公开(公告)号：US20060012864A1

公开(公告)日：2006-01-19

申请号：US10967316

申请日：2004-10-19

申请人： Joerg-Michael Funk ,  Ralf Wolleschensky ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Ralf Engelmann

发明人： Joerg-Michael Funk ,  Ralf Wolleschensky ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Ralf Engelmann

IPC分类号： G02B21/06

CPC分类号： G02B21/002 ,  G02B21/0032

摘要： Raster Scanning Light Microscope with line pattern scanning with at least one illumination module, in which the means to achieve a variable partition of the laser light into least two illumination channels are envisioned and joint illumination of a sample takes place at the same or at different areas of the sample.

摘要翻译： 光栅扫描光显微镜，其具有至少一个照明模块的线图案扫描，其中实现将激光可变分割成最少两个照明通道的手段，并且在相同或不同的区域发生样品的联合照明 的样品。

公开(公告)号：US20060011857A1

公开(公告)日：2006-01-19

申请号：US10967325

申请日：2004-10-19

申请人： Joerg-Michael Funk ,  Ralf Wolleschensky ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Ralf Engelmann

发明人： Joerg-Michael Funk ,  Ralf Wolleschensky ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Ralf Engelmann

IPC分类号： G01N21/64

CPC分类号： G02B21/0032

摘要： Raster Scanning Light Microscope with line pattern scanning with at least one illumination module, in which the means to achieve a variable partition of the laser light into least two illumination channels are envisioned and joint illumination of a sample takes place at the same or at different areas of the sample.

公开(公告)号：US20100097694A1

公开(公告)日：2010-04-22

申请号：US12578202

申请日：2009-10-13

申请人： Bernhard Zimmermann ,  Ralf Netz ,  Frank Hecht ,  Joerg-Michael Funk ,  Ralf Engelmann

发明人： Bernhard Zimmermann ,  Ralf Netz ,  Frank Hecht ,  Joerg-Michael Funk ,  Ralf Engelmann

IPC分类号： G02B21/06

CPC分类号： G02B21/06 ,  G02B21/00 ,  G02B21/0032 ,  G02B21/0076 ,  G02B27/0972

摘要： Method for actuation control of a microscope, in particular of a Laser Scanning Microscope, in which, at least one first illumination light, preferably moving at least in one direction, as well as at least one second illumination light moving at least in one direction, illuminate a sample through a beam combiner, a detection of the light coming from the sample takes place, whereby, at least one part of the illumination light is generated through the splitting of the light from a common illuminating unit, characterized in that, by means of a common control unit, a controlled splitting into the first and the second illumination light takes place, in which the intensity of the first illuminating light, specified by the user or specified automatically, is assigned a higher priority (is prioritized) compared to the specified value for the second illumination light, and an adjustment for the second illumination light takes place until a maximum value is obtained, which is determined by the value specified for the first illumination light.

摘要翻译： 显微镜，特别是激光扫描显微镜的致动控制方法，其中至少一个至少在一个方向上移动的第一照明光以及至少沿一个方向移动的至少一个第二照明光， 通过光束组合器照射样品，发生来自样品的光的检测，由此通过从公共照明单元分离光而产生照明光的至少一部分，其特征在于，通过装置 发生公共控制单元的受控分割，进入第一和第二照明光，其中由用户指定或自动指定的第一照明光的强度被分配为比较高的优先级（优先化） 对于第二照明光的指定值，并且进行第二照明光的调整，直到获得最大值，其由v 为第一个照明灯指定。

公开(公告)号：US20080068709A1

公开(公告)日：2008-03-20

申请号：US11783290

申请日：2007-04-06

申请人： Bernhard Zimmermann ,  Ralf Netz ,  Frank Hecht ,  Joerg-Michael Funk ,  Ralf Engelmann

发明人： Bernhard Zimmermann ,  Ralf Netz ,  Frank Hecht ,  Joerg-Michael Funk ,  Ralf Engelmann

IPC分类号： G02B21/06

CPC分类号： G02B21/06 ,  G02B21/00 ,  G02B21/0032 ,  G02B21/0076 ,  G02B27/0972

摘要： Method for actuation control of a microscope, in particular of a Laser Scanning Microscope, in which, at least one first illumination light, preferably moving at least in one direction, as well as at least one second illumination light moving at least in one direction, illuminate a sample through a beam combination, a detection of the light coming from the sample takes place, whereby, at least one part of the illumination light is generated through the splitting of the light from a common illuminating unit, characterized in that, by means of a common control unit, a controlled splitting into the first and the second illumination light takes place, in which the intensity of the first illuminating light, specified by the user or specified automatically, is assigned a higher priority (is prioritized) compared to the specified value for the second illumination light, and an adjustment for the second illumination light takes place until a maximum value is obtained, which is determined by the value specified for the first illumination light.

