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公开(公告)号：US08302781B2
公开(公告)日：2012-11-06
申请号：US10588695
申请日：2005-02-15
CPC分类号： B01D69/08 , B01D67/0013 , B01D67/0088 , B01D67/0095 , B01D67/0097 , B01D69/02 , B01D71/64 , B01D71/68 , B01D2323/02 , B01D2323/12 , B01D2323/36 , B01D2325/14 , B01D2325/20
摘要： A hydrophilic, semipermeable hollow-fiber membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fiber membrane possesses on its inner surface a porous separating layer and an open-pored supporting layer adjoining the separating layer, and has an ultrafiltration rate in albumin solution of 25 to 60 ml/(h·m2·mmHg). The hollow-fiber membrane is free from pore-stabilizing additives, and has a minimum sieving coefficient for cytochrome c of 0.8 and maximum sieving coefficient for albumin of 0.005. Method for the preparation of such membranes based on coagulation induced by a non-solvent, whereby a spinning solution of a synthetic first polymer and possibly a hydrophilic second polymer is extruded into a hollow fiber through the annular slit of a hollow-fiber die with simultaneous extrusion of a coagulation medium as the interior filler through the central opening of the hollow-fiber die, the interior filler initiating coagulation in the interior of the hollow fiber as a result of which a separating layer on the inner surface of the hollow-fiber membrane is formed as well as the membrane structure, the method being characterized in that the interior filler contains a polyelectrolyte with negative fixed charges.
摘要翻译： 用于血液处理的亲水性半透性中空纤维膜，具有基于合成聚合物的整体不对称结构。 中空纤维膜在其内表面具有邻接分离层的多孔分离层和开孔支撑层，并且在白蛋白溶液中的超滤速率为25至60ml /（h·m 2·mmHg）。 中空纤维膜不含孔稳定添加剂，细胞色素c的筛分系数最小为0.8，白蛋白筛分系数为0.005。 基于由非溶剂引起的凝结制备这种膜的方法，由此将合成的第一聚合物和可能的亲水性第二聚合物的纺丝溶液通过中空纤维模具的环形狭缝挤出成中空纤维，同时 通过中空纤维模头的中心开口挤出凝固介质作为内部填料，内部填料在中空纤维内部引发凝结，由此在中空纤维膜的内表面上形成分离层 形成膜结构，该方法的特征在于内部填充物含有具有负固定电荷的聚电解质。
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公开(公告)号：US20080000828A1
公开(公告)日：2008-01-03
申请号：US10588695
申请日：2005-02-15
申请人： Friedbert Wechs , Arne Gehlen , Bodo Harten , Richard Kruger , Oliver Schuster
发明人： Friedbert Wechs , Arne Gehlen , Bodo Harten , Richard Kruger , Oliver Schuster
IPC分类号： B01D63/02 , B01D39/14 , B01D67/00 , B01D69/00 , B01D69/02 , B01D69/08 , B29C47/00 , B29C47/02
CPC分类号： B01D69/08 , B01D67/0013 , B01D67/0088 , B01D67/0095 , B01D67/0097 , B01D69/02 , B01D71/64 , B01D71/68 , B01D2323/02 , B01D2323/12 , B01D2323/36 , B01D2325/14 , B01D2325/20
摘要： A hydrophilic, semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fibre membrane possesses on its inner surface a porous separating layer and an open-pored supporting layer adjoining the separating layer, and has an ultrafiltration rate in albumin solution of 25 to 60 ml/(h·m2·mmHg). The hollow-fibre membrane is free from pore-stabilising additives, and has a minimum sieving coefficient for cytochrome c of 0.8 and maximum sieving coefficient for albumin of 0.005. Method for the preparation of such membranes based on coagulation induced by a non-solvent, whereby a spinning solution of a synthetic first polymer and possibly a hydrophilic second polymer is extruded into a hollow fibre through the annular slit of a hollow-fibre die with simultaneous extrusion of a coagulation medium as the interior filler through the central opening of the hollow-fibre die, the interior filler initiating coagulation in the interior of the hollow fibre as a result of which a separating layer on the inner surface of the hollow-fibre membrane is formed as well as the membrane structure, the method being characterised in that the interior filler contains a polyelectrolyte with negative fixed charges.
