公开(公告)号：US20180333458A1

公开(公告)日：2018-11-22

申请号：US16047129

申请日：2018-07-27

Applicant: Ramot at Tel-Aviv University Ltd. ,  BrainStorm Cell Therapeutics Ltd.

Inventor： Avinoam KADOURI ,  Avihay BAR-ILAN ,  Eldad MELAMED ,  Daniel OFFEN ,  Ofer SADAN ,  Merav BAHAT-STROMZA

IPC: A61K38/18 ,  C12N5/0775 ,  A61K35/28 ,  C12N5/079 ,  A61K35/12 ,  C12N5/077

CPC classification number: A61K38/185 ,  A61K35/12 ,  A61K35/28 ,  C12N5/0618 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N5/0669 ,  C12N2500/84 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/1353

Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.

公开(公告)号：US20180112185A1

公开(公告)日：2018-04-26

申请号：US15820521

申请日：2017-11-22

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel OFFEN ,  Merav BAHAT-STROMZA ,  Eldad MELAMED

IPC: C12N5/077 ,  C12N5/079

CPC classification number: A61K35/28 ,  A61K35/30 ,  C12N5/0622 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/40 ,  C12N2506/1353

Abstract: An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.

公开(公告)号：US20210077520A1

公开(公告)日：2021-03-18

申请号：US17042441

申请日：2019-03-27

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Shulamit LEVENBERG ,  Shaowei GUO ,  Daniel OFFEN ,  Nisim PERETS

IPC: A61K31/713 ,  A61K35/28 ,  A61K38/51 ,  C12N15/113

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

公开(公告)号：US20200370040A1

公开(公告)日：2020-11-26

申请号：US16769260

申请日：2018-12-06

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel OFFEN ,  Roy RABINOWITZ

IPC: C12N15/11 ,  A61K38/46 ,  C12N9/22

Abstract: A method of treating Parkinson's Disease (PD) characterized by the presence of a mutant allele of leucine-rich repeat kinase 2 (LRRK2) gene in a subject is disclosed. The method comprises administering to the subject a CRISPR-Cas system guide RNA (gRNA) which specifically binds to the mutant allele of said leucine-rich repeat kinase 2 (LRRK2) gene and a CRISPR endonuclease, thereby treating the Parkinson's Disease (PD).

公开(公告)号：US20190201452A1

公开(公告)日：2019-07-04

申请号：US16353680

申请日：2019-03-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Daniel OFFEN ,  Michal DADON-NACHUM ,  Tali BEN-ZUR ,  Eldad MELAMED ,  David YAFFE

IPC: A61K35/34 ,  C12N5/077 ,  A61K38/18 ,  A61K38/30

Abstract: An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.

公开(公告)号：US20170121381A1

公开(公告)日：2017-05-04

申请号：US15404378

申请日：2017-01-12

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel OFFEN ,  Israel AHARONY

IPC: C07K14/47 ,  C07K14/81

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/8139 ,  C07K2319/10

Abstract: An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X1X2X3X4 X5, wherein X1 is a hydrophobic amino acid or threonine, X2 is a hydrophobic amino acid, X3 is a hydrophobic amino acid, X4 is an acidic amino acid and X5 is selected from the group consisting of glycine, serine and alanine, the peptide capable of specifically inhibiting the activity of caspase 6.

公开(公告)号：US20140140968A1

公开(公告)日：2014-05-22

申请号：US14164286

申请日：2014-01-27

Applicant: BrainStorm Cell Therapeutics Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Avinoam KADOURI ,  Avihay BAR-ILAN ,  Eldad MELAMED ,  Daniel OFFEN ,  Ofer SADAN ,  Merav BAHAT-STROMZA

IPC: C12N5/0775 ,  A61K38/18

CPC classification number: A61K38/185 ,  A61K35/12 ,  A61K35/28 ,  C12N5/0618 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N5/0669 ,  C12N2500/84 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/1353

Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.

Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其使用方法。

公开(公告)号：US20220251153A1

公开(公告)日：2022-08-11

申请号：US17675910

申请日：2022-02-18

Applicant: THE GEORGE WASHINGTON UNIVERSITY ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Santiago CUEVAS GONZALEZ ,  Pedro A. JOSE ,  Daniel OFFEN ,  Rolondo EISEN

IPC: C07K14/47 ,  A61P13/12

Abstract: Provided are methods for treating a renal disorder using DJ-1 related peptides and compositions thereof.

公开(公告)号：US20200009180A1

公开(公告)日：2020-01-09

申请号：US16494790

申请日：2018-03-28

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel OFFEN ,  Ariel ANGEL

IPC: A61K31/7105 ,  C12N15/113 ,  A61K9/00 ,  A61P25/28

Abstract: A method of treating Alzheimer's Disease (AD) comprising administering to a subject in need thereof a therapeutically effective amount of a polynucleotide agent which downregulates an amount and/or activity of caspase-6 in the brain of the subject.

公开(公告)号：US20190209621A1

公开(公告)日：2019-07-11

申请号：US16325445

申请日：2017-08-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel OFFEN ,  Nisim PERETS

IPC: A61K35/28 ,  A61P25/28 ,  A61P25/18 ,  A61K9/00 ,  A61K9/127

CPC classification number: A61K35/28 ,  A61K9/0043 ,  A61K9/127 ,  A61P25/18 ,  A61P25/28

Abstract: A method of treating a neurological disease (such as autism) in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of microparticles derived from mesenchymal stem cells.