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公开(公告)号：US20180243556A1
公开(公告)日：2018-08-30
申请号：US15852845
申请日：2017-12-22
CPC分类号： A61N1/30 , A61B17/60 , A61B17/86 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00734 , A61F2/0077 , A61F2/0095 , A61F2/28 , A61F2/30 , A61F2/30724 , A61F2/30744 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3609 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2002/009 , A61F2002/2821 , A61F2002/30235 , A61F2002/30322 , A61F2002/30329 , A61F2002/30354 , A61F2002/30405 , A61F2002/30438 , A61F2002/305 , A61F2002/30535 , A61F2002/30589 , A61F2002/30604 , A61F2002/30668 , A61F2002/30677 , A61F2002/30718 , A61F2002/30795 , A61F2002/30932 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/368 , A61F2002/3692 , A61F2002/482 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0069 , A61F2250/0001 , A61F2250/0026 , A61F2250/0043 , A61F2250/0058 , A61F2310/00029 , A61F2310/00059 , A61F2310/00065 , A61F2310/00071 , A61F2310/00077 , A61F2310/00083 , A61F2310/00107 , A61F2310/00113 , A61F2310/00149 , A61F2310/00155 , A61F2310/00395 , A61F2310/00413 , A61F2310/00449 , A61F2310/00455 , A61F2310/00461 , A61F2310/00467 , A61F2310/00473 , A61F2310/00514 , A61F2310/0052 , A61F2310/00562 , A61F2310/00568 , A61L2/0082 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/606 , A61L2430/02 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/205
摘要： A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
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公开(公告)号：US20160325094A1
公开(公告)日：2016-11-10
申请号：US15216197
申请日：2016-07-21
CPC分类号： A61N1/30 , A61B17/60 , A61B17/86 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00734 , A61F2/0077 , A61F2/0095 , A61F2/28 , A61F2/30 , A61F2/30724 , A61F2/30744 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3609 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2002/009 , A61F2002/2821 , A61F2002/30235 , A61F2002/30322 , A61F2002/30329 , A61F2002/30354 , A61F2002/30405 , A61F2002/30438 , A61F2002/305 , A61F2002/30535 , A61F2002/30589 , A61F2002/30604 , A61F2002/30668 , A61F2002/30677 , A61F2002/30718 , A61F2002/30795 , A61F2002/30932 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/368 , A61F2002/3692 , A61F2002/482 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0069 , A61F2250/0001 , A61F2250/0026 , A61F2250/0043 , A61F2250/0058 , A61F2310/00029 , A61F2310/00059 , A61F2310/00065 , A61F2310/00071 , A61F2310/00077 , A61F2310/00083 , A61F2310/00107 , A61F2310/00113 , A61F2310/00149 , A61F2310/00155 , A61F2310/00395 , A61F2310/00413 , A61F2310/00449 , A61F2310/00455 , A61F2310/00461 , A61F2310/00467 , A61F2310/00473 , A61F2310/00514 , A61F2310/0052 , A61F2310/00562 , A61F2310/00568 , A61L2/0082 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/606 , A61L2430/02 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/205
摘要： A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
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公开(公告)号：US09421285B2
公开(公告)日：2016-08-23
申请号：US14644497
申请日：2015-03-11
IPC分类号： A61N1/00 , A61L2/00 , A61B17/86 , A61F2/30 , A61F2/36 , A61L27/30 , A61L27/54 , A61N1/20 , A61N1/18 , A61B17/60 , A61B17/00 , A61F2/00 , A61F2/32 , A61F2/34 , A61F2/28 , A61F2/48
CPC分类号： A61N1/30 , A61B17/60 , A61B17/86 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00734 , A61F2/0077 , A61F2/0095 , A61F2/28 , A61F2/30 , A61F2/30724 , A61F2/30744 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3609 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2002/009 , A61F2002/2821 , A61F2002/30235 , A61F2002/30322 , A61F2002/30329 , A61F2002/30354 , A61F2002/30405 , A61F2002/30438 , A61F2002/305 , A61F2002/30535 , A61F2002/30589 , A61F2002/30604 , A61F2002/30668 , A61F2002/30677 , A61F2002/30718 , A61F2002/30795 , A61F2002/30932 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/368 , A61F2002/3692 , A61F2002/482 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0069 , A61F2250/0001 , A61F2250/0026 , A61F2250/0043 , A61F2250/0058 , A61F2310/00029 , A61F2310/00059 , A61F2310/00065 , A61F2310/00071 , A61F2310/00077 , A61F2310/00083 , A61F2310/00107 , A61F2310/00113 , A61F2310/00149 , A61F2310/00155 , A61F2310/00395 , A61F2310/00413 , A61F2310/00449 , A61F2310/00455 , A61F2310/00461 , A61F2310/00467 , A61F2310/00473 , A61F2310/00514 , A61F2310/0052 , A61F2310/00562 , A61F2310/00568 , A61L2/0082 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/606 , A61L2430/02 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/205