摘要翻译： 用于血液处理的亲水性半透性中空纤维膜，具有基于合成聚合物的整体不对称结构。 中空纤维膜在其内表面具有邻接分离层的多孔分离层和开孔支撑层，并且在白蛋白溶液中的超滤速率为25至60ml /（hm 2 / .mmHg）。 中空纤维膜不含孔稳定添加剂，细胞色素c的筛分系数最小为0.8，白蛋白筛分系数为0.005。 基于由非溶剂引起的凝结制备这种膜的方法，由此将合成的第一聚合物和可能的亲水性第二聚合物的纺丝溶液通过中空纤维模具的环形狭缝挤出成中空纤维，同时 通过中空纤维模头的中心开口挤出凝固介质作为内部填料，内部填料在中空纤维内部引发凝结，由此在中空纤维膜的内表面上形成分离层 形成膜结构，该方法的特征在于内部填充物含有具有负固定电荷的聚电解质。
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公开(公告)号：US20070163949A1
公开(公告)日：2007-07-19
申请号：US10588696
申请日：2005-02-15
申请人： Friedbert Wechs , Arne Gehlen , Bodo Harten , Kruger Richard , Schuster Oliver
发明人： Friedbert Wechs , Arne Gehlen , Bodo Harten , Kruger Richard , Schuster Oliver
IPC分类号： B01D71/06
CPC分类号： B01D71/68 , B01D67/0011 , B01D67/0016 , B01D67/0088 , B01D67/0095 , B01D67/0097 , B01D69/02 , B01D69/08 , B01D2323/02 , B01D2323/12 , B01D2323/36 , B01D2325/14 , B01D2325/20 , Y10T428/2975
摘要： A hydrophilic semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fibre membrane possesses on its inner surface a separating layer and an adjoining open-pored supporting layer, and has an ultrafiltration rate in albumin solution of 5 to 25 ml/(h·m2·mmHg). The hollow-fibre membrane is free from pore-stabilizing additives and has a maximum sieving coefficient for albumin of 0.005 and a sieving coefficient for cytochrome c that satisfies the equation SCCC≧5·10−5·UFRAlb3−0.004·UFRAlb2+1.081·UFRAlb−0.25A method for producing such membranes by a coagulation process induced by a non-solvent, in which a spinning solution comprising a synthetic first polymer and possibly a hydrophilic second polymer is extruded through the annular slit of a hollow-fibre die to give a hollow fibre, and a coagulation medium that initiates coagulation in the interior of the hollow fibre is simultaneously extruded through the central opening of the hollow-fibre die, the coagulation medium initiating coagulation in the interior of the hollow fibre for formation of a separating layer on the inner surface of the hollow fibre and formation of the membrane structure, the method being characterized in that the interior filler contains a polyelectrolyte with negative fixed charges.
摘要翻译： 一种用于血液处理的亲水性半透性中空纤维膜，具有基于合成聚合物的整体不对称结构。 中空纤维膜的内表面具有分离层和相邻的开孔支撑层，并且在白蛋白溶液中具有5至25ml /（h.m 2 SUP·mmHg）的超滤速率。 中空纤维膜不含孔稳定添加剂，白蛋白的最大筛分系数为0.005，细胞色素c的筛分系数满足方程式<？in-line-formula description =“In-Line Formulas”end = “铅”？> SC = 5.10 。 3 3 -0.004.UFR Alb + 1.081.UFR -0.25 <？in-line-formula description =“In-line Formulas”end =“tail”？> 通过由非溶剂诱导的凝结过程制造这种膜的方法，其中将包含合成的第一聚合物和可能的亲水性第二聚合物的纺丝溶液通过中空纤维模头的环形狭缝挤出，得到中空纤维 ，并且在中空纤维内部引发凝结的凝固介质通过中空纤维模的中心孔同时挤出，凝固介质在中空纤维的内部起始凝结形成为 在中空纤维的内表面上形成渗透层并形成膜结构，该方法的特征在于，内部填料含有具有负固定电荷的聚电解质。
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公开(公告)号：US5919370A
公开(公告)日：1999-07-06
申请号：US952025
申请日：1997-11-14
申请人： Henning Rottger , Friedbert Wechs
发明人： Henning Rottger , Friedbert Wechs
IPC分类号： A61M1/16 , B01D67/00 , B01D69/02 , B01D69/04 , B01D69/06 , B01D69/08 , B01D69/12 , B01D71/68 , B32B5/18 , D01D5/24 , D01F6/76 , D01F6/94 , B01D61/00 , B01D69/00
CPC分类号： B01D67/0018 , B01D67/0013 , B01D67/0016 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2325/022 , B01D2325/20
摘要： Membranes suitable for use in haemodialysis include a separating layer A with a cut-off between 500 and 5,000,000, a support layer B and a layer C which partly determines the hydraulic permeability. The cut-off and hydraulic permeability can be set independently of one another. The membranes are integral, multi-asymmetric, semi-permeable membranes made from .epsilon.-caprolactam-soluble polymers. The membranes may be in the form of flat, tubular or hollow fiber membranes.
