公开(公告)号：US6138681A

公开(公告)日：2000-10-31

申请号：US949308

申请日：1997-10-13

申请人： James C. Chen ,  Brian D. Wilkerson ,  Darrin Huston

发明人： James C. Chen ,  Brian D. Wilkerson ,  Darrin Huston

IPC分类号： A61B19/00 ,  A61B5/06 ,  A61F2/02 ,  A61N1/378 ,  H02J17/00

CPC分类号： A61B5/06 ,  A61F2250/0001

摘要： The alignment and positioning of an external device relative to an internal device is indicated on a display and/or by an acoustical signal. In the disclosed application, the external device transcutaneously transmits electromagnetic energy to an internal receiver to provide electrical power for an implanted medical device. To ensure optimal coupling between the external transmitter and the internal receiver, two permanent magnets are disposed at spaced-apart positions on the internal receiver. The magnetic field strength of the permanent magnets is sensed by a pair of correspondingly spaced-apart Hall effect sensor on the external transmitter. As the external transmitter is moved about over the internal receiver, the signals produced by the Hall effect sensors drive a display of light emitting diodes (LEDs) that indicates when the maximum magnetic field strength is achieved, i.e., when the Hall effect sensors on the external transmitter are each positioned directly opposite the corresponding permanent magnets on the internal receiver.

摘要翻译： 外部设备相对于内部设备的对准和定位在显示器和/或声学信号上指示。 在所公开的应用中，外部设备经常地将电磁能量传输到内部接收器以为植入的医疗设备提供电力。 为了确保外部发射器和内部接收器之间的最佳耦合，两个永磁体设置在内部接收器上的间隔位置。 永磁体的磁场强度由外部发射器上的一对相应间隔的霍尔效应传感器感测。 当外部发射器在内部接收器上移动时，由霍尔效应传感器产生的信号驱动发光二极管（LED）的显示器，该发光二极管指示何时实现最大磁场强度，即当霍尔效应传感器 外部发射器分别与内部接收器上相应的永久磁铁正好相对。

公开(公告)号：US6096066A

公开(公告)日：2000-08-01

申请号：US151844

申请日：1998-09-11

申请人： James C. Chen ,  Brent Wiscombe

发明人： James C. Chen ,  Brent Wiscombe

IPC分类号： A61N5/06 ,  A61N5/00

CPC分类号： A61N5/062 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A flexible patch provided with a plurality of light sources mounted in spaced-apart array on its undersurface and covered with an optically transparent polymer material. The light sources are energized with an electrical current supplied by a flexible polymer battery, which is preferably rechargeable. Electrical current is conveyed through a lead that extends from the flexible battery to the flexible patch and then through an electrical circuit that includes a plurality of conductive traces formed using a conductive ink applied to the surface of a flexible substrate that supports the light sources. The thickness of the flexible patch at its maximum is less than 1.0 millimeters. The light sources can be separately grouped, and the electrical current supplied to each group individually controlled to achieve a desired light intensity and/or duration exposure to the light therapy over different portions of the undersurface of the flexible patch and different portions of the treatment site. An adhesive applied to the treatment site on the patient's body or on the undersurface of the flexible patch is used to mount the flexible patch to the treatment site. A plurality of slots that extend through the flexible substrate provide passages for air and moisture and enable the flexible substrate to freely and more readily conform to irregular, non-planar shapes of the treatment site. The flexible substrate can also be adhesively secured to a non-planar surface within a patient's body to render the light therapy internally.

