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公开(公告)号：US06448005B1
公开(公告)日：2002-09-10
申请号：US09456455
申请日：1999-12-08
IPC分类号： C07K100
CPC分类号： C07K14/705 , C07K14/723
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, including congestive heart failure. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
摘要翻译： 本发明涉及属于G蛋白偶联受体的超家族的新鉴定的受体。 本发明还涉及编码受体的多核苷酸。 本发明还涉及使用受体多肽和多核苷酸作为受体介导的障碍，特别是心血管疾病包括充血性心力衰竭的诊断和治疗的靶标的方法。 本发明还涉及使用受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于受体多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生受体多肽和多核苷酸的方法。
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12.发明申请Novel nucleic acid sequences encoding adenylate kinases, alcohol dehydrogenases, ubiquitin proteases, lipases, adenylate cyclases, and GTPase activators 审中-公开编码腺苷酸激酶，醇脱氢酶，泛素蛋白酶，脂肪酶，腺苷酸环化酶和GTP酶激活剂的新型核酸序列公开(公告)号：US20090280482A1
公开(公告)日：2009-11-12
申请号：US12001737
申请日：2007-12-12
CPC分类号： C12N9/6472
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。
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13.发明申请Novel TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, alpha2delta-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084Fl and 67084alt molecules and uses therefor 审中-公开新颖的TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2delta-4,8099,46455,5414,53763,97076,97102,44181,67084F1和67084altalt分子， 用它公开(公告)号：US20080032289A1
公开(公告)日：2008-02-07
申请号：US11050947
申请日：2005-02-04
IPC分类号： C07K14/435 , C07K16/18 , C12N1/00 , C12N15/12 , C12N15/63 , C12N5/00 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： G01N33/57415 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/705 , C07K16/18 , C07K2319/00 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/6872 , G01N2800/32 , G01N2800/325 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, which encode novel ion channel family molecules, including calcium channels, potassium channels, and NMDA receptors. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt gene has been introduced or disrupted. The invention still further provides isolated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt polypeptides, fusion polypeptides, antigenic peptides and anti-TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，称为TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ-4,8099， 46455,55414,53763,97076,97102,44181,67084FL和67084alt核酸分子，其编码新的离子通道家族分子，包括钙通道，钾通道和NMDA受体。 本发明还提供反义核酸分子，含有TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ- 4,8099,46455,54144,53763,97076,97102,44181,67084FL和67084alt核酸分子，其中引入了表达载体的宿主细胞，以及非人转基因动物，其中TWIK-6，TWIK-7 ，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ-4,8099,46455,5414,53763,97076,97102,44181,67084FL和67084alt基因 已被引入或中断。 本发明还进一步提供了分离的TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2ΔΔ4,8099,46455,5444 ，53763,97076,97102,44181,67084FL和67084alt多肽，融合多肽，抗原肽和抗TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9， 3Δ-4，8099,46455,5414,53763,97076,97102,44181,67084FL和67084alt抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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14.发明授权Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, ATPase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor 失效编码黑素瘤相关抗原分子，氨基转移酶分子，ATP酶分子，酰基转移酶分子，吡哆醛 - 磷酸依赖性酶分子的核酸序列及其用途公开(公告)号：US07256010B2
公开(公告)日：2007-08-14
申请号：US11245400
申请日：2005-10-06
CPC分类号： G01N33/5743 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N9/1029 , C12N9/1096 , C12N9/14 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US06586205B1
公开(公告)日：2003-07-01
申请号：US09585876
申请日：2000-06-01
IPC分类号： C12P2106
CPC分类号： C07K14/705 , A61K38/00
摘要： Novel GPCR-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GPCR-like proteins, the invention further provides isolated GPCR-like fusion proteins, antigenic peptides, and anti-GPCR-like antibodies. The invention also provides GPCR-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GPCR-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 公开了新的GPCR样多肽，蛋白质和核酸分子。 除了分离的全长GPCR样蛋白之外，本发明还提供了分离的GPCR样融合蛋白，抗原肽和抗GPCR样抗体。 本发明还提供了GPCR样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经导入或破坏了GPCR样基因的非人转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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16.发明申请NOVEL 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 AND 49933 MOLECULES AND USES THEREFOR 审中-公开新型25869,25934,26335,50365,211117,38692,46508,16816,16839,49937,49931和49933分子及其用途公开(公告)号：US20110150860A1
