a syringe pump which is connected to a probe and performs the body aspiration and discharge, a feed pump which feeds washing water for washing the inside of the probe to the probe via the syringe pump and a controller which controls the dispensing mechanism and the syringe pump, in which the controller, in a case of washing the probe by sucking a detergent in the probe a plurality of times, controls the syringe pump so as to discharge the detergent after sucking the detergent and to suck the next detergent without feeding the washing water to the probe by the feed pump.
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公开(公告)号：US11327089B2
公开(公告)日：2022-05-10
申请号：US16483458
申请日：2018-01-16
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Masafumi Shimada , Isao Yamazaki , Masaharu Nishida , Yoko Inoue
Abstract: The purpose of the present invention is to provide an automatic analysis device capable of determining, through a simple processing, whether or not idle aspirate has occurred. The automatic analysis device according to the present invention determines whether or not idle aspirate has occurred, by calculating a parameter which specifies whether or not the length of a portion of a path through which the sample passes inside a dispensing probe is shorter than that during normal aspirate, the portion being actually filled with a sample (see FIG. 4).
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公开(公告)号：US11788971B2
公开(公告)日：2023-10-17
申请号：US16620697
申请日：2018-04-10
Applicant: Hitachi High-Technologies Corporation
Inventor： Akihiro Nojima , Takamichi Mori , Isao Yamazaki , Kohei Nonaka
CPC classification number: G01N21/82 , G01N35/00623 , G01N35/1004
Abstract: An object of the present invention is to provide a technology in which an amount of pigment carried from a pigment solution can be accurately measured at the time of testing a surface state of a dispensing probe on the basis of the amount of carried pigment. In a test method according to the present invention, a surface state of a dispensing probe is evaluated on the basis of an amount of pigment carried from an acidic pigment solution into a solution including no pigment.
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公开(公告)号：US11169166B2
公开(公告)日：2021-11-09
申请号：US15552335
申请日：2016-02-05
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Hideto Tamezane , Isao Yamazaki , Masaharu Nishida , Ryota Kamoshida
Abstract: An automatic analyzer which is capable of detecting a dispensing abnormality with a high degree of accuracy without causing the decrease in the determination performance or the increase in the calculation amount caused by the configuration balance of the reference database is implemented. A dispensing nozzle of a sample dispensing mechanism 50 is immersed in a dispensing target contained in a specimen container 11 and sucks the dispensing target, and internal pressure of the dispensing nozzle of the sample dispensing mechanism 50 of ejecting the sucked dispensing target to a reaction container 41 is detected through a pressure sensor 54. A plurality of feature quantities are extracted from a waveform of the detected pressure, and a determination result is output through a linear combination formula using an optimal coefficient for a determination function that receives a plurality of feature quantities and outputs one value. The determination result indicates whether or not dispensing of the sample dispensing mechanism 50 is performed normally in accordance with the magnitude of the output result of the determination function.
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Patent Agency Ranking
公开(公告)号：US10288637B2
公开(公告)日：2019-05-14
申请号：US15310808
申请日：2015-04-22
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Hideto Tamezane , Isao Yamazaki , Masaharu Nishida , Kumiko Kamihara
Abstract: A pressure signal process unit acquires data under a predetermined condition and a statistic distance between the acquired data and determination-purpose reference data stored in a storage unit is calculated. It is determined whether or not dispensing is abnormal and whether the determination-purpose reference data is suitable for an abnormality detection function to be properly fulfilled. If the determination-purpose reference data is not suitable for an abnormality detection function to be properly fulfilled, temporary determination-purpose reference data is prepared so as to be compared with the previously acquired data under a predetermined condition. If a difference therebetween is greater than a predetermined threshold value, a possibility that an automatic analyzer may have an abnormal component or that a failure may occur in the automatic analyzer is determined, and the result is transmitted to cause a display device to display an alarm.
