公开(公告)号：US07064193B1

公开(公告)日：2006-06-20

申请号：US09508832

申请日：1998-09-17

Applicant: Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

Inventor： Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

IPC: C12N15/11 ,  C07K14/00

CPC classification number: C07K14/4747 ,  A61K38/00

Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.

公开(公告)号：US20050064593A1

公开(公告)日：2005-03-24

申请号：US10479307

申请日：2002-05-30

Applicant: Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine O'reilly ,  David Huang

Inventor： Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine O'reilly ,  David Huang

IPC: A01K67/027 ,  A61K38/00 ,  A61K45/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12N15/11 ,  C12N15/12 ,  C12P21/08 ,  G01N33/53 ,  A61K48/00 ,  C07H21/04

CPC classification number: C07K14/4747 ,  A01K2217/05 ,  A61K38/00

Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bmf”, and to genetic sequences encoding same and to regulatory sequences such as a promoter sequence directing expression of Bmf. Bmf comprises a BH3 domain which facilitates interaction to pro-survival Bcl-2 family members thereby triggering apoptosis. Bmf is regarded, therefore, as a BH3-only molecule. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry. The present invention further contemplates genetically modified animals in which one or both alleles of Bmf are mutated or partially or wholly deleted alone or in combination with a mutation in one or both alleles of another Bcl-2-type molecule such as but not limited to Bim. The genetically modified animals are useful inter alia in screening for agents which ameliorate the symptoms of diseases caused by defects in apoptosis or which specifically promote apoptosis of target cells.

Abstract translation: 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bmf”，以及编码它们的遗传序列以及调节序列，例如引导Bmf表达的启动子序列。 Bmf包含BH3结构域，其促进与生存Bcl-2家族成员的相互作用，从而引发细胞凋亡。 因此，Bmf被认为是仅BH3分子。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。 本发明进一步考虑了遗传修饰的动物，其中Bmf的一个或两个等位基因单独突变或部分或全部缺失，或与另一个Bcl-2型分子的一个或两个等位基因中的突变组合，例如但不限于Bim 。 遗传修饰的动物尤其可用于筛选改善由凋亡缺陷引起的疾病症状或特异性促进靶细胞凋亡的药剂。

公开(公告)号：US20130065075A1

公开(公告)日：2013-03-14

申请号：US13230123

申请日：2011-09-12

Applicant: Klemens Pruegl ,  Juergen Zimmer ,  Andreas Strasser ,  Wolfgang Raberg ,  Thomas Bever

Inventor： Klemens Pruegl ,  Juergen Zimmer ,  Andreas Strasser ,  Wolfgang Raberg ,  Thomas Bever

IPC: G01R33/09 ,  B05D1/36 ,  B32B15/04

CPC classification number: H01L43/08 ,  G01R33/098 ,  H01L43/12 ,  Y10T428/12465 ,  Y10T428/265 ,  Y10T428/31678

Abstract: Embodiments relate to magnetoresistive (MR) sensors, sensor elements and structures, and methods. In particular, embodiments relate to MR, such as giant MR (GMR) or tunneling MR (TMR), spin valve layer systems and related sensors having improved stability. Embodiments include at least one of a multi-layer pinned layer or a multi-layer reference layer, making the stack more stable and therefore suitable for use at higher temperatures and magnetic fields than conventional systems and sensors.

