-
公开(公告)号：US08394772B2
公开(公告)日：2013-03-12
申请号：US13395139
申请日：2010-10-20
申请人： Gregory Raymond Bebernitz , Mark Gary Bock , Debnath Bhuniya , Laxmikant Datrange , Suresh Eknath Kurhade , P. Venkata Palle , Dumbala Srinivas Reddy
发明人： Gregory Raymond Bebernitz , Mark Gary Bock , Debnath Bhuniya , Laxmikant Datrange , Suresh Eknath Kurhade , P. Venkata Palle , Dumbala Srinivas Reddy
CPC分类号： C07H17/00 , A61K31/351 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61K38/28 , A61K45/06 , C07D309/10 , C07D309/30 , C07D405/10 , C07D407/10 , C07D407/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/10 , C07D491/107 , C07D493/10 , C07D498/04 , C07H15/203 , C07H15/26 , C07H19/04 , A61K2300/00
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
-
公开(公告)号：US20120196813A1
公开(公告)日：2012-08-02
申请号：US13395139
申请日：2010-10-20
申请人： Gregory Raymond Bebernitz , Mark Gary Bock , Debnath Bhuniya , Laxmikant Datrange , Suresh Eknath Kurhade , P. Venkata Palle , Dumbala Srinivas Reddy
发明人： Gregory Raymond Bebernitz , Mark Gary Bock , Debnath Bhuniya , Laxmikant Datrange , Suresh Eknath Kurhade , P. Venkata Palle , Dumbala Srinivas Reddy
IPC分类号： A61K31/7004 , A61K31/352 , C07D209/04 , A61K31/404 , C07H15/20 , A61P3/06 , A61K31/536 , A61P3/10 , A61P3/00 , A61P3/08 , A61P3/04 , C07D311/96 , C07D265/36
CPC分类号： C07H17/00 , A61K31/351 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61K38/28 , A61K45/06 , C07D309/10 , C07D309/30 , C07D405/10 , C07D407/10 , C07D407/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/10 , C07D491/107 , C07D493/10 , C07D498/04 , C07H15/203 , C07H15/26 , C07H19/04 , A61K2300/00
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
-
公开(公告)号：US08163704B2
公开(公告)日：2012-04-24
申请号：US12906682
申请日：2010-10-18
申请人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
发明人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
CPC分类号： A61K31/7052 , A61K31/7048 , A61K31/706 , C07D405/10 , C07D407/10 , C07D413/10 , C07H7/04
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
-
14.发明申请PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION 有权作为GLUCOKINASE激活剂的吡咯-2-羧酰胺衍生物，其工艺和药物应用公开(公告)号：US20100292143A1
公开(公告)日：2010-11-18
申请号：US12600577
申请日：2008-06-05
申请人： Debnath Bhuniya , S. Gobind Kapkoti , S. Jayakumar Warrier , Gagan Kukrejka , N. Jagadeesh Mavinahalli , P. Venkata Palle , A. Kasim Mookhtiar
发明人： Debnath Bhuniya , S. Gobind Kapkoti , S. Jayakumar Warrier , Gagan Kukrejka , N. Jagadeesh Mavinahalli , P. Venkata Palle , A. Kasim Mookhtiar
IPC分类号： A61K31/427 , C07D417/12 , A61K31/428 , A61K31/702 , A61K38/26 , A61P3/04 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14
摘要： Pyrrole-2-carboxamide derivatives, their polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, beneficial for prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these pyrrole-2-carboxamides.
摘要翻译： 吡咯-2-甲酰胺衍生物，它们的多晶型物，立体异构体，前药，溶剂合物，其药学上可接受的盐和制剂，有利于预防，治疗，控制进展或辅助治疗疾病和/或医学状况，其中葡萄糖激酶 将是有益的，被披露。 本公开还提供了制备这些吡咯-2-甲酰胺的方法。
-
15.发明授权Acetamide derivatives as glucokinase activators, their process and medicinal applications 有权乙酰胺衍生物作为葡萄糖激酶活化剂，其工艺和药物应用公开(公告)号：US09340506B2
公开(公告)日：2016-05-17
申请号：US13399721
申请日：2012-02-17
申请人： Debnath Bhuniya , Anil Deshpande , Sachin Kandalkar , Balasaheb Kobal , Santosh Kurhade , Vinod Vyavahare , Rahul Kaduskar
发明人： Debnath Bhuniya , Anil Deshpande , Sachin Kandalkar , Balasaheb Kobal , Santosh Kurhade , Vinod Vyavahare , Rahul Kaduskar
IPC分类号： C07D277/34 , C07D277/38 , C07D513/04 , A61K31/397 , A61K31/44 , A61K31/437 , A61K31/427 , C07D213/80 , C07D241/26 , C07D277/46 , C07D277/54 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , A61K38/26
CPC分类号： C07D213/80 , A61K38/26 , C07D241/26 , C07D277/46 , C07D277/54 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04 , A61K2300/00
摘要： Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.