摘要： A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
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公开(公告)号：US09180027B2
公开(公告)日：2015-11-10
申请号：US12670465
申请日：2008-07-10
申请人： Thomas Kettwig , Sven Zarling , Bernard Garus , Felix Ruess
发明人： Thomas Kettwig , Sven Zarling , Bernard Garus , Felix Ruess
CPC分类号： A61F2/80 , A61B5/0408 , A61B5/6804 , A61F2/0077 , A61F2/70 , A61F2/72 , A61F2/7812 , A61F2002/30024 , A61F2002/3007 , A61F2002/501 , A61F2002/705 , A61F2002/7806 , A61F2250/0021 , A61F2310/0052 , A61N1/0452 , A61N1/0456 , A61N1/0472 , A61N1/0484 , D04B1/265 , D10B2403/021
摘要： The invention relates to an orthopedic interface (1) comprising a planar 3D textile (2) having a top (22) and a bottom (21), which are held at a distance from each other by supporting threads (24) and are connected to each other, wherein the bottom (21) of the spaced knitted fabric (2) is configured for resting on the skin of an interface user. The side of the bottom (21) facing the skin is provided with an adhesive coating (23) at least in some regions.
摘要翻译： 本发明涉及一种包括具有顶部（22）和底部（21）的平面3D织物（2）的整形外科界面（1），它们通过支撑螺纹（24）彼此保持一定距离，并连接到 彼此相对，其中间隔开的针织物（2）的底部（21）被配置为搁置在界面使用者的皮肤上。 至少在一些区域中，面向皮肤的底部（21）的侧面设置有粘合剂涂层（23）。
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5.发明授权公开(公告)号：US09107903B2
公开(公告)日：2015-08-18
申请号：US14147405
申请日：2014-01-03
申请人： PACESETTER, INC.
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61K9/14 , A61K33/38 , A61F2/02 , B05D1/00 , A61N1/375 , A61F2/82 , A61N1/05 , B82Y5/00 , B22F1/00 , A61L29/16 , A61F2/00 , A61F2/30 , A61L31/16 , B82Y30/00 , A61L29/10 , A61L31/08 , A61K9/16
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译： 本文公开了包括抗微生物层的可植入医疗装置。 抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。 抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。
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公开(公告)号：US09008770B2
公开(公告)日：2015-04-14
申请号：US14090699
申请日：2013-11-26
IPC分类号： A61N1/00 , A61L27/54 , A61B17/86 , A61F2/30 , A61F2/36 , A61L27/30 , A61N1/20 , A61B17/60 , A61B17/00 , A61F2/00 , A61F2/32 , A61F2/34 , A61F2/28 , A61F2/48
CPC分类号： A61N1/30 , A61B17/60 , A61B17/86 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00734 , A61F2/0077 , A61F2/0095 , A61F2/28 , A61F2/30 , A61F2/30724 , A61F2/30744 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3609 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2002/009 , A61F2002/2821 , A61F2002/30235 , A61F2002/30322 , A61F2002/30329 , A61F2002/30354 , A61F2002/30405 , A61F2002/30438 , A61F2002/305 , A61F2002/30535 , A61F2002/30589 , A61F2002/30604 , A61F2002/30668 , A61F2002/30677 , A61F2002/30718 , A61F2002/30795 , A61F2002/30932 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/368 , A61F2002/3692 , A61F2002/482 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0069 , A61F2250/0001 , A61F2250/0026 , A61F2250/0043 , A61F2250/0058 , A61F2310/00029 , A61F2310/00059 , A61F2310/00065 , A61F2310/00071 , A61F2310/00077 , A61F2310/00083 , A61F2310/00107 , A61F2310/00113 , A61F2310/00149 , A61F2310/00155 , A61F2310/00395 , A61F2310/00413 , A61F2310/00449 , A61F2310/00455 , A61F2310/00461 , A61F2310/00467 , A61F2310/00473 , A61F2310/00514 , A61F2310/0052 , A61F2310/00562 , A61F2310/00568 , A61L2/0082 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/606 , A61L2430/02 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/205
摘要： A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
摘要翻译： 描述了用于抑制与关节假体植入物相关联的感染的医疗植入系统。 本发明的系统包括由生物相容性材料制成的植入体，其具有设置在植入物本体的外表面上的金属部件。 允许电流流向金属部件，刺激金属离子释放对细菌，原生动物，真菌和病毒等微生物有毒。 一个详细的系统完全可手术植入患者体内，使得在系统使用时，系统的任何部分都不在病人的外部。 此外，提供允许植入部件的调制的外部控制装置。
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公开(公告)号：US08945363B2
公开(公告)日：2015-02-03
申请号：US12539028
申请日：2009-08-11
CPC分类号： A61L27/54 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2002/30929 , A61F2002/30967 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/0052 , A61F2310/00592 , A61F2310/00598 , A61F2310/00796 , A61L27/04 , A61L27/306 , A61L27/32 , A61L2300/104 , A61L2300/404 , A61L2420/02 , A61L2430/02 , C25D11/02 , C25D11/26
摘要： A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodizing, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.
