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11.发明授权Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection 失效利巴韦林 - 干扰素α联合治疗用于根除慢性丙型肝炎感染患者可检测的HCV-RNA公开(公告)号：US07115578B2
公开(公告)日：2006-10-03
申请号：US10885374
申请日：2004-07-06
申请人： Ashit K. Ganguly , Jinping McCormick , Raymond G. Lovey , Frank Bennett , Anil K. Saksena , Viyyoor M. Girijavallabhan
发明人： Ashit K. Ganguly , Jinping McCormick , Raymond G. Lovey , Frank Bennett , Anil K. Saksena , Viyyoor M. Girijavallabhan
CPC分类号： C07H19/056 , Y10S514/894
摘要： Ribavirin derivatives represented by the formula V, pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula V for the preparation of a medicament for the treatment of susceptible viral infections, for example, chronic hepatitis C infections administrating, the ribavirin derivatives being represented by formula V are disclosed.
摘要翻译： 由式V表示的利巴韦林衍生物，含有它们的药物组合物以及由式V表示的利巴韦林衍生物用于制备用于治疗易感病毒感染的药物的用途，例如，施用的慢性丙型肝炎感染， 公开了由式V表示的利巴韦林衍生物。
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12.发明授权Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase 失效可用作法呢基蛋白转移酶抑制剂的三环N-氰基亚胺
公开(公告)号：US5925648A
公开(公告)日：1999-07-20
申请号：US902372
申请日：1997-07-29
申请人： Alan B. Cooper , James J-S Wang , Raymond G. Lovey , Jagdish A. Desai , Anil K. Saksena , Viyyoor M. Girijavallabhan , Ronald J. Doll
发明人： Alan B. Cooper , James J-S Wang , Raymond G. Lovey , Jagdish A. Desai , Anil K. Saksena , Viyyoor M. Girijavallabhan , Ronald J. Doll
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/44
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14
摘要： Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions of formula (1.0) ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein a, b, c, d, R.sup.1 -R.sup.8, X and Z are defined herein. Such compounds are inhibitors of the enzyme, farnesyl protein transferase. The compounds are useful for inhibiting Ras function and therefore inhibiting the abnormal growth of cells, in a mammals such as a human.
摘要翻译： 新的三环N-氰基亚胺化合物和式（1.0）的药物组合物或其药学上可接受的盐或溶剂合物，其中a，b，c，d，R 1 -R 8，X和Z在本文中定义。 这些化合物是酶的抑制剂，法呢基蛋白转移酶。 该化合物可用于抑制Ras功能，从而抑制哺乳动物如人的细胞的异常生长。
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公开(公告)号：US5714490A
公开(公告)日：1998-02-03
申请号：US458543
申请日：1995-06-02
申请人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
发明人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
IPC分类号： C07D405/14 , A61K31/41 , A61K31/495 , A61K31/675 , A61P31/00 , A61P31/10 , C07D521/00 , C07F9/6558
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07F9/65586
摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two amino acid ester groups (e.g., an amino acid ester group convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个氨基酸酯基（例如，在体内可转化为羟基的氨基酸酯基）或其药学上可接受的盐取代的直链或支链（C3至C8）烷基和其药物组合物 有用于治疗和/或预防真菌感染。
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公开(公告)号：US5703236A
公开(公告)日：1997-12-30
申请号：US458551
申请日：1995-06-02
申请人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
发明人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
IPC分类号： C07D405/14 , A61K31/41 , A61K31/495 , A61K31/675 , A61P31/00 , A61P31/10 , C07D521/00 , C07F9/6558
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07F9/65586
摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two hydroxy moieties, an ether ester (e.g., a polyetherester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个羟基部分取代的直链或支链（C3至C8）烷基，其醚酯（例如，聚醚酯或磷酸酯）或其药学上可接受的盐和用于治疗和/ 或预防真菌感染。
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公开(公告)号：US5703079A
公开(公告)日：1997-12-30
申请号：US460400
申请日：1995-06-02
申请人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
发明人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
IPC分类号： C07D405/14 , A61K31/41 , A61K31/495 , A61K31/675 , A61P31/00 , A61P31/10 , C07D521/00 , C07F9/6558
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07F9/65586
摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two polyetyher ester groups (e.g., a polyether ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个聚烯酯基团取代的直链或支链（C3至C8）烷基（例如，可在体内转化为羟基的聚醚酯）或其药学上可接受的盐和其用于治疗的药物组合物 和/或预防真菌感染。
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公开(公告)号：US5693626A
公开(公告)日：1997-12-02
申请号：US459145
申请日：1995-06-02
申请人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
发明人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
IPC分类号： C07D405/14 , A61K31/41 , A61K31/495 , A61K31/675 , A61P31/00 , A61P31/10 , C07D521/00 , C07F9/6558 , C07D413/14 , C07F9/6518
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07F9/65586
摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two phosphate ester groups (e.g., a phosphate ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个磷酸酯基团取代的直链或支链（C3至C8）烷基（例如，可在体内转化为羟基的磷酸酯）或其药学上可接受的盐和用于治疗的药物组合物 和/或预防真菌感染。
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公开(公告)号：US5661151A
公开(公告)日：1997-08-26
申请号：US460752
申请日：1995-06-02
申请人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
发明人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
IPC分类号： C07D405/14 , A61K31/41 , A61K31/495 , A61K31/675 , A61P31/00 , A61P31/10 , C07D521/00 , C07F9/6558 , C07D413/14 , C07F9/6518
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07F9/65586
摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个羟基部分取代的直链或支链（C3至C8）烷基，其醚或酯（例如，聚醚酯氨基酸酯或磷酸酯）或其药学上可接受的盐和药物组合物 其用于治疗和/或预防真菌感染。
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公开(公告)号：US5795874A
公开(公告)日：1998-08-18
申请号：US770469
申请日：1996-12-20
申请人： Viyyoor M. Girijavallabhan , Anil K. Saksena , Frank Bennett , Edwin Jao , Naginbhai M. Patel , Ashit Ganguly
发明人： Viyyoor M. Girijavallabhan , Anil K. Saksena , Frank Bennett , Edwin Jao , Naginbhai M. Patel , Ashit Ganguly
IPC分类号： A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/04 , A81K31/72 , C07H15/24
CPC分类号： C07H17/04
摘要： The compound of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are as defined herein, are described. These compounds are antibacterial agents.