摘要翻译： 柔性贴片，其设置有多个光源，其间隔开地阵列安装在其下表面上，并被光学透明的聚合物材料覆盖。 光源由柔性聚合物电池提供的电流通电，柔性聚合物电池优选是可再充电的。 电流通过从柔性电池延伸到柔性贴片的引线传送，然后通过包括使用施加到支撑光源的柔性基板的表面的导电油墨形成的多个导电迹线的电路传送。 柔性贴片最大厚度小于1.0毫米。 光源可以分开分组，并且提供给每个组的电流被单独控制以实现对柔性贴片的下表面的不同部分和处理部位的不同部分的光疗的期望的光强度和/或持续时间 。 使用施加到患者身体或柔性贴片的下表面上的治疗部位的粘合剂将柔性贴片安装到治疗部位。 延伸穿过柔性基底的多个槽提供用于空气和湿气的通道，并且使得柔性基底能够自由地且更容易地符合治疗部位的不规则的非平面形状。 柔性基底还可以粘合地固定到患者体内的非平面表面以在内部进行光疗。

公开(公告)号：US3933588A

公开(公告)日：1976-01-20

申请号：US499818

申请日：1974-08-23

申请人： Robert G. Dworschack ,  William H. White ,  James C. Chen

发明人： Robert G. Dworschack ,  William H. White ,  James C. Chen

IPC分类号： C12N9/44 ,  C12N9/96 ,  C12N11/10 ,  C07G7/02

CPC分类号： C12N11/10 ,  C12N9/2414 ,  C12N9/2451 ,  C12N9/2457 ,  C12N9/96 ,  C12Y302/01041

摘要： Upon storage, the activity of immobilized enzymes slowly decreases in the presence of moisture. This decrease in activity can be reduced by a significant extent by treating the immobilized enzymes in the presence of moisture with a long chain quaternary ammonium compound.

公开(公告)号：US08685005B2

公开(公告)日：2014-04-01

申请号：US12445061

申请日：2007-10-11

申请人： Jonathan S. Dahm ,  William Louis Barnard ,  James C. Chen ,  David B. Shine

发明人： Jonathan S. Dahm ,  William Louis Barnard ,  James C. Chen ,  David B. Shine

IPC分类号： A61B18/18 ,  A61N5/06 ,  A61B19/00 ,  A61N1/30

CPC分类号： A61N5/062 ,  A61B18/24 ,  A61N5/0601 ,  A61N2005/0652

摘要： A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.

摘要翻译： 向患者提供光治疗的光递送系统包括具有多个光源的导管组件，所述多个光源向患者内的目标部位透射光。 在一个实施例中，光输送系统具有安装到柔性透明基底的多个光源，其至少部分延伸穿过导管组件的远端。 光源可以引线键合或以倒装芯片布置安装在基座上。 在产生远端的一个实施例中，光能源阵列可以由固定装置的支架阵列保持。 施加真空以将每个光能源固定在相应的支架中。 当施加真空时，能量源通过引线接合电连接。 可以减少或停止真空，从而允许从固定装置移除光能源。

公开(公告)号：US20120149986A1

公开(公告)日：2012-06-14

申请号：US13401747

申请日：2012-02-21

申请人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichtlenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick YEO ,  Hugh Narciso

发明人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichtlenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick YEO ,  Hugh Narciso

IPC分类号： A61B1/06

CPC分类号： A61N5/062 ,  A61N2005/0652

摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：US08057464B2

公开(公告)日：2011-11-15

申请号：US11416783

申请日：2006-05-03

申请人： James C. Chen ,  Steven R. Daly ,  Zihong Guo ,  Llew Keltner ,  Jeffrey R. Storm

发明人： James C. Chen ,  Steven R. Daly ,  Zihong Guo ,  Llew Keltner ,  Jeffrey R. Storm

IPC分类号： A61B18/18

CPC分类号： A61N5/062 ,  A61B50/30 ,  A61N5/0601 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.

摘要翻译： 向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。 集成光导管和控制模块与光活化药物组合使用。 所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。 防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。 为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

公开(公告)号：US20110236402A1

公开(公告)日：2011-09-29

申请号：US13154156

申请日：2011-06-06

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： A61K41/0038 ,  A61K2039/545 ,  A61N5/06 ,  C07K16/2818

摘要： The efficacy of light activated therapy treatment is enhanced by stimulating the immune system of the patient substantially above a normal level. Abnormal tissue that is destroyed by the light activated therapy releases factors that stimulate the immune system, leading to systemic reductions in abnormal tissue (i.e., reduction beyond the region treated using light). By further stimulating the immune system using an anti-CTLA-4 antibody, the systemic destruction of abnormal tissue is enhanced.

