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43 条记录 (耗时 0.054 秒)

    Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin
    12.
    发明申请
    Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin 审中-公开
    使用标记蝎氯毒素的基质金属蛋白酶表达的分子成像

    公开(公告)号：US20090004105A1

    公开(公告)日：2009-01-01

    申请号：US12215136

    申请日：2008-06-25

    申请人： Zhen Cheng ,  Sanjiv S. Gambhir

    发明人： Zhen Cheng ,  Sanjiv S. Gambhir

    IPC分类号： A61K51/00 ,  G01N1/30

    CPC分类号： A61K51/1096 ,  G01N1/30

    摘要： Embodiments of the present disclosure provide for: methods for imaging MMP-2 positive tissue; methods of diagnosing the presence of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; method of monitoring the progress of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; pharmaceutical compositions for imaging one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases; compositions; kits; and the like.

    摘要翻译： 本公开的实施方案提供：用于成像MMP-2阳性组织的方法; 在组织中诊断MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病的存在的方法; 监测组织中MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病中一种或多种的进展的方法; 用于成像MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病中的一种或多种的药物组合物; 组成; 工具包 等等。

    Luciferases and methods for making and using the same
    14.
    发明授权
    Luciferases and methods for making and using the same 有权
    萤光素酶及其制备和使用方法

    公开(公告)号：US08378086B2

    公开(公告)日：2013-02-19

    申请号：US13562881

    申请日：2012-07-31

    申请人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    发明人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC分类号： C07H21/04 ,  C12N5/00

    CPC分类号： C12Q1/66

    摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。

    Luciferases and methods for making and using the same
    16.
    发明授权
    Luciferases and methods for making and using the same 有权

    公开(公告)号：US08258277B2

    公开(公告)日：2012-09-04

    申请号：US13426790

    申请日：2012-03-22

    申请人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    发明人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC分类号： C07H21/04 ,  C12N5/00

    CPC分类号： C12Q1/66

    摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    METHODS AND SYSTEMS FOR PET/CT SCANNING FOR EVALUATION OF MALIGNANCY
    17.
    发明申请
    METHODS AND SYSTEMS FOR PET/CT SCANNING FOR EVALUATION OF MALIGNANCY 审中-公开
    用于PET / CT扫描评估恶性肿瘤的方法和系统

    公开(公告)号：US20100032575A1

    公开(公告)日：2010-02-11

    申请号：US12534458

    申请日：2009-08-03

    申请人： Andrei Iagaru ,  Michael L. Goris ,  Sanjiv S. Gambhir

    发明人： Andrei Iagaru ,  Michael L. Goris ,  Sanjiv S. Gambhir

    IPC分类号： G01T1/164

    CPC分类号： G01T1/1611 ,  A61B6/032 ,  A61B6/505 ,  A61B6/5235

    摘要： Embodiments of the methods of the present disclosure allow interpretation of the 18F and 18F-FDG tissue distribution, even though the two radiopharmaceuticals are administered at the same time. This approach is based on the eventual localization of the 18F almost exclusively to the skeletal structures. Another aspect of the disclosure is a computer-based method for overlapping PET and CT scan images obtained after the simultaneous administration of 18F and 18F-FDG, thereby proving improved clarity and detection of malignancies.

    摘要翻译： 本公开的方法的实施方案允许解释18F和18F-FDG组织分布，即使两个放射性药物同时施用。 这种方法是基于18F的最终本地化几乎完全用于骨骼结构。 本公开的另一方面是用于重叠同时施用18F和18F-FDG之后获得的PET和CT扫描图像的基于计算机的方法，从而证明改善的清晰度和恶性肿瘤的检测。

    Probes for In Vivo Targeting of Active Cysteine Proteases
    19.
    发明申请
    Probes for In Vivo Targeting of Active Cysteine Proteases 有权
    体内靶向活性半胱氨酸蛋白酶的探针

    公开(公告)号：US20090252677A1

    公开(公告)日：2009-10-08

    申请号：US12418116

    申请日：2009-04-03

    申请人： Matthew S. Bogyo ,  Galia Blum ,  Alicia Berger ,  Zhen Cheng ,  Sanjiv S. Gambhir

    发明人： Matthew S. Bogyo ,  Galia Blum ,  Alicia Berger ,  Zhen Cheng ,  Sanjiv S. Gambhir

    IPC分类号： A61K51/04 ,  A61K49/00 ,  A61P35/00

    CPC分类号： A61K51/08 ,  A61B6/508 ,  A61K49/0032 ,  A61K49/0056 ,  A61K51/0495 ,  A61K51/088

    摘要： Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as 64Cu, 125I (SPECT) and 99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.

    摘要翻译： 公开了基于活性的探针，其特异于某些活性半胱氨酸蛋白酶（半胱天冬酶，组织蛋白酶和legumain）和携带放射性标记。 本发明的探针包括只与活性酶结合的酰氧基甲基酮（AOMK）“弹头”。 探针进一步包含将探针靶向特定半胱氨酸蛋白酶或蛋白酶家族的肽样结构，以及与靶向酶结合的探针上的放射性标记。 已经发现本发明的探针在体内是稳定的，并且可以在背景下区分特定的目标图像。 优选的探针用正电子发射剂如64Cu，125I（SPECT）和99mTc（PET）标记。 探针显示体内半衰期和稳定性，非常适合成像。

    LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME
    20.
    发明申请
    LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME 有权
    润滑剂及其制备和使用方法

    公开(公告)号：US20090136998A1

    公开(公告)日：2009-05-28

    申请号：US11995586

    申请日：2006-09-06

    申请人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    发明人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC分类号： C12P21/04 ,  C12N15/11 ,  C12N15/00 ,  C07K16/18 ,  C12N9/02 ,  C12N1/21

    CPC分类号： C12Q1/66

    摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。