公开(公告)号：US09428800B2

公开(公告)日：2016-08-30

申请号：US14195358

申请日：2014-03-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： John Linton ,  Arrin Katz ,  Colin Brenan ,  Karl Yoder ,  Robert Hess ,  Leila Madrone ,  Robert Ellis ,  Tanya Kanigan ,  Kristine Friesen ,  Thomas Morrison ,  Javier Garcia

IPC: G01N31/22 ,  G01N21/01 ,  G01N21/77 ,  C12Q1/68 ,  B01L3/00 ,  G01N21/03 ,  G01N21/15 ,  G01N21/25 ,  B01L7/00 ,  G01N21/05

CPC classification number: C12Q1/6858 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/508 ,  B01L3/50853 ,  B01L3/50857 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/16 ,  B01L2300/1822 ,  B01L2300/1838 ,  G01N21/03 ,  G01N21/15 ,  G01N21/253 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2021/158 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Abstract translation: 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。

公开(公告)号：US09266108B2

公开(公告)日：2016-02-23

申请号：US14042458

申请日：2013-09-30

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tanya S. Kanigan ,  Steve Smith ,  John Linton ,  Robert Hess ,  Karl Yoder ,  Colin John Herbert Brenan

IPC: B01L3/00 ,  B01L3/02

CPC classification number: B01L3/5085 ,  B01L3/0241 ,  B01L3/0244 ,  B01L3/5025 ,  B01L3/50857 ,  B01L3/563 ,  B01L2200/021 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0636 ,  B01L2200/0642 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/12 ,  B01L2300/161 ,  B33Y70/00 ,  B33Y80/00 ,  Y10T137/0318 ,  Y10T137/1624 ,  Y10T137/206 ,  Y10T436/2525

Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.

公开(公告)号：US20140179566A1

公开(公告)日：2014-06-26

申请号：US14195358

申请日：2014-03-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： John LINTON ,  Arrin Katz ,  Colin Brenan ,  Karl Yoder ,  Robert Hess ,  Leila Hasan ,  Robert Ellis ,  Tanya Kanigan ,  Kristine Friesen ,  Thomas Morrison ,  Javier Garcia

IPC: C12Q1/68

CPC classification number: C12Q1/6858 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/508 ,  B01L3/50853 ,  B01L3/50857 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/16 ,  B01L2300/1822 ,  B01L2300/1838 ,  G01N21/03 ,  G01N21/15 ,  G01N21/253 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2021/158 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Abstract translation: 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。