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公开(公告)号：US08353969B2
公开(公告)日：2013-01-15
申请号：US13480747
申请日：2012-05-25
Applicant: Jack Barger , James Sinclair , Michael P. Emery
Inventor： Jack Barger , James Sinclair , Michael P. Emery
IPC: B01D9/00
CPC classification number: B01D3/346 , B01D1/14 , B01L3/06 , B01L3/50853 , B01L2200/0678 , B01L2300/048 , B01L2300/049 , B01L2300/0829 , G01N2001/4027
Abstract: Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, a method for controlled evaporation of solvent from at least one solution includes filling a selected first set of wells in a multi-well plate with a first solution comprising at least one first solvent. The method also includes attaching an inlet manifold to the plate, the inlet manifold comprising an inlet port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method further includes attaching an exhaust manifold to the plate, the exhaust manifold comprising an exhaust port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method also includes introducing a gas into the inlet port and removing solvent vapor from the selected first set of wells.
Abstract translation: 提供了从溶液中控制溶剂蒸发的方法和装置。 在一个实施方案中，用于从至少一种溶液控制蒸发溶剂的方法包括用包含至少一种第一溶剂的第一溶液填充多孔板中选定的第一组孔。 该方法还包括将入口歧管连接到板上，入口歧管包括连接到所选择的第一组井中的每个井中并仅与其中的每个井连通并且仅在其中流体连通的入口歧管。 所述方法还包括将排气歧管连接到所述板上，所述排气歧管包括与所选择的第一组井中的每个孔连接并且仅与所述第一组井中的每个井相连通的排气口。 该方法还包括将气体引入入口并从所选择的第一组孔中除去溶剂蒸气。
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公开(公告)号：US20120241100A1
公开(公告)日：2012-09-27
申请号：US13480747
申请日：2012-05-25
Applicant: Jack Barger , James Sinclair , Michael P. Emery
Inventor： Jack Barger , James Sinclair , Michael P. Emery
IPC: B01D1/14
CPC classification number: B01D3/346 , B01D1/14 , B01L3/06 , B01L3/50853 , B01L2200/0678 , B01L2300/048 , B01L2300/049 , B01L2300/0829 , G01N2001/4027
Abstract: Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, a method for controlled evaporation of solvent from at least one solution includes filling a selected first set of wells in a multi-well plate with a first solution comprising at least one first solvent. The method also includes attaching an inlet manifold to the plate, the inlet manifold comprising an inlet port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method further includes attaching an exhaust manifold to the plate, the exhaust manifold comprising an exhaust port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method also includes introducing a gas into the inlet port and removing solvent vapor from the selected first set of wells.
Abstract translation: 提供了从溶液中控制溶剂蒸发的方法和装置。 在一个实施方案中，用于从至少一种溶液控制蒸发溶剂的方法包括用包含至少一种第一溶剂的第一溶液填充多孔板中选定的第一组孔。 该方法还包括将入口歧管连接到板上，入口歧管包括连接到所选择的第一组井中的每个井中并仅与其中的每个井连通并且仅在其中流体连通的入口歧管。 所述方法还包括将排气歧管连接到所述板上，所述排气歧管包括与所选择的第一组井中的每个孔连接并且仅与所述第一组井中的每个井相连通的排气口。 该方法还包括将气体引入入口并从所选择的第一组孔中除去溶剂蒸气。
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公开(公告)号：US20050283426A1
公开(公告)日：2005-12-22
申请号：US11125110
申请日：2005-05-10
Applicant: Srivathsan Krishnasami , James Sinclair
Inventor： Srivathsan Krishnasami , James Sinclair
CPC classification number: G06Q40/04 , G06Q30/02 , G06Q30/0603 , G06Q40/06
Abstract: An anonymous trading system comprises an interconnected network of broking nodes arranged in cliques which receive buy and sell orders from trader terminals via connected trading engines and which match persistent orders, executed deals and distribute price information to trader terminals. The system has the ability for a trader to call out for a quote (request for a quote) anonymously. RFQs are only transmitted on to potential counterparties if they are within a predetermined price range. The RFQs include a price at which the requesting party is willing to deal, but this price is not communicated potential counterparties. Counterparty responses are matches on a time, price basis and non-matched responses may be matched with themselves. Similarly, non-matched RFQs may be matched with each other.
