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11.发明授权公开(公告)号：US07311970B2
公开(公告)日：2007-12-25
申请号：US10944319
申请日：2004-09-17
Applicant: Eugene T. Michal , Murthy Simhambhatla , Charles D. Claude
Inventor： Eugene T. Michal , Murthy Simhambhatla , Charles D. Claude
IPC: B05D3/04 , C07D225/04 , C07D225/08 , C08F2/46 , C08J7/18
CPC classification number: C08J7/123 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0014 , A61M25/1027 , A61M25/1029 , A61M25/1034 , B05D1/62 , Y10S623/926 , Y10T428/26 , Y10T428/263 , Y10T428/265 , Y10T428/31504 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31721 , Y10T428/31855
Abstract: A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality.
Abstract translation: 一种医疗装置，其包括具有结合到所述基底的至少一部分的等离子体聚合功能的基底。 通过与等离子体聚合官能团的结合，具有与等离子体聚合官能团互补的官能团的超氧化物歧化酶模拟剂与基板的该部分结合。
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公开(公告)号：US20070110787A1
公开(公告)日：2007-05-17
申请号：US11644771
申请日：2006-12-21
Applicant: Syed Hossainy , Murthy Simhambhatla
Inventor： Syed Hossainy , Murthy Simhambhatla
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/606 , A61L2300/62 , A61L2400/12
Abstract: Coatings for implantable medical devices including nanoparticles incorporating an active agent, and methods for fabricating the coatings.
Abstract translation: 用于可植入医疗装置的涂层，包括掺入活性剂的纳米颗粒，以及制造涂层的方法。
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公开(公告)号：US07008411B1
公开(公告)日：2006-03-07
申请号：US10262151
申请日：2002-09-30
Applicant: Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy
Inventor： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy
CPC classification number: A61M25/0084 , A61B2017/22081 , A61M25/0026 , A61M25/1006 , A61M2025/0096
Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.
Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送生物活性剂以稳定易损斑块。
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14.发明申请公开(公告)号：US20050031874A1
公开(公告)日：2005-02-10
申请号：US10944319
申请日：2004-09-17
Applicant: Eugene Michal , Murthy Simhambhatla , Charles Claude
Inventor： Eugene Michal , Murthy Simhambhatla , Charles Claude
CPC classification number: C08J7/123 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0014 , A61M25/1027 , A61M25/1029 , A61M25/1034 , B05D1/62 , Y10S623/926 , Y10T428/26 , Y10T428/263 , Y10T428/265 , Y10T428/31504 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31721 , Y10T428/31855
Abstract: A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality.
Abstract translation: 一种医疗装置，其包括具有结合到所述基底的至少一部分的等离子体聚合功能的基底。 通过与等离子体聚合官能团的结合，具有与等离子体聚合官能团互补的官能团的超氧化物歧化酶模拟剂与基板的该部分结合。
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15.发明授权Assembly including an active matrix liquid crystal display module and having plural environmental seals 失效组件包括有源矩阵液晶显示模块并具有多个环境密封公开(公告)号：US06246459B1
公开(公告)日：2001-06-12
申请号：US09095427
申请日：1998-06-10
Applicant: Murthy Simhambhatla , David Barry , Nils Wydler
Inventor： Murthy Simhambhatla , David Barry , Nils Wydler
IPC: G02F11333
CPC classification number: G02F1/133385 , G02F1/133308
Abstract: An active matrix liquid crystal display module (10) is contained in a base (20). Improved environmental sealing is provided by a primary seal (36) along the edge of the liquid crystal display module and a secondary seal (14a, 14b) at the base. The liquid crystal display module is affixed to a cover (12) which in turn is affixed to the base, such that the liquid crystal display module is suspended in a cavity (21) in the base, spaced apart from physical contact with the base. In this way, any thermomechanical stresses that may develop in the base are not transmitted to the liquid crystal display module. Thermal contact between the liquid crystal display module and the base is made via a thermally conductive material (19), to permit efficient heat dissipation.
Abstract translation: 有源矩阵液晶显示模块（10）包含在基座（20）中。 通过沿着液晶显示模块的边缘的主要密封件（36）和在底部的辅助密封件（14a，14b）提供改进的环境密封。 液晶显示模块固定在盖子12上，盖子又固定在基座上，使得液晶显示模块悬挂在底座中的空腔（21）中，与基座的物理接触间隔开。 以这种方式，在基底中可能产生的任何热机械应力都不会传递到液晶显示模块。 通过导热材料（19）制造液晶显示模块和基座之间的热接触，以允许有效的散热。
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Patent Agency Ranking
公开(公告)号：US08652194B1
公开(公告)日：2014-02-18
申请号：US11388899
申请日：2006-03-23
Applicant: Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
Inventor： Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
IPC: A61F2/82
CPC classification number: A61F2/07 , A61B17/22 , A61B2017/22077 , A61B2017/22082 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/075 , A61F2250/0067 , A61L27/3808 , A61L27/3843 , A61L31/16 , A61M25/0084 , A61M29/02 , A61M2025/0086
Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.
Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。 在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。 可扩张管屏蔽易损斑块与体腔。
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公开(公告)号：US07641643B2
公开(公告)日：2010-01-05
申请号：US10414767
申请日：2003-04-15
Applicant: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
Inventor： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC: A61M31/00
CPC classification number: A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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18.发明授权公开(公告)号：US07470469B1
公开(公告)日：2008-12-30
申请号：US11773881
申请日：2007-07-05
Applicant: Eugene T. Michal , Murthy Simhambhatla , Charles D. Claude
Inventor： Eugene T. Michal , Murthy Simhambhatla , Charles D. Claude
IPC: B05D3/04 , C07D225/04 , C07D225/08 , C08F2/46 , C08J7/18
CPC classification number: C08J7/123 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0014 , A61M25/1027 , A61M25/1029 , A61M25/1034 , B05D1/62 , Y10S623/926 , Y10T428/26 , Y10T428/263 , Y10T428/265 , Y10T428/31504 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31721 , Y10T428/31855
Abstract: A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality. The functionalities can be carboxylate, amine, or sulfate groups and/or polyethylene glycol and can optionally include crosslinking groups.
Abstract translation: 一种医疗装置，其包括具有结合到所述基底的至少一部分的等离子体聚合功能的基底。 通过与等离子体聚合官能团的结合，具有与等离子体聚合官能团互补的官能团的超氧化物歧化酶模拟剂结合到基底的该部分。 官能团可以是羧酸盐，胺或硫酸盐基团和/或聚乙二醇，并且可任选地包括交联基团。
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公开(公告)号：US20080125851A1
公开(公告)日：2008-05-29
申请号：US12023971
申请日：2008-01-31
Applicant: Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
Inventor： Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
CPC classification number: A61F2/07 , A61B17/22 , A61B2017/22077 , A61B2017/22082 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/075 , A61F2250/0067 , A61L27/3808 , A61L27/3843 , A61L31/16 , A61M25/0084 , A61M29/02 , A61M2025/0086
Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.
Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。 在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。 可扩张管屏蔽易损斑块与体腔。
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公开(公告)号：US20060265043A1
公开(公告)日：2006-11-23
申请号：US11388355
申请日：2006-03-24
Applicant: Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
Inventor： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
IPC: A61F2/06
CPC classification number: A61F2/07 , A61B5/02007 , A61B2017/22077 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/077 , A61F2220/0058 , A61F2250/0067 , A61M1/3613 , A61M25/104 , A61M2025/105 , A61M2025/1056 , A61M2025/107 , A61M2025/1086 , A61M2025/1095
Abstract: Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.
Abstract translation: 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。
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