-
公开(公告)号：US20120208788A1
公开(公告)日：2012-08-16
申请号：US13391407
申请日：2010-08-27
申请人： Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
发明人： Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
IPC分类号： A61K31/65 , A61P31/04 , C07C237/26
CPC分类号： C07C311/08 , C07C237/26 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2103/40 , C07C2103/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/40 , C07C2603/44 , C07C2603/46 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
摘要： The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
摘要翻译： 本发明涉及由结构式（1）表示的化合物或其药学上可接受的盐。 结构式（I）的变量在本文中定义。 还描述了包含结构式（I）的化合物及其治疗用途的药物组合物。
-
12.发明申请公开(公告)号：US20070238720A1
公开(公告)日：2007-10-11
申请号：US11706932
申请日：2007-02-13
IPC分类号： A61K31/4709
CPC分类号： A61K9/2018 , A61K9/0019
摘要： The present invention relates to methods for reducing the risk of infection due to surgical or invasive medical procedures. The present invention also relates to methods for preventing infection due to surgical or invasive medical procedures.
-
13.发明授权Use of heteroaryl substituted N-(indole-2-carbonyl-) amides for treatment of infection 失效杂芳基取代的N-（吲哚-2-羰基 - ）酰胺用于治疗感染的用途公开(公告)号：US06555569B2
公开(公告)日：2003-04-29
申请号：US09785146
申请日：2001-02-16
IPC分类号： A61K31405
CPC分类号： A61K31/404 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377
摘要： A pharmaceutical composition containing a glycogen phosphorylase inhibitor of Formula I or IA as defined herein is administered to a mammal to treat infection.
摘要翻译： 向哺乳动物施用含有本文定义的式I或IA的糖原磷酸化酶抑制剂的药物组合物以治疗感染。
-
公开(公告)号：US09624166B2
公开(公告)日：2017-04-18
申请号：US13391407
申请日：2010-08-27
申请人： Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
发明人： Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
IPC分类号： A61K31/65 , A61P31/04 , C07C237/26 , C07C311/08 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
CPC分类号： C07C311/08 , C07C237/26 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2103/40 , C07C2103/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/40 , C07C2603/44 , C07C2603/46 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
摘要： The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
-
公开(公告)号：US08470990B2
公开(公告)日：2013-06-25
申请号：US12645877
申请日：2009-12-23
申请人： Thomas A. Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
发明人： Thomas A. Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
-
公开(公告)号：US07666849B2
公开(公告)日：2010-02-23
申请号：US11067522
申请日：2005-02-25
申请人： Thomas A. Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
发明人： Thomas A. Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
IPC分类号： A61K38/00
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。
-
公开(公告)号：US08841263B2
公开(公告)日：2014-09-23
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
-
公开(公告)号：US20120252747A1
公开(公告)日：2012-10-04
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/7056 , C07H17/08 , A61P1/14 , A61P31/00 , A61P29/00 , A61P35/00 , C07H17/00 , A61K31/706
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
-
公开(公告)号：US08202843B2
公开(公告)日：2012-06-19
申请号：US10590782
申请日：2005-02-25
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
-
公开(公告)号：US20100204253A1
公开(公告)日：2010-08-12
申请号：US12645877
申请日：2009-12-23
申请人： Thomas Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
发明人： Thomas Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
IPC分类号： A61K31/505 , A61P31/04
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.058 秒)
