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公开(公告)号：US5795874A
公开(公告)日：1998-08-18
申请号：US770469
申请日：1996-12-20
申请人： Viyyoor M. Girijavallabhan , Anil K. Saksena , Frank Bennett , Edwin Jao , Naginbhai M. Patel , Ashit Ganguly
发明人： Viyyoor M. Girijavallabhan , Anil K. Saksena , Frank Bennett , Edwin Jao , Naginbhai M. Patel , Ashit Ganguly
IPC分类号： A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/04 , A81K31/72 , C07H15/24
CPC分类号： C07H17/04
摘要： The compound of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are as defined herein, are described. These compounds are antibacterial agents.
摘要翻译： 描述了其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义的式I化合物。 这些化合物是抗菌剂。
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公开(公告)号：US5652226A
公开(公告)日：1997-07-29
申请号：US577656
申请日：1995-12-22
申请人： Viyyoor M. Girijavallabhan , Anil K. Saksena , Frank Bennett , Edwin Jao , Naginbhai M. Patel , Ashit Ganguly
发明人： Viyyoor M. Girijavallabhan , Anil K. Saksena , Frank Bennett , Edwin Jao , Naginbhai M. Patel , Ashit Ganguly
IPC分类号： A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/04 , C07H15/24 , C07H15/00 , C07H19/01 , C12P19/60
CPC分类号： C07H17/04
摘要： The compound of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are as defined herein, are described. These compounds are antibacterial agents.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义的式I化合物。 这些化合物是抗菌剂。
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公开(公告)号：US6043245A
公开(公告)日：2000-03-28
申请号：US160997
申请日：1998-09-25
申请人： Frank Bennett , Viyyoor M. Girijavallabhan , Naginbhai M. Patel , Anil K. Saksena , Ashit Ganguly
发明人： Frank Bennett , Viyyoor M. Girijavallabhan , Naginbhai M. Patel , Anil K. Saksena , Ashit Ganguly
IPC分类号： C07D405/14 , A61K31/496 , A61K31/675 , C07F9/6509
CPC分类号： C07D405/14
摘要： A compound of the formula I ##STR1## wherein G is H or PO.sub.3 H.sub.2 or a pharmaceutical acceptable salt thereof, pharmaceutical compositions containing such compounds and method of using such compounds or pharmaceutical compositions containing them to treat or prevent fungal infection are disclosed.
摘要翻译： 公开了其中G为H或PO3H2的式I化合物或其药学上可接受的盐，含有这些化合物的药物组合物和使用这些化合物的方法或含有它们的药物组合物来治疗或预防真菌感染。
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4.发明授权公开(公告)号：US06894072B2
公开(公告)日：2005-05-17
申请号：US10348094
申请日：2003-01-21
申请人： Ashok Arasappan , Frank Bennett , Stephane L. Bogen , Kevin X. Chen , Edwin Jao , Yi-Tsung Liu , Raymond G. Lovey , Vincent S. Madison , Latha G. Nair , F. George Njoroge , Anil K. Saksena , Mousumi Sannigrahi , Srikanth Venkatraman , Viyyoor M. Girijavallabhan
发明人： Ashok Arasappan , Frank Bennett , Stephane L. Bogen , Kevin X. Chen , Edwin Jao , Yi-Tsung Liu , Raymond G. Lovey , Vincent S. Madison , Latha G. Nair , F. George Njoroge , Anil K. Saksena , Mousumi Sannigrahi , Srikanth Venkatraman , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/403 , A61K31/7052 , A61K38/21 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/75 , C07D217/26 , C07D233/68 , C07D243/12 , C07D253/06 , C07D271/06 , C07D277/06 , C07D277/46 , C07D277/56 , C07D295/15 , C07D307/68 , C07D317/58 , C07D335/10 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D209/02
CPC分类号： C07D207/27 , C07D207/16 , C07D209/08 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/75 , C07D217/26 , C07D233/68 , C07D243/12 , C07D253/06 , C07D271/06 , C07D277/06 , C07D277/46 , C07D277/56 , C07D295/15 , C07D307/68 , C07D317/58 , C07D335/10 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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5.发明授权公开(公告)号：US07186747B2
公开(公告)日：2007-03-06
申请号：US11065531
申请日：2005-02-24
申请人： Ashok Arasappan , F. George Njoroge , Angela I. Padilla-Acevedo , Kevin X. Chen , Frank Bennett , Mousumi Sannigrahi , Stephane L. Bogen , Srikanth Venkatraman , Edwin Jao , Anil K. Saksena , Viyyoor M. Girijavallabhan
发明人： Ashok Arasappan , F. George Njoroge , Angela I. Padilla-Acevedo , Kevin X. Chen , Frank Bennett , Mousumi Sannigrahi , Stephane L. Bogen , Srikanth Venkatraman , Edwin Jao , Anil K. Saksena , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/401 , C07D207/08
