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    Use of avocado pit for obtaining an avocado oil enriched with alkyl polyols and/or acetylated derivatives thereof
    11.
    发明授权
    Use of avocado pit for obtaining an avocado oil enriched with alkyl polyols and/or acetylated derivatives thereof 有权
    使用鳄梨坑获得富含烷基多元醇和/或其乙酰化衍生物的鳄梨油

    公开(公告)号：US09416333B2

    公开(公告)日：2016-08-16

    申请号：US14371057

    申请日：2013-01-14

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

    IPC: A01N65/00 ,  C11B1/06 ,  A23L1/30 ,  A61K36/54 ,  A23L1/212 ,  A23D9/007 ,  A23D9/02 ,  C11B1/08 ,  A61Q19/06 ,  A61Q19/08 ,  A61K8/92 ,  A23L2/52

    CPC classification number: C11B1/06 ,  A23D9/007 ,  A23D9/02 ,  A23L2/52 ,  A23L19/07 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K8/922 ,  A61K36/54 ,  A61Q19/06 ,  A61Q19/08 ,  C11B1/08

    Abstract: The present invention relates to the use of avocado seeds in order to obtain avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado oil enriched in alkyl polyols or acetylated derivatives thereof from at least avocado seeds, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable by the present method. The invention also relates to the use of avocado oil in order to prepare an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, or to prepare an avocado unsaponifiable enriched in alkyl polyols. Lastly, the invention relates to an avocado unsaponifiable enriched in alkyl polyols or an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable from said avocado oil, for use as a drug, advantageously in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

    Abstract translation: 本发明涉及鳄梨种子的使用以获得富含烷基多元醇和/或其乙酰化衍生物的鳄梨油，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及从至少鳄梨种子获得富含烷基多元醇或其乙酰化衍生物的鳄梨油的方法，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及通过本方法获得的富含烷基多元醇和/或其乙酰化衍生物的鳄梨油。 本发明还涉及鳄梨油的用途，以制备富含烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，或制备不可皂化的富含烷基多元醇的鳄梨油。 最后，本发明涉及一种不可皂化的富含鳄梨油的富含烷基多元醇的牛油果油或富含其烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，其可从所述鳄梨油获得，有利地用于预防和/或治疗 结膜组织疾病如关节病，关节病变如风湿病，或牙周病如牙龈炎或牙周炎。

    USE OF BIOMARKERS FOR EVALUATING THE EFFECTIVENESS OF ACTIVE INGREDIENTS
    12.
    发明申请
    USE OF BIOMARKERS FOR EVALUATING THE EFFECTIVENESS OF ACTIVE INGREDIENTS 审中-公开
    使用生物标记物评估活性成分的有效性

    公开(公告)号：US20160084822A1

    公开(公告)日：2016-03-24

    申请号：US14785212

    申请日：2014-04-22

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Caroline Baudouin ,  Stephanie Bredif

    IPC: G01N33/50

    CPC classification number: G01N33/5023 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/6881

    Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.

    Abstract translation: 本发明涉及一种用于评估选自C7鳄梨糖（也称为鳄梨坚果）用于预防或治疗皮肤屏障缺陷的活性成分的有效性的方法，所述方法包括测定表达水平和/或激活 的至少一种生物标志物，其中所述生物标志物选自表皮成熟标志物，脂质屏障标记物，水合调节标记物和颗粒颗粒调节标记物。

    Use of avocado skin for obtaining an avocado unsaponifiable material enriched with saturated aliphatic hydrocarbons and with sterols
    14.
    发明授权
    Use of avocado skin for obtaining an avocado unsaponifiable material enriched with saturated aliphatic hydrocarbons and with sterols 有权
    使用鳄梨皮肤获得富含饱和脂肪烃和甾醇的鳄梨不皂化物质

    公开(公告)号：US09439938B2

    公开(公告)日：2016-09-13

    申请号：US14370892

    申请日：2013-01-14

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

    IPC: A61K36/54 ,  A23L1/30 ,  A23D9/00 ,  A23D9/02 ,  C11B1/08 ,  A61K31/01 ,  A61K31/575

    CPC classification number: A61K36/54 ,  A23D9/00 ,  A23D9/02 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K31/01 ,  A61K31/575 ,  C11B1/08

