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公开(公告)号：US20190381502A1
公开(公告)日：2019-12-19
申请号：US16426631
申请日：2019-05-30
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan Foster , Jorge Fonseca , Kevin Maher
IPC: B01L3/00 , C12Q1/6806 , G03F7/20 , C12Q1/686
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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公开(公告)号：US20230201839A1
公开(公告)日：2023-06-29
申请号：US18086416
申请日：2022-12-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan Foster , Jorge Fonseca , Kevin Maher
IPC: B01L3/00 , C12Q1/6806 , G03F7/20 , C12Q1/686
CPC classification number: B01L3/50857 , B01L3/50 , C12Q1/6806 , G03F7/2002 , B01L3/50851 , C12Q1/686 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , B01L2300/0654 , B01L2300/0829 , B01L2200/142 , B01L2300/046 , B01L2200/0642 , B01L7/52
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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Patent Agency Ranking
公开(公告)号：US11590506B2
公开(公告)日：2023-02-28
申请号：US16426631
申请日：2019-05-30
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan Foster , Jorge Fonseca , Kevin Maher
IPC: B01L3/00 , C12Q1/6806 , G03F7/20 , C12Q1/686 , B01L7/00
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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公开(公告)号：US11493526B2
公开(公告)日：2022-11-08
申请号：US16852830
申请日：2020-04-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eliodor Ghenciu , Theodore E. Straub , Evan W. Foster , Michael C. Pallas
Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
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公开(公告)号：US20150044686A1
公开(公告)日：2015-02-12
申请号：US14385765
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael Pallas , James C. Nurse , Kevin Maher , Jorge Fonseca , Eliodor Ghenciu , Evan Foster
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.
Abstract translation: 用于保持多个生物样品的制品包括基材，其包含基材中的第一表面和相对的第二表面和多个反应位点。 每个反应位点从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状并且被配置为通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应部位的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。
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公开(公告)号：US20150080247A1
公开(公告)日：2015-03-19
申请号：US14385730
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan W. Foster , Jorge Fonseca , Kevin Maher
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
Abstract translation: 提供了用于进行生物反应的系统。 该系统包括包括基底和多个反应位点的芯片。 多个反应位点各自被配置为包括至多一个纳升级的液体样品。 此外，该系统包括被配置为启动液体样品内的生物反应的控制系统。 该系统还包括被配置为检测芯片上的生物反应的检测系统。 根据各种实施方案，芯片包括至少20000个反应位点。 在其它实施方案中，芯片包括至少30000个反应位点。
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公开(公告)号：US20150051118A1
公开(公告)日：2015-02-19
申请号：US14385740
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eliodor Ghenciu , Theodore E. Straub , Evan W. Foster , Michael C. Pallas
IPC: B01L3/00
Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
Abstract translation: 提供了用于生物反应的装置。 该装置包括衬底和衬底内的多个反应位点。 衬底的表面被配置为具有第一亲水性，并且多个反应位点的每个表面被配置为具有第二亲水性，以加载具有样品体积的大量反应位点。 每个加载的反应位点的样品体积基本上限于其各自的反应位点。 样品体积被配置为在反应位点内进行生物反应。
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