Abstract translation: 一个匿名交易系统包括一个互相排列的经纪商节点网络，这些交易网络通过连接的交易引擎从交易者终端接收买卖订单，并且与交易者终端匹配持续订单，执行交易和分发价格信息。 该系统能够让一个交易者匿名提出报价（报价请求）。 如果RFQ在预定的价格范围内，则仅传送给潜在的对手方。 RFQ包括请求方愿意交易的价格，但这个价格不是潜在的交易对手。 对手反应是时间上的匹配，价格基础和不匹配的响应可能与自己匹配。 类似地，不匹配的RFQ可以彼此匹配。
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公开(公告)号：US20050235762A1
公开(公告)日：2005-10-27
申请号：US10833496
申请日：2004-04-27
Applicant: James Sinclair
Inventor： James Sinclair
CPC classification number: B01L3/0217 , B01L99/00 , B01L2400/0487 , B01L2400/0633 , G01N35/1004 , G01N35/1074 , G01N2035/1006
Abstract: Disclosed herein is a volume displacement pipette that includes a channel within the piston. The channel allows for cleaning fluids to be continuously run through the pipette tip for cleaning the tip. One end of the channel may be closed during normal operation of the pipette. Multiple pipettes may be combined into an array pipetter.
Abstract translation: 这里公开了一种体积位移移液管，其包括活塞内的通道。 该通道允许清洁流体连续地通过移液管尖以清洁尖端。 在移液器的正常操作期间，通道的一端可能被关闭。 多个移液管可以组合成阵列移液器。
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公开(公告)号：US6113479A
公开(公告)日：2000-09-05
申请号：US900184
申请日：1997-07-25
Applicant: James Sinclair , Lawrence L. Lee
Inventor： James Sinclair , Lawrence L. Lee
CPC classification number: B24B37/30 , B24B41/061 , B24B49/04
Abstract: An apparatus, and particularly, a wafer carrier for polishing the face of a semiconductor wafer are provided. The wafer carrier forms a first cavity which can be pressure controlled to vary the shape of a face of a platen which contacts the wafer during polishing. A second cavity within the first cavity is provided. The second cavity can be independently pressure controlled to form a vacuum for holding the wafer against the platen surface or for forming a pressure stream to separate the wafer from the platen and/or to purge the holes in the surface of the platen. A non-contact displacement sensor capable of measuring a distance between the wafer carrier mount and the platen, may be provided. An endpoint detector capable of detecting a relative surface roughness of the wafer, to determine when the wafer has been sufficiently polished, may also be provided. A ring is peripherally located about an outer edge of the platen, and is mounted and positioned to resist lateral forces on the wafer during polishing. The ring is adjustably mounted so as to be variably and controllably vertically positioned, with respect to the wafer to help control standing waves in the polishing media and uneven polishing of the wafer surface.
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Patent Agency Ranking
公开(公告)号：US08969529B2
公开(公告)日：2015-03-03
申请号：US13142556
申请日：2010-01-21
Applicant: Alison O'Brien , Angela Melton-Celsa , Michael Smith , James Sinclair
Inventor： Alison O'Brien , Angela Melton-Celsa , Michael Smith , James Sinclair
CPC classification number: A61K39/0283 , A61K38/00 , A61K39/0258 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/25 , C07K16/1232 , C07K2317/34 , Y02A50/473
Abstract: The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.
Abstract translation: 本发明基于11 E1O抗体的Stx2蛋白中的表位的发现。 本发明的特征在于包含非全长Stx2多肽的组合物，其包括11E1O单克隆抗体表位。 本发明还具有产生对Stx2蛋白的11E1O表位特异的抗Stx2抗体的方法。 另外，本发明的特征在于用包含11个E1O的多肽治疗具有或有发展志贺毒素相关疾病（例如，溶血性尿毒症综合征和与大肠杆菌和痢疾杆菌感染相关的疾病）的受试者的方法 表位或使用本发明的方法开发的抗Stx2抗体。 此外，本发明的特征在于使用使用本发明的方法开发的抗体检测样品中的Stx2。
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公开(公告)号：US08775297B2
公开(公告)日：2014-07-08
申请号：US13487321
申请日：2012-06-04
Applicant: Karen Ilse Setz , Snezhana Malkin , Leong Fai Mah , Steven J. Scully , Tracey Riordan , Edward R. Howorka , James Sinclair
Inventor： Karen Ilse Setz , Snezhana Malkin , Leong Fai Mah , Steven J. Scully , Tracey Riordan , Edward R. Howorka , James Sinclair
Abstract: A computer trading system includes a quote screening function configured to accept quotes specifying a quote amount in a price where the quote amount is greater than a minimum quote amount to produce screen quote messages and to reject quotes specifying a quote amount less than the minimum quote amount. A market view generator generates market views from those quotes which specify an amount greater than or equal to the minimum quote amount. An order screening function only-accepts orders specifying an amount less than a maximum transaction amount submitted in response to the market views to produce screened order messages. A transaction processor receives screened quote messages and screened order messages and matches appropriate messages with each other. The minimum quote amount is substantially equal to or greater than the maximum transaction amount whereby a screened order message can be matched entirely with one screened quote message.