    Abstract: The present invention relates to the use of avocado peels in order to obtain avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols from at least avocado peels, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, obtainable by this method. Lastly, the invention relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, for use as a drug, advantageously in the in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

    Abstract translation: 本发明涉及鳄梨皮的使用以获得不可皂化的富含饱和脂肪烃的牛油果和甾醇，所述鳄梨皮相对于所用鳄梨的总重量占5至50重量％。 本发明还涉及一种用于从至少鳄梨皮中获得富含饱和脂肪烃和甾醇的鳄梨不可皂化的方法，所述鳄梨皮相对于所用牛油的总重量计算为5至50重量％。 本发明还涉及可通过该方法获得的不可皂化的富含饱和脂肪烃和甾醇的鳄梨。 最后，本发明涉及不可皂化的富含饱和脂族烃和固醇的鳄梨，用作药物，有利地用于预防和/或治疗结缔组织疾病如关节病，关节病变如风湿病或牙周病 疾病如牙龈炎或牙周炎。

    CORNEODESOMOSOMES AND BARRIER FUNCTION MATURATION
    15.
    发明申请
    CORNEODESOMOSOMES AND BARRIER FUNCTION MATURATION 审中-公开
    CORNEODESOMOSOMES和BARRIER功能成熟

    公开(公告)号：US20160195515A1

    公开(公告)日：2016-07-07

    申请号：US14915702

    申请日：2014-09-03

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Nadege Lachmann ,  Caroline Baudouin

    IPC: G01N33/50 ,  G01N33/68

    CPC classification number: G01N33/5044 ,  G01N33/5023 ,  G01N33/6881 ,  G01N2333/47

    Abstract: The present invention thus relates to a method for determining the degree of maturation of the skin surface of a subject. In particular, the present invention relates to method for determining whether the skin surface of a subject is mature/immature in its organization/function, said method comprising the steps of taking a skin sample of the said subject; and determining the corneodesmosome distribution within the stratum corneum of the sample.

    Abstract translation: 因此，本发明涉及一种用于确定受试者的皮肤表面的成熟程度的方法。 特别地，本发明涉及用于确定受试者的皮肤表面在其组织/功能中是否成熟/不成熟的方法，所述方法包括以下步骤：摄取所述受试者的皮肤样品; 并测定样品角质层内的角质层分布。

    USE OF AVOCADO SKIN FOR OBTAINING AN AVOCADO UNSAPONIFIABLE MATERIAL ENRICHED WITH SATURATED ALIPHATIC HYDROCARBONS AND WITH STEROLS
    17.
    发明申请
    USE OF AVOCADO SKIN FOR OBTAINING AN AVOCADO UNSAPONIFIABLE MATERIAL ENRICHED WITH SATURATED ALIPHATIC HYDROCARBONS AND WITH STEROLS 有权
    使用AVOCADO皮肤获得饱和饱和脂肪和碳水化合物的AVOCADO不可释放材料

    公开(公告)号：US20150005273A1

    公开(公告)日：2015-01-01

    申请号：US14370892

    申请日：2013-01-14

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

    IPC: A61K36/54 ,  A61K31/575 ,  A61K31/01

    CPC classification number: A61K36/54 ,  A23D9/00 ,  A23D9/02 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K31/01 ,  A61K31/575 ,  C11B1/08

    Abstract: The present invention relates to the use of avocado peels in order to obtain avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols from at least avocado peels, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, obtainable by this method. Lastly, the invention relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, for use as a drug, advantageously in the in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

    Abstract translation: 本发明涉及鳄梨皮的使用以获得不可皂化的富含饱和脂肪烃的牛油果和甾醇，所述鳄梨皮相对于所用鳄梨的总重量占5至50重量％。 本发明还涉及一种用于从至少鳄梨皮中获得富含饱和脂肪烃和甾醇的鳄梨不可皂化的方法，所述鳄梨皮相对于所用牛油的总重量计算为5至50重量％。 本发明还涉及可通过该方法获得的不可皂化的富含饱和脂肪烃和甾醇的鳄梨。 最后，本发明涉及不可皂化的富含饱和脂族烃和固醇的鳄梨，用作药物，有利地用于预防和/或治疗结缔组织疾病如关节病，关节病变如风湿病或牙周病 疾病如牙龈炎或牙周炎。

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