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    Optical systems and methods for biological analysis
    14.
    发明授权
    Optical systems and methods for biological analysis 有权

    公开(公告)号：US09702823B2

    公开(公告)日：2017-07-11

    申请号：US14348878

    申请日：2012-09-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kevin Maher ,  Mingsong Chen ,  Jacob Freudenthal ,  Kuan Moon Boo ,  Soo Yong Lau ,  David Fortescue ,  Ming Shen ,  Woon Liang Terence Soh

    IPC: G01N21/64

    CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/062

    Abstract: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

    Systems and Methods for Assessing of Biological Samples
    15.
    发明申请
    Systems and Methods for Assessing of Biological Samples 审中-公开
    生物样品评估系统和方法

    公开(公告)号：US20150045252A1

    公开(公告)日：2015-02-12

    申请号：US14385766

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kevin Maher

    IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00

    CPC classification number: C12Q1/686 ,  B01L3/50857 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0893 ,  B01L2300/0896 ,  C12Q2563/159 ,  C12Q2565/619

    Abstract: A system for determining the number of target nucleotide molecules in a sample includes a sample holder, an excitation optical system, an optical sensor, and an emission optical system. The sample holder is configured to receive an article comprising at least 20,000 separate reaction sites. The excitation optical system comprises a light source configured to simultaneously illuminate the at least 20,000 separate reaction sites. The optical sensor comprises a predetermined number of pixels, the predetermined number of pixels being at least 20 times the number of separate reaction sites. The emission optical system comprises a system working distance from the sample holder, wherein the working distance is less than or equal to 60 millimeters.

    Abstract translation: 用于确定样品中目标核苷酸分子数目的系统包括样品架，激发光学系统，光学传感器和发射光学系统。 样品架被配置为接收包含至少20,000个单独的反应位点的制品。 激发光学系统包括被配置为同时照亮至少20,000个单独的反应位点的光源。 光学传感器包括预定数量的像素，预定数量的像素是分离反应位点数量的至少20倍。 发射光学系统包括与样品保持器的系统工作距离，其中工作距离小于或等于60毫米。

    Systems and Methods for Containing Biological Samples
    16.
    发明申请
    Systems and Methods for Containing Biological Samples 审中-公开
    包含生物样品的系统和方法

    公开(公告)号：US20150044686A1

    公开(公告)日：2015-02-12

    申请号：US14385765

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Michael Pallas ,  James C. Nurse ,  Kevin Maher ,  Jorge Fonseca ,  Eliodor Ghenciu ,  Evan Foster

    IPC: C12Q1/68 ,  B01L3/00 ,  G03F7/20

    CPC classification number: B01L3/50857 ,  B01L3/50 ,  B01L3/50851 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/142 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/161 ,  C12Q1/6806 ,  C12Q1/686 ,  G03F7/2002

    Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.

    Abstract translation: 用于保持多个生物样品的制品包括基材，其包含基材中的第一表面和相对的第二表面和多个反应位点。 每个反应位点从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状并且被配置为通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应部位的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。

    Optical Systems and Methods for Biological Analysis
    17.
    发明申请
    Optical Systems and Methods for Biological Analysis 有权
    光学系统和生物分析方法

    公开(公告)号：US20140248693A1

    公开(公告)日：2014-09-04

    申请号：US14348878

    申请日：2012-09-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kevin Maher

    IPC: G01N21/64

    CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/062

    Abstract: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

    Abstract translation: 用于处理和/或测量生物过程的仪器包含激发源，样品架，光学传感器，激发光学系统和发射光学系统。 样品架被配置为接收多个生物样品。 光学传感器被配置为接收来自生物样品的发射。 激发光学系统沿着激发光路设置并且被配置为将来自激发源的电磁辐射引导到生物样品。 发射光学系统沿着发射光路设置并且被配置为将来自生物样品的电磁辐射引导到光学传感器。 该仪器还包括多个过滤器组件，其被配置为沿着至少一个光路可互换地定位。 多个滤波器部件包括第一滤波器组件，其特征在于第一光功率和具有第一滤波器功能的第一滤波器，第一滤波器功能的特征在于第一低通波长或第一高通波长中的至少一个。 第二滤波器组件的特征在于具有第二滤波器功能的第二光功率和第二滤波器，所述第二滤波器功能包括不同于第一低通波长的第二低通波长或第二低通波长中的至少一个 通过波长不同于第一高通波长。

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