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公开(公告)号：US09897624B2
公开(公告)日：2018-02-20
申请号：US14410113
申请日：2013-06-20
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Hideto Tamezane , Isao Yamazaki , Masaharu Nishida , Kumiko Kamihara
CPC classification number: G01N35/1016 , G01N35/00584 , G01N35/00663 , G01N35/1002 , G01N35/1009 , G01N2035/00673 , G01N2035/1018 , G01N2035/1025
Abstract: An automatic analyzer that accurately detects dispensation abnormality in dispensation conditions with small suction quantities has a statistical distance calculation unit that calculates characteristic variables regarding a sucking operation in the first dispensation and calculates a statistical distance D from reference data to the characteristic variables extracted from a memory. A comparison unit compares the statistical distance D with a preset threshold value stored in memory and if the statistical distance D is less than the preset threshold value, the first discharging operation is performed. A controller judges whether a single-handed judgment based on a dispensation quantity condition of the second or subsequent dispensation is possible or not. If the single-handed judgment is impossible, reference data is selected based on a judgment quantity regarding the first dispensation. Whether the sucking operation in the second or subsequent dispensation is normal or abnormal is judged based on the selected reference data.
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公开(公告)号：US09857388B2
公开(公告)日：2018-01-02
申请号：US14763225
申请日：2014-01-27
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Hideto Tamezane , Isao Yamazaki , Masaharu Nishida , Kumiko Kamihara
CPC classification number: G01N35/00623 , G01N35/00871 , G01N35/1002 , G01N35/1016 , G01N2035/00633
Abstract: The dispensing mechanisms dips a dispensing nozzle in a dispensing target contained in a container 11, 21, and 31, aspirates the dispensing target, and discharges the dispensing target to a reaction container 41. One item of determination-purpose reference data is selected from multiple items of the determination-purpose reference data which is stored in a storage unit 93 and used in determining whether or not the dispensing mechanisms 50, 60, and 70 are abnormal, based on the detection result from a pressure sensor 54 when the dispensing mechanisms 50, 60, and 70 dispense a reference dispensing target configured to contain a known ingredient; and whether or not the dispensing mechanisms 50, 60, and 70 are abnormal is determined, based on the detection result from the pressure sensor 54 and the selected determination-purpose reference data when the dispensing mechanisms 50, 60, and 70 dispense a dispensing target used in analysis.
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公开(公告)号：US09335335B2
公开(公告)日：2016-05-10
申请号：US14422278
申请日：2013-07-11
Applicant: Hitachi High-Technologies Corporation
Inventor： Tomonori Mimura , Kumiko Kamihara , Isao Yamazaki , Hideto Tamezane
CPC classification number: G01N35/00623 , G01N35/00871 , G01N35/1016 , G01N2035/00891 , G01N2035/1018 , Y10T436/11
Abstract: Provided is an automatic analyzer capable of detecting not only clogging and air suction of the dispensation probe but also a decrease in the dispensation quantity caused by a bubble film, air bubbles or a highly viscous sample. Each of a sample/reagent suction operation time and a sample/reagent discharge operation time of a probe is segmented into multiple time sections. For each of the time sections determined by the segmentation, a parameter is calculated by applying a detected pressure waveform to an approximation formula. For each of the time section, the presence/absence of a dispensation abnormality is judged by comparing the calculated parameter with a parameter in cases of normal dispensation. An automatic analyzer capable of judging the presence/absence of an abnormality specific to each time section and making abnormality judgments difficult for conventional techniques can be realized.
Abstract translation: 本发明提供一种能够不仅检测分注用探针的堵塞和吸气的自动分析装置，还能够检测由气泡膜，气泡或高粘度样品引起的分配量的降低。 探针的样品/试剂抽吸操作时间和样品/试剂放电操作时间分别被分割成多个时间段。 对于通过分割确定的每个时间段，通过将检测到的压力波形应用于近似公式来计算参数。 对于每个时间段，通过将计算出的参数与正常分配情况下的参数进行比较来判断分配异常的存在/不存在。 可以实现能够判断各时间段特有的异常的有无的自动分析装置，并且可以实现常规技术难以进行异常判断。
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公开(公告)号：US10786835B2
公开(公告)日：2020-09-29
申请号：US15580910
申请日：2016-06-27
Applicant: Hitachi High-Technologies Corporation
Inventor： Yosuke Horie , Tomohiro Inoue , Takamichi Mori , Kouhei Nonaka , Masato Ishizawa , Isao Yamazaki , Hitoshi Tokieda , Akihiro Nojima
Abstract: An ultrasonic cleaner according to the present invention includes a vibrating part 222 for enlarging ultrasonic vibration of a BLT 100 on a side surface side in a cleaning tank 211, generates cavitation by the ultrasonic vibration with respect to cleaning liquid supplied into the cleaning tank 211 by driving the BLT 100 on the periphery of a nozzle without unevenness, and is capable of performing effective nozzle cleaning.
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