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153 条记录 (耗时 0.04 秒)

    Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
    17.
    发明授权
    Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase 有权
    核苷衍生物作为RNA依赖性RNA病毒聚合酶的抑制剂

    公开(公告)号：US07202224B2

    公开(公告)日：2007-04-10

    申请号：US11496338

    申请日：2006-07-31

    申请人： Anne B. Eldrup ,  Marija Prhavc ,  Phillip Dan Cook ,  Steven S. Carroll ,  David B. Olsen

    发明人： Anne B. Eldrup ,  Marija Prhavc ,  Phillip Dan Cook ,  Steven S. Carroll ,  David B. Olsen

    IPC分类号： A61K31/70 ,  C07H19/14

    CPC分类号： C07H19/16 ,  A61K9/4858 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  C07D473/00 ,  C07D487/04 ,  C07H19/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/20 ,  Y02P20/582 ,  A61K2300/00

    摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

    摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

    Nucleobase heterocyclic combinatorialization
    18.
    发明授权
    Nucleobase heterocyclic combinatorialization 失效
    核碱基杂环组合

    公开(公告)号：US06893815B1

    公开(公告)日：2005-05-17

    申请号：US08884873

    申请日：1997-06-30

    申请人： Phillip Dan Cook

    发明人： Phillip Dan Cook

    IPC分类号： C07B61/00 ,  C07D473/00 ,  C07H19/16 ,  C12Q1/68

    CPC分类号： C07D473/00 ,  C07H19/16 ,  C40B40/00

    摘要： Mixtures of chemical compounds are provided having antibacterial and other utility. The mixtures are formed, preferably in solution phase, from the reaction of a purine or pyrimiding heterocyclic scaffold with a set of related chemical substituients, optionally through employment of a tether moiety. Libraries formed in accordance with the invention have utility per se and are articles of commerce. They can be used to screen for pesticides, drugs and other biologically active compounds.

    摘要翻译： 提供化合物的混合物具有抗菌和其他效用。 混合物优选在溶液相中由嘌呤或嘧啶杂环支架与一组相关的化学取代基的反应形成，任选地通过使用系链部分。 根据本发明形成的图书馆本身具有效用，并且是商品。 它们可用于筛选农药，药物和其他生物活性化合物。

    Peptide nucleic acid combinatorial libraries and improved methods of synthesis
    20.
    发明授权
    Peptide nucleic acid combinatorial libraries and improved methods of synthesis 失效
    肽核酸组合文库和改进的合成方法

    公开(公告)号：US06756199B1

    公开(公告)日：2004-06-29

    申请号：US08466395

    申请日：1995-06-06

    申请人： Phillip Dan Cook ,  John Kiely ,  Kelly Sprankle

    发明人： Phillip Dan Cook ,  John Kiely ,  Kelly Sprankle

    IPC分类号： C12Q168

    CPC分类号： C07K14/003 ,  B01J2219/00592 ,  B01J2219/00729 ,  C07K7/02

    摘要： New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are method of making random libraries of peptide nucleic acids using the fully preformed monomers. Chimeric oligomers and libraries of the same are also disclosed.

    摘要翻译： 公开了用于制备肽核酸低聚结构的新的亚单体合成方法，其提供预定义的序列肽核酸寡聚体以及随机序列肽核酸寡聚体的合成。 此外，这些方法还提供了嵌合肽核酸 - 氨基酸化合物中肽核酸单元或这些单元的串与氨基酸或氨基酸序列的结合。 进一步公开的是使用完全预制的单体制备肽核酸的随机文库的方法。 也公开了嵌合低聚物和其文库。