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公开(公告)号：US20170360992A1
公开(公告)日：2017-12-21
申请号：US15536860
申请日：2015-12-18
Applicant: Northwestern University
Inventor： Guillermo A. Ameer , Jason A. Wertheim , Bin Jiang
IPC: A61L27/54 , C08G63/685 , A61L33/00 , A61L27/34 , A61L27/36 , A61L33/08 , A61L27/20 , A61L27/50 , A61L27/48 , C08G63/91 , A61L33/18
CPC classification number: A61L27/54 , A61L27/18 , A61L27/20 , A61L27/34 , A61L27/3633 , A61L27/48 , A61L27/507 , A61L33/0011 , A61L33/0088 , A61L33/08 , A61L33/18 , A61L2300/236 , A61L2300/42 , C08G63/6854 , C08G63/914 , C08L67/04 , C08L77/04
Abstract: Provided herein are bioactivated polymer/extracellular matrix (ECM) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ECM composites, and methods of preparation and use thereof, are provided. In some embodiments, provided herein are compositions comprising a composite of: (a) extracellular matrix (ECM), and (b) a polyester covalently linked to a bioactive agent. In some embodiments, the composite is a homogeneous composite. In some embodiments, the ECM is decellularized ECM. In some embodiments, the ECM is not substantially crosslinked.
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12.发明申请Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques 有权药物组合物和消化动脉粥样硬化斑块的方法公开(公告)号：US20140322190A1
公开(公告)日：2014-10-30
申请号：US14326904
申请日：2014-07-09
Applicant: Northwestern University
Inventor： Melina R. Kibbe , Guillermo A. Ameer , Vinit N. Varu
IPC: A61K38/48 , A61B17/22 , A61M25/10 , A61K31/724 , A61K45/06
CPC classification number: A61K38/4886 , A61B17/2202 , A61K9/0019 , A61K31/724 , A61K38/49 , A61K38/54 , A61K45/06 , A61M25/1011 , A61M37/0092 , C12Y304/21068 , C12Y304/24003 , C12Y304/24024 , C12Y304/24035 , A61K2300/00
Abstract: Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
Abstract translation: 公开了用于在有需要的患者中消化动脉粥样硬化斑块的药物组合物和方法。 组合物包括并且方法利用胶原酶的混合物来消化斑块，并且任选地可以包括或利用另外的试剂例如环糊精，螯合剂和组织纤溶酶原激活剂。
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公开(公告)号：US12171910B2
公开(公告)日：2024-12-24
申请号：US16612540
申请日：2018-05-11
Applicant: Northwestern University
Inventor： Guillermo A. Ameer , Paul D. Puglisi
Abstract: Provided herein are intravascular retrievable cell delivery systems and methods of use thereof for cell transplantation.
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公开(公告)号：US11559609B2
公开(公告)日：2023-01-24
申请号：US16468224
申请日：2017-12-08
Applicant: Northwestern University
Inventor： Guillermo A. Ameer , Simona Morochnik
IPC: A61L27/52 , A61K9/00 , A61K9/06 , A61K31/661 , A61K33/06 , A61K38/06 , A61L27/54 , A61K39/385 , A61K39/00
Abstract: Provided herein are injectable, thermoresponsive hydrogels that are liquid at room temperature, provide a carrier material, and gel at body temperature to allow for controlled release. In particular, PPCN-based hydrogels are provided with therapeutic agents (e.g., drugs, ions, etc.) incorporated within or appended thereto, and methods of preparation and use thereof, for example, for the promotion of bone formation/repair and/or the treatment of bone diseases.
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公开(公告)号：US20200179574A1
公开(公告)日：2020-06-11
申请号：US16795185
申请日：2020-02-19
Applicant: Northwestern University
Inventor： Jian Yang , Evan C. Baker , Henry O. T. Ware , Fan Zhou , Cheng Sun , Guillermo A. Ameer , Robert Van Lith
IPC: A61L31/06 , C08J3/24 , B33Y80/00 , B29C64/135 , B29C41/22 , B29C41/00 , B33Y30/00 , B33Y70/00 , B29C64/20 , A61L31/16 , A61L31/18 , C09D167/06
Abstract: Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants. In particular, methods and systems are provided for 3D printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).
