公开(公告)号：US20060228173A1

公开(公告)日：2006-10-12

申请号：US11103973

申请日：2005-04-12

申请人： Christopher Dunmire ,  Trung Tran ,  Christopher Scott

发明人： Christopher Dunmire ,  Trung Tran ,  Christopher Scott

IPC分类号： F16C3/03

CPC分类号： F16D1/10 ,  F16D2001/103 ,  Y10T29/4984 ,  Y10T29/49936 ,  Y10T403/52 ,  Y10T403/7026

摘要： A grease seal cup for a splined joint between a drive shaft and a driven shaft comprises a cylindrical portion adapted to form a seal with the outer surface of the drive shaft and a seal with a sealing member, such as a spanner nut, of the driven shaft. The grease seal cup, comprising a flexible polymer material, tightly squeezed during installation to form the seals. The pre-fabricated light weight grease seal cup can be used in existing splined joints without adversely affecting the weight balance.

摘要翻译： 用于驱动轴和从动轴之间的花键连接的油脂密封杯包括适于与驱动轴的外表面形成密封的圆柱形部分，以及与被驱动的驱动轴的密封构件（例如扳手螺母）的密封 轴。 包含柔性聚合物材料的润滑脂密封杯在安装过程中紧紧挤压以形成密封。 预制轻质润滑脂密封杯可用于现有花键接头，不会对重量平衡产生不利影响。

公开(公告)号：US20050169964A1

公开(公告)日：2005-08-04

申请号：US11059864

申请日：2005-02-17

申请人： Joseph Zitelli ,  Paul Higham ,  Paresh Dalal ,  Christopher Scott

发明人： Joseph Zitelli ,  Paul Higham ,  Paresh Dalal ,  Christopher Scott

IPC分类号： A61L27/32 ,  A61L27/54 ,  A61L2/00 ,  A61K9/14

CPC分类号： A61L27/54 ,  A61L27/32 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/606

摘要： A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.

摘要翻译： 将具有治疗剂如抗生素或骨形态发生蛋白如OP-1蛋白的涂层施用于植入物的方法使用磷酸钙涂覆的金属植入物的高表面积作为治疗剂的储存库。 植入物涂覆有一层或多层磷酸钙矿物质，如羟基磷灰石。 在通常在水溶液中进行结晶层之后，将植入物干燥并包装。 在植入之前，立即从包装中取出植入物，并用含有治疗剂的水溶液润湿磷酸钙的结晶层。

公开(公告)号：US08962032B2

公开(公告)日：2015-02-24

申请号：US13515884

申请日：2010-12-17

申请人： Christopher Scott ,  James Johnston ,  Shaun Spence ,  Danny McAuley ,  Francois Fay

发明人： Christopher Scott ,  James Johnston ,  Shaun Spence ,  Danny McAuley ,  Francois Fay

IPC分类号： A61P11/00 ,  A61P31/06 ,  A61P11/06 ,  A61P11/08 ,  A61P31/00 ,  A61P9/00 ,  A61P37/00 ,  A61P3/10 ,  A61P25/00 ,  A61K9/14 ,  A61K31/702 ,  A61K47/48 ,  A61K45/06

CPC分类号： A61K47/48853 ,  A61K45/06 ,  A61K47/593 ,  A61K47/61 ,  A61K47/6921 ,  A61K47/6937 ,  A61K47/6939 ,  Y10S977/773 ,  Y10S977/906

摘要： There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject.

摘要翻译： 提供了一种抑制细胞中促炎免疫应答的方法，包括提供给唾液酸或其类似物的细胞，其中唾液酸或类似物由底物呈递，使得细胞中的促炎免疫应答 被抑制或抗细胞免疫应答增加。 此外，提供了在有需要的受试者中治疗炎症性疾病的方法。 还提供了可以调节受试者的炎症反应的药物递送装置和生物材料。

公开(公告)号：US08343157B2

公开(公告)日：2013-01-01

申请号：US11807210

申请日：2007-05-25

申请人： Christopher Scott ,  Joseph C. Jenkins, II ,  Rodney P. Johnson

发明人： Christopher Scott ,  Joseph C. Jenkins, II ,  Rodney P. Johnson

IPC分类号： A61B17/00

CPC分类号： A61B17/1666

摘要： A bone-reaming system for use in bone cavities which allows for a less invasive and more precise surgical procedure is disclosed. An apparatus according to such a system may include a housing, a motor disposed within the housing, and a cutter attached to the motor and extendable through the aperture, wherein the housing is capable of articulating with respect to a bone cavity so as to allow the cutter to cut at least a portion of the bone cavity. A routing guide is used in conjunction with the apparatus to provide a template through which to cut preselected portions of a bone cavity. Also disclosed is a method for using such a bone-reaming system.

