公开(公告)号：US20150202348A1

公开(公告)日：2015-07-23

申请号：US14581540

申请日：2014-12-23

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Tal DVIR ,  Dan PEER ,  Michal SHEVACH ,  Neta SOFFER TSUR

IPC: A61L27/36 ,  A61K35/34 ,  A61K35/44 ,  A61L27/38 ,  C12N5/071 ,  C12N5/074 ,  C12N5/077 ,  A61L27/52

CPC classification number: A61L27/3633 ,  A61K35/34 ,  A61K35/44 ,  A61L27/14 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/52 ,  A61L27/58 ,  A61L2430/20 ,  A61L2430/40 ,  C12N5/0657 ,  C12N5/0691 ,  C12N5/0696

Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.

Abstract translation: 公开了包含脱细胞网膜的物质组合物。 组合物可以是支架，水凝胶或水凝胶前体组合物。 公开了生成组合物的方法及其用途。

公开(公告)号：US20140356439A1

公开(公告)日：2014-12-04

申请号：US14459569

申请日：2014-08-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Rimona MARGALIT ,  Dan PEER

IPC: A61K9/50 ,  A61K31/704 ,  A61K31/407 ,  A61K45/06 ,  A61K38/38 ,  A61K38/28 ,  A61K38/21 ,  A61K31/711 ,  A61K31/196 ,  A61K31/165

CPC classification number: A61K9/5052 ,  A61K9/1629 ,  A61K9/1658 ,  A61K9/5089 ,  A61K31/14 ,  A61K31/165 ,  A61K31/196 ,  A61K31/351 ,  A61K31/407 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/711 ,  A61K38/212 ,  A61K38/28 ,  A61K38/385 ,  A61K45/06 ,  A61K47/545 ,  A61K48/0008 ,  A61K49/0002 ,  A61K49/0043 ,  A61K51/08 ,  A61K51/1265

Abstract: Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs.

Abstract translation: 通过将糖蛋白（通常为胶原）与至少一种脂质共价连接来制备脂质化的微粒或大颗粒。 糖蛋白中的氨基与脂质中的伯胺结合。 这些颗粒可用于包封活性成分，如药物。

公开(公告)号：US20230357353A1

公开(公告)日：2023-11-09

申请号：US17988893

申请日：2022-11-17

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Niels DAMMES ,  Dan PEER

IPC: C07K14/705 ,  A61P29/00 ,  G01N33/50

CPC classification number: C07K14/705 ,  A61P29/00 ,  G01N33/5008 ,  C07K2319/30

Abstract: MAdCAM-1 polypeptides are provided. Accordingly there is provided a polypeptide comprising an amino acid sequence of MAdCAM-1 capable of binding alpha4beta7 integrin, wherein said polypeptide is in association with a therapeutic or a detectable moiety. Also provided are methods of treating and diagnosing inflammation mediated by MAdCAM-1.

公开(公告)号：US20210108228A1

公开(公告)日：2021-04-15

申请号：US17128736

申请日：2020-12-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan PEER ,  Shiri WEINSTEIN ,  Itai Antoine TOKER ,  Srinivas RAMISHETTI

IPC: C12N15/88 ,  A61K39/395 ,  C07K16/28 ,  A61K47/68 ,  A61K31/7105 ,  A61K31/713 ,  A61K31/105 ,  A61K47/69 ,  A61P35/02 ,  A61K9/00 ,  A61K9/51 ,  A61K48/00

Abstract: Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.

公开(公告)号：US20190292130A1

公开(公告)日：2019-09-26

申请号：US16347995

申请日：2017-11-07

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan PEER ,  Srinivas RAMISHETTI

IPC: C07C211/22 ,  C07C243/16 ,  C07C243/00 ,  C07D295/15 ,  C07C229/12 ,  C07C243/28 ,  C07C215/08 ,  A61K47/18 ,  C12N15/113

Abstract: The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

公开(公告)号：US20170128367A1

公开(公告)日：2017-05-11

申请号：US15320903

申请日：2015-06-25

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan PEER

IPC: A61K9/127 ,  C12N15/88 ,  C12N15/113

CPC classification number: A61K9/1272 ,  A61K9/1271 ,  A61K47/6911 ,  C12N15/111 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/32

Abstract: There are provided liposomes, comprising cationic lipids, a membrane stabilizing lipid and at least one lipid conjugated to a polyethylene glycol (PEG) derivative, in particular PEG-amine, the liposomes are coated with a glycosaminoglycan, in particular, Hyaluronic Acid (HA), compositions comprising the same, methods for their preparation and uses thereof for the efficient delivery of nucleic acids, such as, si RNA molecules and for treating various conditions, such as cancer.