摘要翻译： PCT No.PCT / EP96 / 01814 Sec。 371日期：1997年11月14日 102（e）日期1997年11月14日PCT提交1996年5月2日PCT公布。 WO96 / 37282 PCT公开号 日期1996年11月28日适用于血液透析的膜包括分隔层A，截留值在500和5,000,000之间，支撑层B和层C，其部分地决定水力渗透性。 截止和水力渗透率可以彼此独立设置。 膜是由ε-己内酰胺可溶性聚合物制成的整体的，多不对称的半透膜。 膜可以是扁平的，管状的或中空纤维膜的形式。
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15.发明授权
公开(公告)号：US4976859A
公开(公告)日：1990-12-11
申请号：US401859
申请日：1989-09-01
申请人： Friedbert Wechs
发明人： Friedbert Wechs
CPC分类号： C08J3/091 , B01D69/00 , B01D71/68 , C08J2381/06
摘要： An integral polyether-sulfone membrane with a pore system open at the outer boundaries is in the form of flat films, tubular films or hollow fibers having a maximum pore diameter of 0.02 .mu.m to 2 .mu.m. The pore system is cellular throughout with cells having polyhedrally symmetrical boundaries. The cells are arranged asymmetrically from one surface of the membrane to the other, the asymmetry factor AF relative to the maximum pore diameter being 0.01 to 2.0. The ratio of the maximum mean free path length of the flow path to the diameter of the largest pore is greater than 3. The cell size changes steadily from one surface to the other surface. The membrane is produced by dissolving 12 to 35% by weight, relative to the total solution, of polyethersulfone in a mixture of 15 to 65% by weight of .epsilon.-caprolactam, 0 to 85% by weight of latent solvent, 0 to 15% by weight of thickener and 0 to 50% by weight of non-solvent, and if appropriate up to 1% by weight of auxiliaries, forming the solution into flat films, tubular films or hollow fibers (the latter preferably with the aid of an internal fluid), and transformation into the solid phase and removal of the mixture forming the solvent. The membrane may be used for ultrafiltration and microfiltration.
摘要翻译： 在外边界处开孔的整体式聚醚砜膜呈最大孔径为0.02μm〜2μm的扁平薄膜，管状薄膜或中空纤维的形式。 细孔系统是具有多边形对称边界的细胞。 细胞从膜的一个表面不对称地排列到另一个表面，相对于最大孔径的不对称因子AF为0.01至2.0。 流路的最大平均自由路径长度与最大孔的直径的比值大于3.细胞尺寸从一个表面稳定地变化到另一个表面。 该膜通过将15至65重量％的ε-己内酰胺，0至85重量％的潜在溶剂，0至15重量％的ε-己内酰胺，0至15重量％的聚氧乙烯醚溶解在聚环氧乙烷中的相对于总溶液的12至35重量％ 的增稠剂和0至50重量％的非溶剂，如果合适的话，最多可添加1重量％的助剂，将溶液形成平片，管状膜或中空纤维（后者优选借助于内部 流体），并转化成固相并除去形成溶剂的混合物。 该膜可用于超滤和微滤。
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公开(公告)号：US4968733A
公开(公告)日：1990-11-06
申请号：US401854
申请日：1989-09-01
IPC分类号： B01D61/14 , A61M1/16 , B01D67/00 , B01D71/16 , B01D71/30 , B01D71/32 , B01D71/34 , B01D71/38 , B01D71/40 , B01D71/50 , B01D71/64 , B01D71/66 , B01D71/68 , C08J3/14 , C08J9/28 , D01D5/24 , D01F6/76 , D01F6/78 , D01F6/94
CPC分类号： B01D67/0018 , B01D67/003 , B01D71/68 , C08J3/14 , C08J9/28 , B01D2323/12 , B01D2325/022 , C08J2201/052 , C08J2201/0544 , Y10S424/07
摘要： A process produces microporous powders or shaped articles, in particular membranes in the form of flat films, tubular films or hollow fibers, which may be used for controlled release of an active compound, for dialysis, gas separation, ultrafiltration or microfiltration, from polyvinylidene fluoride and/or polyphenylene sulfide and/or polysulfone and/or polyacrylonitrile and/or ethylene/vinyl alcohol copolymer and/or ethylene/chlorotrifluoroethylene copolymer and/or polyethersulfone and/or polyether-imide and/or polymethyl methacrylate and/or polycarbonate and/or cellulose triacetate. The process utilizes phase separation by means of thermally induced triggering or triggering induced by a non-solvent of a solution of the polymer in a mixture containing .epsilon.-caprolactam as the essential dissolving constituent. The solution may be formed before the phase separation is triggered.