摘要翻译： 用于外科手术的金属植入物具有与金属基底成一体的表面层，并且其包含杀生物材料。 表面层可以通过阳极氧化从金属基底生长，并通过离子交换在其中掺入生物杀伤材料。 或者，可以通过电镀沉积该层，然后进行扩散接合，以便与金属基底成为一体。 在任一情况下，银是合适的杀生物材料; 并且杀生物材料的释放速率和数量均应低，以避免对身体细胞的毒性作用。 在形成表面层之前对表面进行电抛光也是有益的，并且这可以通过电解抛光来实现。
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8.发明申请Interbody Spinal Fusion Implant Having A Trailing End With At Least One Stabilization Element 有权具有至少一个稳定元素的后端的椎间融合植入物公开(公告)号：US20130096688A1
公开(公告)日：2013-04-18
申请号：US13705099
申请日：2012-12-04
发明人： Gary K. Michelson
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/1757 , A61B17/8042 , A61B17/86 , A61B17/8875 , A61F2/30767 , A61F2/4455 , A61F2/4465 , A61F2/4611 , A61F2/4637 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30187 , A61F2002/30266 , A61F2002/30405 , A61F2002/30476 , A61F2002/30512 , A61F2002/30517 , A61F2002/30578 , A61F2002/30769 , A61F2002/30774 , A61F2002/30777 , A61F2002/30785 , A61F2002/30787 , A61F2002/4475 , A61F2002/4627 , A61F2002/4638 , A61F2002/4642 , A61F2210/0004 , A61F2220/0025 , A61F2230/0034 , A61F2230/0082 , A61F2310/00023 , A61F2310/00179 , A61F2310/0052 , Y10S606/907 , Y10S606/909 , Y10S623/908
摘要： A flanged interbody spinal fusion implant for insertion at least in part between adjacent vertebral bodies has opposed upper and lower surfaces adapted to contact each of the adjacent vertebral bodies from within the disc space, a leading end for insertion between the adjacent vertebral bodies, and a trailing end opposite the leading end. The trailing end has a height greater than the maximum height of the disc space forming a flanged portion adapted to overlie a part of the anterior aspects of the vertebral bodies adjacent and proximate the disc space to be fused. The flanged portion has at least two bone screw receiving holes, at least one each adapted to overlie each of the adjacent vertebral bodies at least in part. The implant has at least one locking element to lock one or more of the bone screws inserted in the bone screw receiving holes. Instrumentation for inserting the implant, forming screw holes in the vertebral body, and for locking the locking elements are disclosed.
