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1.发明申请2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION 有权2,2,2-三取代的乙酰胺衍生物作为GLUCOKINASE激活剂，其过程和药物应用公开(公告)号：US20100144772A1
公开(公告)日：2010-06-10
申请号：US12528770
申请日：2008-02-25
申请人： Kasim A. Mookhtiar , Debnath Bhuniya , Bhavesh Dave , Gobind S. Kapkoti , Sujay Basu , Anita Chugh , Siddhartha De , Venkata P. Palle
发明人： Kasim A. Mookhtiar , Debnath Bhuniya , Bhavesh Dave , Gobind S. Kapkoti , Sujay Basu , Anita Chugh , Siddhartha De , Venkata P. Palle
IPC分类号： A61K31/427 , C07D417/12 , C07D277/38 , C07D239/22 , A61K31/4439 , A61K31/426 , A61K31/505 , A61P3/10 , A61P3/04 , C12Q1/48
CPC分类号： C07D277/46 , C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/82 , C07D285/135 , C07D417/12
摘要： Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the disclosure. The disclosure also describes method to characterize partial glucokinase activators.
摘要翻译： 本公开的化合物是可用作葡糖苷酶活化剂的式（I）的2,2,2-三取代乙酰胺衍生物，其多晶型物，立体异构体，前药，溶剂化物，药学上可接受的盐和制剂。 本发明还描述了其制备方法。 本公开还描述了表征部分葡糖激酶激活剂的方法。
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2.发明授权2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application 有权2,2,2-三取代的乙酰胺衍生物作为葡糖激酶活化剂，其工艺和药物应用公开(公告)号：US08940900B2
公开(公告)日：2015-01-27
申请号：US12528770
申请日：2008-02-25
申请人： Kasim A. Mookhtiar , Debnath Bhuniya , Bhavesh Dave , Gobind S. Kapkoti , Sujay Basu , Anita Chugh , Siddhartha De , Venkata P. Palle
发明人： Kasim A. Mookhtiar , Debnath Bhuniya , Bhavesh Dave , Gobind S. Kapkoti , Sujay Basu , Anita Chugh , Siddhartha De , Venkata P. Palle
IPC分类号： C07D417/12 , C07D277/82 , C07D277/44 , A61K31/44 , A61K31/425 , C07D277/46 , C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D285/135
CPC分类号： C07D277/46 , C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/82 , C07D285/135 , C07D417/12
摘要： Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the disclosure. The disclosure also describes method to characterize partial glucokinase activators.
摘要翻译： 本公开的化合物是可用作葡糖苷酶活化剂的式（I）的2,2,2-三取代乙酰胺衍生物，其多晶型物，立体异构体，前药，溶剂化物，药学上可接受的盐和制剂。 本发明还描述了其制备方法。 本公开还描述了表征部分葡糖激酶激活剂的方法。
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3.发明授权Acetamide derivatives as glucokinase activators, their process and medicinal application 有权乙酰胺衍生物作为葡萄糖激酶活化剂，其工艺和药用应用公开(公告)号：US08501955B2
公开(公告)日：2013-08-06
申请号：US12681845
申请日：2008-10-07
申请人： Debnath Bhuniya , Sandeep Bhausaheb Bhosale , Gobind Sing Kapkoti , Venkata Poornapragnacharyulu Palle , Siddhartha De , Kasim A. Mookhtiar , Bhavesh Dave , Anil Deshpande , Santosh Kurhade , Balasaheb Kobal , Keshav Naik , Sachin Kandalkar
发明人： Debnath Bhuniya , Sandeep Bhausaheb Bhosale , Gobind Sing Kapkoti , Venkata Poornapragnacharyulu Palle , Siddhartha De , Kasim A. Mookhtiar , Bhavesh Dave , Anil Deshpande , Santosh Kurhade , Balasaheb Kobal , Keshav Naik , Sachin Kandalkar
IPC分类号： C07D277/34 , C07D277/38 , C07D513/04 , A61K31/397 , A61K31/44 , A61K31/437 , A61K31/427
CPC分类号： C07D277/46 , C07D213/80 , C07D241/26 , C07D277/54 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.
