公开(公告)号：US12110494B2

公开(公告)日：2024-10-08

申请号：US17273621

申请日：2019-09-05

Applicant: Korea University Research and Business Foundation

Inventor： Kyoung Heon Kim ,  Yong Su Jin ,  Dong-Hyun Kim ,  Eun-Ju Yun

IPC: C12N15/81 ,  C07K14/195 ,  C12N9/24 ,  C12N9/38 ,  C12P7/18

CPC classification number: C12N15/81 ,  C07K14/195 ,  C12N9/2471 ,  C12P7/18 ,  C12Y101/01021 ,  C12Y302/01023

Abstract: The present invention relates to a method for biologically producing, from seaweeds, 3,6-anhydro-L-galactitol (L-AHGol) which is a novel sugar alcohol, and agarobititol (ABol) which is in a disaccharide form having 3,6-anhydro-L-galactitol (L-AHGol) as a reducing end, by using a genetic engineering technique in GRAS strains.

公开(公告)号：US11872253B2

公开(公告)日：2024-01-16

申请号：US17724386

申请日：2022-04-19

Applicant: Korea University Research and Business Foundation

Inventor： Kyoung Heon Kim ,  Yong-Su Jin ,  Eun-Ju Yun ,  Dong-Hyun Kim ,  Sora Yu ,  Kyung-Mun Cho ,  Na Jeong Park

IPC: C12P19/00 ,  A61K35/44 ,  A23L33/125 ,  A23L33/135 ,  A23L33/00 ,  A61K35/745 ,  A61K47/26 ,  A61K35/00

CPC classification number: A61K35/44 ,  A23L33/125 ,  A23L33/135 ,  A23L33/40 ,  A61K35/745 ,  A61K47/26 ,  C12P19/00 ,  A23V2002/00 ,  A23V2400/529 ,  A61K2035/115

Abstract: The present invention relates to a method for producing marine algae-derived agarotriose, and a use thereof as a prebiotic. More specifically, the present invention investigates the characteristics of agarotriose as a prebiotic which is selectively metabolized by probiotic microorganisms, thereby enabling agarotriose to be used as an anti-cancer or anti-inflammatory agent in the fields of food and pharmaceuticals, and enabling agarotriose to be obtained at high yield through efficient purification with minimal loss after enzymatic hydrolysis of a red algae-derived polysaccharide without pre-treatment.

公开(公告)号：US11458152B2

公开(公告)日：2022-10-04

申请号：US16985850

申请日：2020-08-05

Applicant: Korea University Research and Business Foundation

Inventor： Kyoung Heon Kim ,  Eun-Ju Yun ,  Sora Yu ,  Dong-Hyun Kim ,  Sang-Hyun Lee ,  Jung Yeon Kim

IPC: A61K8/73 ,  A61Q11/00 ,  A61K31/702 ,  A23L33/125 ,  A61P1/02 ,  A61P31/04 ,  A61K8/60 ,  A61K9/00 ,  A61K31/7016 ,  A61K31/729

Abstract: The present invention relates to a use of an agarobiose or agarooligosaccharides having anticariogenic activity. More specifically, a lower concentration of agarobiose or agarooligosaccharides than the concentration of xylitol suppresses the growth of Streptococcus mutans and suppresses acid production, and thus can be used for anti-cariogenic purposes.

公开(公告)号：US20220241349A1

公开(公告)日：2022-08-04

申请号：US17724386

申请日：2022-04-19

Applicant: Korea University Research and Business Foundation

Inventor： Kyoung Heon KIM ,  Yong-Su Jin ,  Eun-Ju Yun ,  Dong-Hyun Kim ,  Sora Yu ,  Kyung-mun Cho ,  Na Jeong Park

IPC: A61K35/74 ,  A23L33/125 ,  A23L33/135 ,  A23L33/00 ,  A61K35/745 ,  A61K47/26 ,  C12P19/00

Abstract: The present invention relates to a method for producing marine algae-derived agarotriose, and a use thereof as a prebiotic. More specifically, the present invention investigates the characteristics of agarotriose as a prebiotic which is selectively metabolized by probiotic microorganisms, thereby enabling agarotriose to be used as an anti-cancer or anti-inflammatory agent in the fields of food and pharmaceuticals, and enabling agarotriose to be obtained at high yield through efficient purification with minimal loss after enzymatic hydrolysis of a red algae-derived polysaccharide without pre-treatment.

