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公开(公告)号：US20240110932A1
公开(公告)日：2024-04-04
申请号：US18541624
申请日：2023-12-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Johannes Pflieger , Nicole Pirkl , Martin Rempt , Christoph Zuth
CPC classification number: G01N33/743 , G01N30/7233 , G01N33/6848 , H01J49/0009 , G01N2030/027 , G01N2333/575 , G01N2496/00
Abstract: The present invention relates to a method of determining an analyte in a sample by mass spectrometry (MS), the method comprising (a) admixing a pre-determined amount of internal calibrator to said sample, wherein said internal calibrator comprises at least two non-identical isotopologues of the analyte at predetermined amounts; (b) determining MS signals of ions generated from said analyte (analyte signal) and from said at least two isotopologues (isotopologue signals); (c) providing a calibration based on the analyte signal and the isotopologue signals determined in step (b); and (d) determining said analyte based on the calibration provided in step (c). Further, the present invention relates to devices, systems, and uses related thereto.
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公开(公告)号：US20230127289A1
公开(公告)日：2023-04-27
申请号：US17990714
申请日：2022-11-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Hahn , Dieter Heindl , Thomas Hoffmann , Hans-Peter Josel , Uwe Kobold , Hannes Kuchelmeister , Simon Ferdinand Loibl , Daniela Mazzier , Jelena Milic , Giuseppe Prencipe , Martin Rempt , Christoph Seidel
IPC: C07D213/56 , C07D401/04 , C07D213/74 , C07D213/30 , H01J49/00
Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.
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公开(公告)号：US20190293612A1
公开(公告)日：2019-09-26
申请号：US16438797
申请日：2019-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Thomas Heinemeyer , Uwe Kobold , Martin Rempt , Christoph Seidel
Abstract: A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being above a detection level of the mass spectrometer, processing the reagent together with the chemical substance with the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.
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公开(公告)号：US20190293611A1
公开(公告)日：2019-09-26
申请号：US16438775
申请日：2019-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Uwe Kobold , Christoph Seidel , Martin Rempt
Abstract: A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being below a detection level of the mass spectrometer, enriching the chemical substance within the liquid chromatograph to a concentration above the detection level of the mass spectrometer, processing the reagent together with the enriched chemical substance by means of the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.
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公开(公告)号：US12203905B2
公开(公告)日：2025-01-21
申请号：US16438775
申请日：2019-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Uwe Kobold , Christoph Seidel , Martin Rempt
IPC: G01N30/08 , G01N30/02 , G01N30/06 , G01N30/28 , G01N30/46 , G01N30/72 , G01N33/58 , G01N33/68 , B01D15/34 , B01D59/44 , H01J49/06 , H01J49/10
Abstract: A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being below a detection level of the mass spectrometer, enriching the chemical substance within the liquid chromatograph to a concentration above the detection level of the mass spectrometer, processing the reagent together with the enriched chemical substance by means of the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.
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Patent Agency Ranking
公开(公告)号：US20240159631A1
公开(公告)日：2024-05-16
申请号：US18393378
申请日：2023-12-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Martin Rempt , Manuel Josef Seitz , Christoph Zuth
IPC: G01N1/40
CPC classification number: G01N1/405
Abstract: A method for detecting at least one analyte (110) in a sample (112) is disclosed. The method comprises the following steps:
a) providing at least one sample (112) having at least one analyte (110);
b) incubating the sample (112) with microparticles (118) having at least one surface (120) whereby the analyte (110) is adsorbed on the surface (120) of the microparticles (118) and an analyte-microparticle-complex (122) is formed;
c) providing at least one fiber sheet material (128) having at least one tip (130) and contacting the tip (130) of the fiber sheet material (128) to the sample (112) comprising the analyte-microparticle-complex (122), whereby at least the analyte-microparticle-complex (122) is sucked into the tip (130) of the fiber sheet material (128);
d) contacting the tip (130) of the fiber sheet material (128) to a port of an analytical device;
e) adding an extracting solvent (138) to the fiber sheet material (128) and applying an electrical voltage to the fiber sheet material (128) whereby ions of the analyte (110) are generated and are expelled from the tip (130) of the fiber sheet material (128); and
f) detecting the at least one analyte (110) with the analytical device (134).-
公开(公告)号：US20240092742A1
公开(公告)日：2024-03-21
申请号：US18500149
申请日：2023-11-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04
CPC classification number: C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04 , G01N30/72
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US20230314444A1
公开(公告)日：2023-10-05
申请号：US18328104
申请日：2023-06-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Samir Karaca , Nicole Pirkl , Martin Rempt
CPC classification number: G01N33/6848 , H01J49/165 , G01N33/743
Abstract: The present invention relates to a method, a diagnostic system, a dopand and the use thereof for the enhancement of detection of an analyte of interest by Cross Spray ESI mass spectrometry.
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公开(公告)号：US20210188788A1
公开(公告)日：2021-06-24
申请号：US17154501
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Robert Hahn , Nicole Pirkl
IPC: C07D257/04 , C07D249/06 , H01J49/00
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US12031962B2
公开(公告)日：2024-07-09
申请号：US16438797
申请日：2019-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Thomas Heinemeyer , Uwe Kobold , Martin Rempt , Christoph Seidel
CPC classification number: G01N30/466 , G01N30/06 , G01N30/28 , G01N30/7233 , G01N33/58 , G01N2030/027 , G01N2030/067
Abstract: A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being above a detection level of the mass spectrometer, processing the reagent together with the chemical substance with the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.
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