Abstract translation: 实施例涉及磁阻（MR）传感器，传感器元件和结构以及方法。 特别地，实施例涉及MR，例如巨磁（GMR）或隧道MR（TMR），自旋阀层系统和具有改进的稳定性的相关传感器。 实施例包括多层被钉扎层或多层参考层中的至少一个，使得堆叠更加稳定，因此适合于在比常规系统和传感器更高的温度和磁场下使用。

公开(公告)号：US20080211328A1

公开(公告)日：2008-09-04

申请号：US11814394

申请日：2006-09-11

Applicant: Karl Frauhammer ,  Gerhard Meixner ,  Martin Rittner ,  Heinz Schnerring ,  Andreas Strasser

Inventor： Karl Frauhammer ,  Gerhard Meixner ,  Martin Rittner ,  Heinz Schnerring ,  Andreas Strasser

IPC: H01R39/44 ,  H02K7/14

CPC classification number: B25F5/00 ,  B25D16/006 ,  Y10S388/937

Abstract: The invention relates to a machine tool comprising an electric motor (2) which serves to drive a tool and which has an adjustable, electric brush arrangement (3), and comprising a mode selector switch (6) having various switch positions. Provision is made for an adjusting device (8) to displace the brush arrangement (3) as a function of the switch position of the mode selector switch (6). Furthermore, the invention relates to a corresponding method.

Abstract translation: 本发明涉及一种包括电动机（2）的机床，其用于驱动工具并具有可调整的电刷装置（3），并且包括具有各种开关位置的模式选择器开关（6）。 根据模式选择器开关（6）的开关位置，调整装置（8）用于移动刷子装置（3）。 此外，本发明涉及一种相应的方法。

公开(公告)号：US20070074883A1

公开(公告)日：2007-04-05

申请号：US10556477

申请日：2005-02-02

Applicant: Andreas Strasser ,  Markus Leupert

Inventor： Andreas Strasser ,  Markus Leupert

IPC: B25D11/00

CPC classification number: B25D16/006 ,  B25D2216/0015 ,  B25D2216/0023 ,  B25D2216/0046 ,  B25D2216/0084 ,  B25D2250/141 ,  B25D2250/145 ,  B25D2250/221

Abstract: A hand-held power tool, in particular a rotary hammer, is indicated that includes a machine housing (10) with a tool fitting (12) integrated therein, the tool fitting (12) being rotatably drivable in a first mode and being non-rotatably fixable on the machine housing (10) in a second mode, and that includes a duty-type switch (20) with a coupling element (21) capable of being displaced to activate the modes, and an actuating element (22) that induces its displacement. To prevent maloperation and resultant damage to the machine when the operator switches between modes, the actuating element is designed as an electrical actuator (23), preferably as an electromagnet (25) controlled by an electronic control unit (24).

Abstract translation: 一种手持式电动工具，特别是一种旋转锤，其特征在于包括一具有集成在其中的工具配件（12）的机器壳体（10），该工具配件（12）可转动地以第一模式驱动， 以第二模式可旋转地固定在机器壳体（10）上，并且其包括具有能够被移位以激活模式的联接元件（21）的占空型开关（20）和致动元件（22） 它的位移。 为了防止在操作员在模式之间切换时造成机器的误操作和损坏，致动元件被设计为电动执行器（23），优选地由电子控制单元（24）控制的电磁体（25）。

公开(公告)号：US06971651B2

公开(公告)日：2005-12-06

申请号：US10181578

申请日：2001-01-09

Applicant: Karl Frauhammer ,  Heinz Scherring ,  Joerg Friedrich ,  Andreas Strasser ,  Karsten Blair

Inventor： Karl Frauhammer ,  Heinz Scherring ,  Joerg Friedrich ,  Andreas Strasser ,  Karsten Blair

IPC: B25F5/02 ,  F16H57/04 ,  F16J15/10 ,  F16J15/16 ,  F16J15/324 ,  F16J15/3288 ,  F16N7/28 ,  F16J15/32

CPC classification number: F16H57/04 ,  F16J15/162 ,  F16J15/324 ,  F16J15/3288 ,  Y10T279/17752

Abstract: In a multi-chamber device a chamber with lubricant is sealed off on a rotationally drivable component from a second chamber at a peg of a power tool, by at least one seal sliding at a contact face, and least one stationary component is provided in the chamber with lubricant before the contact face and surrounds a rotationally drivable component at least over a region of a circumference to substantially prevent turbulence in the lubricant in a region of the contact face.

