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公开(公告)号：US5953126A
公开(公告)日：1999-09-14
申请号：US893329
申请日：1997-07-16
Applicant: James M. Zavislan
Inventor： James M. Zavislan
Abstract: A scanning reflection profilometry system utilizes an objective lens which focuses a beam at the surface under test and measures the profile of the surface (its height variations) in accordance with the amount of defocus of the reflected beam. Surface profile distortion which is focus dependent is reduced through the use of a transparent mask over the aperture of the lens in the path of the beam which is incident on and reflected from the surface under test and which covers a portion but not all of the aperture. A photodetector upon which the reflected beam is incident provides output signals representing the change in profile. The system has height sensitivity characteristic of a small spot size on the surface without signal distortion attributable to the diffraction anomalies associated with small spot sizes. A microprofilometer head having the objective lens and other optics is mounted on flexures and driven to execute reciprocal movement so as to scan the surface under test.
Abstract translation: 扫描反射轮廓测量系统利用将光束聚焦在被测表面处的物镜，并根据反射光束的散焦量来测量表面的轮廓（其高度变化）。 聚焦依赖的表面轮廓畸变通过在入射到被测表面上并从被测表面反射并且覆盖一部分而不是全部孔的光束的路径中在透镜的孔径上使用透明掩模来减少 。 反射光束入射的光电检测器提供表示轮廓变化的输出信号。 该系统具有在表面上具有小斑点尺寸的高度灵敏度特性，而不会由于与小斑点尺寸相关的衍射异常而引起信号失真。 具有物镜和其他光学元件的微型流影仪头部安装在弯曲部上并被驱动以执行往复运动，以扫描被测试的表面。
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公开(公告)号：US5836877A
公开(公告)日：1998-11-17
申请号：US805045
申请日：1997-02-24
Applicant: James M. Zavislan
Inventor： James M. Zavislan
CPC classification number: A61B5/0059 , A61B5/0068 , G06F19/321 , G06F19/3425 , A61B5/0066 , G06F19/3418 , G06F19/366 , Y10S128/92 , Y10S128/922
Abstract: In order to facilitate pathological examination of a lesion in in-vivo tissue, a system and method are provided having a computer system in which both a camera for producing a digital macroscopic picture of the lesion and an imager are coupled to the computer system. The imager is responsive to the computer system and has optics for scanning the lesion to generate images representing microscopic sections of the lesion which provide sufficient information for pathological examination of the lesion. The computer system generates location information, referencing the location in the macroscopic picture of the lesion where the lesion was scanned to the images, and stores data in an electronic file structure which contains at least a representation of the images, a representation of the macroscopic picture, and the location information. The file structure may then be sent to another computer system for viewing the images stored in the file structure to facilitate pathological examination of the lesion by persons trained to interpret such images, adding a diagnostic report about the lesion to the data of the file structure, and sending back the file structure to the computer system that originated it.
Abstract translation: 为了促进体内组织中的病变的病理学检查，提供了一种具有计算机系统的系统和方法，其中用于产生损伤的数字宏观图像的照相机和成像器都耦合到计算机系统。 成像仪响应于计算机系统并且具有用于扫描病变的光学器件以产生表示病变的微观切片的图像，其提供用于病变的病理检查的足够信息。 计算机系统生成位置信息，将病变被扫描的病变的宏观图像中的位置引用到图像，并且将数据存储在至少包含图像的表示的电子文件结构中，宏观图像的表示 ，以及位置信息。 然后可以将文件结构发送到另一计算机系统，以查看存储在文件结构中的图像，以便训练有素的人解读此类图像的病人对病变的病理检查，将关于病变的诊断报告添加到文件结构的数据， 并将文件结构发送回发起它的计算机系统。
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公开(公告)号：US5788639A
公开(公告)日：1998-08-04
申请号：US650684
申请日：1996-05-20
Applicant: James M. Zavislan , Jay M. Eastman
Inventor： James M. Zavislan , Jay M. Eastman
CPC classification number: A61B5/444 , A61B5/0059 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B2562/146
Abstract: A handheld confocal imaging system for in vivo observation of dermal and subdermal tissue allows diagnosis of conditions substantially beneath the surface of the skin. A confocal head has optics which scan the tissue so as to provide images of vertical sections of the tissue. Both two and three dimensional imaging may be provided for diagnosis and location of basal cell carcinomas and melanomas, and so as to enable visualization of tumor borders prior to excision.