摘要翻译： 乙酰胺衍生物，它们的立体异构体，互变异构体，前药，药学上可接受的盐，多晶型物，溶剂化物及其制剂，用于预防，治疗，控制进展或辅助治疗葡萄糖激酶活化有益的疾病和/或医学病症 ，被披露。 本公开还提供了这些乙酰胺衍生物的制备方法。
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4.发明申请ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATION 有权乙酰胺衍生物作为GLUCOKINASE激活剂，其过程和药物应用公开(公告)号：US20100310493A1
公开(公告)日：2010-12-09
申请号：US12681845
申请日：2008-10-07
申请人： Debnath Bhuniya , Sandeep Bhausaheb Bhosale , Gobind Sing Kapkoti , Venkata Poornapragnacharyulu Palle , Siddhartha De , Kasim A. Mookhtiar , Bhavesh Dave , Anil Deshpande , Santosh Kurhade , Balasaheb Kobal , Keshav Naik , Sachin Kandalkar
发明人： Debnath Bhuniya , Sandeep Bhausaheb Bhosale , Gobind Sing Kapkoti , Venkata Poornapragnacharyulu Palle , Siddhartha De , Kasim A. Mookhtiar , Bhavesh Dave , Anil Deshpande , Santosh Kurhade , Balasaheb Kobal , Keshav Naik , Sachin Kandalkar
IPC分类号： A61K31/785 , C07D277/46 , A61K31/426 , A61P3/10 , A61P3/04 , A61P9/12 , A61P3/06 , C07D285/135 , A61K31/433 , C07D241/20 , A61K31/4965 , C07D231/40 , A61K31/415 , C07D213/75 , A61K31/4402 , C07D417/12 , A61K31/5377 , A61K38/26 , A61K31/715 , A61K31/44 , A61K31/397
CPC分类号： C07D277/46 , C07D213/80 , C07D241/26 , C07D277/54 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.
摘要翻译： 乙酰胺衍生物，它们的立体异构体，互变异构体，前药，药学上可接受的盐，多晶型物，溶剂化物及其制剂，用于预防，治疗，控制进展或辅助治疗葡萄糖激酶活化有益的疾病和/或医学病症 ，被披露。 本公开还提供了这些乙酰胺衍生物的制备方法。
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5.发明授权Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application 有权吡咯-2-甲酰胺衍生物作为葡萄糖激酶活化剂，其工艺和药物应用公开(公告)号：US08299115B2
公开(公告)日：2012-10-30
申请号：US12600577
申请日：2008-06-05
申请人： Debnath Bhuniya , S. Gobind Kapkoti , S. Jayakumar Warrier , Gagan Kukrejka , N. Jagadeesh Mavinahalli , P. Venkata Palle , A. Kasim Mookhtiar
发明人： Debnath Bhuniya , S. Gobind Kapkoti , S. Jayakumar Warrier , Gagan Kukrejka , N. Jagadeesh Mavinahalli , P. Venkata Palle , A. Kasim Mookhtiar
IPC分类号： A61K31/4025 , C07D207/34
CPC分类号： C07D417/12 , C07D417/14
摘要： Pyrrole-2-carboxamide derivatives, their polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, beneficial for prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these pyrrole-2-carboxamides.
