公开(公告)号：US11969329B2

公开(公告)日：2024-04-30

申请号：US17735248

申请日：2022-05-03

申请人： Medtronic Vascular, Inc.

发明人： Raymond Ryan ,  David Clarke ,  Kshitija Garde ,  Ya Guo ,  Benjamin Wong ,  Yogesh Darekar ,  Luke Lehmann ,  Wei Wang ,  Laura McKinley ,  Paul Devereux ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/00 ,  A61F2/24 ,  A61L2/20 ,  A61L2/26 ,  B65D81/18 ,  B65D81/22 ,  A61L2/08

CPC分类号： A61F2/0095 ,  A61F2/2412 ,  A61L2/206 ,  A61L2/26 ,  B65D81/18 ,  B65D81/22 ,  A61F2/2418 ,  A61L2/08 ,  A61L2/208 ,  A61L2202/182 ,  A61L2202/21

摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

公开(公告)号：US10660748B2

公开(公告)日：2020-05-26

申请号：US15964403

申请日：2018-04-27

申请人： Medtronic Vascular, Inc.

发明人： Laura McKinley ,  Benjamin Wong ,  Wei Wang ,  Elliot Howard ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/24 ,  A61L27/36

摘要： Conditioned bioprosthetic tissues for forming prosthetic valves including a sheet of bioprosthetic tissue having a first major surface and a second major surface. The first major surface has a pattern including at least one depressed region and areas of relief adjacent to the at least one depressed region. The at least one depressed region has a first tissue density that is greater than a second tissue density of the areas of relief.

公开(公告)号：US20170209262A1

公开(公告)日：2017-07-27

申请号：US15004086

申请日：2016-01-22

申请人： Medtronic Vascular, Inc.

发明人： Laura McKinley ,  Benjamin Wong ,  Wei Wang ,  Elliot Howard ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/24

CPC分类号： A61F2/2415 ,  A61F2/2418 ,  A61F2240/004 ,  A61F2250/0015 ,  A61F2250/0018 ,  A61F2250/0036 ,  A61L27/36 ,  A61L27/3691 ,  A61L2430/20

摘要： Methods of preparing a sheet of bioprosthetic tissue for use as a prosthetic valve leaflet are disclosed. A method includes positioning a sheet of bioprosthetic tissue across an engagement face of a first patterned substrate. The engagement face defines a pattern having at least one raised region and areas of relief adjacent the at least one raised region. The tissue is compressed against the engagement face to deform the tissue to a deformed state corresponding with the pattern.

公开(公告)号：US20170196686A1

公开(公告)日：2017-07-13

申请号：US15383077

申请日：2016-12-19

申请人： Medtronic Vascular, Inc.

发明人： Tracey Tien ,  Carol Eberhardt ,  Kshitija Garde ,  Benjamin Wong ,  Wei Wang ,  Elliot Howard ,  Laura McKinley ,  Karl Olney ,  Taylor Winters

IPC分类号： A61F2/24 ,  C09J189/00 ,  C09J4/00 ,  A61L27/26 ,  A61L27/50

CPC分类号： A61F2/2415 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2220/005 ,  A61F2220/0075 ,  A61L24/06 ,  A61L24/108 ,  A61L27/26 ,  A61L27/3625 ,  A61L27/50 ,  A61L27/507 ,  A61L2430/20 ,  A61L2430/40 ,  C09J4/00 ,  C09J189/00 ,  C08L35/04

摘要： A method of reinforcing or repairing a bioprosthetic tissue for use as a prosthetic valve leaflet. The method includes evaluating a bioprosthetic tissue, identifying a defect in the bioprosthetic tissue, and selectively applying an adhesive to a surface of the bioprosthetic tissue at the defect prior to implantation in a patient.

公开(公告)号：US20220273425A1

公开(公告)日：2022-09-01

申请号：US17747292

申请日：2022-05-18

申请人： Medtronic Vascular, Inc.

发明人： Wei Wang ,  Benjamin Wong ,  Laura McKinley ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/24 ,  A61F2/95 ,  B65B63/02 ,  B65B63/08

摘要： Devices for, and methods of, compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8° C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.

公开(公告)号：US11344399B2

公开(公告)日：2022-05-31

申请号：US17115205

申请日：2020-12-08

申请人： Medtronic Vascular, Inc.

发明人： Raymond Ryan ,  David Clarke ,  Kshitija Garde ,  Ya Guo ,  Benjamin Wong ,  Yogesh Darekar ,  Luke Lehmann ,  Wei Wang ,  Laura McKinley ,  Paul Devereux ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/00 ,  A61F2/24 ,  B65D81/22 ,  B65D81/18 ,  A61L2/26 ,  A61L2/20 ,  A61L2/08

摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

公开(公告)号：US20210113320A1

公开(公告)日：2021-04-22

申请号：US17115205

申请日：2020-12-08

申请人： Medtronic Vascular, Inc.

发明人： Raymond Ryan ,  David Clarke ,  Kshitija Garde ,  Ya Guo ,  Benjamin Wong ,  Yogesh Darekar ,  Luke Lehmann ,  Wei Wang ,  Laura McKinley ,  Paul Devereux ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/00 ,  B65D81/22 ,  B65D81/18 ,  A61F2/24 ,  A61L2/26 ,  A61L2/20

摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

公开(公告)号：US10299916B2

公开(公告)日：2019-05-28

申请号：US15383077

申请日：2016-12-19

申请人： Medtronic Vascular, Inc.

发明人： Tracey Tien ,  Carol Eberhardt ,  Kshitija Garde ,  Benjamin Wong ,  Wei Wang ,  Elliot Howard ,  Laura McKinley ,  Karl Olney ,  Taylor Winters

IPC分类号： A61F2/24 ,  A61L27/26 ,  A61L27/50 ,  C09J4/00 ,  C09J189/00 ,  A61L27/36 ,  A61L24/06 ,  A61L24/10

摘要： A method of reinforcing or repairing a bioprosthetic tissue for use as a prosthetic valve leaflet. The method includes evaluating a bioprosthetic tissue, identifying a defect in the bioprosthetic tissue, and selectively applying an adhesive to a surface of the bioprosthetic tissue at the defect prior to implantation in a patient.

公开(公告)号：US20180318060A1

公开(公告)日：2018-11-08

申请号：US15968847

申请日：2018-05-02

申请人： Medtronic Vascular, Inc.

发明人： Raymond Ryan ,  David Clarke ,  Kshitija Garde ,  Ya Guo ,  Benjamin Wong ,  Yogesh Darekar ,  Luke Lehmann ,  Wei Wang ,  Laura McKinley ,  Paul Devereux ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/00 ,  B65D81/22

CPC分类号： A61F2/0095 ,  A61F2/2412 ,  A61F2/2418 ,  A61L2/206 ,  B65D81/18 ,  B65D81/22

摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

公开(公告)号：US20180243089A1

公开(公告)日：2018-08-30

申请号：US15964403

申请日：2018-04-27

申请人： Medtronic Vascular, Inc.

发明人： Laura McKinley ,  Benjamin Wong ,  Wei Wang ,  Elliot Howard ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/24

摘要： Conditioned bioprosthetic tissues for forming prosthetic valves including a sheet of bioprosthetic tissue having a first major surface and a second major surface. The first major surface has a pattern including at least one depressed region and areas of relief adjacent to the at least one depressed region. The at least one depressed region has a first tissue density that is greater than a second tissue density of the areas of relief.