公开(公告)号：US08784867B2

公开(公告)日：2014-07-22

申请号：US13716496

申请日：2012-12-17

Applicant: Novartis AG

Inventor： Newton T. Samuel ,  Nirupama Kenkare ,  Peter D. Lackey ,  Jessie Chen

IPC: A61K9/00 ,  G02B1/04 ,  A61K31/355 ,  C07C403/24 ,  A61F9/00 ,  C09B61/00

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61K31/355 ,  C07C403/24 ,  C09B61/00 ,  G02B1/043

Abstract: The instant invention pertains to a method for producing contact lenses with improved oxidative stability of Carotenoids in the contact lens. The method of the invention involves adding a vitamin E material into a contact lens in an amount sufficient to reduce oxidative degradation of Carotenoids in the lens by at least about 30% in comparison with an identical contact lens without the vitamin E material.

Abstract translation: 本发明涉及一种具有改善隐形眼镜中类胡萝卜素的氧化稳定性的隐形眼镜的方法。 本发明的方法涉及将隐形眼镜中的维生素E添加到相对于没有维生素E材料的相同隐形眼镜相比，其量足以减少透镜中类胡萝卜素的氧化降解至少约30％。

公开(公告)号：US11256003B2

公开(公告)日：2022-02-22

申请号：US16204641

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  C08L83/04 ,  B05D5/00 ,  B65B55/22 ,  B05D3/00 ,  B05D5/10 ,  B05D1/38 ,  B05D3/02 ,  B05D1/18 ,  B29K83/00 ,  B29K105/00

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US10830923B2

公开(公告)日：2020-11-10

申请号：US16204729

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Kasey Jon Minick ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Kelly Kayi Tallau ,  Matthew McCollum ,  Richard Govan

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  B65B55/22 ,  B29K83/00 ,  B29K105/00

Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.

公开(公告)号：US10308835B2

公开(公告)日：2019-06-04

申请号：US15646291

申请日：2017-07-11

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: C09D177/06 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  B29D11/00 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US08944592B2

公开(公告)日：2015-02-03

申请号：US13948206

申请日：2013-07-23

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: G02C7/00 ,  G02C7/02 ,  G02B1/04 ,  G02C7/04

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

Abstract translation: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

公开(公告)号：US20130148077A1

公开(公告)日：2013-06-13

申请号：US13706737

申请日：2012-12-06

Applicant: Novartis AG

Inventor： Newton T. Samuel ,  Nirupama Kenkare

IPC: G02B1/04

CPC classification number: G02B1/043

Abstract: The invention is related to a disposable contact lens comprising a top coating which is made of a hydrophilic polymeric material including dangling hydrophilic polymer chains covalently linked to the hydrophilic polymeric material through oligo-caprolactone linkages susceptible to enzymatic degradation in the eyes. The top coating is stable to lens processing/storage and confers lubricity to the lens. However, it slowly is degraded during the lens wear due to the action of enzymes (e.g., Lipase) in tear film. The loss in lubricity will be experienced as a drop in comfort for the lens wearer and thereby serves as the built-in compliance features of the disposable contact lens.

Abstract translation: 本发明涉及一次性隐形眼镜，其包括由亲水性聚合材料制成的顶部涂层，其包括通过易于在眼睛中酶促降解的低聚己内酯键与亲水性聚合物材料共价连接的悬浮的亲水性聚合物链。 顶部涂层对透镜加工/储存稳定，并赋予透镜润滑性。 然而，由于在泪液膜中的酶（例如脂肪酶）的作用，它在镜片佩戴期间缓慢地降解。 润滑性的损失将作为镜片佩戴者的舒适度降低，从而用作一次性隐形眼镜的内置柔顺特征。

公开(公告)号：US11029447B2

公开(公告)日：2021-06-08

申请号：US16204705

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Angela Driver-Scott ,  Ciara Dauenhauer ,  Rita Anand

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B05D5/00 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  B65B55/22 ,  B05D3/00 ,  B05D5/10 ,  B05D1/38 ,  B05D3/02 ,  B05D1/18 ,  B29K83/00 ,  B29K105/00

Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.

公开(公告)号：US11029446B2

公开(公告)日：2021-06-08

申请号：US16204664

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B05D5/00 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  B65B55/22 ,  B05D3/00 ,  B05D5/10 ,  B05D1/38 ,  B05D3/02 ,  B05D1/18 ,  B29K83/00 ,  B29K105/00

Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a 30-days lens care regime.

公开(公告)号：US20200157378A1

公开(公告)日：2020-05-21

申请号：US16720932

申请日：2019-12-19

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: C09D177/06 ,  C09D171/02 ,  C09D133/26 ,  C09D133/14 ,  C09D133/02 ,  C09D5/16 ,  C08J5/00 ,  C08G77/388 ,  C08L83/04 ,  C08J7/04 ,  G02B1/18 ,  G02B1/10 ,  G02C7/04 ,  G02B1/04 ,  B29D11/00

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US10563090B2

公开(公告)日：2020-02-18

申请号：US16397255

申请日：2019-04-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: C08L83/04 ,  C09D177/06 ,  B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.