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54 条记录 (耗时 0.051 秒)

    Cell having modified cell membrane
    11.
    发明授权
    Cell having modified cell membrane 有权
    细胞具有改变的细胞膜

    公开(公告)号：US07198945B2

    公开(公告)日：2007-04-03

    申请号：US10211587

    申请日：2002-08-05

    申请人： Teruyuki Nagamune ,  Chika Itoh ,  Tohru Yasukohchi ,  Syunsuke Ohhashi ,  Kazuhiro Kubo

    发明人： Teruyuki Nagamune ,  Chika Itoh ,  Tohru Yasukohchi ,  Syunsuke Ohhashi ,  Kazuhiro Kubo

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0006

    摘要： A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).

    摘要翻译： 其中待修饰物质和两亲性化合物的反应产物与细胞膜非共价结合的细胞，其中所述化合物具有以下特征

    Counter weight
    12.
    发明授权
    Counter weight 有权
    配重

    公开(公告)号：US07147250B2

    公开(公告)日：2006-12-12

    申请号：US10769983

    申请日：2004-02-03

    申请人： Kazuhiro Kubo ,  Masatoshi Kajiya ,  Morihiko Kawahashi

    发明人： Kazuhiro Kubo ,  Masatoshi Kajiya ,  Morihiko Kawahashi

    IPC分类号： B60R21/00

    CPC分类号： B66C23/74 ,  B62D49/085 ,  E02F9/18

    摘要： To provide a counter weight capable of forming an attaching part to a vehicle frame with high precision, capable of improving attaching precision to this vehicle frame, and further, capable of decreasing a manufacture cost thereof. The counter weight includes a base made of cast iron having an attaching part, whereby the counter weight is attached to a vehicle frame; and a weight part made of a slab material having a block body made of a slab material; wherein the weight part made of the slab material is attached on the above-described base made of cast iron. The outer surface of the above-described weight part made of the slab material is coated with the cover. In addition, the connection plate is attached to the above-described base made of cast iron, the lower end edge of the above-described cover is joined to the base made of cast iron through the above-described connection plate, and the upper end edge of the above-described cover is joined to the upper part of the above-described weight part made of the slab material. Since the base made of cast iron is attached to the vehicle frame, it is possible to form the attaching part to the vehicle frame at a low cost, simply, and with high precession.

    摘要翻译： 为了提供能够高精度地形成车架的安装部的配重，能够提高该车架的安装精度，并且还能够降低制造成本。 配重包括由铸铁制成的基座，该基座具有安装部，由此将配重安装在车架上; 以及由具有由坯料制成的块体的板坯材料制成的重量部件; 其特征在于，由所述板坯材料构成的所述重量部分安装在上述由铸铁制成的基座上。 由板坯材料制成的上述重量部分的外表面涂覆有盖。 另外，连接板安装在上述由铸铁制成的基座上，上述盖的下端缘通过上述连接板与铸铁底座接合，上端 上述盖的边缘连接到由板坯材料制成的上述重量部分的上部。 由于将铸铁制成的基座安装在车架上，所以能够以低成本，简单且高进动地将安装部件形成在车架上。

    Fungal inhibiting composition comprising Bacillus subtilis FERM BP-3418
    13.
    发明授权
    Fungal inhibiting composition comprising Bacillus subtilis FERM BP-3418 失效
    包含枯草芽孢杆菌FERM BP-3418的真菌抑制组合物

    公开(公告)号：US5667779A

    公开(公告)日：1997-09-16

    申请号：US660235

    申请日：1996-06-07

    申请人： Kazuhiro Kubo

    发明人： Kazuhiro Kubo

    IPC分类号： A01N63/00 ,  A23K1/00 ,  A23K1/18 ,  C12N1/20

    CPC分类号： C12R1/10 ,  A01N63/00 ,  A23K10/18 ,  A23K50/30 ,  C12R1/125 ,  Y10S426/807 ,  Y10S435/822 ,  Y10S435/839

    摘要： A bacterium belonging to Bacillus subtilis and having aflatoxin decomposing ability, as well as a fungal growth inhibitor, fermentation promoter and livestock fattening agent, all containing the bacterium as an active or effective ingredient. The Bacillus subtilis is strain FERM BP-3418. Also disclosed are methods for inhibiting or controlling a pathogenic fungus on a plant or animal.

    摘要翻译： 属于枯草芽孢杆菌的具有黄曲霉毒素分解能力的细菌，以及真菌生长抑制剂，发酵促进剂和家畜育肥剂，均含有细菌作为活性成分或有效成分。 枯草芽孢杆菌是菌株FERM BP-3418。 还公开了用于抑制或控制植物或动物上的病原真菌的方法。

    Hypotensive piperidine derivatives
    15.
    发明授权
    Hypotensive piperidine derivatives 失效
    低血压哌啶衍生物

    公开(公告)号：US4446141A

    公开(公告)日：1984-05-01

    申请号：US191339

    申请日：1980-02-02

    申请人： Nobuhiro Nakamizo ,  Hiroyuki Obase ,  Kazuhiro Kubo ,  Yutaka Kasuya

    发明人： Nobuhiro Nakamizo ,  Hiroyuki Obase ,  Kazuhiro Kubo ,  Yutaka Kasuya

    IPC分类号： A61K31/41 ,  A61P9/12 ,  C07D401/04 ,  C07D405/14 ,  A61K31/445

    CPC分类号： C07D401/04 ,  C07D405/14

    摘要： The present invention relates to a novel compound represented by the general formula: ##STR1## wherein Ar represents a naphthyl, phenyl or substituted phenyl group, Q represents ##STR2## wherein R.sub.1 represents a hydrogen atom, or an alkyl, alkanoyl or alkoxycarbonyl group, R represents a hydrogen atom or an alkyl group, and Z represents a substituted benzimidazolinyl group; the broken line in piperidine ring means that 3,4-positions in the piperidine ring are saturated or form a double bond. Said compound and the pharmaceutically acceptable acid addition salts thereof have a hypotensive action and therefore are useful as medicine.