摘要翻译： 乙酰胺衍生物，它们的立体异构体，互变异构体，前药，药学上可接受的盐，多晶型物，溶剂化物及其制剂，用于预防，治疗，控制进展或辅助治疗葡萄糖激酶活化有益的疾病和/或医学病症 ，被披露。 本公开还提供了这些乙酰胺衍生物的制备方法。
-
公开(公告)号：US08828951B2
公开(公告)日：2014-09-09
申请号：US13614534
申请日：2012-09-13
申请人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
发明人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
IPC分类号： A61K31/70
CPC分类号： A61K31/7052 , A61K31/7048 , A61K31/706 , C07D405/10 , C07D407/10 , C07D413/10 , C07H7/04
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运体（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
-
17.发明申请ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS 有权乙酰胺衍生物作为GLUCOKINASE激活剂，其过程和药物应用公开(公告)号：US20120214735A1
公开(公告)日：2012-08-23
申请号：US13399721
申请日：2012-02-17
申请人： Debnath Bhuniya , Anil Deshpande , Sachin Kandalkar , Balasaheb Kobal , Santosh Kurhade , Vinod Vyavahare , Rahul Kaduskar
发明人： Debnath Bhuniya , Anil Deshpande , Sachin Kandalkar , Balasaheb Kobal , Santosh Kurhade , Vinod Vyavahare , Rahul Kaduskar
IPC分类号： A61K31/427 , C07D513/04 , A61K31/5377 , C07D417/14 , A61K31/428 , C07D213/80 , A61K31/44 , C07D405/12 , A61K31/4433 , A61K31/4439 , C07D277/54 , A61K31/437 , C07D277/46 , A61K31/4155 , A61K31/506 , C07D413/12 , C07D401/04 , C07D241/26 , A61K31/4965 , C07D417/04 , C07F7/18 , A61K31/695 , C07D405/14 , A61K38/02 , A61K31/702 , A61K38/26 , A61K31/4985 , A61K31/454 , A61K31/455 , A61K31/4184 , A61K31/4422 , A61K31/585 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/12 , C07D417/12
CPC分类号： C07D213/80 , A61K38/26 , C07D241/26 , C07D277/46 , C07D277/54 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04 , A61K2300/00
摘要： Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.
摘要翻译： 乙酰胺衍生物，它们的立体异构体，互变异构体，前药，药学上可接受的盐，多晶型物，溶剂化物及其制剂，用于预防，治疗，控制进展或辅助治疗葡萄糖激酶活化有益的疾病和/或医学病症 ，被披露。 本公开还提供了这些乙酰胺衍生物的制备方法。
-
18.发明授权2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application 有权2,2,2-三取代的乙酰胺衍生物作为葡糖激酶活化剂，其工艺和药物应用公开(公告)号：US08940900B2
公开(公告)日：2015-01-27
申请号：US12528770
申请日：2008-02-25
申请人： Kasim A. Mookhtiar , Debnath Bhuniya , Bhavesh Dave , Gobind S. Kapkoti , Sujay Basu , Anita Chugh , Siddhartha De , Venkata P. Palle
发明人： Kasim A. Mookhtiar , Debnath Bhuniya , Bhavesh Dave , Gobind S. Kapkoti , Sujay Basu , Anita Chugh , Siddhartha De , Venkata P. Palle
IPC分类号： C07D417/12 , C07D277/82 , C07D277/44 , A61K31/44 , A61K31/425 , C07D277/46 , C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D285/135
CPC分类号： C07D277/46 , C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/82 , C07D285/135 , C07D417/12
摘要： Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the disclosure. The disclosure also describes method to characterize partial glucokinase activators.
摘要翻译： 本公开的化合物是可用作葡糖苷酶活化剂的式（I）的2,2,2-三取代乙酰胺衍生物，其多晶型物，立体异构体，前药，溶剂化物，药学上可接受的盐和制剂。 本发明还描述了其制备方法。 本公开还描述了表征部分葡糖激酶激活剂的方法。
-
公开(公告)号：US08466114B2
公开(公告)日：2013-06-18
申请号：US13425888
申请日：2012-03-21
申请人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
发明人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
CPC分类号： A61K31/7052 , A61K31/7048 , A61K31/706 , C07D405/10 , C07D407/10 , C07D413/10 , C07H7/04
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
-
公开(公告)号：US20110269700A1
公开(公告)日：2011-11-03
申请号：US13063863
申请日：2009-09-17
IPC分类号： A61K31/7056 , C07H7/04 , A61K31/706 , A61K31/7034 , A61P3/10 , A61P7/02 , A61P5/48 , A61P3/06 , A61P3/04 , A61P9/12 , A61P13/12 , A61P7/00 , C07H7/06 , A61P3/00
CPC分类号： C07D309/10 , C07D405/06
摘要： The present invention relates to compounds of formula I and pharmaceutically acceptable salts thereof, and to formulations and uses of the compounds of formula (I) in the treatment of metabolic disorders.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，以及式（I）化合物在治疗代谢紊乱中的制剂和用途。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.033 秒)