CPC分类号： C07D209/52 , A61K38/00 , C07K5/0202 , C07K5/06034 , C07K5/06078 , C07K5/06191 , C07K5/0808 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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6.发明授权Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease 有权硫化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US08067379B2
公开(公告)日：2011-11-29
申请号：US11064673
申请日：2005-02-24
申请人： Frank Bennett , Raymond G. Lovey , Yuhua Huang , Siska Hendrata , Anil K. Saksena , Stephane L. Bogen , Yi-Tsung Liu , F. George Njoroge , Srikanth Venkatraman , Kevin X. Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor M. Girijavallabhan , Francisco Velazquez , Latha G. Nair
发明人： Frank Bennett , Raymond G. Lovey , Yuhua Huang , Siska Hendrata , Anil K. Saksena , Stephane L. Bogen , Yi-Tsung Liu , F. George Njoroge , Srikanth Venkatraman , Kevin X. Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor M. Girijavallabhan , Francisco Velazquez , Latha G. Nair
IPC分类号： A61K38/06
CPC分类号： C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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7.发明授权Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection 失效利巴韦林 - 干扰素α联合治疗用于根除慢性丙型肝炎感染患者可检测的HCV-RNA公开(公告)号：US06673775B2
公开(公告)日：2004-01-06
申请号：US09837609
申请日：2001-04-18
申请人： Ashit K. Ganguly , Jinping McCormick , Raymond G. Lovey , Frank Bennett , Anil K. Saksena , Viyyoor M. Girijavallabhan
发明人： Ashit K. Ganguly , Jinping McCormick , Raymond G. Lovey , Frank Bennett , Anil K. Saksena , Viyyoor M. Girijavallabhan
IPC分类号： A01N4304
CPC分类号： C07H19/056 , A61K31/7056 , A61K38/212 , A61K45/06 , Y02A50/393 , Y10S514/894 , A61K2300/00
摘要： Ribavirin derivatives represented by formula I wherein at least one of R2, R3 or R5 is a straight or branched chain polyalkylene oxide polymer conjugate, and pharmaceutical compositions containing them as well as their use to treat patients having susceptible viral infections, alone and in combination with a therapeutically effective amount of interferon-alpha are disclosed.
摘要翻译： 由式I表示的利巴韦林衍生物，其中R 2，R 3或R 5中的至少一个是直链或支链聚环氧烷聚合物缀合物，以及含有它们的药物组合物及其用于治疗易感的患者 公开了单独的和与治疗有效量的干扰素-α组合的病毒感染。
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公开(公告)号：US5710154A
公开(公告)日：1998-01-20
申请号：US459225
申请日：1995-06-02
申请人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
发明人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
IPC分类号： C07D405/14 , A61K31/41 , A61K31/495 , A61K31/675 , A61P31/00 , A61P31/10 , C07D521/00 , C07F9/6558 , C07D413/14 , C07F9/6518
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07F9/65586
摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two groups convertible in vivo into hydroxy moieties, (e.g., a polyether ester, amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被体内转化成羟基的一个或两个基团（例如，其聚醚酯，氨基酸酯或磷酸酯）或其药学上可接受的盐和药学上可接受的盐取代的直链或支链（C3至C8）烷基 公开了可用于治疗和/或预防真菌感染的组合物。
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公开(公告)号：US07205330B2
公开(公告)日：2007-04-17
申请号：US11065572
申请日：2005-02-24
申请人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
发明人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/401 , C07D207/08
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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10.发明授权Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection 失效利巴韦林 - 干扰素α联合治疗用于根除慢性丙型肝炎感染患者可检测的HCV-RNA公开(公告)号：US06924270B2
公开(公告)日：2005-08-02
申请号：US09837491
申请日：2001-04-18
申请人： Ashit K. Ganguly , Jinping Mc Cormick , Raymond G. Lovey , Frank Bennett , Anil K. Saksena , Viyyoor M. Girijavallabhan
发明人： Ashit K. Ganguly , Jinping Mc Cormick , Raymond G. Lovey , Frank Bennett , Anil K. Saksena , Viyyoor M. Girijavallabhan
IPC分类号： A61P31/12 , C07H19/056 , A01N43/04 , A61K31/70
CPC分类号： C07H19/056 , Y10S514/894
摘要： Ribavirin derivatives represented by the formula II, pharmaceutical compositions containing them as well as methods of using the ribavirin derivatives represented by the formula II for the treatment of susceptible viral infections, for example, chronic hepatitis C infections administrating, the ribavirin derivatives being represented by formula II are disclosed.
摘要翻译： 由式II表示的利巴韦林衍生物，含有它们的药物组合物以及使用由式II表示的利巴韦林衍生物用于治疗易感病毒感染的方法，例如施用的慢性丙型肝炎感染，利巴韦林衍生物由式 II被公开。
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