公开(公告)号：US11337999B2

公开(公告)日：2022-05-24

申请号：US16764742

申请日：2018-11-15

Applicant: Korea University Research and Business Foundation

Inventor： Kyoung Heon Kim ,  Yong-Su Jin ,  Eun-Ju Yun ,  Dong-Hyun Kim ,  Sora Yu ,  Kyung-mun Cho ,  Na Jeong Park

IPC: A61K35/741 ,  A61K35/74 ,  A23L33/125 ,  A23L33/135 ,  A23L33/00 ,  A61K35/745 ,  A61K47/26 ,  C12P19/00 ,  A61K35/00

Abstract: The present invention relates to a method for producing marine algae-derived agarotriose, and a use thereof as a prebiotic. More specifically, the present invention investigates the characteristics of agarotriose as a prebiotic which is selectively metabolized by probiotic microorganisms, thereby enabling agarotriose to be used as an anti-cancer or anti-inflammatory agent in the fields of food and pharmaceuticals, and enabling agarotriose to be obtained at high yield through efficient purification with minimal loss after enzymatic hydrolysis of a red algae-derived polysaccharide without pre-treatment.

公开(公告)号：US10655118B2

公开(公告)日：2020-05-19

申请号：US16067730

申请日：2017-01-17

Applicant: Korea University Research and Business Foundation

Inventor： Kyoung Heon Kim ,  In-Geol Choi ,  Jung Hyun Kim ,  Eun-Ju Yun

IPC: C12P19/14 ,  C12N9/38 ,  C12P19/02

Abstract: The present invention relates to a heat-resistant agarase and a monosaccharide production method using same. More particularly, in the present invention, a heat-resistant agarase may be used to produce galactose and 3,6-anhydro-L-galactose at high yield by efficiently breaking down agarose or agar without a chemical pretreatment, a neutralization process, or an agarotriose hydrolase treatment process.

公开(公告)号：US10548828B2

公开(公告)日：2020-02-04

申请号：US15764732

申请日：2016-10-14

Applicant: Korea University Research and Business Foundation

Inventor： Kyoung Heon Kim ,  In-Geol Choi ,  Eun-Ju Yun ,  Ah-Reum Lee

IPC: A61K8/60 ,  A61K31/7004 ,  A61K9/00 ,  A61Q11/00 ,  A23L33/125

Abstract: The present invention relates to a use of 3,6-anhydro-L-galactose for preventing dental caries. More specifically, 3,6-anhydro-L-galactose inhibits the growth of oral microorganisms and exhibits anti-caries activity to inhibit the production of acids caused by the consumption of a carbon source by the oral microorganisms. Thus, 3,6-anhydro-L-galactose can be used in pharmaceuticals, food products, oral hygiene preparations, etc. for preventing, ameliorating or treating oral diseases caused by oral microorganisms, such as dental caries, gingivitis, periodontitis, oral mucosal ulcer, halitosis or xerostomia.

公开(公告)号：US09637761B2

公开(公告)日：2017-05-02

申请号：US14889376

申请日：2014-05-07

Applicant: Korea University Research and Business Foundation

Inventor： Kyoung Heon Kim ,  In-Geol Choi ,  Eun-Ju Yun ,  Sae Young Lee ,  Hee Taek Kim

IPC: C12P7/06 ,  C12N15/52 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90

CPC classification number: C12P7/065 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y102/01 ,  C12Y207/00 ,  C12Y207/01058 ,  C12Y401/02014 ,  C12Y505/01 ,  Y02E50/17

Abstract: The present invention relates to a recombinant microorganism metabolizing 3,6-anhydro-L-galactose and a use thereof, and, more particularly, can produce ethanol from a recombinant microorganism expressing an enzyme group involved in a metabolic pathway of 3,6-AHG.

公开(公告)号：US20160115504A1

公开(公告)日：2016-04-28

申请号：US14889376

申请日：2014-05-07

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Kyoung Heon Kim ,  In-Geol Choi ,  Eun-Ju Yun ,  Sae Young Lee ,  Hee Taek Kim

IPC: C12P7/06 ,  C12N9/88 ,  C12N9/12 ,  C12N9/02 ,  C12N9/90

CPC classification number: C12P7/065 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y102/01 ,  C12Y207/00 ,  C12Y207/01058 ,  C12Y401/02014 ,  C12Y505/01 ,  Y02E50/17

Abstract: The present invention relates to a recombinant microorganism metabolizing 3,6-anhydro-L-galactose and a use thereof, and, more particularly, can produce ethanol from a recombinant microorganism expressing an enzyme group involved in a metabolic pathway of 3,6-AHG.

Abstract translation: 本发明涉及代谢3,6-脱水-L-半乳糖的重组微生物及其用途，更具体地说，可以从表达参与3,6-AHG代谢途径的酶组的重组微生物产生乙醇 。