    摘要翻译： PCT No.PCT / JP79 / 00141 Sec。 371日期1980年2月2日 102（e）日期1980年1月31日PCT申请日1979年6月1日PCT公布。 出版物WO80 / 1980年1月10日。本发明涉及以下通式表示的新化合物：其中Ar表示萘基，苯基或取代苯基，Q表示其中R1表示氢原子，或 烷基，烷酰基或烷氧基羰基，R表示氢原子或烷基，Z表示取代的苯并咪唑啉基; 哌啶环中的虚线表示哌啶环中的3,4-位饱和或形成双键。 所述化合物及其药学上可接受的酸加成盐具有降血压作用，因此可用作药物。

    Hypotensive piperidine derivatives
    16.
    发明授权
    Hypotensive piperidine derivatives 失效
    低血压哌啶衍生物

    公开(公告)号：US4410528A

    公开(公告)日：1983-10-18

    申请号：US264810

    申请日：1981-05-18

    申请人： Masayuki Teranishi ,  Hiroyuki Obase ,  Nobuhiro Nakamizo ,  Kazuhiro Kubo ,  Yutaka Kasuya

    发明人： Masayuki Teranishi ,  Hiroyuki Obase ,  Nobuhiro Nakamizo ,  Kazuhiro Kubo ,  Yutaka Kasuya

    IPC分类号： C07D211/58 ,  A61K31/505 ,  C07D401/04

    CPC分类号： C07D211/58

    摘要： A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R.sub.1 is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); (A).sub.m and R.sub.2 are usually used substituents; and Y is a monovalent group or a divalent group and is one of the following three groups: ##STR2## wherein when p is 0, B is --N.dbd.N--, ##STR3## and when p is 1, B is ##STR4## wherein (R.sub.3).sub.n is a usually used substituent, has hypotensive activity.

    摘要翻译： 由下式表示的新的哌啶衍生物：其中X是氧，硫，羰基，羟基亚甲基或亚甲基; R1是具有或不具有低级烷基取代基的具有1-4个碳原子的直链亚烷基; （A）m和R 2通常是取代基; （1）其中当p为0时，B为-N = N-，，当p为1时，B为 （3）其中（R3）n是通常使用的取代基，具有降血压作用。

    Method for producing biodegradable polyoxyalkylene derivative
    17.
    发明授权
    Method for producing biodegradable polyoxyalkylene derivative 有权
    生产可降解聚氧化烯衍生物的方法

    公开(公告)号：US08557929B2

    公开(公告)日：2013-10-15

    申请号：US11863977

    申请日：2007-09-28

    申请人： Kazuhiro Kubo ,  Shigeru Kitano ,  Chika Ito

    发明人： Kazuhiro Kubo ,  Shigeru Kitano ,  Chika Ito

    IPC分类号： C08F4/46 ,  C08G65/329

    CPC分类号： C08L71/02 ,  C08L2205/05 ,  C08L2666/18

    摘要： A method for producing a biodegradable polyoxyalkylene derivative, includes: reacting a biodegradable polyoxyalkylene compound represented by the formula (1) as defined herein with a compound represented by one of the formulae (I) to (IV) as defined herein in a presence of an alkaline solid salt, the biodegradable polyoxyalkylene derivative being represented by the formula (2) as defined herein.

    摘要翻译： 一种可生物降解的聚氧化烯衍生物的制造方法，其特征在于，包括：使如本文所定义的式（1）表示的生物可降解聚氧化烯化合物与本文所定义的式（I）〜（IV）之一所表示的化合物在 碱性固体盐，可生物降解的聚氧化烯衍生物由如本文所定义的式（2）表示。

    Phospholipid derivative
    19.
    发明授权
    Phospholipid derivative 有权
    磷脂衍生物

    公开(公告)号：US07399877B2

    公开(公告)日：2008-07-15

    申请号：US10549630

    申请日：2004-03-19

    申请人： Chika Itoh ,  Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Takahashi ,  Hitoshi Yamauchi

    发明人： Chika Itoh ,  Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Takahashi ,  Hitoshi Yamauchi

    IPC分类号： C07F9/02

    CPC分类号： A61K9/127 ,  C07F9/10 ,  C11D1/345

    摘要： A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome

    摘要翻译： 由下式（I）表示的磷脂衍生物，其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数， 符号“b”表示0或1，条件是当a为0时，b为0; X表示氢原子，碱金属原子，铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基，其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m，n和q满足以下条件：5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /（m + n + q）和q /（m + n + q）<= 0.8，这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳，从而增加稳定性 的脂质体