摘要翻译： 显微镜，特别是激光扫描显微镜的致动控制方法，其中至少一个至少在一个方向上移动的第一照明光以及至少沿一个方向移动的至少一个第二照明光， 通过光束组合照射样品，发生来自样品的光的检测，由此通过从公共照明单元分离光而产生照明光的至少一部分，其特征在于，通过装置 发生公共控制单元的受控分割，进入第一和第二照明光，其中由用户指定或自动指定的第一照明光的强度被分配为比较高的优先级（优先化） 对于第二照明光的指定值，并且进行第二照明光的调整，直到获得由th确定的最大值 为第一个照明灯指定的e值。

公开(公告)号：US20110288780A1

公开(公告)日：2011-11-24

申请号：US13110685

申请日：2011-05-18

申请人： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

发明人： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC分类号： G06F19/00 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  G06F19/00 ,  G06F19/12 ,  G06F19/18 ,  G06F19/22 ,  G06F19/34 ,  G16H50/30

摘要： Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.

摘要翻译： 本文公开了非侵入性产前倍性呼叫的方法。 本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。 通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态， 并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。 在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

公开(公告)号：US07119898B2

公开(公告)日：2006-10-10

申请号：US10763649

申请日：2004-01-23

申请人： Bernhard Zimmermann ,  Eva Simbuerger ,  Mary Dickinson

发明人： Bernhard Zimmermann ,  Eva Simbuerger ,  Mary Dickinson

IPC分类号： G01J3/30

CPC分类号： G02B21/008 ,  G01N21/64 ,  G01N2021/6419 ,  G01N2021/6441 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/0084 ,  G02B21/16

摘要： A method for the detection and evaluation of the light generated in a fluorescing specimen by a short pulse laser, wherein at least a first and a second fluorophore and/or a self-fluorescing specimen are separately irradiated with different wavelengths and the specimen light is recorded in a wavelength-dependent manner with at least one nondescanned detector as reference spectrum and a separation into individual spectra is carried out during the irradiation of at least two fluorophores and/or self-fluorescing specimens simultaneously from the measured spectrum and the reference spectra through regression analysis, wherein the wavelength of the short pulse laser is advantageously changed continuously in at least one wavelength region.

摘要翻译： 一种用于通过短脉冲激光检测和评估在荧光样品中产生的光的方法，其中至少第一和第二荧光团和/或自发荧光样品被不同波长分开照射并且记录样本光 以至少一个非扫描检测器作为参考光谱的波长依赖性方式，并且在从测量的光谱和参考光谱通过回归同时从至少两个荧光团和/或自发荧光样品的照射期间进行分离成单个光谱 分析，其中短脉冲激光器的波长有利地在至少一个波长区域中连续地改变。

公开(公告)号：US20050032830A1

公开(公告)日：2005-02-10

申请号：US10916125

申请日：2004-08-11

申请人： Joseph Dellaria ,  Kyle Lindstrom ,  Luke Dressel ,  Daniel Duffy ,  Philip Heppner ,  John Jacobsen ,  Joan Moseman ,  William Moser ,  Matthew Radmer ,  Doris Stoermer ,  Bernhard Zimmermann

发明人： Joseph Dellaria ,  Kyle Lindstrom ,  Luke Dressel ,  Daniel Duffy ,  Philip Heppner ,  John Jacobsen ,  Joan Moseman ,  William Moser ,  Matthew Radmer ,  Doris Stoermer ,  Bernhard Zimmermann

IPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/506 ,  A61K31/5377 ,  A61P7/00 ,  A61P17/00 ,  A61P17/14 ,  A61P17/16 ,  A61P25/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D471/04 ,  C07D471/14 ,  C07D471/02 ,  A61K31/4745