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Patent Agency Ranking
公开(公告)号：US10463769B2
公开(公告)日：2019-11-05
申请号：US15536860
申请日：2015-12-18
Applicant: Northwestern University
Inventor： Guillermo A. Ameer , Jason A. Wertheim , Bin Jiang
IPC: A61K9/00 , A61L27/54 , A61L27/36 , A61L33/00 , A61L27/20 , A61L27/34 , A61L27/48 , A61L27/50 , A61L33/08 , A61L33/18 , C08G63/685 , C08G63/91
Abstract: Provided herein are bioactivated polymer/extracellular matrix (ECM) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ECM composites, and methods of preparation and use thereof, are provided. In some embodiments, provided herein are compositions comprising a composite of: (a) extracellular matrix (ECM), and (b) a polyester covalently linked to a bioactive agent. In some embodiments, the composite is a homogeneous composite. In some embodiments, the ECM is decellularized ECM. In some embodiments, the ECM is not substantially crosslinked.
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公开(公告)号：US20180236122A1
公开(公告)日：2018-08-23
申请号：US15537054
申请日：2015-12-18
Applicant: Northwestern University
Inventor： Jisheng Xiao , Guillermo A. Ameer
CPC classification number: A61L15/26 , A61K31/555 , A61K47/34 , A61L15/18 , A61L15/20 , A61L15/42 , A61L15/425 , A61L15/44 , A61L2300/102 , A61L2300/412 , A61L2400/12 , A61L2420/00 , A61P17/02
Abstract: Provided herein are polymer and metal organic frameworks (MOFs) composites, and methods of use and preparation thereof. In particular, Poly(polyethyleneglycol citrate-co-N-isopropylacrylamide) (PPCN) and copper MOF composites are provided.
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公开(公告)号：US20180125990A1
公开(公告)日：2018-05-10
申请号：US15573166
申请日：2016-05-12
Applicant: Northwestern University
Inventor： Yunxiao Zhu , Zdravka Cankova , Milan Mrksich , Guillermo A. Ameer
CPC classification number: A61K47/58 , A61K38/39 , A61K47/585 , A61K47/593 , A61L26/0014 , A61L26/0066 , A61L26/008 , A61L2300/252 , A61L2300/412 , A61L2430/00
Abstract: Provided herein are materials for the promotion of tissue regeneration, and methods of promoting tissue regeneration and wound healing therewith. In particular, materials displaying laminin-derived peptide sequences that facilitate cell migration into the material, and methods of use thereof, are provided.
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公开(公告)号：US20180117219A1
公开(公告)日：2018-05-03
申请号：US15569670
申请日：2016-04-28
Applicant: Northwestern University
Inventor： Jian Yang , Evan C. Baker , Henry O. T. Ware , Fan Zhou , Cheng Sun , Guillermo A. Ameer , Robert Van Lith
IPC: A61L31/06 , B33Y30/00 , B29C64/135 , B29C64/20 , B33Y80/00 , B33Y70/00 , A61L31/18 , A61L31/16 , C08J3/24 , C09D167/06
CPC classification number: A61L31/06 , A61L31/16 , A61L31/18 , B29C41/00 , B29C41/22 , B29C64/135 , B29C64/20 , B29K2033/00 , B29K2105/0005 , B29K2995/0056 , B29K2995/006 , B29L2031/7534 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , C08J3/24 , C08J2367/06 , C09D167/06
Abstract: Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants. In particular, methods and systems are provided for 3D printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).
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公开(公告)号：US20170368377A1
公开(公告)日：2017-12-28
申请号：US15536858
申请日：2015-12-18
Applicant: Northwestern University
Inventor： Guillermo A. Ameer , Robert van Lith , Jian Yang
IPC: A61Q17/04 , A61K31/5365 , A61K8/49 , A61K8/85 , G02B1/04 , A61K31/787
CPC classification number: A61Q17/04 , A61K8/49 , A61K8/85 , A61K31/5365 , A61K31/787 , A61L27/50 , A61L2430/16 , C08G69/40 , C08G69/44 , G02B1/043
Abstract: Provided herein are compositions comprising panthenol-citrate containing materials. In particular, panthenol citrate compounds, oligomers, and polymers, and methods of use and synthesis thereof, are provided herein. Panthenol-citrate containing materials are a class of nontoxic, photoluminescent-chromophore-containing compounds, oligomers, and polymers with high absorption in the UVA and UVB range that can be incorporated and/or engineered into a variety of optically-active biomaterials (e.g., sunscreen products).
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