摘要翻译： 描述了其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义的式I化合物。 这些化合物是抗菌剂。
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公开(公告)号：US5559133A
公开(公告)日：1996-09-24
申请号：US167812
申请日：1993-12-16
申请人： Viyyoor M. Girijavallabhan , Ashit K. Ganguly , Richard W. Versace , Anil K. Saksena , Patrick A. Pinto
发明人： Viyyoor M. Girijavallabhan , Ashit K. Ganguly , Richard W. Versace , Anil K. Saksena , Patrick A. Pinto
IPC分类号： A61K31/085 , A61K31/09 , A61K31/185 , A61K31/235 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/421 , A61P31/00 , C07C43/205 , C07C43/225 , C07C43/23 , C07C69/92 , C07C205/38 , C07C233/25 , C07C255/54 , C07C317/22 , C07C323/19 , C07D213/30 , C07D213/65 , C07D263/12 , C07D263/14 , C07D307/12 , C07D307/28 , C07D307/42 , C07D333/16 , A61K31/44 , C07D213/63
CPC分类号： C07D213/30 , C07C43/225 , C07C43/23 , C07C69/92 , C07D263/14 , C07D307/12 , C07D307/28 , C07D307/42 , C07D333/16
摘要： A compound represented by formula I, Ar.sub.1 --O--M--O--Ar.sub.2, wherein Ar.sub.1 and Ar.sub.2 are independently substituted phenyl or substituted pyridinyl, the substituents on said phenyl or pyridinyl being independently selected from one, two or three of (C.sub.1 -C.sub.10) alkyl, (C.sub.1 -C.sub.10) alkoxy, halogen, carbamyl, (C.sub.1 -C.sub.10) alkoxycarbonyl, oxazoyl, and (C.sub.1 -C.sub.10) alkyl substituted by halogen, (C.sub.1 -C.sub.10) alkoxy, hydroxy, or (C.sub.1 -C.sub.10) alkoxycarbonyl; ##STR1## O is oxygen; R' is (C.sub.1 -C.sub.3 alkyl or H; A is oxygen or sulfur; Q is selected from hydrogen, halogen, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.1 C.sub.6) perhaloalkyl, (C.sub.1 -C.sub.6) alkylthio (C.sub.1 -C.sub.6) or alkyl sulfonyl; the dotted lines in M-3 and M-4 between carbons, 2 and 3 and 3 and 4, and 4 and 5 mean that the bonds between carbons 2 and 3, and 3 and 4, and 5 and 6, may each be a single or double bond; n=1 or 2; m=1 or 2; p=0 or 1; or pharmaceutically acceptable salts thereof as well as pharmaceutical compositions containing such compounds and methods of treating or preventing viral infections, especially picornaviral infections using the compounds of formula I, are disclosed.
摘要翻译： PCT No.PCT / US92 / 04961 Sec。 371日期：1993年12月16日 102（e）日期1993年12月16日PCT提交1992年6月17日PCT公布。 出版物WO92 / 22520 日期1992年12月23日由式I表示的化合物Ar1-OMO-Ar2，其中Ar1和Ar2独立地为取代的苯基或取代的吡啶基，所述苯基或吡啶基上的取代基独立地选自（C1- （C 1 -C 10）烷氧基，羟基或（C 1 -C 10）烷基，（C 1 -C 10）烷基，（C 1 -C 10）烷氧基，卤素，氨基甲酰基，（C 1 -C 10）烷氧基羰基，恶唑基， 烷氧基羰基 M是图像M-1图像M-2图像M-3图像M-3 O是氧气; R 1是（C 1 -C 6烷基或H; A是氧或硫; Q选自氢，卤素，硝基，（C 1 -C 6）烷基，（C 1 -C 6）全卤烷基，（C 1 -C 6）烷硫基 或烷基磺酰基;碳原子数2和3，3和4以及4和5之间的M-3和M-4中的虚线意味着碳2和3之间，3和4和5和6之间的键， 可以是单键或双键; n = 1或2; m = 1或2; p = 0或1;或其药学上可接受的盐以及含有这些化合物的药物组合物和治疗或预防病毒感染的方法，特别是 公开了使用式I化合物的小RNA病毒感染。
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公开(公告)号：US4999428A
公开(公告)日：1991-03-12
申请号：US338244
申请日：1989-04-14
IPC分类号： C07D473/00
CPC分类号： C07D473/00
摘要： Novel process for preparing cyclopentyl purine derivatives is disclosed.
摘要翻译： 公开了制备环戊基嘌呤衍生物的新方法。
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