摘要翻译： 吡咯-2-甲酰胺衍生物，它们的多晶型物，立体异构体，前药，溶剂合物，其药学上可接受的盐和制剂，有利于预防，治疗，控制进展或辅助治疗疾病和/或医学状况，其中葡萄糖激酶 将是有益的，被披露。 本公开还提供了制备这些吡咯-2-甲酰胺的方法。
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公开(公告)号：US08394772B2
公开(公告)日：2013-03-12
申请号：US13395139
申请日：2010-10-20
申请人： Gregory Raymond Bebernitz , Mark Gary Bock , Debnath Bhuniya , Laxmikant Datrange , Suresh Eknath Kurhade , P. Venkata Palle , Dumbala Srinivas Reddy
发明人： Gregory Raymond Bebernitz , Mark Gary Bock , Debnath Bhuniya , Laxmikant Datrange , Suresh Eknath Kurhade , P. Venkata Palle , Dumbala Srinivas Reddy
CPC分类号： C07H17/00 , A61K31/351 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61K38/28 , A61K45/06 , C07D309/10 , C07D309/30 , C07D405/10 , C07D407/10 , C07D407/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/10 , C07D491/107 , C07D493/10 , C07D498/04 , C07H15/203 , C07H15/26 , C07H19/04 , A61K2300/00
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
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7.发明申请Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them 失效苯并嗪和苯并噻嗪衍生物和含有它们的药物组合物公开(公告)号：US20050113368A1
公开(公告)日：2005-05-26
申请号：US10492454
申请日：2002-10-15
IPC分类号： A61K9/08 , A61K9/10 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/538 , A61K31/5415 , A61P1/04 , A61P1/14 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/10 , A61P21/04 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07B61/00 , C07C227/04 , C07C227/18 , C07C229/34 , C07C229/42 , C07D265/36 , C07D279/16
CPC分类号： C07C229/42 , C07C229/34 , C07D265/36 , C07D279/16
摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. The present invention also relates to processes for the preparation of the compounds of formula (I), novel intermediates, processes for their preparation, their use in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.
摘要翻译： 本发明涉及式（I）衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物的新型抗糖尿病，降血脂，抗胆固醇和低胆固醇血症化合物 涉及制备这种化合物的方法。 更具体地说，本发明涉及通用的衍生物，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物的新型烷基羧酸， 制备此类化合物的方法。 本发明还涉及式（I）化合物的制备方法，新型中间体，其制备方法，它们在制备上述化合物中的用途及其作为抗糖尿病，降血脂症，抗肥胖症和低胆固醇血症化合物的用途。
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8.发明申请Novel compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them 审中-公开新型化合物及其在药物制备中的应用及含有它们的药物组合物公开(公告)号：US20050096331A1
公开(公告)日：2005-05-05
申请号：US10499852
申请日：2002-12-17
IPC分类号： A61K31/395 , A61K31/519 , A61P3/06 , A61P3/10 , A61P9/10 , A61P19/10 , A61P29/02 , A61P35/00 , C07D231/40 , C07D473/00 , C07D487/04
CPC分类号： C07D487/04 , C07D231/40
摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
摘要翻译： 本发明涉及新型抗糖尿病，降血脂症，抗肥胖症和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型烷基羧酸，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和药学上可接受的组合物，其含有 他们。
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公开(公告)号：US20120196813A1
公开(公告)日：2012-08-02
申请号：US13395139
申请日：2010-10-20
申请人： Gregory Raymond Bebernitz , Mark Gary Bock , Debnath Bhuniya , Laxmikant Datrange , Suresh Eknath Kurhade , P. Venkata Palle , Dumbala Srinivas Reddy
发明人： Gregory Raymond Bebernitz , Mark Gary Bock , Debnath Bhuniya , Laxmikant Datrange , Suresh Eknath Kurhade , P. Venkata Palle , Dumbala Srinivas Reddy
IPC分类号： A61K31/7004 , A61K31/352 , C07D209/04 , A61K31/404 , C07H15/20 , A61P3/06 , A61K31/536 , A61P3/10 , A61P3/00 , A61P3/08 , A61P3/04 , C07D311/96 , C07D265/36
CPC分类号： C07H17/00 , A61K31/351 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61K38/28 , A61K45/06 , C07D309/10 , C07D309/30 , C07D405/10 , C07D407/10 , C07D407/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/10 , C07D491/107 , C07D493/10 , C07D498/04 , C07H15/203 , C07H15/26 , C07H19/04 , A61K2300/00
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
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公开(公告)号：US08163704B2
公开(公告)日：2012-04-24
申请号：US12906682
申请日：2010-10-18
申请人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
发明人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
CPC分类号： A61K31/7052 , A61K31/7048 , A61K31/706 , C07D405/10 , C07D407/10 , C07D413/10 , C07H7/04
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
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