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57 条记录 (耗时 0.042 秒)

    Compounds useful for inhibition of farnesyl protein transferase
    3.
    发明授权
    Compounds useful for inhibition of farnesyl protein transferase 失效
    可用于抑制法呢基蛋白转移酶的化合物

    公开(公告)号：US06689789B2

    公开(公告)日：2004-02-10

    申请号：US10235027

    申请日：2002-09-04

    申请人： Alan B. Cooper ,  Ronald J. Doll ,  Anil K. Saksena ,  Viyyoor M. Girijavallabhan

    发明人： Alan B. Cooper ,  Ronald J. Doll ,  Anil K. Saksena ,  Viyyoor M. Girijavallabhan

    IPC分类号： A61K31438

    CPC分类号： C07D401/14

    摘要： Novel compounds of the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO−; R1 and R3 are the same or different and each represents halo; R2 and R4 are the same or different and each is selected from H and halo, provided that at least one of R2 and R4 is H; T is a substituent selected from SO2R or Z is O or S; n is zero or an integer from 1 to 6; R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R5)2; R5 is H, alkyl, aryl, heteroaryl or cycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.

    摘要翻译： 新的下式化合物或其药学上可接受的盐或溶剂化物，其中：a表示N或NO - ; R 1和R 3相同或不同，各自表示卤素; R 2和 R 4相同或不同，各自选自H和卤素，条件是R 2和R 4中的至少一个为H; T为选自SO 2 R或Z的取代基为O或S; n R为烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基，杂环烷基或N（R 5）2; R 5为H，烷基，芳基，杂芳基或环烷基 还公开了抑制法呢基蛋白转移酶的方法和治疗肿瘤细胞的方法。

    Compounds useful for inhibition of farnesyl protein transferase
    4.
    发明授权
    Compounds useful for inhibition of farnesyl protein transferase 失效
    可用于抑制法呢基蛋白转移酶的化合物

    公开(公告)号：US06239140B1

    公开(公告)日：2001-05-29

    申请号：US09094689

    申请日：1998-06-15

    申请人： Alan B. Cooper ,  Ronald J. Doll ,  Anil K. Saksena ,  Viyyoor M. Girijavallabhan

    发明人： Alan B. Cooper ,  Ronald J. Doll ,  Anil K. Saksena ,  Viyyoor M. Girijavallabhan

    IPC分类号： C07D48700

    CPC分类号： C07D401/14

    摘要： Novel compounds of the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO−; R1 and R3 are the same or different and each represents halo; R2 and R4 are the same or different and each is selected from H and halo, provided that at least one of R2 and R4 is H; T is a substituent selected from SO2R or: Z is O or S; n is zero or an integer from 1 to 6; R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R5)2; R5 is H, alkyl, aryl, heteroaryl or cycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.

    摘要翻译： 新的下式化合物或其药学上可接受的盐或溶剂合物，其中：a表示N或NO-; R 1和R 3相同或不同，各自表示卤素; R 2和R 4相同或不同，各自选自 H和卤素，条件是R 2和R 4中的至少一个是H; T是选自SO 2 R的取代基或：Z是O或S; n是0或1-6的整数; R是烷基，芳基，芳基烷基， 杂芳基，杂芳基烷基，环烷基，杂环烷基或N（R5）2; R5是H，烷基，芳基，杂芳基或环烷基。还公开了抑制法呢基蛋白转移酶的方法和治疗肿瘤细胞的方法。

    Soluble azole antifungal salt
    6.
    发明授权
    Soluble azole antifungal salt 失效
    可溶性唑类抗真菌盐

    公开(公告)号：US5883097A

    公开(公告)日：1999-03-16

    申请号：US61502

    申请日：1998-04-16

    申请人： Raymond G. Lovey ,  Viyyoor M. Girijavallabhan ,  Anil K. Saksena ,  Bruce E. Reidenberg

    发明人： Raymond G. Lovey ,  Viyyoor M. Girijavallabhan ,  Anil K. Saksena ,  Bruce E. Reidenberg

    IPC分类号： C07D521/00 ,  A61K31/495 ,  C07D405/14

    CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

    摘要： The lactic acid�CH.sub.3 CH(OH)CO.sub.2 H! addition salt of the compound of formula I ##STR1## wherein the molar ratio of lactic acid, preferably L-lactic acid, to the compound of formula I is preferably about 1:1, pharmaceutical compositions of the lactic acid addition salt in an aqueous lactic acid carrier suitable for intravenous administration, and methods of using either of them to treat and/or prevent susceptible fungal infections in a host such as a mammal are disclosed.

    摘要翻译： 式I化合物的乳酸[CH 3 CH（OH）CO 2 H]加成盐，其中乳酸，优选L-乳酸与式I化合物的摩尔比优选为约1： 1，公开了适用于静脉内给药的乳酸载体的乳酸加成盐的药物组合物，以及使用它们之一来治疗和/或预防哺乳动物宿主易感真菌感染的方法。