摘要翻译： 公开了一种用于骨腔的骨扩孔系统，其允许较少侵入性和更精确的外科手术。 根据这种系统的装置可以包括壳体，设置在壳体内的马达和附接到马达并可通过孔延伸的切割器，其中壳体能够相对于骨腔铰接，以便允许 切割器以切割至少一部分骨腔。 路线引导件与该装置结合使用以提供模板，通过该模板切割骨腔的预选部分。 还公开了使用这种骨扩孔系统的方法。

公开(公告)号：US07939642B2

公开(公告)日：2011-05-10

申请号：US11918102

申请日：2006-04-10

申请人： Christopher Scott ,  Roberta Burden ,  Shane Olwill ,  Brian Walker ,  Jim Johnston

发明人： Christopher Scott ,  Roberta Burden ,  Shane Olwill ,  Brian Walker ,  Jim Johnston

IPC分类号： C12P21/08

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

摘要： Described are specific binding members e.g. antibodies which may be used in the treatment of diseases associated with cathepsin S activity. The specific binding members binds cathepsin S and inhibits its proteolytic activity. The binding members may be used in the treatment of diseases such as cancer, inflammatory diseases, neurodegenerative disorders, autoimmune disorders, and other diseases associated with excessive, deregulated or inappropriate angiogenesis.

摘要翻译： 描述的是具体的结合成员，例如 可用于治疗与组织蛋白酶S活性相关的疾病的抗体。 特异性结合成员结合组织蛋白酶S并抑制其蛋白水解活性。 结合成员可用于治疗诸如癌症，炎性疾病，神经变性疾病，自身免疫性疾病以及与过度，失调或不合适的血管生成相关的其它疾病的疾病。

公开(公告)号：US20090317405A2

公开(公告)日：2009-12-24

申请号：US11918102

申请日：2006-04-10

申请人： Christopher Scott ,  Roberta Burden ,  Shane Olwill ,  Brian Walker ,  Jim Johnston

发明人： Christopher Scott ,  Roberta Burden ,  Shane Olwill ,  Brian Walker ,  Jim Johnston

IPC分类号： A61K39/395 ,  A61K31/7052 ,  C07K16/00 ,  C07H21/00 ,  C12P21/00 ,  A61P35/00 ,  A61P29/00 ,  A61P27/02 ,  A61K48/00

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

摘要： Described are specific binding members e.g. antibodies which may be used in the treatment of diseases associated with cathepsin S activity. The specific binding members bind cathepsin S and inhibit its proteolytic activity. The binding members may be used in the treatment of diseases such as cancer, inflammatory diseases, neurodegenerative disorders, autoimmune disorders, and other diseases associated with excessive, deregulated or inappropriate angiogenesis.

摘要翻译： 描述的是具体的结合成员，例如 可用于治疗与组织蛋白酶S活性相关的疾病的抗体。 特异性结合成员结合组织蛋白酶S并抑制其蛋白水解活性。 结合成员可用于治疗诸如癌症，炎性疾病，神经变性疾病，自身免疫性疾病以及与过度，失调或不合适的血管生成相关的其它疾病的疾病。

公开(公告)号：US07534072B1

公开(公告)日：2009-05-19

申请号：US10983487

申请日：2004-11-08

申请人： Christopher Scott

发明人： Christopher Scott

IPC分类号： B08B9/02

CPC分类号： B08B3/026 ,  E02B17/0034 ,  E02B17/021 ,  E02B2017/006 ,  E02B2017/0082

摘要： The present invention discloses a method and an apparatus enabling the cleaning of a jack-up vessel, particularly the lower end portion of one of its legs. The method of the present invention discloses cleaning of a jack-up vessel having a hull, a leg that extends through a hull opening surrounded by a railing includes the steps of attaching a support to the railing, the support being selectively attachable to a desire location on the railing. A monitor is mounted upon the support, the monitor having a water blasting nozzle. Water is transmitted under the pressure to the monitor and the leg is water blasted using pressurized fueled that flows through the nozzle and is directed selectively to mudded or dirtied portion of the leg to be cleaned.

