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    Binding molecules and computer-based methods of increasing the binding affinity thereof
    13.
    发明授权
    Binding molecules and computer-based methods of increasing the binding affinity thereof 失效
    结合分子和基于计算机的增加其结合亲和力的方法

    公开(公告)号：US6127524A

    公开(公告)日：2000-10-03

    申请号：US732708

    申请日：1996-10-18

    申请人： Clayton L. Casipit ,  Hing C. Wong ,  Bee Y. Huang

    发明人： Clayton L. Casipit ,  Hing C. Wong ,  Bee Y. Huang

    IPC分类号： G01N33/566 ,  C07K16/00 ,  C07K16/36 ,  C12N15/09 ,  G06F17/30 ,  A61K39/395

    CPC分类号： C07K16/36 ,  C07K16/00 ,  C07K2319/00

    摘要： The present invention features novel binding molecules and methods of improving the specific binding affinity of binding molecules, which methods do not use X-ray crystallography. For example, in one aspect, the invention features methods of making antibodies with improved specific binding affinity for a polypeptide produced during prothrombin activation. The present invention is useful for a variety of applications including, e.g., producing binding molecules with improved binding affinity; and screening for binding molecules which are in low abundance.

    摘要翻译： 本发明的特征在于新颖的结合分子和改善结合分子的特异性结合亲和力的方法，该方法不使用X射线晶体学。 例如，在一个方面，本发明的特征在于制备抗体对凝血酶原激活期间产生的多肽具有改善的特异性结合亲和力的方法。 本发明可用于多种应用，包括例如产生具有改善的结合亲和力的结合分子; 并筛选低丰度的结合分子。

    ANTIBODIES FOR INHIBITING BLOOD COAGULATION AND METHODS OF USE THEREOF
    18.
    发明申请
    ANTIBODIES FOR INHIBITING BLOOD COAGULATION AND METHODS OF USE THEREOF 有权
    用于抑制血液凝聚的抗体及其使用方法

    公开(公告)号：US20090252726A1

    公开(公告)日：2009-10-08

    申请号：US12404256

    申请日：2009-03-13

    申请人： Jin-an JIAO ,  Hing C. Wong ,  Esperanza Liliana Nieves ,  Luis A. Mosquera

    发明人： Jin-an JIAO ,  Hing C. Wong ,  Esperanza Liliana Nieves ,  Luis A. Mosquera

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C12P21/02 ,  A61P7/02

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K16/467 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF.

    摘要翻译： 本发明包括通过以高亲和力和特异性结合天然人TF而提供优异的抗凝血活性的抗体。 本发明的抗体可有效抑制体内血液凝固。 本发明的抗体可以单独或存在于TF：FVIIa复合物中的天然人TF结合，有效地防止因子X或FIX与TF或该复合物的结合，从而减少血液凝固。 本发明优选的抗体特异性结合主要为天然人TF的构象表位，该表位提供意想不到的强抗体结合位点。 还提供了结合TF的人源化抗体及其片段。