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公开(公告)号：US08853209B2
公开(公告)日：2014-10-07
申请号：US13088206
申请日：2011-04-15
申请人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
发明人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
IPC分类号： C07D209/42 , C07D403/04
CPC分类号： C07D209/42 , C07D403/04
摘要： Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mdl-1 protein, such as leukemia and lymphoma, are disclosed.
摘要翻译： 其中A1，B1，C1，D1，E1，F1和L1如本文所定义的式I化合物，其抑制抗细胞凋亡Mcl-1蛋白的活性，含有该化合物的组合物，以及治疗涉及过表达或未调节的疾病的方法 公开了诸如白血病和淋巴瘤的Md1-1蛋白。
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公开(公告)号：US07981888B2
公开(公告)日：2011-07-19
申请号：US12104319
申请日：2008-04-16
申请人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
发明人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
IPC分类号： A61K31/535
CPC分类号： C07D209/42 , C07D403/04
摘要： Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein, such as leukemia and lymphoma, are disclosed.
摘要翻译： 其中A1，B1，C1，D1，E1，F1和L1如本文所定义的式I化合物，其抑制抗细胞凋亡Mcl-1蛋白的活性，含有该化合物的组合物，以及治疗涉及过表达或未调节的疾病的方法 公开了Mcl-1蛋白，如白血病和淋巴瘤。
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公开(公告)号：US20090054402A1
公开(公告)日：2009-02-26
申请号：US12104294
申请日：2008-04-16
申请人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
发明人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC分类号： A61K31/55 , C07D209/04 , A61K31/404 , C07D413/02 , A61K31/5377 , C07D401/02 , A61K31/4439 , C07D215/00 , A61K31/4709 , C07D403/02 , A61K31/496 , C07D413/14 , C07D265/36 , A61K31/538 , A61K31/517 , C07D417/02 , A61K31/541 , C07D223/16 , A61P43/00
CPC分类号： C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译： 公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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公开(公告)号：US20110263599A1
公开(公告)日：2011-10-27
申请号：US13088206
申请日：2011-04-15
申请人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
发明人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
IPC分类号： A61K31/404 , C07D401/10 , A61K31/454 , C07D413/10 , A61K31/5377 , A61P35/00 , C07D403/04 , A61K31/4155 , C07D413/06 , C07D403/06 , A61K31/496 , C07D209/42 , A61K31/4439
CPC分类号： C07D209/42 , C07D403/04
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译： 公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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公开(公告)号：US20090124616A1
公开(公告)日：2009-05-14
申请号：US12104319
申请日：2008-04-16
申请人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
发明人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
IPC分类号： A61K31/404 , C07D209/00 , C07D401/02 , C07D413/02 , C07D403/02 , A61K31/5377 , A61K31/454 , A61K31/4439 , A61K31/4155
CPC分类号： C07D209/42 , C07D403/04
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译： 公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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16.发明授权公开(公告)号：US08557983B2
公开(公告)日：2013-10-15
申请号：US12793413
申请日：2010-06-03
申请人： George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
发明人： George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
IPC分类号： C07D403/14 , C07D413/14
CPC分类号： C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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17.发明申请BCL-XL Inhibitory Compounds and Antibody Drug Conjugates Including the Same 审中-公开BCL-XL抑制剂及其抗体药物结合物公开(公告)号：US20160158377A1
公开(公告)日：2016-06-09
申请号：US14963510
申请日：2015-12-09
申请人： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
发明人： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC分类号： A61K47/48 , C07K16/18 , C07D513/04 , C07D417/14 , C07D487/04
CPC分类号： C07K16/18 , A61K47/6803 , C07D417/14 , C07D487/04 , C07D513/04 , C07K2317/73
摘要： Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
摘要翻译： 本文公开了包含小分子Bcl-xL抑制剂的小分子Bcl-xL抑制剂和抗体药物偶联物（ADC）。 本公开的Bcl-xL抑制剂和ADC尤其可用于抑制抗凋亡Bcl-xL蛋白作为治疗涉及失调性凋亡途径的疾病的治疗方法。
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公开(公告)号：US08445679B2
公开(公告)日：2013-05-21
申请号：US12104294
申请日：2008-04-16
申请人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron K. Kunzer
发明人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron K. Kunzer
IPC分类号： C07D403/04 , A61K31/497
CPC分类号： C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译： 公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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19.发明申请公开(公告)号：US20100184766A1
公开(公告)日：2010-07-22
申请号：US12689133
申请日：2010-01-18
申请人： Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
发明人： Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
IPC分类号： A61K31/496 , C07D409/02 , C07D409/14 , C07D417/02 , C07D413/02 , A61K31/4535 , A61K31/5377 , A61P35/00 , A61P35/02
CPC分类号： C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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20.发明授权Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 有权凋亡诱导剂用于治疗癌症和免疫和自身免疫性疾病公开(公告)号：US08338466B2
公开(公告)日：2012-12-25
申请号：US12689133
申请日：2010-01-18
申请人： Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
发明人： Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
IPC分类号： C07D277/00
CPC分类号： C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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