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11.发明授权公开(公告)号：US08679518B2
公开(公告)日：2014-03-25
申请号：US13407961
申请日：2012-02-29
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译： 抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物在不离开基团的情况下的挥发性。 可以使用几乎任何可水解的离去基团。 除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。
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公开(公告)号：US07955512B2
公开(公告)日：2011-06-07
申请号：US11674607
申请日：2007-02-13
申请人： Eunsung Park , Catherine E. Taylor , Kevin Casey
发明人： Eunsung Park , Catherine E. Taylor , Kevin Casey
IPC分类号： B44C1/22
CPC分类号： A61L27/50 , A61B17/68 , A61B17/7002 , A61B17/7059 , A61B17/86 , A61B17/866 , A61C8/0012 , A61F2/0077 , A61F2/30767 , A61F2/3094 , A61F2/3099 , A61F2/38 , A61F2/44 , A61F2/82 , A61F2002/30677 , A61F2002/30925 , A61F2002/3097 , A61F2240/001 , A61F2250/0067 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00071 , A61F2310/00089 , A61F2310/00101 , A61F2310/00131 , A61F2310/00149 , A61F2310/00395 , A61F2310/0052 , A61F2310/00574 , A61F2310/0058 , A61F2310/00598 , A61F2310/0073 , A61F2310/00856 , A61F2310/00976 , A61L29/14 , A61L31/14 , A61N1/00
摘要： Disclosed are medical devices having textured surfaces and related methods for texturing. Methods of surface texturing using gas-phase plasma provide medical devices with myriad complex surface morphologies.
摘要翻译： 公开了具有纹理表面的医疗装置和用于纹理的相关方法。 使用气相等离子体的表面纹理方法为医疗器械提供了无数复杂的表面形态。
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公开(公告)号：US20110060402A1
公开(公告)日：2011-03-10
申请号：US12946585
申请日：2010-11-15
CPC分类号： B05D3/144 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B05D3/147 , B05D5/04 , B05D7/02 , Y10T428/1393 , Y10T428/31544 , C08L27/18 , C08L33/14
摘要： Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
摘要翻译： 提供了用于表面改性疏水性聚合物基材以增加润湿性的方法，包括以下步骤：用射频（RF）生成的第一等离子体和RF产生的第二等离子体预处理疏水聚合物基材，其中第一等离子体和第二等离子体 依次施加，用亲水涂层涂覆疏水性聚合物基材; 并通过暴露于RF产生的第三等离子体在疏水聚合物基底上聚合亲水涂层。
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公开(公告)号：US09682229B2
公开(公告)日：2017-06-20
申请号：US13537249
申请日：2012-06-29
IPC分类号： A61N1/05
CPC分类号： A61N1/0568 , A61N1/056 , Y10T29/49194
摘要： An electrode of an implantable medical lead is coated with a polymeric composition that includes (i) a terpolymer formed from monomer subunits consisting essentially of vinyl acetate, alkyl methyl acrylate and n-vinyl pyrrolidone; (ii) a copolymer formed from monomer subunits consisting essentially of vinyl acetate and alkyl methacrylate; and (iii) polyvinyl pyrrolidone. The coating does not substantially adversely affect impedance properties of the electrode.
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15.发明授权公开(公告)号：US08173622B2
公开(公告)日：2012-05-08
申请号：US12192268
申请日：2008-08-15
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
IPC分类号： A01N55/00
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译： 抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物的挥发性而不用离去基团。 可以使用几乎任何可水解的离去基团。 除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。
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16.发明申请公开(公告)号：US20090047321A1
公开(公告)日：2009-02-19
申请号：US12192268
申请日：2008-08-15
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
IPC分类号： A61K31/695 , A61K31/575 , A61P31/00 , A61K9/00 , C07F7/08
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译： 抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物的挥发性而不用离去基团。 可以使用几乎任何可水解的离去基团。 除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。
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公开(公告)号：US06077567A
公开(公告)日：2000-06-20
申请号：US911706
申请日：1997-08-15
CPC分类号： C23C16/402
摘要： A silica coated substrate comprises a substrate having a zinc containing surface. A plasma polymerized coating is adhered to the surface. The coating consists essentially of silicon and oxygen and contains minimal amounts of carbon.
摘要翻译： 二氧化硅涂覆的基材包括具有含锌表面的基材。 等离子体聚合涂层粘附在表面上。 涂层基本上由硅和氧组成，并含有最少量的碳。
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公开(公告)号：US20140005762A1
公开(公告)日：2014-01-02
申请号：US13537249
申请日：2012-06-29
CPC分类号： A61N1/0568 , A61N1/056 , Y10T29/49194
摘要： An electrode of an implantable medical lead is coated with a polymeric composition that includes (i) a terpolymer formed from monomer subunits consisting essentially of vinyl acetate, alkyl methyl acrylate and n-vinyl pyrrolidone; (ii) a copolymer formed from monomer subunits consisting essentially of vinyl acetate and alkyl methacrylate; and (iii) polyvinyl pyrrolidone. The coating does not substantially adversely affect impedance properties of the electrode.
摘要翻译： 可植入医用引线的电极涂覆有聚合物组合物，其包括（i）由基本上由乙酸乙烯酯，丙烯酸烷基酯和N-乙烯基吡咯烷酮组成的单体亚基形成的三元共聚物; （ii）由基本上由乙酸乙烯酯和甲基丙烯酸烷基酯组成的单体亚单元形成的共聚物; 和（iii）聚乙烯吡咯烷酮。 涂层对电极的阻抗特性基本上不会有不利影响。
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公开(公告)号：US08029562B2
公开(公告)日：2011-10-04
申请号：US12946585
申请日：2010-11-15
IPC分类号： A61F2/06
CPC分类号： B05D3/144 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B05D3/147 , B05D5/04 , B05D7/02 , Y10T428/1393 , Y10T428/31544 , C08L27/18 , C08L33/14
摘要： Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
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