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57 条记录 (耗时 0.038 秒)

    Effects of apolipoprotein B inhibition on gene expression profiles in animals
    11.
    发明申请
    Effects of apolipoprotein B inhibition on gene expression profiles in animals 审中-公开
    载脂蛋白B抑制对动物基因表达谱的影响

    公开(公告)号：US20060009410A1

    公开(公告)日：2006-01-12

    申请号：US11123656

    申请日：2005-05-05

    申请人： Rosanne Crooke ,  Mark Graham

    发明人： Rosanne Crooke ,  Mark Graham

    IPC分类号： A61K48/00

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/13 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

    摘要： Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.

    摘要翻译： 提供了用于调节参与脂质代谢的基因的表达的方法，其可用于治疗与心血管风险相关的病症。 靶向载脂蛋白B的反义寡核苷酸降低载脂蛋白B mRNA的水平，降低血清胆固醇，并将肥胖动物的肝脏基因表达谱从精子动物转移到肝脏基因表达谱。 还提供了通过载脂蛋白B的反义抑制来改善受试者的心血管风险的方法。还提供了使用靶向载脂蛋白B的反义寡核苷酸调节细胞途径或代谢过程的方法。

    Frame design for electronic spectacles
    15.
    发明授权
    Frame design for electronic spectacles 有权
    电子眼镜框架设计

    公开(公告)号：US08783861B2

    公开(公告)日：2014-07-22

    申请号：US13175633

    申请日：2011-07-01

    申请人： Ronald D. Blum ,  Claudio Dalla Longa ,  Mark Graham ,  Yongping Wang

    发明人： Ronald D. Blum ,  Claudio Dalla Longa ,  Mark Graham ,  Yongping Wang

    IPC分类号： G02C5/22

    CPC分类号： G02C11/10 ,  G02C5/146 ,  G02C7/081 ,  G02C7/101

    摘要： A first device is provided that comprises a frame. The frame further comprises a lens housing adapted to support a first lens and a second lens, a first temple movable coupled to the lens housing, and a second temple movably coupled to the lens housing. The first device further comprises a first spring mechanism coupled to the first temple and the lens housing. A first conductive path is provided from the first temple to the lens housing for at least one position of the first temple relative to the frame.

    摘要翻译： 提供了包括框架的第一装置。 框架还包括适于支撑第一透镜和第二透镜的透镜壳体，可移动地联接到透镜壳体的第一光阑以及可移动地联接到透镜壳体的第二光阑。 第一装置还包括联接到第一镜腿和镜片壳体的第一弹簧机构。 第一导电路径从第一镜腿提供到透镜外壳，用于第一镜腿相对于镜框的至少一个位置。

    HOSE ATTACHMENT PARTICULATE SPREADER
    16.
    发明申请
    HOSE ATTACHMENT PARTICULATE SPREADER 审中-公开
    软管接头颗粒挤出机

    公开(公告)号：US20130092748A1

    公开(公告)日：2013-04-18

    申请号：US13690949

    申请日：2012-11-30

    申请人： Thomas Waggoner ,  Mario Restive ,  Tom Remms ,  Mark Graham ,  Steve Domik

    发明人： Thomas Waggoner ,  Mario Restive ,  Tom Remms ,  Mark Graham ,  Steve Domik

    IPC分类号： B05B7/14

    CPC分类号： B05B7/149 ,  A01C15/02

    摘要： A hose attachment particulate spreader device is provided that includes a housing having a particulate egress aperture. A first funnel channel is provided for conveying dry flowable particulate. A selector controls a first gate in communication with the first funnel channel. The first gate meters dry flowable particulate within the first funnel channel. A water inlet is also provided for engaging a water supply hose. A water trigger is included for simultaneously opening a second gate in communication with the first gate and the egress aperture, as well as applying a water spray to exhaust a content from the funnel hose out the egress aperture. A process for field spreading is provided that includes attaching a bottle to such a device, the bottle containing a content of a dry flowable particulate or a slurry. The device is coupled to a water supply hose and by exhausting a water spray from the water supply hose through the device to exhaust a portion of the content while the content remaining in the bottle does not contact the water spray and remains in an unchanged form.

