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    Analyte detection system
    11.
    发明申请
    Analyte detection system 审中-公开
    分析物检测系统

    公开(公告)号：US20050037384A1

    公开(公告)日：2005-02-17

    申请号：US10824946

    申请日：2004-04-15

    申请人： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

    发明人： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

    IPC分类号： G01N21/03 ,  G01N21/35 ,  G01N21/86 ,  C12Q1/68 ,  C12M1/34

    CPC分类号： G01N21/8483 ,  G01N21/0303 ,  G01N21/35 ,  G01N21/3577

    摘要： Disclosed herein is a system for estimating the concentration of an analyte in a material sample. The system comprises a source of electromagnetic radiation; a detector positioned to detect radiation emitted by the source, so that the source and the detector define an optical path therebetween; and a sample element configured to be positioned in the optical path. The sample element comprises a sample chamber at least partially defined by opposed first and second windows which are substantially transmissive of at least a portion of the radiation emitted by the source, and which define an optical pathlength through the sample element. The sample chamber has an internal volume of less than 2 microliters. When the material sample is positioned in the sample chamber and the sample chamber is positioned in the optical path, the system computes estimated concentrations of the analyte in the material sample. The estimated concentrations deviate from corresponding actual concentrations of the analyte in the material sample by an RMS error of less than 15 mg/dL.

    摘要翻译： 本文公开了一种用于估计材料样品中分析物浓度的系统。 该系统包括电磁辐射源; 检测器，定位成检测由源发射的辐射，使得源和检测器在其间限定光路; 以及构造成定位在光路中的样本元件。 样品元件包括至少部分地由相对的第一和第二窗口限定的样品室，其基本上透射由源发射的辐射的至少一部分，并且通过样品元件限定光程长度。 样品室的体积小于2微升。 当材料样品定位在样品室中并且样品室位于光路中时，系统计算材料样品中分析物的估计浓度。 估计的浓度偏离材料样品中分析物的相应实际浓度，RMS误差小于15 mg / dL。

    Analyte detection system for multiple analytes
    13.
    发明申请
    Analyte detection system for multiple analytes 有权
    多种分析物的分析物检测系统

    公开(公告)号：US20060189858A1

    公开(公告)日：2006-08-24

    申请号：US11314176

    申请日：2005-12-21

    申请人： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    发明人： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    IPC分类号： A61B5/00 ,  A61M31/00

    CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

    摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.

    摘要翻译： 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。 在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

    Apparatus and methods for analyzing body fluid samples
    15.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20070060872A1

    公开(公告)日：2007-03-15

    申请号：US11352956

    申请日：2006-02-13

    申请人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00 ,  A61B5/00 ,  A61D5/00

    CPC分类号： A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Apparatus and methods for analyzing body fluid samples
    16.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20060189926A1

    公开(公告)日：2006-08-24

    申请号：US11316407

    申请日：2005-12-21

    申请人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00 ,  A61B5/00

    CPC分类号： A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength B. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Analyte detection system with periodic sample draw and body fluid analyzer
    17.
    发明申请
    Analyte detection system with periodic sample draw and body fluid analyzer 审中-公开
    分析物检测系统，定期抽样和体液分析仪

    公开(公告)号：US20070179435A1

    公开(公告)日：2007-08-02

    申请号：US11316212

    申请日：2005-12-21

    申请人： James Braig ,  Peter Rule

    发明人： James Braig ,  Peter Rule

    IPC分类号： A61M31/00 ,  G01N33/487 ,  A61B5/00

    CPC分类号： A61B5/1486 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B2562/0295 ,  A61M5/14232 ,  A61M2005/1726 ,  A61M2230/201 ,  G01N27/3271 ,  G01N33/49

    摘要： An embodiment of a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.

    摘要翻译： 用于分析患者体液的系统的实施例包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。 泵系统耦合到流体输送网络。 泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体 运输网络通过病人端。 至少一个电化学测试元件位于流体输送网络的流体输送点附近。 电化学测试元件被定位成接收由流体输送网络输送到输送点的体液的一部分。 分析物检测系统被配置为接收测试元件并测量体液部分中的至少一种分析物。

    Near-patient module for analyte detection system
    19.
    发明申请
    Near-patient module for analyte detection system 审中-公开
    用于分析物检测系统的近距离模块

    公开(公告)号：US20070082342A1

    公开(公告)日：2007-04-12

    申请号：US11316681

    申请日：2005-12-21

    申请人： James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： A61B5/14546 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M2230/20 ,  G01N35/1095

    摘要： In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The at least one pump has an infusion mode in which the pump is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further includes an analyte detection system accessible via the first fluid passageway such that the analyte detection system can receive at least one component of the drawn sample of bodily fluid and determine a concentration of at least one analyte. The analyte detection system is spaced from the patient end of the first fluid passageway. The apparatus further includes a fluid sensor located at or near the patient end of the first fluid passageway and spaced from the analyte detection system. The fluid sensor is configured to sense a property of a fluid within the first fluid passageway.

    摘要翻译： 在某些实施例中，用于分析体液组成的装置包括具有患者端的第一流体通道，该患者端构造成提供与患者体内的体液的流体连通。 该装置还包括耦合到第一流体通道的至少一个泵。 所述至少一个泵具有输注模式，其中所述泵可操作以通过患者端向患者输送输注流体，以及抽样模式，其中所述泵可操作以从患者抽取体液样本通过 病人结束 该装置还包括可经由第一流体通道接近的分析物检测系统，使得分析物检测系统可以接收抽取的体液样本的至少一个组分并确定至少一种分析物的浓度。 分析物检测系统与第一流体通道的患者端隔开。 该装置还包括位于第一流体通道的患者端处或附近的流体传感器，并与分析物检测系统间隔开。 流体传感器构造成感测第一流体通道内的流体的性质。

    Methods of treating diabetes
    20.
    发明申请
    Methods of treating diabetes 审中-公开
    治疗糖尿病的方法

    公开(公告)号：US20060253097A1

    公开(公告)日：2006-11-09

    申请号：US11256277

    申请日：2005-10-21

    申请人： James Braig ,  Kenneth Li ,  Peter Rule ,  Richard Keenan

    发明人： James Braig ,  Kenneth Li ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00

    CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61B5/1455

    摘要： A method of treating a diabetic condition of a patient comprises providing a glucose detection system which is portable and usable by the patient, and which is configured to measure glucose levels with a standard error of less than about 30 mg/dL. The method further comprises making a plurality of measurements of the patient's glucose level with the portable, patient-usable glucose detection system. The method further comprises administering a diabetes treatment to the patient based on one or more of the measurements of the patient's glucose level.

    摘要翻译： 一种治疗患者糖尿病状况的方法包括提供可由患者携带和使用的葡萄糖检测系统，其被配置为以小于约30mg / dL的标准误差测量葡萄糖水平。 该方法还包括利用便携式，病人可用的葡萄糖检测系统对患者的葡萄糖水平进行多次测量。 该方法还包括基于对患者血糖水平的一个或多个测量值向患者施用糖尿病治疗。