Abstract translation: 用于体内观察皮肤和皮下组织的手持共聚焦成像系统允许诊断基本上在皮肤表面下方的状况。 共焦头具有扫描组织以便提供组织的垂直部分的图像的光学元件。 可以提供二维和三维成像用于诊断和定位基底细胞癌和黑素瘤，并且可以在切除前使肿瘤边界可视化。
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14.发明授权Bar code scanning and reading apparatus and diffractive light collection device suitable for use therein. 失效适用于其中的条形码扫描读取装置和衍射光采集装置。
公开(公告)号：US5714750A
公开(公告)日：1998-02-03
申请号：US320888
申请日：1994-10-05
Applicant: Jay M. Eastman , Anna M. Quinn , Kevin Whitcomb , James M. Zavislan
Inventor： Jay M. Eastman , Anna M. Quinn , Kevin Whitcomb , James M. Zavislan
CPC classification number: G06K7/10881 , G02B26/10 , G02B27/4227 , G06K7/10653 , G06K7/1098 , G06K2007/10524 , G06K2207/1013 , G06K2207/1016
Abstract: A miniature scan engine for scanning a beam of monochromatic (laser) light across a bar code and receiving return light at a detector that provides electrical signals representing the code, utilizes an integral assembly of a laser (laser diode), the detector and a light collector mounted on flexures and rotated so as to scan the beam and receive the return light from the code. The collector is a body of material transmissive at the laser wavelength. The body presents an orientable surface so that the return light is incident at or close to perpendicular to the surface. In the body, parallel to the surface, is a volume hologram grating having Bragg planes arranged in rings around a center region in alignment with the detector. The angles of the Bragg planes vary progressively and decreases in a direction toward the center region so that light incident on the collector at angles of incidence, which vary from perpendicular to the surface by about + or -5.degree., are diffracted and propagate by guided mode propagation, including reflections at the internal surfaces of the body and transmission through the grating (because the light propagating along the paths intersects the grating Bragg planes off Bragg that is at an angle other than the Bragg angle) to the detector. Efficient collection of the light returned from the bar code symbol is obtained. The entire scan engine may occupy a volume of less than 1.25 cubic inch, thereby enabling bar code scanning and reading facilities in devices such as hand-held data collection terminals where space is at a premium.
Abstract translation: 一种用于在条形码上扫描单色（激光）光的微型扫描引擎，并在提供表示代码的电信号的检测器处接收返回光，利用激光（激光二极管），检测器和光的整体组件 收集器安装在弯曲上并旋转，以扫描光束并从代码接收返回光。 收集器是在激光波长下透射的材料体。 身体呈现可定向的表面，使得返回光入射到或接近垂直于表面。 在体内平行于表面，是一种体积全息图光栅，其具有布置在与检测器对准的中心区域周围的环中。 布拉格平面的角度逐渐变化，并且朝向中心区域的方向逐渐变小，从而入射到集电体上的入射角（其垂直于表面变化约+或-5°）入射的光被衍射并通过引导传播 模式传播，包括身体内表面的反射和通过光栅的透射（因为沿着路径传播的光将光栅布拉格平面与布拉格角以外的角度相交）到检测器。 获得从条形码符号返回的光的有效收集。 整个扫描引擎可能占用小于1.25立方英寸的体积，从而使得诸如手持式数据采集终端之类的设备中的条形码扫描和阅读设施是空间有限的。
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公开(公告)号：US5684582A
公开(公告)日：1997-11-04
申请号：US471617
申请日：1995-05-22
Applicant: Jay M. Eastman , James M. Zavislan
Inventor： Jay M. Eastman , James M. Zavislan
CPC classification number: G01J3/50 , G01J3/02 , G01J3/0202 , G01J3/0256 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/06 , G01J3/18 , G01J3/28 , G01J3/502 , G01J3/524 , G01J2003/2866
Abstract: A robust spectrophotometer (also known as a color spectrometer or colorimeter) is self contained in a housing which is adapted to be held-held and has all of the electrical, optical and electro optic elements mounted on a board captured within the housing at one end of which light from a sample is restricted to an object area and projected after being dispersed spectrally, as with a reflection grating, to an image area at a photodetector via a lens which has an optical axis and converges the dispersed light at the image area. The dispersive element is mounted on an arm having a pivot laterally offset from the dispersive element's surface where a diverging beam of light from the object area is incident and is deflected to the image area. The geometry is such that the dispersive element may be rotated to a position where the beam is specularly deflected (zeroth order diffraction), and the spectrometer calibrated when the dispersive element is in the specular reflection/deflection position. The path from the object area is approximately perpendicular to the optical axis, and then is folded by mirrors to direct the beam to incidence on the dispersive element, from which the beam is deflected and focused by the lens, the focal length of which is such that the image and object areas are in conjugate relationship. Radiant or electroluminescent sources, for example, the screen of a CRT monitor, can directly illuminate the object area. A pivotal foot on the housing having an aperture may be used to facilitate alignment of the sample with the entrance opening to the housing of the spectrophotometer.
