公开(公告)号：US20240219307A1

公开(公告)日：2024-07-04

申请号：US18429280

申请日：2024-01-31

Applicant: Meso Scale Technologies, LLC.

Inventor： Charles M. CLINTON ,  Eli N. GLEZER ,  Sharon WEST ,  George SIGAL ,  Carl STEVENS ,  Michael L. VOCK

IPC: G01N21/76 ,  G01N21/69 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N2035/00524 ,  G01N2035/0425 ,  G01N35/1079 ,  Y10T436/114165

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20220097072A1

公开(公告)日：2022-03-31

申请号：US17492207

申请日：2021-10-01

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Kenneth PAGE ,  Sandor KOVACS ,  Sudeep KUMAR ,  Kristian ROTH

IPC: B01L3/00 ,  F16K11/074

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

公开(公告)号：US20210291168A1

公开(公告)日：2021-09-23

申请号：US17215962

申请日：2021-03-29

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. GLEZER ,  Sudeep KUMAR ,  Pankaj OBEROI ,  George SIGAL ,  Michael TSIONSKY

IPC: B01L3/00 ,  C12Q1/6804 ,  G01N33/68 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6876

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20210190778A1

公开(公告)日：2021-06-24

申请号：US17132380

申请日：2020-12-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit AGHVANYAN ,  Eli N. GLEZER ,  John KENTEN ,  George SIGAL ,  Martin STENGELIN

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/53 ,  G01N33/533 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/58

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

公开(公告)号：US20240375109A1

公开(公告)日：2024-11-14

申请号：US18597358

申请日：2024-03-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Eli N. GLEZER ,  Sudeep KUMAR ,  Pankaj OBEROI ,  George SIGAL ,  Michael TSIONSKY

IPC: B01L3/00 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/543 ,  G01N33/68

Abstract: The invention relates to methods for conducting solid-phase binding assays. Onc example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20230407380A1

公开(公告)日：2023-12-21

申请号：US18320411

申请日：2023-05-19

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Eli N. GLEZER ,  John H. KENTEN

IPC: C12Q1/6844 ,  G01N33/543 ,  C12Q1/682 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6804 ,  G01N33/542

CPC classification number: C12Q1/6844 ,  G01N33/54306 ,  C12Q1/682 ,  C12Q1/6837 ,  G01N2458/10 ,  C12Q1/6804 ,  G01N33/542 ,  C12Q2531/125 ,  C12Q2533/107 ,  C12Q1/6848

Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

公开(公告)号：US20220357318A1

公开(公告)日：2022-11-10

申请号：US17813965

申请日：2022-07-21

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit AGHVANYAN ,  Eli N. GLEZER ,  John KENTEN ,  George SIGAL ,  Martin STENGELIN ,  David ROUTENBERG

IPC: G01N33/543 ,  C12Q1/6832 ,  C12Q1/6837 ,  C12Q1/6844

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

公开(公告)号：US20210339243A1

公开(公告)日：2021-11-04

申请号：US17378294

申请日：2021-07-16

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. GLEZER ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Sudeep M. Kumar ,  George B. Sigal ,  Bisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC: B01L3/00 ,  G01N33/543 ,  G01N33/53

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

公开(公告)号：US20190277855A1

公开(公告)日：2019-09-12

申请号：US16420724

申请日：2019-05-23

Applicant: Meso Scale Technologies, LLC

Inventor： Charles M. CLINTON ,  Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Sandor L. KOVACS ,  Sudeep M. KUMAR ,  George SIGAL ,  Carl STEVENS ,  Michael VOCK

IPC: G01N33/58 ,  G01N21/66 ,  G01N33/53 ,  G01N35/02 ,  B67B7/00 ,  G01N35/10 ,  G01N21/64

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20190187060A1

公开(公告)日：2019-06-20

申请号：US16270062

申请日：2019-02-07

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Charles M. CLINTON ,  Eli N. GLEZER ,  Sharon WEST ,  George SIGAL ,  Carl STEVENS ,  Michael L. VOCK

IPC: G01N21/76 ,  G01N35/02 ,  G01N21/69 ,  G01N35/00

CPC classification number: G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N35/1079 ,  G01N2035/0425 ,  Y10T436/114165

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.