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    Immobilized analytes
    11.
    发明授权
    Immobilized analytes 有权

    公开(公告)号：US11585811B2

    公开(公告)日：2023-02-21

    申请号：US16389066

    申请日：2019-04-19

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Uwe Kobold ,  Robert Lang ,  Andreas Leinenbach

    IPC: G01N33/53 ,  G01N33/566 ,  G01N33/68 ,  G01N33/543 ,  G01N33/573

    Abstract: A method for detecting an analyte involving a) contacting the analyte, a capture agent and a solid surface to form a capture complex attached to a solid surface, b) cleaving at least one covalent bond within the analyte and/or within said capture agent in the capture complex and, thereby, releasing the analyte or a fragment thereof from the capture complex, and c) detecting at least one fragment of the analyte and, thereby, detecting the analyte is disclosed herein. A kit having i) a capture agent binding to an analyte; and ii) an agent cleaving at least one covalent bond within the analyte and/or within the capture agent; and to the use of a protease for releasing fragments of an analyte for detecting the analyte, wherein the analyte is bound to a solid surface via a capture agent is also disclosed herein.

    Copy protection for antibodies
    12.
    发明授权
    Copy protection for antibodies 有权

    公开(公告)号：US11491236B2

    公开(公告)日：2022-11-08

    申请号：US16852931

    申请日：2020-04-20

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Harmut Duefel ,  Uwe Kobold ,  Andreas Leinenbach

    IPC: A61K47/68 ,  G01N33/68 ,  G01N30/88

    Abstract: The present disclosure is directed at an antibody conjugate having an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of the one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.

    Method for determining a concentration of a target analyte in a sample of bodily fluid
    13.
    发明授权
    Method for determining a concentration of a target analyte in a sample of bodily fluid 有权

    公开(公告)号：US11016098B2

    公开(公告)日：2021-05-25

    申请号：US16158931

    申请日：2018-10-12

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Uwe Kobold ,  Roland Thiele ,  Noah Weiss ,  Benjamin Tiemann

    IPC: G01N33/68 ,  H01J49/00 ,  G01N33/58 ,  G01N33/96 ,  B01D59/44 ,  G01N30/72 ,  G01N1/28

    Abstract: A method and an apparatus for determining a concentration of a target analyte in a sample of bodily fluid are disclosed. The method involves providing a sample of bodily fluid including the target analyte, providing an internal standard solution including a mixture of components having a plurality of isotopes of the target analyte, wherein a concentration of each isotope is unknown, adding the internal standard solution to the sample, analyzing the sample including the internal standard solution using a mass spectrometer, creating a sample function curve based on signal intensities, wherein the signal intensities define arbitrary units, transferring an analyte signal into a corresponding arbitrary analyte unit by means of the sample function curve, and transferring the arbitrary analyte unit into the concentration of a target analyte by means of a standardization function representing a curve of concentrations depending on the arbitrary units.

    METHOD FOR IDENTIFYING A REAGENT DURING A PROCESS IN AN ANALYSIS SYSTEM
    15.
    发明申请
    METHOD FOR IDENTIFYING A REAGENT DURING A PROCESS IN AN ANALYSIS SYSTEM 审中-公开

    公开(公告)号：US20190293611A1

    公开(公告)日：2019-09-26

    申请号：US16438775

    申请日：2019-06-12

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Dieter Heindl ,  Uwe Kobold ,  Christoph Seidel ,  Martin Rempt

    IPC: G01N30/08 ,  G01N30/72 ,  G01N33/68

    Abstract: A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being below a detection level of the mass spectrometer, enriching the chemical substance within the liquid chromatograph to a concentration above the detection level of the mass spectrometer, processing the reagent together with the enriched chemical substance by means of the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.

    AUTOMATED CLINICAL DIAGNOSTIC SYSTEM AND METHOD
    16.
    发明申请
    AUTOMATED CLINICAL DIAGNOSTIC SYSTEM AND METHOD 审中-公开

    公开(公告)号：US20180292368A1

    公开(公告)日：2018-10-11

    申请号：US16009434

    申请日：2018-06-15

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Tobias Franz ,  Uwe Kobold ,  Peter Kupser ,  Roland Thiele

    IPC: G01N30/88 ,  G01N30/24 ,  G01N35/00 ,  G01N30/08 ,  G01N30/46 ,  G01N30/72

    Abstract: A clinical diagnostic system is presented and comprises a sample preparation station for automatically preparing samples comprising analytes of interest, a liquid chromatography (LC) separation station comprising a plurality of LC channels and a sample preparation/LC interface for inputting prepared samples into the LC channels. The system further comprises a controller to assign samples to pre-defined sample preparation workflows each comprising a pre-defined sequence of sample preparation steps and requiring a pre-defined time for completion depending on the analytes. The controller further assigns an LC channel for each prepared sample depending on the analytes and plans an LC channel input sequence for inputting the prepared samples that allows analytes from different LC channels to elute in a non-overlapping LC eluate output sequence based on expected elution times. The controller further sets and initiates a start sequence that generates a prepared sample output sequence that matches the LC channel input sequence.

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