Abstract translation: 坚固的分光光度计（也称为彩色光谱仪或色度计）被容纳在壳体中，该壳体适于被保持并且具有安装在在一端的壳体内捕获的板上的所有电学，光学和电学光学元件 其中来自样品的光被限制在物体区域，并且如通过反射光栅一样在与光学检测器之间的光学检测器上的像面分散之后被投影，通过具有光轴的透镜并将分散的光会聚在图像区域。 分散元件安装在具有横向偏离分散元件表面的枢轴的臂上，其中来自物体区域的发散光束入射并偏转到图像区域。 几何形状使得色散元件可以旋转到光束被镜面偏转的位置（零级衍射），并且当色散元件处于镜面反射/偏转位置时校准光谱仪。 来自物体区域的路径大致垂直于光轴，然后被反射镜折叠以引导光束入射到色散元件上，光束被透镜偏转和聚焦，其焦距等于 图像和对象区域处于共轭关系。 辐射或电致发光源，例如CRT监视器的屏幕，可以直接照亮对象区域。 可以使用具有孔的壳体上的枢转脚来促进样品与分光光度计的壳体的入口的对准。
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Patent Agency Ranking
公开(公告)号：US5375138A
公开(公告)日：1994-12-20
申请号：US951688
申请日：1992-09-25
Applicant: William J. Kozlovsky , James M. Zavislan
Inventor： William J. Kozlovsky , James M. Zavislan
CPC classification number: G02F1/37 , G02F2001/3542
Abstract: Nonlinear optical cavities comprising a single or multiple ring paths for use with diode lasers are presented. In one embodiment, the total internal reflection surface of a monolithic or composite cavity is fabricated into a plurality of nonparallel planes. In another embodiment, a composite cavity with either a single end piece or a plurality of end pieces bound to a nonlinear resonator crystal is used to generate either a single or multiple ring paths. In several of the embodiments, incident laser beams entering one end of the cavity follow the ring paths and transmit from the other end of the cavity as a plurality of second-harmonic beams with a pre-defined spatial layout.
Abstract translation: 提出了包括用于二极管激光器的单个或多个环路径的非线性光学腔。 在一个实施例中，单片或复合空腔的全内反射表面制造成多个非平行平面。 在另一个实施例中，使用与非线性谐振器晶体结合的单个端部件或多个端部件的复合腔体来产生单个或多个环形路径。 在几个实施例中，进入腔的一端的入射激光束遵循环形路径并且以具有预定义的空间布局的多个二次谐波束从腔的另一端发射。
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公开(公告)号：US5031993A
公开(公告)日：1991-07-16
申请号：US438300
申请日：1989-11-16
Applicant: Rahul Asthana , Robert D. Miller , Franklin M. Schellenberg , Glenn T. Sincerbox , James M. Zavislan
Inventor： Rahul Asthana , Robert D. Miller , Franklin M. Schellenberg , Glenn T. Sincerbox , James M. Zavislan
CPC classification number: G11B11/10543 , G01J4/00 , G11B11/10576
Abstract: An improved apparatus and method for detecting the polarization state of an optical wavefront is disclosed, which is especially suitable for use in an integrated magneto-optic recording head. An optically transparent waveguide structure transmits TE and TM modes of the wavefront propagated as a beam coupled into the waveguide by a TE/TM grating coupler. In the waveguide structure is a periodic structure comprising a birefringent mode separator that splits the propagating beam into TE and TM modes. The mode separator comprises an array of uniformly spaced volumes of identical configuration. Photosensitive devices detect the intensity of the light contained within each of the separated beams. The signals from these photosensitive devices are used to determine the state of polarization of the optical wavefront. The periodic structure may, if desired, comprise regions of alternating birefringence, such as a Bragg grating, either in a waveguide layer or a cladding layer. Focal power is introduced (1) by providing focal power in the input grating coupler to the waveguide with a curved grating structure, (2) by varying the pitch of the birefringent mode separator extending in a direction transverse to the optical axis of the propagating beam, or (3) by introducing a surface grating with a varying pitch in a direction transverse of the optical axis.
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公开(公告)号：US08606343B2
公开(公告)日：2013-12-10
申请号：US11784128
申请日：2007-04-05
Applicant: James M. Zavislan
Inventor： James M. Zavislan
IPC: A61B5/00
CPC classification number: A61B5/6842 , A61B5/0068 , A61B5/061 , A61B5/441 , A61B5/444 , A61B5/445 , A61B5/6834 , A61B5/6835 , A61B5/6843 , A61B5/704
Abstract: An improved system for confocal imaging within dermal tissue of a patient is provided which minimizes instability in confocal images by reducing the relative motion of the tissue with respect to the confocal imaging optics of the system. The system includes a mechanism for maintaining an area of skin tissue under stress by application of force at the edges of the area, and an imaging head coupled to this mechanism for imaging the stressed skin. The mechanism includes a mechanical structure, such as a platen, brace, or attachment, which both supports the imaging head of the system and applies stress to a limited surface area of the tissue to minimize skin motion during confocal imaging.
