公开(公告)号：US07991447B2

公开(公告)日：2011-08-02

申请号：US10577944

申请日：2004-07-01

申请人： Hiroki Sato ,  Masashi Kiguchi ,  Atsushi Maki ,  Tsuyoshi Yamamoto

发明人： Hiroki Sato ,  Masashi Kiguchi ,  Atsushi Maki ,  Tsuyoshi Yamamoto

IPC分类号： A61B5/1455

CPC分类号： A61B5/14553

摘要： To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also changing the ratio of irradiated light intensities under the prespecified value.

摘要翻译： 通过在峰值波长不同的多个波长范围内控制指向试验体的光的强度比，通过控制比现有技术更高的精度从内部获得的生物体的信息， 可以通过改变第一波长范围内的光的强度与第二波长范围内的光的强度的比例来控制从生物体获得的信息中包括的测量误差。 当照射光的强度从安全性的角度受限于试验对象时，将照射在试验体上的光的第1波长范围内的光与第2波长范围内的光的比例保持在规定值以下， 照射光强度的比例在预先指定的值之下。

公开(公告)号：US20100256468A1

公开(公告)日：2010-10-07

申请号：US12600285

申请日：2008-02-01

申请人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

发明人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

IPC分类号： A61B5/1455 ,  G06N5/02

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/14553

摘要： The efficiency of separating normal control subjects from non-normal control subjects and separating disorders from one another is improved. Plural classification models having a stratified structure are used, and areas from which measurement data used in the plural classification models are acquired differ among the classification models.

摘要翻译： 将正常对照受试者与非正常对照受试者分离并将疾病彼此分离的效率提高。 使用具有分层结构的多个分类模型，并且获取在多个分类模型中使用的测量数据的区域在分类模型之间不同。

公开(公告)号：US20130102907A1

公开(公告)日：2013-04-25

申请号：US13806790

申请日：2011-07-06

申请人： Tsukasa Funane ,  Hirokazu Atsumori ,  Takusige Katura ,  Masashi Kiguchi ,  Tsuyoshi Takatera ,  Michiyuki Fujiwara

发明人： Tsukasa Funane ,  Hirokazu Atsumori ,  Takusige Katura ,  Masashi Kiguchi ,  Tsuyoshi Takatera ,  Michiyuki Fujiwara

IPC分类号： A61B6/00

CPC分类号： A61B6/00 ,  A61B5/0042 ,  A61B5/0075 ,  A61B5/6814 ,  G01N21/359 ,  G01N21/49

摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.

摘要翻译： 本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。 此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。 一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而 分离脑起始信号和皮肤起始信号。 对各个测量点获得的数据进行单独分量分析（ICA）。 然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

公开(公告)号：US08229531B2

公开(公告)日：2012-07-24

申请号：US11914701

申请日：2006-02-13

申请人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

发明人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

公开(公告)号：US20060100526A1

公开(公告)日：2006-05-11

申请号：US11205184

申请日：2005-08-17

申请人： Yukari Yamamoto ,  Atsushi Maki ,  Masashi Kiguchi ,  Tsuyoshi Yamamoto

发明人： Yukari Yamamoto ,  Atsushi Maki ,  Masashi Kiguchi ,  Tsuyoshi Yamamoto

IPC分类号： A61B6/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/064 ,  A61B5/6814 ,  A61B5/7425 ,  A61B5/743 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/2063

摘要： In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.

公开(公告)号：US20090088616A1

公开(公告)日：2009-04-02

申请号：US11914701

申请日：2006-02-13

申请人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

发明人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

公开(公告)号：US07613502B2

公开(公告)日：2009-11-03

申请号：US11205184

申请日：2005-08-17

申请人： Yukari Yamamoto ,  Atsushi Maki ,  Masashi Kiguchi ,  Tsuyoshi Yamamoto

发明人： Yukari Yamamoto ,  Atsushi Maki ,  Masashi Kiguchi ,  Tsuyoshi Yamamoto

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/064 ,  A61B5/6814 ,  A61B5/7425 ,  A61B5/743 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/2063

摘要： In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.

摘要翻译： 在探针定位技术中，光学生物仪器包括区域选择单元，其用于描绘对象的解剖图像中的感兴趣区域，计算单元，其根据感兴趣的区域确定推荐的探针位置，探针位置 检测当前探头位置的传感器，计算推荐探测位置与当前探测位置之间的距离的计算单元，以及当距离在预定范围内时产生报警声等的报警装置。 此外，生物体的光学生物仪器还包括存储单元，其中探测位置与测量数据一起被保存。

公开(公告)号：US20060025659A1

公开(公告)日：2006-02-02

申请号：US11069963

申请日：2005-03-03

申请人： Masashi Kiguchi ,  Tatsuya Tomaru ,  Hideaki Koizumi ,  Atsushi Maki ,  Hideo Kawaguchi

发明人： Masashi Kiguchi ,  Tatsuya Tomaru ,  Hideaki Koizumi ,  Atsushi Maki ,  Hideo Kawaguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/14558

摘要： In order to provide a compact device easy to handle and adjust for use in bloodless measurement of the glucose concentration, in which the angle of polarization varies in synchronism with the magnetic field modulation, the direction of applying the magnetic field is so arranged as to cross the optical axis.

摘要翻译： 为了提供容易处理和调节的紧凑装置，用于无血液测量葡萄糖浓度，其中偏振角与磁场调制同步地变化，施加磁场的方向被布置为交叉 光轴。

公开(公告)号：US20140107439A1

公开(公告)日：2014-04-17

申请号：US14117154

申请日：2012-06-15

申请人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

发明人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

IPC分类号： A61B5/16 ,  A61B5/1455

CPC分类号： A61B5/165 ,  A61B5/14551

摘要： Disclosed is a device using a biological optical measurement technology to evaluate mood states in daily life of an examinee by presenting a first task once or a plurality of times and then presents a second task a plurality of times, calculating a hemoglobin signal of a predetermined measurement point for the first task and a hemoglobin signal of a predetermined measurement point for the second task, and calculating quantitative values using the obtained hemoglobin signals.

摘要翻译： 公开了一种使用生物光学测量技术的装置，通过呈现第一任务一次或多次来评估受试者的日常生活中的情绪状态，然后多次呈现第二任务，计算预定测量的血红蛋白信号 指定第一任务和第二任务的预定测量点的血红蛋白信号，以及使用获得的血红蛋白信号计算定量值。

公开(公告)号：US20120245443A1

公开(公告)日：2012-09-27

申请号：US13512020

申请日：2010-11-11

申请人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

发明人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/16 ,  A61B5/165 ,  A61B5/6814

摘要： The mental state, such as mood or emotion, of an individual can be apprehended by a method using non-invasive biological light measurement technology. A biological light measurement device, which has an irradiation section, presents different tasks (at least a first task and a second task) to a subject, hemoglobin signals based on changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin in the subject are calculated from the strength of light detected by a detection section, and a relative value using the hemoglobin signal at a predetermined measurement channel with respect to the first task, and the hemoglobin signal at a different predetermined measurement channel with respect to the second task is calculated.

摘要翻译： 可以通过使用非侵入性生物光测量技术的方法来理解个体的精神状态，例如情绪或情绪。 具有照射部的生物体光测量装置向受试者呈现不同的任务（至少第一任务和第二任务），基于受试者中氧合血红蛋白和脱氧血红蛋白浓度的变化的血红蛋白信号从 计算由检测部检测到的光的强度，以及使用相对于第一任务的预定测量通道处的血红蛋白信号的相对值和相对于第二任务的不同预定测量通道的血红蛋白信号。