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31 条记录 (耗时 0.035 秒)

    Benzothiophene alkanol piperazine derivatives and their use as antidepressant
    14.
    发明授权
    Benzothiophene alkanol piperazine derivatives and their use as antidepressant 失效
    苯并噻吩烷醇哌嗪衍生物及其用作抗抑郁药

    公开(公告)号：US08680097B2

    公开(公告)日：2014-03-25

    申请号：US13001998

    申请日：2009-06-30

    申请人： Jianqi Li ,  Kai Gao ,  Na Lv

    发明人： Jianqi Li ,  Kai Gao ,  Na Lv

    IPC分类号： A61K31/496 ,  A61K31/5377 ,  C07D333/58 ,  C07D409/12 ,  C07D413/12

    CPC分类号： C07D409/06 ,  C07D409/14

    摘要： The invention discloses benzothiophene alkanol piperazine derivatives and their use as antidepressants. The invention discloses the said benzothiophene alkanol piperazine derivative having triple inhibition effect on the reuptake of 5-HT, NA and DA. Compared with clinical used antidepressants so far having single target, e.g. desipramine and fluoxetine, and clinical used antidepressants so far having double targets, e.g venlafaxine and duloxetine, the said benzothiophene alkanol piperazine derivatives of the present invention may have a broader indication range and less toxic and side effects to nervous system. The benzothiophene alkanol piperazine derivatives are the compounds with the following formula or their pharmaceutically acceptable salts, wherein Ar1, R1-R4, X, Y, m and n have the same definition as defined in claim 1.

    摘要翻译： 本发明公开了苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁药的用途。 本发明公开了对5-HT，NA和DA的再摄取具有三重抑制作用的所述苯并噻吩烷醇哌嗪衍生物。 与迄今为止具有单一目标的临床使用的抗抑郁药相比， 本发明的所述苯并噻吩烷醇哌嗪衍生物可能具有更广泛的适应范围和对神经系统的毒副作用较小的临床用途的抗抑郁药，目前为止具有双重目标，例如文拉法辛和度洛西汀。 苯并噻吩烷醇哌嗪衍生物是具有下式的化合物或其药学上可接受的盐，其中Ar1，R1-R4，X，Y，m和n具有与权利要求1中所定义的相同的定义。

    POLYCYCLIC QUINAZOLINES, PREPARATION THEREOF, AND USE THEREOF
    17.
    发明申请
    POLYCYCLIC QUINAZOLINES, PREPARATION THEREOF, AND USE THEREOF 审中-公开
    多环喹诺酮类，其制备方法及其用途

    公开(公告)号：US20110288086A1

    公开(公告)日：2011-11-24

    申请号：US13112354

    申请日：2011-05-20

    申请人： Jianqi Li ,  Zixue Zhang ,  Peng Xie ,  Qingwei Zhang

    发明人： Jianqi Li ,  Zixue Zhang ,  Peng Xie ,  Qingwei Zhang

    IPC分类号： A61K31/535 ,  A61P35/00 ,  A61K31/4985 ,  C07D487/04 ,  A61K31/519

    CPC分类号： C07D487/04

    摘要： At least one active pharmaceutical ingredient is chosen from polycyclic quinazolines of formula V, pharmaceutically acceptable salts thereof, and hydrates of the pharmaceutically acceptable salts. The active pharmaceutical ingredients disclosed may be inhibitors of protein tyrosine kinase inhibitors and/or aurora kinase. The active pharmaceutical ingredients can be used for treating cancers susceptible to treatment with protein tyrosine kinase inhibitors and/or aurora kinase inhibitors.

    摘要翻译： 至少一种活性药物成分选自式V的多环喹唑啉，其药学上可接受的盐和药学上可接受的盐的水合物。 所公开的活性药物成分可以是蛋白酪氨酸激酶抑制剂和/或极光激酶的抑制剂。 活性药物成分可用于治疗易于用蛋白酪氨酸激酶抑制剂和/或极光激酶抑制剂治疗的癌症。

    DETECTION SYSTEM AND DETECTION METHOD OF DISTRBUTED GENERATION ISLANDING BASED ON POWER FREQUENCY CARRIER
    18.
    发明申请
    DETECTION SYSTEM AND DETECTION METHOD OF DISTRBUTED GENERATION ISLANDING BASED ON POWER FREQUENCY CARRIER 审中-公开
    基于功率频率载波的分布式生成岛屿的检测系统和检测方法

    公开(公告)号：US20140146427A1

    公开(公告)日：2014-05-29

    申请号：US13885686

    申请日：2011-10-31

    申请人： Biyao Huang ,  Jianqi Li ,  Guojun Liu ,  Zhihui Wang ,  Nan Quan ,  Xiaofeng Qu ,  Tao Zhao ,  Licheng Wang

    发明人： Biyao Huang ,  Jianqi Li ,  Guojun Liu ,  Zhihui Wang ,  Nan Quan ,  Xiaofeng Qu ,  Tao Zhao ,  Licheng Wang

    IPC分类号： H02H3/38

    CPC分类号： H02H3/38 ,  H02H1/0061 ,  H02H7/28 ,  H02J3/38 ,  H02J13/0051 ,  H02J2003/388 ,  Y02B90/263 ,  Y02E40/72 ,  Y02E60/723 ,  Y02E60/725 ,  Y02E60/783 ,  Y02P80/14 ,  Y04S10/12 ,  Y04S10/16 ,  Y04S10/20 ,  Y04S40/123

    摘要： This present inversion relates to a detection system and detection method of distributed generation islanding based on power frequency carrier. The system includes a power frequency carrier signal generating device near the terminal power distribution substation, a power frequency carrier signal detection device in distributed power grid; the power frequency carrier signal generating device is connected to the substation bus through a signal coupling transformer; the power frequency carrier signal generating device is connected with signal coupling transformer though phase A, B C live wires and the N middle wire, that results in the signal can be send by anyone signal phase, any two phases parallel way or three phases parallel way. The power frequency carrier signal detection device is connected with the low voltage power network though phase A, B and C live wires and the N middle wire. The system of distributed generation islanding detection based on power frequency carrier has low cost of implementation advantage and the test methods to meet the requirements of relevant standards. The present invention provides an effective method for islanding signal detection of distributed generation and micro-grid signal, anti-islanding protection. There is very high technical and economic performance applying the distribution network under high permeability condition.

    摘要翻译： 本反演涉及基于功率载波的分布式发电孤岛的检测系统和检测方法。 该系统包括终端配电站附近的功率载频信号发生装置，分布式电网中的工频载波信号检测装置， 电力载波信号发生装置通过信号耦合变压器连接到变电站总线; 电力载波信号发生装置通过A相，B C线和N线连接信号耦合变压器，使信号可以由任何信号相，任意两相并联或三相并联发送。 工频载波信号检测装置通过A，B，C线和N线连接低压电网。 基于电力载波的分布式孤岛检测系统具有较低的实施成本优势和符合相关标准要求的测试方法。 本发明提供了分散式发电和微电网信号孤岛信号检测的有效方法，防孤岛保护。 在高渗透条件下应用配送网络具有非常高的技术和经济性能。