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

摘要翻译： 在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。 还公开了制备可用于制备化合物的化合物和中间体的方法。

公开(公告)号：US5453728A

公开(公告)日：1995-09-26

申请号：US962792

申请日：1992-12-28

申请人： Bernhard Zimmermann ,  Gerhard Niklewski

发明人： Bernhard Zimmermann ,  Gerhard Niklewski

IPC分类号： H01C10/30 ,  H01H9/06 ,  H05K1/18 ,  H01C10/36 ,  H01C10/50

CPC分类号： H01C10/30 ,  H05K1/181 ,  H01H2011/0075 ,  H01H9/061 ,  H05K2201/10022 ,  H05K2201/10196 ,  H05K2201/10636 ,  Y02P70/611

摘要： An electric tool rheostatic device in a switching arrangement is provided for regulating the speed of an electric motor in an electric tool. A circuit board for receiving electronic components is disposed in a switch housing. A potentiometer disposed within the switch housing includes a potentiometer slider operatively connected with a manually-operated actuating member and a resistance track that is constituted by a chip resistance element produced independently of the circuit board according to surface mounted device technology and mounted on the circuit board independently of the potentiometer slider. Upon assembly of the switching arrangement the potentiometer slide is adjustably located on the resistance track by the manually-operated actuating member for controlling resistance.

摘要翻译： PCT No.PCT / DE91 / 00529 Sec。 371日期1992年12月28日 102（e）日期1992年12月28日PCT Filed 1991年6月27日PCT Pub。 出版物WO92 / 00594 日期1992年1月9日。设置有用于调节电动工具中的电动机的速度的开关装置中的电动工具变阻器。 用于接收电子部件的电路板设置在开关壳体中。 设置在开关壳体内的电位器包括与手动操作的致动构件可操作地连接的电位计滑块和由根据表面安装器件技术独立于电路板制造的芯片电阻元件构成的电阻轨迹，并安装在电路板上 独立于电位器滑块。 在组装开关装置时，电位器滑块通过用于控制电阻的手动操作的致动构件可调节地位于阻力轨道上。

公开(公告)号：US09580751B2

公开(公告)日：2017-02-28

申请号：US13029995

申请日：2011-02-17

申请人： Sinuhe Hahn ,  Wolfgang Holzgreve ,  Bernhard Zimmermann ,  Ying Li

发明人： Sinuhe Hahn ,  Wolfgang Holzgreve ,  Bernhard Zimmermann ,  Ying Li

IPC分类号： C12Q1/68 ,  C07H21/02

CPC分类号： C12Q1/6883 ,  C12Q1/6806 ,  C12Q2600/156 ,  C12Q2565/125

摘要： Blood plasma of pregnant women contains fetal and (generally >90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains ≦500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of

摘要翻译： 孕妇的血浆含有胎儿和（一般> 90％）母体循环细胞外DNA。 大多数所述胎儿DNA含有≤500个碱基对，所述母体DNA具有更大的尺寸。 分离<500碱基对的循环细胞外DNA导致胎儿与母体DNA分离。 由于尺寸分离（例如通过色谱法，密度梯度离心或纳米技术方法），怀孕妇女血浆或血清样品的一小部分含有基本上包含≤500个碱基对的细胞外DNA，可用于非侵入性检测胎儿遗传 性状（包括胎儿RhD基因在妊娠中存在HDN风险;胎儿Y染色体特异性序列在X染色体相关疾病风险的妊娠中;染色体异常;遗传性孟德尔遗传疾病和相应的遗传标记;以及决定亲子鉴别的特征） 通过例如 PCR，配体链反应或探针杂交技术或核酸阵列。

公开(公告)号：US08825412B2

公开(公告)日：2014-09-02

申请号：US13110685

申请日：2011-05-18

申请人： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

发明人： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC分类号： G01N33/48 ,  G06F19/00 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58 ,  G06F19/12 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  G06F19/00 ,  G06F19/12 ,  G06F19/18 ,  G06F19/22 ,  G06F19/34 ,  G16H50/30

摘要： Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.

摘要翻译： 本文公开了非侵入性产前倍性呼叫的方法。 本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。 通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态， 并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。 在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。