Abstract translation: 在多腔室装置中，具有润滑剂的腔室通过至少一个在接触面处滑动的密封件从电动工具的钉子处的第二腔室在可旋转驱动的部件上被密封，并且在该腔室中设置至少一个固定部件 在接触面之前具有润滑剂的腔室，并且至少在圆周的区域周围包围可旋转驱动的部件，以基本上防止在接触面的区域中的润滑剂中的湍流。

公开(公告)号：US20050230130A1

公开(公告)日：2005-10-20

申请号：US11103262

申请日：2005-04-11

Applicant: Andreas Strasser ,  Erhard Hoffmann ,  Dietmar Hahn

Inventor： Andreas Strasser ,  Erhard Hoffmann ,  Dietmar Hahn

IPC: B23B45/16 ,  B21J1/00 ,  B23B45/02 ,  B23Q17/20 ,  B25D17/00 ,  B25F5/00

CPC classification number: B25F5/00

Abstract: The present invention is based on a method for operating a guided power tool (10), in particular an electric power tool, with a rotatably and/or percussively driven insert tool (36), whereby the insert tool (36) is driven into a work piece (34) in a work process. It is proposed that at least one measured signal detected at the power tool (10) during the work process is evaluated to derive a property of the work piece (34) located in the working direction of the insert tool (36), and the power tool (10) is operated in accordance with the property. A guided power tool is also proposed.

Abstract translation: 本发明基于一种用于操作具有可旋转和/或冲击式驱动的插入工具（36）的引导电动工具（10），特别是电动工具的方法，由此插入工具（36）被驱动成 工件（34）在工作过程中。 提出在工作过程中在电动工具（10）处检测到的至少一个测量信号被评估以得出位于插入工具（36）的工作方向上的工件（34）的特性，并且功率 工具（10）根据属性进行操作。 还提出了一种引导电动工具。

公开(公告)号：US06863479B2

公开(公告)日：2005-03-08

申请号：US10170107

申请日：2002-06-12

Applicant: Karl Frauhammer ,  Gerhard Meixner ,  Andreas Strasser

Inventor： Karl Frauhammer ,  Gerhard Meixner ,  Andreas Strasser

IPC: B25D17/04 ,  B25F5/00 ,  B25F5/02 ,  B23B45/00

CPC classification number: B25D17/043 ,  B25F5/006 ,  B25F5/026 ,  Y10S16/90 ,  Y10T16/4713 ,  Y10T16/476 ,  Y10T408/96

Abstract: A supplemental handle for a hand-held machining tool (18), has at least one grip element (10, 12, 14, 16) that is connectable with a housing (26) of the hand-held machine (18) by means of an insulating device (20, 22, 24) for insulating oscillations. The insulating device (20, 22, 24) includes at least one bearing unit (28, 30, 32, 34), and the grip element (10, 12, 14, 16) is guided in at least one direction by means of the bearing unit (28, 30, 32, 34). The bearing unit (28) has at least one bearing bolt (26), about which the grip element (10, 12) is pivotable. The insulating device may include at least one torsion spring.

Abstract translation: 一种用于手持式加工工具（18）的辅助手柄具有至少一个抓握元件（10,12,14,16），其可通过手持式机器（18）的壳体（26）与所述手持式机器 用于绝缘振荡的绝缘装置（20,22,24）。 所述绝缘装置（20,22,24）包括至少一个轴承单元（28,30,32,34），并且所述夹紧元件（10,12,14,16）通过所述至少一个方向被引导至少一个方向 轴承单元（28,30,32,34）。 所述轴承单元（28）具有至少一个轴承螺栓（26），所述夹紧元件（10,12）围绕所述轴承螺栓枢转。 绝缘装置可以包括至少一个扭簧。

