公开(公告)号：US20050077192A1

公开(公告)日：2005-04-14

申请号：US10498359

申请日：2002-12-19

申请人： Makoto Yuasa ,  Masahiko Abe ,  Aritomo Yamaguchi ,  Asako Shiozawa ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Shigeru Kido

发明人： Makoto Yuasa ,  Masahiko Abe ,  Aritomo Yamaguchi ,  Asako Shiozawa ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Shigeru Kido

IPC分类号： A61B5/00 ,  C08G61/12 ,  C08G73/06 ,  C11D3/00 ,  C11D3/20 ,  C11D3/50 ,  G01N27/30 ,  G01N27/49 ,  G01N33/49 ,  G01N27/48

CPC分类号： G01N27/3335 ,  A61B5/1473 ,  C11D3/0015 ,  C11D3/2093 ,  C11D3/50 ,  G01N27/3271 ,  G01N33/4925

摘要： An electrode for active oxygen species comprising a conductive component with a polymer membrane of a metal porphyrin complex formed on the surface is disclosed. The electrode for active oxygen species can detect active oxygen species such as superoxide anion radicals, hydrogen peroxide, and .OH and other active radical species (NO, ONOO—, etc.) in any environment including in vivo environment as well as in vitro environment. The electrode thus can be used for specifying various diseases and examining active oxygen species in food or in water such as tap water and sewage water.

摘要翻译： 公开了一种用于活性氧物质的电极，其包含在表面上形成的具有金属卟啉络合物的聚合物膜的导电组分。 用于活性氧的电极可以在包括体内环境以及体外环境的任何环境中检测活性氧，如超氧阴离子自由基，过氧化氢和.OH等活性自由基（NO，ONOO-等） 。 因此，电极可以用于指定各种疾病并检查食物或水中的活性氧，例如自来水和污水。

公开(公告)号：US08298387B2

公开(公告)日：2012-10-30

申请号：US10547142

申请日：2004-02-24

申请人： Makoto Yuasa ,  Fumio Mizoguchi ,  Hitoshi Takebayashi ,  Masahiko Abe ,  Masumi Koishi ,  Shigeru Kido ,  Masamitsu Nagahama ,  Masayuki Kawasaki ,  Masahiko Yokosuka ,  Takashi Ishihara ,  Rizwangul Ibrahim

发明人： Makoto Yuasa ,  Fumio Mizoguchi ,  Hitoshi Takebayashi ,  Masahiko Abe ,  Masumi Koishi ,  Shigeru Kido ,  Masamitsu Nagahama ,  Masayuki Kawasaki ,  Masahiko Yokosuka ,  Takashi Ishihara ,  Rizwangul Ibrahim

IPC分类号： C12Q1/32

CPC分类号： G01N27/404 ,  A61B5/14542 ,  A61B5/14865 ,  G01N27/3271

摘要： A reactive oxygen species measuring device according to the present invention comprises a reactive oxygen species sensor provided with an electrode assembly capable of detecting the presence of reactive oxygen species or the like in terms of an electric current, a power source means for applying a measuring voltage to the reactive oxygen species sensor, and a reactive oxygen species concentration measuring means for measuring a concentration of the reactive oxygen species or the like from the current detected by the reactive oxygen species sensor. According to the present invention, a concentration of reactive oxygen species or the like such as in vivo or in vitro superoxide anion radical (O2−.) can be measured reliably, and the entire device can be formed in a smaller size and always mounted to a living body.

摘要翻译： 根据本发明的活性氧物质测量装置包括具有电极组件的活性氧物质传感器，该电极组件能够根据电流检测活性氧等的存在，用于施加测量电压的电源装置 和活性氧物质浓度测定单元，用于从活性氧物质传感器检测出的电流测定活性氧等的浓度。 根据本发明，可以可靠地测量体内或体外超氧化物阴离子自由基（O2-）等活性氧等的浓度，整个装置可以形成为更小的尺寸并且始终安装到 一个活体。

公开(公告)号：US20110118583A1

公开(公告)日：2011-05-19

申请号：US12736720

申请日：2008-05-07

申请人： Makoto Yuasa ,  Tsuyoshi Maekawa ,  Motoki Fujita ,  Shigeru Kido

发明人： Makoto Yuasa ,  Tsuyoshi Maekawa ,  Motoki Fujita ,  Shigeru Kido

IPC分类号： A61B5/04

CPC分类号： A61B5/14503 ,  A61B5/01 ,  A61B5/02152 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/4076 ,  A61B5/412 ,  A61B5/6852 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2210/0693

摘要： The device for diagnosing tissue injury of the invention has a catheter insertable into the body and a radical sensor provided in the catheter, and is characterized in that the radical sensor has a sensor electrode capable of measuring superoxide anion radicals provided at a tip end of the catheter, a lead wire connector for a sensor provided at a basal portion of the catheter, and a lead wire for a sensor for connecting the sensor electrode portion to the lead wire connector for a sensor. With the device, in vivo free radicals typified by superoxide anions in systemic organ or tissue injury caused by cerebral ischemia reperfusion injury, severe infection or sepsis can be promptly and quantitatively monitored, and whether the in vivo tissue conditions are good or not can be accurately diagnosed.