    摘要翻译： 提供了一种软管附件颗粒撒布机装置，其包括具有颗粒出口孔的壳体。 提供用于输送干燥可流动颗粒的第一漏斗通道。 选择器控制与第一漏斗通道通信的第一门。 第一个门在第一个漏斗通道内可以流动干燥的颗粒。 还提供进水口用于接合供水软管。 包括水触发器，用于同时打开与第一门和出口孔连通的第二门，以及施加喷水以从漏斗管排出出口出口的内容物。 提供了一种用于现场扩散的方法，其包括将瓶附接到这种装置，该瓶含有干燥可流动颗粒或浆料的内容物。 该装置连接到供水软管，并且通过装置从供水软管排出喷水，以排出一部分内容物，同时保留在瓶中的内容物不接触水喷雾并保持不变的形式。

    ELECTRO-ACTIVE SPECTACLE FRAMES
    17.
    发明申请
    ELECTRO-ACTIVE SPECTACLE FRAMES 有权
    电活动框架

    公开(公告)号：US20130010256A1

    公开(公告)日：2013-01-10

    申请号：US13179219

    申请日：2011-07-08

    申请人： Joshua N. Haddock ,  Ronald D. Blum ,  Claudio Dalla Longa ,  Mark Graham ,  Yongping Wang

    发明人： Joshua N. Haddock ,  Ronald D. Blum ,  Claudio Dalla Longa ,  Mark Graham ,  Yongping Wang

    IPC分类号： G02C7/06 ,  G02C11/00

    CPC分类号： G02C11/10 ,  G02C5/2272

    摘要： A first device is provided. The first device includes a lens comprising at least a first electrical contact and a lens housing holding the lens. The lens housing includes at least a second electrical contact. The first device further comprises a compliant conductive element disposed between the first and the second electrical contact. The compliant conductive element electrically connects the first and second electrical contacts.

    摘要翻译： 提供第一个设备。 第一装置包括至少包括第一电触头和保持透镜的透镜壳体的透镜。 透镜壳体至少包括第二电触点。 第一装置还包括设置在第一和第二电触点之间的柔性导电元件。 柔性导电元件电连接第一和第二电触点。

    VEHICLE EMAIL NOTIFICATION USING TEMPLATES
    19.
    发明申请
    VEHICLE EMAIL NOTIFICATION USING TEMPLATES 有权
    车辆电子邮件通知使用模板

    公开(公告)号：US20070179706A1

    公开(公告)日：2007-08-02

    申请号：US11618210

    申请日：2006-12-29

    申请人： Shane McCutchen ,  Mark Graham

    发明人： Shane McCutchen ,  Mark Graham

    IPC分类号： G01C21/00

    CPC分类号： G07C5/008 ,  G06Q10/00 ,  G06Q10/06 ,  G06Q10/107 ,  G06Q30/02 ,  G06Q30/0278 ,  G06Q50/30 ,  G07C5/085 ,  Y10S370/908

    摘要： A vehicle email notification system and method in which templates are used to automatically generate email messages that provide the recipient with diverse types of dynamic vehicle information. The email notifications are triggered by different events, some of which are independent of the vehicle (e.g., a monthly trigger), and others of which occur at the vehicle, such as a mileage or low oil life trigger. The notification system selects an appropriate template based on the type of trigger and uses that template to build and send to the subscriber an email message that contains the dynamic vehicle information and identifies any detected vehicle condition for which action is needed. In addition to trigger type, different templates can be defined for each combination of vehicle type (e.g., make of vehicle), trigger type, and a language preference (e.g., English, Spanish).

    摘要翻译： 一种车辆电子邮件通知系统和方法，其中使用模板来自动生成向接收者提供不同类型的动态车辆信息的电子邮件消息。 电子邮件通知由不同的事件触发，其中一些事件是独立于车辆（例如，每月触发器），其他事件发生在车辆上，例如里程或低油寿命触发。 通知系统基于触发器的类型选择适当的模板，并使用该模板来构建并向用户发送包含动态车辆信息的电子邮件，并且识别需要动作的任何检测到的车辆状况。 除了触发类型之外，可以为车辆类型（例如，车辆形式），触发类型和语言偏好（例如，英语，西班牙语）的每个组合定义不同的模板。