公开(公告)号：US06116352A

公开(公告)日：2000-09-12

申请号：US262687

申请日：1999-03-04

Applicant: Karl Frauhammer ,  Frank Mueller ,  Andreas Strasser

Inventor： Karl Frauhammer ,  Frank Mueller ,  Andreas Strasser

IPC: B25D9/04 ,  B23B45/16 ,  B25D9/18 ,  B25D11/00 ,  B25D11/12 ,  B25D17/08 ,  B25D11/04

CPC classification number: B25D9/18 ,  B25D11/005 ,  B25D11/125 ,  B25D2250/035

Abstract: A drilling and a percussion power tool and the tool holder, a housing, an air cushion percussion mechanism arranged in the housing and including a guiding tube, a piston reciprocating in the guiding tool, a striker reciprocating in the guiding tube, an air cushion chamber formed on the guiding tube between the striker and the piston, at least one control opening ventilating the air cushion chamber in an idling position of the percussion mechanism, a control part which in a percussion operation closes the at least one control opening for forming an air cushion in the air cushion chamber, and at least one additional opening formed in the guiding tube for ventilating of the air cushion chamber and arranged forwardly of the at least one control opening at a side of a tool so that in the percussion operation the at least one additional opening is covered by the striker.

Abstract translation: 一种钻孔和冲击动力工具以及工具架，壳体，气垫冲击机构，其布置在壳体中并且包括引导管，在引导工具中往复运动的活塞，在引导管中往复运动的冲击器，气垫室 形成在所述引导管之间的所述撞针和所述活塞之间的至少一个控制开口，所述至少一个控制开口使所述气垫室在所述冲击机构的怠速位置通风;控制部，其在冲击操作中闭合所述至少一个控制开口以形成空气 气垫室中的缓冲垫，以及形成在引导管中的至少一个附加开口，用于使气垫室通风并且在工具的一侧安置在至少一个控制开口的前方，使得在打击操作中至少 一个额外的开口被前锋覆盖。

公开(公告)号：US08614616B2

公开(公告)日：2013-12-24

申请号：US13008591

申请日：2011-01-18

Applicant: Stefan Willkofer ,  Uwe Wahl ,  Bernhard Knott ,  Markus Hammer ,  Andreas Strasser

Inventor： Stefan Willkofer ,  Uwe Wahl ,  Bernhard Knott ,  Markus Hammer ,  Andreas Strasser

IPC: H01F5/00 ,  H01F27/28

CPC classification number: H01L23/4952 ,  H01F2017/0086 ,  H01L23/48 ,  H01L23/49575 ,  H01L23/5227 ,  H01L23/645 ,  H01L24/45 ,  H01L24/48 ,  H01L24/49 ,  H01L25/0657 ,  H01L28/10 ,  H01L2224/32145 ,  H01L2224/32245 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48247 ,  H01L2224/4903 ,  H01L2224/49107 ,  H01L2224/73215 ,  H01L2224/73265 ,  H01L2924/00014 ,  H01L2924/01322 ,  H01L2924/14 ,  H01L2924/19042 ,  H01L2924/19102 ,  H01L2924/19104 ,  H01L2924/19107 ,  Y10T29/4902 ,  H01L2924/00 ,  H01L2224/45015 ,  H01L2924/207

Abstract: A semiconductor device, a method of manufacturing a semiconductor device and a method for transmitting a signal are disclosed. In accordance with an embodiment of the present invention, the semiconductor device comprises a first semiconductor chip comprising a first coil, a second semiconductor chip comprising a second coil inductively coupled to the first coil, and an isolating intermediate layer between the first semiconductor chip and the second semiconductor chip.

Abstract translation: 公开了半导体器件，半导体器件的制造方法和发送信号的方法。 根据本发明的实施例，半导体器件包括第一半导体芯片，其包括第一线圈，第二半导体芯片，包括感应耦合到第一线圈的第二线圈，以及在第一半导体芯片和第二线圈之间的隔离中间层 第二半导体芯片。