摘要翻译： 用于诊断本发明的组织损伤的装置具有可插入体内的导管和设置在导管中的根部传感器，其特征在于，该自由基传感器具有能够测量超氧阴离子自由基的传感器电极， 导管，用于设置在导管的基部的传感器的引线连接器，以及用于传感器的引线，用于将传感器电极部分连接到用于传感器的引线连接器。 使用该装置，可以迅速和定量地监测体内自由基以及由脑缺血再灌注损伤引起的系统性器官或组织损伤中的超氧阴离子代谢，可以准确地监测体内组织条件是否良好 诊断出

公开(公告)号：US20140061063A1

公开(公告)日：2014-03-06

申请号：US14071265

申请日：2013-11-04

申请人： Makoto Yuasa ,  Hitoshi Takebayashi ,  Masahiko Abe

发明人： Makoto Yuasa ,  Masahiko Abe ,  Aritomo Yamaguchi ,  Asako Shiozawa ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Shigeru Kido

IPC分类号： G01N27/333 ,  G01N27/327

CPC分类号： G01N27/3335 ,  A61B5/1473 ,  C11D3/0015 ,  C11D3/2093 ,  C11D3/50 ,  G01N27/3271 ,  G01N33/4925

摘要： An electrode for active oxygen species comprising a conductive component with a polymer membrane of a metal porphyrin complex formed on the surface is disclosed. The electrode for active oxygen species can detect active oxygen species such as superoxide anion radicals, hydrogen peroxide, and .OH and other active radical species (NO, ONOO—, etc.) in any environment including in vivo environment as well as in vitro environment. The electrode thus can be used for specifying various diseases and examining active oxygen species in food or in water such as tap water and sewage water.

摘要翻译： 公开了一种用于活性氧物质的电极，其包含在表面上形成的具有金属卟啉络合物的聚合物膜的导电组分。 用于活性氧的电极可以在包括体内环境以及体外环境的任何环境中检测活性氧，如超氧阴离子自由基，过氧化氢和.OH等活性自由基（NO，ONOO-等） 。 因此，电极可以用于指定各种疾病并检查食物或水中的活性氧，例如自来水和污水。

公开(公告)号：US20050008687A1

公开(公告)日：2005-01-13

申请号：US10788263

申请日：2004-03-01

申请人： Makoto Yuasa ,  Noriyoshi Matsukura ,  Aritomo Yamaguchi ,  Hiroyoshi Kawakami ,  Shoji Nagaoka ,  Masahiko Abe ,  Hitoshi Takebayashi ,  Aiko Horiuchi ,  Akihiko Ogata ,  Takeshi Sakaya

发明人： Makoto Yuasa ,  Noriyoshi Matsukura ,  Aritomo Yamaguchi ,  Hiroyoshi Kawakami ,  Shoji Nagaoka ,  Masahiko Abe ,  Hitoshi Takebayashi ,  Aiko Horiuchi ,  Akihiko Ogata ,  Takeshi Sakaya

IPC分类号： A61K9/127 ,  A61K31/409 ,  A61K31/4439 ,  A61K31/555

CPC分类号： A61K31/409 ,  A61K9/127 ,  A61K31/4439 ,  A61K31/555

摘要： An metalloporphyrin-complex-embedded liposome, comprising a cationic metalloporphyrin complex and a lipid having liposome forming ability is disclosed. As metalloporphyrin-complex-embedded liposomes according to the present invention act on superoxide anion radicals (O2−), and can surely lower their concentration, they can exhibit superb effects for the treatment of cancers and have excellent characteristics as antioxidants.

摘要翻译： 公开了包含阳离子金属卟啉络合物和具有脂质体形成能力的脂质的金属卟啉 - 复合物嵌入的脂质体。 由于根据本发明的金属卟啉 - 复合物嵌入的脂质体作用于超氧化物阴离子自由基（O 2 - ），并且可以确定地降低它们的浓度，它们对于治疗癌症表现出极好的效果，并且具有作为抗氧化剂的优异特征。