摘要翻译： 一种方法产生微孔粉末或成型制品，特别是可以用于透明，气体分离，超滤或微滤的用于透析，气体分离，超滤或微过滤的平板，管状膜或中空纤维形式的膜，由聚偏二氟乙烯 和/或聚苯硫醚和/或聚砜和/或聚丙烯腈和/或乙烯/乙烯醇共聚物和/或乙烯/氯三氟乙烯共聚物和/或聚醚砜和/或聚醚酰亚胺和/或聚甲基丙烯酸甲酯和/或聚碳酸酯和/或 三醋酸纤维素。 该方法利用通过由含有ε-己内酰胺作为必需溶解成分的混合物的聚合物溶液的非溶剂引起的热引发触发或引发相分离。 在触发相分离之前可以形成溶液。
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公开(公告)号：US08727136B2
公开(公告)日：2014-05-20
申请号：US12789593
申请日：2010-05-28
CPC分类号： B01D63/081 , B01D67/0011 , B01D67/0013 , B01D67/0016 , B01D67/0027 , B01D69/02 , B01D69/06 , B01D71/68 , B01D2325/022 , B01D2325/023 , B01D2325/24 , B01D2325/36 , B01D2325/38
摘要： Method for producing this membrane from a casting solution comprising the hydrophobic first sulfone polymer and the hydrophilic second polymer in a solvent system, the method comprising the steps of pouring the casting solution, conditioned to a molding temperature, onto a carrier to form a film, which carrier has a temperature that is higher in comparison to the molding temperature, conveying the film through a climate-controlled zone, initiating the coagulation in a coagulation bath for the formation of a membrane structure, withdrawing the membrane structure from the carrier with a speed that is increased in comparison to the carrier speed, stabilizing, extracting, and subsequently drying the membrane.
摘要翻译： 在溶剂系统中由包含疏水性第一砜聚合物和亲水性第二聚合物的流延溶液制备该膜的方法，该方法包括以下步骤：将调节至模塑温度的浇铸溶液倒入载体上以形成膜， 该载体的温度与成型温度相比较高，将膜输送通过气候控制区，在用于形成膜结构的凝固浴中引发凝结，以速度从载体中取出膜结构 其与载体速度相比增加，稳定，提取和随后干燥膜。
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18.发明授权公开(公告)号：US07811507B2
公开(公告)日：2010-10-12
申请号：US10588696
申请日：2005-02-15
CPC分类号： B01D71/68 , B01D67/0011 , B01D67/0016 , B01D67/0088 , B01D67/0095 , B01D67/0097 , B01D69/02 , B01D69/08 , B01D2323/02 , B01D2323/12 , B01D2323/36 , B01D2325/14 , B01D2325/20 , Y10T428/2975
摘要： A hydrophilic semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fiber membrane possess on its inner surface a separating layer and an adjoining open-pored supporting layer, and has an ultrafiltration rate in albumin solution of 5 to ≦25 ml/(h·m2·mmHg). The hollow fiber membrane is free from pore-stabilizing additives and has a maximum sieving coefficient for albumin of 0.005 and a sieving coefficient of cytochrome c that satisfies the equation SCcc≧5·10−5·UFRAlb3−0.004·UFRAlb2+0.1081·UFRAlb−0.25.