摘要翻译： 用于至少部分地相邻椎骨体之间插入的凸缘体间脊柱融合植入物具有相对的上表面和下表面，其适于从椎间盘空间内的每个相邻的椎骨体接合，用于在相邻椎骨体之间插入的前端和 尾端与前端相对。 尾端的高度大于形成法兰部分的盘片空间的最大高度，该凸缘部分适于覆盖与待融合的椎间盘空间相邻并靠近椎体的前部方面的一部分。 凸缘部分具有至少两个骨螺钉接收孔，至少一个适于至少部分地覆盖每个相邻椎体的至少一个。 植入物具有至少一个锁定元件以锁定插入在骨螺钉接收孔中的一个或多个骨螺钉。 公开了用于插入植入物，在椎体中形成螺钉孔并锁定锁定元件的仪器。
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9.发明授权Laser based metal deposition (LBMD) of antimicrobials to implant surfaces 失效抗菌剂的激光基金属沉积（LBMD）到植入物表面公开(公告)号：US07951412B2
公开(公告)日：2011-05-31
申请号：US11624041
申请日：2007-01-17
CPC分类号： A61F2/30767 , A61C8/0012 , A61F2/3099 , A61F2/36 , A61F2/3662 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/40 , A61F2/4225 , A61F2/4241 , A61F2/4261 , A61F2002/30451 , A61F2002/30604 , A61F2002/30733 , A61F2002/30805 , A61F2002/30878 , A61F2002/30922 , A61F2002/30925 , A61F2002/30929 , A61F2002/30934 , A61F2002/30967 , A61F2002/3097 , A61F2002/30971 , A61F2002/3611 , A61F2002/3625 , A61F2002/3652 , A61F2002/4253 , A61F2220/0058 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/00095 , A61F2310/00131 , A61F2310/00149 , A61F2310/00293 , A61F2310/00395 , A61F2310/00401 , A61F2310/00407 , A61F2310/00413 , A61F2310/00467 , A61F2310/00473 , A61F2310/00485 , A61F2310/00491 , A61F2310/00514 , A61F2310/0052 , A61F2310/00532 , A61F2310/00544 , A61F2310/00556 , A61F2310/00562 , A61F2310/00568 , A61L27/04 , A61L27/30 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , B23K26/144 , B23K26/147 , B23K26/32 , B23K26/34 , B23K2103/50 , C23C4/12 , C23C24/10 , C23C26/00 , C23C26/02 , Y10T428/12458 , Y10T428/12479 , Y10T428/12493 , Y10T428/12771 , Y10T428/12847
摘要： A method is provided for depositing a hard wear resistant surface onto a porous or non-porous base material of a medical implant. The wear resistant surface of the medical implant device may be formed by a Laser Based Metal Deposition (LBMD) method such as Laser Engineered Net Shaping (LENS). The wear resistant surface may include a blend of multiple different biocompatible materials. Further, functionally graded layers of biocompatible materials may be used to form the wear resistant surface. Usage of a porous material for the base may promote bone ingrowth to allow the implant to fuse strongly with the bone of a host patient. The hard wear resistant surface provides device longevity, particularly when applied to bearing surfaces such as artificial joint bearing surfaces or a dental implant bearing surfaces. An antimicrobial material such as silver may be deposited in combination with a metal to form an antimicrobial surface deposit.
摘要翻译： 提供了一种将硬耐磨表面沉积到医用植入物的多孔或非多孔基材上的方法。 医疗植入装置的耐磨表面可以通过激光基金属沉积（LBMD）方法形成，例如激光工程网整形（LENS）。 耐磨表面可以包括多种不同生物相容性材料的混合物。 此外，生物相容性材料的功能梯度层可用于形成耐磨表面。 用于基底的多孔材料的使用可以促进骨向内生长以允许植入物与宿主患者的骨骼牢固地融合。 耐磨损的表面提供了设备寿命，特别是当应用于诸如人造关节轴承表面或牙科植入物轴承表面的支承表面时。 抗微生物材料如银可以与金属组合沉积以形成抗微生物表面沉积物。
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公开(公告)号：US20070225785A1
公开(公告)日：2007-09-27
申请号：US11674607
申请日：2007-02-13
申请人： Eunsung Park , Catherine Taylor , Kevin Casey
发明人： Eunsung Park , Catherine Taylor , Kevin Casey
CPC分类号： A61L27/50 , A61B17/68 , A61B17/7002 , A61B17/7059 , A61B17/86 , A61B17/866 , A61C8/0012 , A61F2/0077 , A61F2/30767 , A61F2/3094 , A61F2/3099 , A61F2/38 , A61F2/44 , A61F2/82 , A61F2002/30677 , A61F2002/30925 , A61F2002/3097 , A61F2240/001 , A61F2250/0067 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00071 , A61F2310/00089 , A61F2310/00101 , A61F2310/00131 , A61F2310/00149 , A61F2310/00395 , A61F2310/0052 , A61F2310/00574 , A61F2310/0058 , A61F2310/00598 , A61F2310/0073 , A61F2310/00856 , A61F2310/00976 , A61L29/14 , A61L31/14 , A61N1/00
摘要： Disclosed are medical devices having textured surfaces and related methods for texturing. Methods of surface texturing using gas-phase plasma provide medical devices with myriad complex surface morphologies.
摘要翻译： 公开了具有纹理表面的医疗装置和用于纹理的相关方法。 使用气相等离子体的表面纹理方法为医疗器械提供了无数复杂的表面形态。
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