摘要翻译： 通过刺激患者的免疫系统显着高于正常水平，提高了光活化治疗的疗效。 由光活化治疗破坏的异常组织释放刺激免疫系统的因素，导致异常组织的系统性减少（即，减少超过使用光治疗的区域）。 通过使用抗CTLA-4抗体进一步刺激免疫系统，增强了异常组织的系统性破坏。

公开(公告)号：US20110077464A1

公开(公告)日：2011-03-31

申请号：US12890480

申请日：2010-09-24

申请人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61B1/06

CPC分类号： A61N5/062 ,  A61N2005/0652

摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：US20100121252A1

公开(公告)日：2010-05-13

申请号：US12522375

申请日：2008-01-08

申请人： Llew Keltner ,  James C. Chen

发明人： Llew Keltner ,  James C. Chen

IPC分类号： A61M35/00

CPC分类号： A61N5/062 ,  A61B18/203 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2090/0436 ,  A61B2090/049 ,  A61N5/0616 ,  A61N2005/0645 ,  A61N2005/0652

摘要： An energy treatment system to treat a patient includes an energy delivery device having a plurality of energy emitters used in combination with an energy activatable drug. A mask can be used to define a treatment area. Energy from the energy emitters passes through an optical window of the mask to activate a cosmetically and/or therapeutically effective amount of the activatable drug at the target site to bring about a desired change of tissue, for example, to reduce visibility of one or more blood vessels, while energy from the energy emitters directed outside of the target site is blocked by the mask.

摘要翻译： 用于治疗患者的能量治疗系统包括具有与能量可激活药物组合使用的多个能量发射器的能量输送装置。 面罩可用于定义治疗区域。 来自能量发射器的能量通过掩模的光学窗口，以在目标位置激活美容和/或治疗有效量的可激活药物，以产生组织的期望变化，例如降低一个或多个 而来自引导到目标部位外部的能量发射器的能量被掩模阻挡。

公开(公告)号：US07117118B2

公开(公告)日：2006-10-03

申请号：US10911904

申请日：2004-08-04

申请人： Matthew J. Kalos ,  Michael T. Benhase ,  James C. Chen ,  Patricia C. Lu

发明人： Matthew J. Kalos ,  Michael T. Benhase ,  James C. Chen ,  Patricia C. Lu

IPC分类号： G06F15/00 ,  G06F17/18 ,  G06F19/00

CPC分类号： G06F11/3409 ,  G06F3/0605 ,  G06F3/0653 ,  G06F3/067 ,  G06F11/3485 ,  G06F2201/88

摘要： Computer networks are provided with a resource efficient ability to generate link performance statistics. Two counters accumulates the number of I/O operations processed by a link and the time required by the link to complete each I/O operation. The average link utilization per I/O operation may then be calculated. The number of operations per second for a link may be computed by dividing the output from the first counter by a predetermined period of time and the average number of operations using the link may be computed by dividing the output from the second counter by the predetermined period of time. An optional third counter may be employed to accumulate the number of bytes transferred by a link during each I/O operation and used to compute the average size of an I/O operation. The generated statistics are useful for such activities as problem resolution, load balancing and capacity planning.

摘要翻译： 计算机网络具有生成链路性能统计资源的资源有效能力。 两个计数器累加链接处理的I / O操作的数量以及链接完成每个I / O操作所需的时间。 然后可以计算每个I / O操作的平均链路利用率。 可以通过将来自第一计数器的输出除以预定时间段来计算链路每秒的操作次数，并且可以通过将来自第二计数器的输出除以预定周期来计算使用该链路的平均操作次数 的时间。 可以使用可选的第三计数器来累积每个I / O操作期间由链路传送的字节数，并用于计算I / O操作的平均大小。 生成的统计信息对于解决问题，负载平衡和容量规划等活动非常有用。