摘要翻译： 一种用于血液处理的亲水性半透性中空纤维膜，具有基于合成聚合物的整体不对称结构。 中空纤维膜的内表面具有分离层和邻接的开孔支撑层，并且在白蛋白溶液中具有5至＆lt; llE; 25ml /（h·m 2·mmHg）的超滤速率。 中空纤维膜不含孔稳定添加剂，白蛋白的最大筛分系数为0.005，细胞色素c的筛分系数满足公式SCcc≥5·10-5·UFRAlb3-0.004·UFRAlb2 + 0.1081·UFRAlb- 0.25。
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公开(公告)号：US06497752B1
公开(公告)日：2002-12-24
申请号：US09868593
申请日：2001-08-24
申请人： Erich Kessler , Thomas Batzilla , Friedbert Wechs , Frank Wiese
发明人： Erich Kessler , Thomas Batzilla , Friedbert Wechs , Frank Wiese
IPC分类号： B01D5322
CPC分类号： B01D67/0018 , B01D67/0027 , B01D67/003 , B01D69/02 , B01D69/08 , B01D71/26 , B01D2325/022
摘要： Process for producing integrally asymmetrical hydrophobic polyolefinic membranes with a separation layer, in particular for gas exchange, via thermally induced liquid-liquid phase separation. A solution of at least one polyolefin in a solvent system containing a compound A and a compound B is extruded to form a shaped object. Compound A is a strong solvent and compound B a weak non-solvent for the polymer. After leaving the die, the shaped object is cooled using a solid or liquid cooling medium, which does not dissolve the polymer and does not react chemically with it, until the phase separation and solidification of the high-polymer-content phase take place. The integrally asymmetrical membrane producible in this manner has a porosity of greater than 30% to 75% by volume, a sponge-like, open-pored, microporous support layer without macrovoids and on average isotropic pores, a separation layer on at least one of its surfaces with pores
摘要翻译： 通过热诱导的液 - 液相分离制备具有分离层，特别是用于气体交换的整体不对称疏水性聚烯烃膜的方法。 将至少一种聚烯烃在含有化合物A和化合物B的溶剂体系中的溶液挤出以形成成形物体。 化合物A是强溶剂，化合物B是聚合物的弱非溶剂。 离开模具后，使用固体或液体冷却介质冷却成形物体，其不溶解聚合物并且不与其发生化学反应，直到发生高分子量含量相的相分离和凝固。 以这种方式生产的整体不对称膜具有大于30体积％至75体积％的孔隙率，不具有大孔和平均各向同性孔的海绵状，开孔，微孔支撑层，在至少一个 其表面具有小于100nm的孔（如果有的话）和至少为1的气体分离因子α（CO 2 / N 2）。膜优选用于血氧。
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公开(公告)号：US06375876B1
公开(公告)日：2002-04-23
申请号：US09869153
申请日：2001-09-04
申请人： Erich Kessler , Thomas Batzilla , Friedbert Wechs , Frank Wiese
发明人： Erich Kessler , Thomas Batzilla , Friedbert Wechs , Frank Wiese
IPC分类号： B29C6500
CPC分类号： B01D67/0018 , B01D67/0027 , B01D67/003 , B01D69/02 , B01D69/08 , B01D71/26 , B01D2323/08 , B01D2323/12 , B01D2325/022 , B01D2325/026 , C08J9/28
摘要： Process for producing an integrally asymmetrical hydrophobic polyolefinic membrane with a sponge-like, open-pored, microporous support structure and a separation layer with a denser structure compared to the support structure, via a thermally induced liquid-liquid phase separation process. A solution of at least one polyolefin in a solvent system consisting of a compound A and a compound B is extruded to form a shaped object. Compound A is a weak solvent and compound B a non-solvent for the polymer. After leaving the die, the shaped object is cooled using a solid or liquid cooling medium that does not dissolve or react chemically with the polymer at temperatures up to the die temperature, until the phase separation and solidification of the high-polymer-content phase take place.
摘要翻译： 通过热诱导的液 - 液相分离方法制备具有海绵状，开孔，微孔载体结构的整体不对称的疏水聚烯烃膜和具有比载体结构更致密结构的分离层的方法。 将至少一种聚烯烃在由化合物A和化合物B组成的溶剂体系中的溶液挤出以形成成形物体。 化合物A是弱溶剂，化合物B是聚合物的非溶剂。 离开模具后，使用固体或液体冷却介质冷却成型物体，该固体或液体冷却介质在高达模具温度的温度下不与聚合物溶解或化学反应，直到高分子量含量相的相分离和凝固 地点。
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