Abstract translation: 提供了一种用于患者真皮组织内的共焦成像的改进系统，其通过减少组织相对于系统的共聚焦成像光学器件的相对运动而使共焦图像中的不稳定性最小化。 该系统包括用于通过在该区域的边缘处施加力来保持应力下的皮肤组织的面积的机构，以及耦合到该机构的用于对应力皮肤成像的成像头。 该机构包括机械结构，例如压板，支架或附件，其均支撑系统的成像头部，并将应力施加到组织的有限表面区域，以使共聚焦成像期间的皮肤运动最小化。
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公开(公告)号：US07864996B2
公开(公告)日：2011-01-04
申请号：US11357234
申请日：2006-02-17
Applicant: Paul Hemmer , Zachary M. Eastman , Jay M. Eastman , William J. Fox , James M. Zavislan
Inventor： Paul Hemmer , Zachary M. Eastman , Jay M. Eastman , William J. Fox , James M. Zavislan
IPC: G06K9/00
CPC classification number: G02B21/0012 , G02B21/0024 , G02B21/365
Abstract: A system for macroscopic and confocal imaging of tissue having a macroscopic imager for capturing a macroscopic image of the tissue's surface, a confocal imager for capturing one or more optically formed sectional microscopic images on or within tissue, a computer for receiving images from such imagers, and a tissue attachment device in which the macroscopic imager and confocal imager are each individually presented to the tissue utilizing the tissue attachment device in a predefined alignment, such that imaging locations of the confocal imager with respect to the tissue surface spatially correlate with macroscopic image. A user interface is operable on the computer to enable display of the macroscopic image on a display coupled to the computer, and to indicate a region within the macroscopic image associated with the field of view of the tissue imagable by the confocal imager. The user interface enables graphical tracking and targeting of imaging locations of the confocal imager in macroscopic image, and marking on the macroscopic image of the locations of confocal images with respect to the tissue surface.
Abstract translation: 一种具有用于捕获组织表面的宏观图像的宏观成像器的组织的宏观和共焦成像系统，用于捕获组织上或组织内的一个或多个光学形成的截面微观图像的共焦成像器，用于从这样的成像器接收图像的计算机， 以及组织附着装置，其中宏观成像器和共聚焦成像器各自以预定对准单独地呈现给组织，使得共焦成像器相对于组织表面的成像位置在空间上与宏观图像相关。 用户界面在计算机上可操作以使得能够在耦合到计算机的显示器上显示宏观图像，并且指示与由共焦成像器可成像的组织的视场相关联的宏观图像内的区域。 用户界面能够在宏观图像中进行图像跟踪和共焦成像器的成像位置的瞄准，并且在相对于组织表面的共聚焦图像的位置的宏观图像上进行标记。
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公开(公告)号：US06937886B2
公开(公告)日：2005-08-30
申请号：US10164681
申请日：2002-06-07
Applicant: James M. Zavislan
Inventor： James M. Zavislan
CPC classification number: A61B5/6842 , A61B5/0068 , A61B5/061 , A61B5/441 , A61B5/444 , A61B5/445 , A61B5/6834 , A61B5/6835 , A61B5/6843 , A61B5/704
Abstract: An improved system for confocal imaging within dermal tissue of a patient is provided which minimizes instability in confocal images by reducing the relative motion of the tissue with respect to the confocal imaging optics of the system. The system includes a mechanism for maintaining an area of skin tissue under stress by application of force at the edges of the area, and an imaging head coupled to this mechanism for imaging the stressed skin. The mechanism includes a mechanical structure, such as a platen, brace, or attachment, which both supports the imaging head of the system and applies stress to a limited surface area of the tissue to minimize skin motion during confocal imaging.
Abstract translation: 提供了一种用于患者真皮组织内的共焦成像的改进系统，其通过减少组织相对于系统的共聚焦成像光学器件的相对运动而使共焦图像中的不稳定性最小化。 该系统包括用于通过在该区域的边缘处施加力来保持应力下的皮肤组织的面积的机构，以及耦合到该机构的用于对应力皮肤成像的成像头。 该机构包括机械结构，例如压板，支架或附件，其均支撑系统的成像头部，并将应力施加到组织的有限表面区域，以使共聚焦成像期间的皮肤运动最小化。
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