摘要翻译： 本发明公开了一种能够清洁自升式容器，特别是其一条腿的下端部分的方法和装置。 本发明的方法公开了一种具有船体的自升式船舶的清扫，一条延伸穿过由栏杆包围的船体开口的腿部，包括将支撑件附接到栏杆的步骤，该支撑件可选择性地附接到期望位置 在栏杆上。 显示器安装在支撑件上，显示器具有喷水喷嘴。 水在压力下传递到监视器，并且使用流经喷嘴的加压燃料对腿进行喷水处理，并且被选择性地导向待清洁的腿部的泥土或脏污部分。

公开(公告)号：US20070295341A1

公开(公告)日：2007-12-27

申请号：US11809072

申请日：2007-05-31

申请人： Christopher Scott ,  Anthony La Rosa

发明人： Christopher Scott ,  Anthony La Rosa

IPC分类号： A61B19/02 ,  A61B19/00

CPC分类号： A61B46/10 ,  A61B2017/00398 ,  A61B2017/00876 ,  A61B2090/508

摘要： A surgical drape with a functional interface for engaging surgical instruments, including a flexible, tube-like sleeve for creating a sterile barrier around a non-sterile holding arm. The drape is open at a proximal end, and has a hub at a distal end for connection to a distal end of the holding arm. The hub has sterile external surfaces that allow surgical instruments to be easily removably attached in a variety of directions and orientations, providing sufficient mechanical strength to transmit forces from the instruments to the holding arm. The hub includes an externally accessible, sterile actuator for actuating an electronic circuit local to the holding arm on the non-sterile side of the barrier.

摘要翻译： 具有用于接合外科器械的功能界面的手术罩，包括柔性的管状套筒，用于在非无菌保持臂周围产生无菌屏障。 悬垂在近端是开放的，并且在远端具有用于连接到保持臂的远端的毂。 轮毂具有无菌的外表面，允许手术器械容易地以各种方向和取向附着，提供足够的机械强度以将力从器械传递到保持臂。 轮毂包括外部可接近的无菌致动器，用于致动位于屏障的非无菌侧上的保持臂局部的电子回路。

公开(公告)号：US20060263875A1

公开(公告)日：2006-11-23

申请号：US11132996

申请日：2005-05-19

申请人： Christopher Scott ,  Brian Foley

发明人： Christopher Scott ,  Brian Foley

IPC分类号： C12M1/34 ,  C12M1/12 ,  B01L11/00

CPC分类号： B01L3/50255 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/0678 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0858

摘要： A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.

公开(公告)号：US20060234222A1

公开(公告)日：2006-10-19

申请号：US10501357

申请日：2002-12-30

申请人： Brendan McKeown ,  Christopher Scott ,  Alan McBride ,  Richard Buick ,  Jim Johnston

发明人： Brendan McKeown ,  Christopher Scott ,  Alan McBride ,  Richard Buick ,  Jim Johnston

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/195 ,  C12N1/21 ,  C12N15/74

CPC分类号： C12N15/62 ,  C07K14/31 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/23 ,  C12N9/10 ,  C12N9/104 ,  C12N15/70 ,  C12P21/02

摘要： Described is a method of producing a soluble bioactive domain of a protein, the method comprising the step of selecting suitable soluble subunits of a protein and assessing the produced protein for desired activity. The method may comprise the steps of amplifying DNA encoding at least one candidate soluble domain, cloning the amplified DNA into at least one expression vector, using each of said vectors into which the DNA has been cloned to each transfect or transform one or more host cell strains, expressing said DNA in one or more host cell strains, and analyzing expression products from said host cells for solubility.

摘要翻译： 描述了产生蛋白质的可溶性生物活性结构域的方法，所述方法包括选择蛋白质的合适的可溶性亚基并评估产生的蛋白质以获得所需活性的步骤。 该方法可以包括以下步骤：使用编码至少一个候选可溶性结构域的DNA，将扩增的DNA克隆到至少一个表达载体中，使用已经将DNA克隆到其中的每个所述载体转染或转化一个或多个宿主细胞 菌株，在一个或多个宿主细胞株中表达所述DNA，并分析来自所述宿主细胞的表达产物的溶解度。