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    SEQUENCING KITS
    11.
    发明申请
    SEQUENCING KITS 有权

    公开(公告)号：US20230063675A1

    公开(公告)日：2023-03-02

    申请号：US17978130

    申请日：2022-10-31

    Applicant: ILLUMINA, INC.

    Inventor： Xi-Jun Chen ,  Yir-Shyuan Wu ,  Tarun Kumar Khurana ,  Liangliang Qiang ,  Andrew J. Price ,  Elisabet Rosas

    IPC: C12Q1/6874 ,  C12N15/10

    Abstract: An example of a sequencing kit includes a flow cell and an encapsulation matrix precursor composition. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid and a polymer selected from the group consisting of agar, agarose, alginate, heparin, alginate sulfate, dextran sulfate, hyaluronan, pectin, carrageenan, gelatin, chitosan, cellulose, a collagen polymer, and combinations thereof.

    OBTAINING INFORMATION FROM A BIOLOGICAL SAMPLE IN A FLOW CELL
    12.
    发明申请
    OBTAINING INFORMATION FROM A BIOLOGICAL SAMPLE IN A FLOW CELL 有权

    公开(公告)号：US20210116436A1

    公开(公告)日：2021-04-22

    申请号：US17254473

    申请日：2020-05-26

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Xi-Jun Chen

    IPC: G01N33/483 ,  G01N33/50 ,  G01N33/53

    Abstract: Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.

    SEQUENCING KITS
    13.
    发明申请
    SEQUENCING KITS 审中-公开

    公开(公告)号：US20200239954A1

    公开(公告)日：2020-07-30

    申请号：US16750897

    申请日：2020-01-23

    Applicant: ILLUMINA, INC.

    Inventor： Xi-Jun Chen ,  Yir-Shyuan Wu ,  Tarun Kumar Khurana ,  Liangliang Qiang ,  Andrew J. Price ,  Elisabet Rosas

    IPC: C12Q1/6874 ,  C12N15/10

    Abstract: An example of a sequencing kit includes a flow cell, an encapsulation matrix precursor composition, and a radical initiator. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid, a monomer or polymer including a radical generating and chain elongating functional group, a radical source, and a crosslinker. The radical initiator is part of the encapsulation matrix precursor composition or is a separate component.

    OBTAINING INFORMATION FROM A BIOLOGICAL SAMPLE IN A FLOW CELL
    16.
    发明申请
    OBTAINING INFORMATION FROM A BIOLOGICAL SAMPLE IN A FLOW CELL 有权

    公开(公告)号：US20210405019A1

    公开(公告)日：2021-12-30

    申请号：US17470228

    申请日：2021-09-09

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Xi-Jun Chen

    IPC: G01N33/483 ,  G01N33/50 ,  G01N33/53

    Abstract: Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.

    SYSTEMS AND METHODS FOR INFORMATION STORAGE AND RETRIEVAL USING FLOW CELLS
    17.
    发明申请
    SYSTEMS AND METHODS FOR INFORMATION STORAGE AND RETRIEVAL USING FLOW CELLS 有权

    公开(公告)号：US20210147833A1

    公开(公告)日：2021-05-20

    申请号：US17254470

    申请日：2020-05-26

    Applicant: ILLUMINA, INC.

    Inventor： Yir-Shyuan Wu ,  Amirali Kia ,  Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Xi-Jun Chen

    IPC: C12N15/10 ,  C12Q1/6874

    Abstract: A method includes grafting oligonucleotides to a flow cell and preparing a library of polynucleotides. Each polynucleotide has been written to contain retrievable information and includes a region complementary to one of the sequencing initiation primers grafted to the flow cell. Each polynucleotide is indexed to permit discrete identification of that polynucleotide and the information it contains over other polynucleotides in the library. Another method includes writing two polynucleotides including two sequences with reverse complementary joining sequences onto a flow cell. One of the polynucleotides is extended to generate a third polynucleotide comprising a sequence that is the combination of the first and second sequences. A fourth polynucleotide is written with a third joining sequence of a fourth sequence. The third joining sequence is a reverse complement of a portion of the third polynucleotide comprising the third sequence and forming a second joining bridge between the third and fourth polynucleotides.

    Spatial Indexing of Genetic Material and Library Preparation Using Hydrogel Beads and Flow Cells
    18.
    发明申请
    Spatial Indexing of Genetic Material and Library Preparation Using Hydrogel Beads and Flow Cells 审中-公开

    公开(公告)号：US20200216895A1

    公开(公告)日：2020-07-09

    申请号：US16626115

    申请日：2018-07-31

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Kumar Khurana ,  Yir-Shyuan Wu ,  Xi-Jun Chen ,  Filiz Gorpe-Yasar ,  Yan-You Lin ,  Victoria Popic ,  Erich B. Jaeger ,  Mostafa Ronaghi

    IPC: C12Q1/6874 ,  C12Q1/6813

    Abstract: Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence reads from individual sequencing libraries to increase efficiency of subsequent data analysis. In some examples, hydrogel beads containing encapsulated sequencing libraries are captured on a sequencing flow cell and degraded in the presence of a liquid diffusion barrier to allow for the spatial segregation and seeding of the sequencing libraries on the surface of the flow cell. Additionally, examples of systems, methods and compositions are provided relating to flow cell devices configured for nucleic acid library preparation and single cell sequencing. Some examples include flow cell devices having a hydrogel with genetic material disposed therein, and which is retained within the hydrogel during nucleic acid processing.

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