Abstract translation: 计算机交易系统包括报价筛选功能，其配置为接受报价指定报价金额的报价，报价金额大于最低报价金额以生成屏幕报价信息，并拒绝报价指定小于最低报价金额的报价 。 市场视图生成器根据这些报价产生市场观点，指定金额大于或等于最低报价金额。 订单筛选功能只能接受指定小于响应市场视图提交的最大交易金额的订单以生成筛选订单消息的订单。 交易处理器接收筛选的报价消息和筛选的订单消息并将适当的消息彼此匹配。 最小报价金额基本上等于或大于最大交易金额，从而筛选的订单消息可以完全与一个已筛选的报价消息相匹配。
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公开(公告)号：US08397592B2
公开(公告)日：2013-03-19
申请号：US12709414
申请日：2010-02-19
Applicant: James Sinclair , B. Albert Griffin , Minh Vuong
Inventor： James Sinclair , B. Albert Griffin , Minh Vuong
IPC: G01N1/20
Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
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公开(公告)号：US20120239549A1
公开(公告)日：2012-09-20
申请号：US13487306
申请日：2012-06-04
Applicant: Karen Ilse Setz , Snezhana Malkin , Leong Fai Mah , Steven J. Scully , Tracey Riordan , Edward R. Howorka , James Sinclair
Inventor： Karen Ilse Setz , Snezhana Malkin , Leong Fai Mah , Steven J. Scully , Tracey Riordan , Edward R. Howorka , James Sinclair
IPC: G06Q40/04
Abstract: A computer trading system includes a quote screening function configured to accept quotes specifying a quote amount in a price where the quote amount is greater than a minimum quote amount to produce screen quote messages and to reject quotes specifying a quote amount less than the minimum quote amount. A market view generator generates market views from those quotes which specify an amount greater than or equal to the minimum quote amount. An order screening function only accepts orders specifying an amount less than a maximum transaction amount submitted in response to the market views to produce screened order messages. A transaction processor receives screened quote messages and screened order messages and matches appropriate messages with each other. The minimum quote amount is substantially equal to or greater than the maximum transaction amount whereby a screened order message can be matched entirely with one screened quote message.
Abstract translation: 计算机交易系统包括报价筛选功能，其配置为接受报价指定报价金额的报价，报价金额大于最低报价金额以生成屏幕报价信息，并拒绝报价指定小于最低报价金额的报价 。 市场视图生成器根据这些报价产生市场观点，指定金额大于或等于最低报价金额。 订单筛选功能仅接受指定小于响应市场视图而提交的最大交易金额的订单以生成筛选订单消息的订单。 交易处理器接收筛选的报价消息和筛选的订单消息并将适当的消息彼此匹配。 最小报价金额基本上等于或大于最大交易金额，从而筛选的订单消息可以完全与一个已筛选的报价消息相匹配。
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公开(公告)号：US20110087136A1
公开(公告)日：2011-04-14
申请号：US12577679
申请日：2009-10-12
Applicant: Philip Salzmann , Trang Nguyen , James Sinclair
Inventor： Philip Salzmann , Trang Nguyen , James Sinclair
CPC classification number: G01N27/028 , A01K1/031 , A01K11/006 , A01K29/005
Abstract: Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.
Abstract translation: 用于监测实验室动物的系统和方法包括标签，其包括电感元件和连接到实验室动物的一部分的电容元件。 通过监视标签对具有不同频率，一个接近标签共振的时变磁场和一个远离标签共振的时变磁场来检测该部分的位置。
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