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公开(公告)号：US07045614B1
公开(公告)日：2006-05-16
申请号：US09959578
申请日：2000-04-28
申请人： Scott D. Boden , Gregory A. Hair
发明人： Scott D. Boden , Gregory A. Hair
IPC分类号： C07H21/04
CPC分类号： C07K14/51 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/52
摘要： The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding splice variants of LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine. Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention.
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公开(公告)号：US06521750B2
公开(公告)日：2003-02-18
申请号：US09986621
申请日：2001-11-09
申请人： Gregory A. Hair , Scott D. Boden
发明人： Gregory A. Hair , Scott D. Boden
IPC分类号： C07H2100
CPC分类号： C07K14/51 , A61K48/00 , C07K14/47 , C12N2799/021
摘要： The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine. Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention.
摘要翻译： 本发明涉及编码LIM矿化蛋白或LMP的分离的核酸分子。 本发明还提供了包含编码LMP的核苷酸序列的载体以及包含这些载体的宿主细胞。 此外，本发明涉及通过用包含编码LIM矿化蛋白的核苷酸序列的分离的核酸分子转染成骨前体细胞诱导骨形成的方法。 转染可以通过直接注射病毒或裸体质粒DNA离体或体内发生。 在一个具体实施方案中，本发明提供了一种通过用具有编码LIM矿化蛋白的核苷酸序列的分离的核酸分子转染成骨前体细胞来融合脊柱的方法，将转染的成骨前体细胞与基质混合并使基质与脊柱 。 最后，本发明涉及通过用本发明的载体稳定转染宿主细胞诱导全身骨形成的方法。
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公开(公告)号：US11179500B2
公开(公告)日：2021-11-23
申请号：US13980593
申请日：2012-02-23
摘要： This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.
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公开(公告)号：US08663672B2
公开(公告)日：2014-03-04
申请号：US11231954
申请日：2005-09-21
申请人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
发明人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
摘要翻译： 提供了一种骨植入物，其包括细长骨颗粒的相干团聚体，所述骨植入物具有预定的尺寸和形状。 骨质植入物具有高吸收性和海绵状。 本文还提供了一种制造骨样植入物的方法以及利用骨植入物修复和/或治疗骨缺损的方法。
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15.发明授权公开(公告)号：US08617585B2
公开(公告)日：2013-12-31
申请号：US11388250
申请日：2006-03-23
IPC分类号： A61F2/00
CPC分类号： A61M25/1011 , A61B17/7061 , A61B17/7098 , A61B17/72 , A61B17/7258 , A61B17/8808 , A61M25/007 , A61M25/0108 , A61M2025/1052
摘要： An intramedullary drug delivery device is disclosed and can be inserted within a bone canal of a bone. The intramedullary drug delivery device can include a housing. A drug delivery region can be established along the housing. Also, the drug delivery region can be configured to substantially span a fracture within the bone.
摘要翻译： 公开了一种髓内药物输送装置，并且可以将其插入到骨的骨管内。 髓内药物递送装置可以包括壳体。 可以沿着房屋建立药物递送区域。 而且，药物递送区域可以构造成基本上跨越骨骼内的骨折。
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公开(公告)号：US08198238B2
公开(公告)日：2012-06-12
申请号：US13233100
申请日：2011-09-15
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
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公开(公告)号：US20120114716A1
公开(公告)日：2012-05-10
申请号：US13353632
申请日：2012-01-19
IPC分类号： A61K9/14 , A61K31/56 , A61P19/08 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/00 , A61P7/00 , A61P3/08 , A61P7/02 , A61P3/06 , A61P9/00 , A61P5/14 , A61P9/12 , A61P1/06 , A61P1/04 , A61P21/00 , A61P37/08 , A61P23/02 , A61P29/00 , A61P11/14 , A61P25/20 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P19/02 , A61P39/06 , A61M5/31 , A61K47/42
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
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18.发明申请公开(公告)号：US20100266660A1
公开(公告)日：2010-10-21
申请号：US12684480
申请日：2010-01-08
申请人： William F. McKay , Scott D. Boden , Neil Beals
发明人： William F. McKay , Scott D. Boden , Neil Beals
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译： 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
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公开(公告)号：US20100119538A9
公开(公告)日：2010-05-13
申请号：US11602120
申请日：2006-11-20
IPC分类号： A61K39/21 , C07H21/04 , C12N15/867 , C07H21/02 , C07K14/16
CPC分类号： C07K16/18 , A61K35/12 , A61K35/13 , A61K48/00 , A61K2121/00 , A61L27/3843 , A61L27/3856 , A61L27/3895 , C07K14/47 , C07K14/78 , C12N2799/022
摘要： Compositions comprising osteogenic factors fused with membrane transduction domains of viral proteins are provided. Also provided are methods of expression and use of such compositions. Further, the methods of making such compositions are also provided. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter and optionally a membrane transduction domain of a viral protein. Transfection may be accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. Methods for treating disc disease associated with trauma or disc degeneration are also described.
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公开(公告)号：US20100112069A1
公开(公告)日：2010-05-06
申请号：US12634323
申请日：2009-12-09
申请人： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
发明人： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
摘要翻译： 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。
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