公开(公告)日：2011-06-23
申请号：US12755449
申请日：2010-04-07
申请人： Rory A.J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
发明人： Rory A.J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
IPC分类号： A61K39/395 , C07H21/04 , C07K14/00 , C07K16/00 , C12P21/06 , G01N33/53 , G01N33/48 , G01N33/50 , C12N5/10 , A61K31/711 , A61K38/16 , A61K31/7088 , A61P35/00 , A61P3/00 , A61P7/00 , A61P19/00 , A61P25/00 , A61P31/12
CPC分类号： C07K14/47 , A61K38/00 , G01N2500/00 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 gene has been introduced or disrupted. The invention still further provides isolated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 proteins, fusion proteins, antigenic peptides and anti-25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为25869,25934,26335,50516,21117,38692,46508,16816,16839,49937,49931和49933核酸分子。 本发明还提供反义核酸分子，包含25869,25934,26335,50521,21117,38692,46508,16816,16839,4467,49931或49933核酸分子的重组表达载体，已经引入了表达载体的宿主细胞 ，以及引入或破坏25869,25934,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933基因的非人类转基因动物。 本发明还进一步提供了分离的25869,2593,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933蛋白，融合蛋白，抗原肽和抗-25869,25934,26335,50365,211117,38692 ，46508,16816,16839,49937,49931或49933抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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公开(公告)号：US07534579B2
公开(公告)日：2009-05-19
申请号：US11283567
申请日：2005-11-18
IPC分类号： G01N33/53 , G01N33/537 , G01N33/567
CPC分类号： C07K14/723
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, including congestive heart failure. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
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18.发明授权NUCLEIC ACID SEQUENCES ENCODING MELANOMA ASSOCIATED ANTIGEN MOLECULES, AMINOTRANSFERASE MOLECULES, ATPASE MOLECULES, ACYLTRANSFERASE MOLECULES, PYRIDOXAL-PHOSPHATE DEPENDENT ENZYME MOLECULES AND USES THEREFOR 失效核酸序列编码相关抗原分子，氨基转移酶分子，ATPase分子，ACYLTRANSFERASE分子，依赖于磷酸的磷酸酯依赖性酶分子及其用途公开(公告)号：US07078205B2
公开(公告)日：2006-07-18
申请号：US10164966
申请日：2002-06-07
CPC分类号： G01N33/5743 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N9/1029 , C12N9/1096 , C12N9/14 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。
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19.发明授权Nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor 失效编码腺苷酸激酶的核酸序列，磷脂类scramblase样，DNA片段化因子样，磷脂酰丝氨酸合酶样和atpase样分子，用于其公开(公告)号：US06953682B2
公开(公告)日：2005-10-11
申请号：US10165800
申请日：2002-06-07
CPC分类号： C12N9/1229 , C07K14/47 , C12N9/1288 , C12N9/14 , G01N33/574 , G01N33/6896
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US06686185B1
公开(公告)日：2004-02-03
申请号：US09723806
申请日：2000-11-28
IPC分类号： C12N902
CPC分类号： C12N9/0071 , A61K38/00 , C12N9/0083
摘要： The invention provides isolated nucleic acids molecules, designated 25934 nucleic acid molecules, which encode a novel desaturase family member. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25934 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25934 gene has been introduced or disrupted. The invention still further provides isolated 25934 proteins, fusion proteins, antigenic peptides and anti-25934 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods for modulating fatty acid metabolism utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing cardiovascular disorders, such atherosclerosis, hypertriglyceridemia, hypercholesterolemia, and hyperlipidemia, are disclosed.
摘要翻译： 本发明提供编码新型去饱和酶家族成员的分离的核酸分子，命名为25934核酸分子。 本发明还提供了反义核酸分子，含有25934个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已导入或破坏了25934基因的非人转基因动物。 本发明还进一步提供了分离的25934蛋白，融合蛋白，抗原肽和抗25934抗体。 还提供了利用本发明组合物的诊断方法。 本发明还提供了利用本发明组合物调节脂肪酸代谢的方法。 因此，公开了治疗，预防和/或诊断心血管疾病，动脉粥样硬化，高甘油三酯血症，高胆固醇血症和高脂血症的方法。
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