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公开(公告)号：US12103977B2
公开(公告)日：2024-10-01
申请号：US17702282
申请日：2022-03-23
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , Anna Kuchnio , Cassandra L. Lowenstein , Ulrike Philippar , Sanjaya Singh , Nele Vloemans , Danlin Yang
CPC classification number: C07K16/2896 , A61P35/00 , C07K16/2878 , C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: Provided herein are multispecific antibodies, including trispecific antibodies that bind to CD79b, CD20 and CD3, and bispecific antibodies that bind to CD79b and CD3, and multispecific antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided multispecific antibodies or multispecific antigen-binding fragments, cells expressing the provided multispecific antibodies or multispecific antigen-binding fragments, as well as associated vectors and detectably labeled multispecific antibodies or multispecific antigen-binding fragments. In addition, methods of producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described. Further provided herein are isolated antibodies that bind to CD79b and antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided CD79b-specific antibodies or antigen-binding fragments, cells expressing the provided CD79b-specific antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled CD79b-specific antibodies or antigen-binding fragments. In addition, methods of producing and using the provided CD79b-specific antibodies and antigen-binding fragments are described.
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12.发明授权公开(公告)号：US12077585B2
公开(公告)日：2024-09-03
申请号：US16937285
申请日：2020-07-23
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , John Lee , Jinquan Luo , Theresa McDevitt , Fei Shen , Degang Song , Raymond Brittingham , Sathyadevi Venkataramani , Sanjaya Singh , Yonghong Zhao , Fang Yi , Sherry Lynn La Porte
CPC classification number: C07K16/2809 , C07K16/34 , C07K2317/14 , C07K2317/31 , C07K2317/565
Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.
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公开(公告)号：US20240262921A1
公开(公告)日：2024-08-08
申请号：US18643356
申请日：2024-04-23
Applicant: Janssen Biotech, Inc.
Inventor： Ricardo ATTAR , Rajkumar Ganesan , Francois Gaudet , Bradley J. Heidrich , Carmen Baca Jones , John Lee , Yingzhe Li , Sanjaya Singh , Sathya Venkataramani
CPC classification number: C07K16/2866 , A61K9/0019 , A61P35/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/74 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor, G-protein coupled receptor family C group 5 member D (GPRC5D), and immunoresponsive cells comprising such CARs, for the treatment of cancer.
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公开(公告)号：US20240247063A1
公开(公告)日：2024-07-25
申请号：US18609023
申请日：2024-03-19
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh , Michael Riis Hansen
IPC: C07K16/28 , A61P35/00 , C07K16/30 , C12N5/0783 , A61K39/00
CPC classification number: C07K16/2809 , A61P35/00 , C07K16/28 , C07K16/2866 , C07K16/2878 , C07K16/3069 , C12N5/0636 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/92
Abstract: Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US11926667B2
公开(公告)日：2024-03-12
申请号：US17499597
申请日：2021-10-12
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar Ganesan , Sanjaya Singh , Iqbal S. Grewal , Michael Riis Hansen
CPC classification number: C07K16/2812 , C07K16/2815 , C07K16/468 , C07K2317/34 , C07K2317/565
Abstract: Provided herein, in certain aspects, are antibodies that bind to CD8, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are antibodies that bind to CD4, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are multispecific antibodies that bind to CD4 and CD8, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making the antibodies are also provided.
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Patent Agency Ranking
公开(公告)号：US11827708B2
公开(公告)日：2023-11-28
申请号：US17388056
申请日：2021-07-29
Applicant: Janssen Biotech, Inc.
Inventor： Natasa Obermajer , Adam Zwolak , Sylvie Laquerre , Dirk Brehmer , Desiree De Lange , Julien Häsler , Shana Versmissen , Theodore D. Petley , Kelly van de Ven , Fang Yi , Sanjaya Singh , Rajkumar Ganesan
CPC classification number: C07K16/2833 , A61P35/00 , C07K16/2809 , A61K2039/505 , A61K2039/545 , C07K2317/31 , C07K2317/55 , C07K2317/622
Abstract: The invention provides antigen binding domains that bind human leukocyte antigen G (HLA-G) protein comprising the antigen binding domains that bind HLA-G, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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公开(公告)号：US20230365683A1
公开(公告)日：2023-11-16
申请号：US18307076
申请日：2023-04-26
Applicant: Janssen Biotech, Inc.
Inventor： Patrick John Doonan , Rajkumar Ganesan , Mehabaw Getahun Derebe , Sathyadevi Venkataramani , Sanjaya Singh , Iqbal S. Grewal , Karla R. Wiehagen
CPC classification number: C07K16/2803 , A61K39/4631 , A61K39/464411 , A61K39/4611 , C07K16/2809 , A61K51/1096 , A61K51/1027 , A61P35/00 , C07K2317/622 , C07K2317/22 , C07K2317/92 , C07K2317/24 , C07K2317/31 , C07K2317/77 , C07K2317/73
Abstract: The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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公开(公告)号：US11667712B2
公开(公告)日：2023-06-06
申请号：US16869401
申请日：2020-05-07
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
CPC classification number: C07K16/2809 , A61K38/1709 , C07K16/2866 , C07K2317/24 , C07K2317/31 , C07K2317/565
Abstract: Anti-TRGV9 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
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公开(公告)号：US20210130440A1
公开(公告)日：2021-05-06
申请号：US17061590
申请日：2020-10-02
Applicant: Janssen Biotech, Inc.
Inventor： Sathyadevi Venkataramani , Rajkumar Ganesan , Sanjaya Singh
Abstract: The invention relates to methods of optimizing an antibody with enhanced stability, the method comprising mutating somatic hypermutation with germline amino acid residues and therefore providing enhanced thermal stability, improved biophysical properties and shelf-life while preserving the affinity for the antigen.
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公开(公告)号：US12264197B2
公开(公告)日：2025-04-01
申请号：US17437771
申请日：2020-03-11
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar Ganesan , Iqbal S. Grewal , Manuel Alejandro Sepulveda
Abstract: Anti-Vβ17/anti-CD123 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies.
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