公开(公告)号：US08288117B2

公开(公告)日：2012-10-16

申请号：US12410046

申请日：2009-03-24

申请人： Kentaro Nakamura ,  Shigeki Kageyama

发明人： Kentaro Nakamura ,  Shigeki Kageyama

IPC分类号： C12Q1/44 ,  C12M1/36 ,  C12M1/34 ,  C12M1/00

CPC分类号： C12Q1/44 ,  G01N2333/92

摘要： It is an object of the present invention to provide: a dry analytical element for analyzing pancreatic lipase wherein the triglyceride is not transcribed on the support to contaminate a transportation slip or other analytical elements and wherein an additive solution of the triglyceride neither reaggregates nor precipitate, so that the dry analytical element is stable and is compatible with production. The present invention provides a dry analytical element for measuring pancreatic lipase contained in body fluid, which comprises triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerin measurement reagent, and which comprises a water-impermeable support and at least one spreading or reagent layer, wherein a hydrophilic polymer at a weight ratio of 1.8:1 or greater with respect to the triglyceride is contained.

摘要翻译： 本发明的目的是提供：用于分析胰脂肪酶的干燥分析元件，其中甘油三酯不在载体上转录以污染运输滑移或其它分析元件，并且其中甘油三酯的添加剂溶液既不再聚集也不沉淀， 使干燥分析元件稳定，与生产兼容。 本发明提供一种用于测量体液中包含的胰脂肪酶的干燥分析元件，其包含具有12-22个碳原子的长链烷基脂肪酸甘油三酯，甘油单酯脂肪酶和甘油测量试剂，并且其包含不透水的载体 和至少一个铺展剂或试剂层，其中含有相对于甘油三酯的1.8:1或更大重量比的亲水性聚合物。

公开(公告)号：US20090011450A1

公开(公告)日：2009-01-08

申请号：US12155890

申请日：2008-06-11

申请人： Shigeki Kageyama ,  Hideaki Tanaka

发明人： Shigeki Kageyama ,  Hideaki Tanaka

IPC分类号： C12Q1/44

CPC分类号： G01N33/526 ,  C12Q1/44 ,  G01N2333/92

摘要： It is an object of the present invention to provide a dry analytical element for pancreatic lipase analysis having high selectivity with respect to pancreatic lipase, whose multianalyte correlation has been improved. The present invention provides a dry analytical element for measurement of pancreatic lipase contained in a body fluid, which comprises at least one development layer and/or reagent layer containing diglyceride or triglyceride of long-chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, wherein the development layer and/or the reagent layer comprise two or more types of anionic surfactants and at least one type of the anionic surfactant is alkylarylsulfonate.

摘要翻译： 本发明的一个目的是提供一种用于胰脂肪酶分析的干燥分析元件，该分析元件具有相对于胰腺脂肪酶具有高选择性，其胰多糖分子相关性得到改善。 本发明提供了一种用于测量包含在体液中的胰脂肪酶的干燥分析元件，其包含至少一个含有12-22个碳原子的长链烷基脂肪酸的甘油二酯或甘油三酸酯的显影层和/或试剂层，单酸甘油酯 脂肪酶和甘油测量试剂，其中显影层和/或试剂层包含两种或更多种类型的阴离子表面活性剂，并且至少一种类型的阴离子表面活性剂是烷基芳基磺酸盐。

公开(公告)号：US5093081A

公开(公告)日：1992-03-03

申请号：US369332

申请日：1989-06-21

申请人： Yukio Sudo ,  Yoshihiro Ashihara ,  Toshikage Hiraoka ,  Isao Nishizono ,  Shigeki Kageyama ,  Tetsuji Tanimoto

发明人： Yukio Sudo ,  Yoshihiro Ashihara ,  Toshikage Hiraoka ,  Isao Nishizono ,  Shigeki Kageyama ,  Tetsuji Tanimoto

IPC分类号： G01N33/543

CPC分类号： G01N33/54386

摘要： A dry-type analytical element for immunoassay having at least one water-permeable layer for measuring a ligand in a sample according to enzyme immunoassay, which comprises,(A) a water-insoluble macromolecular substrate, and(B) an antibody, reacting with the ligand in the sample, conjugated with an enzyme capable of acting on the above water-insoluble macromolecular substrate.The above analytical substance further comprises,(C) a macromolecular substance which is a conjugate of the ligand or its derivative with a macromolecular compound in the above water-permeable layer of the above dry-type analytical element.The invention can conduct a highly sensitive and simple enzyme immunoassay.

公开(公告)号：US4900665A

公开(公告)日：1990-02-13

申请号：US185294

申请日：1988-04-19

申请人： Kaoru Terashima ,  Shigeki Kageyama ,  Harumi Katsuyama

发明人： Kaoru Terashima ,  Shigeki Kageyama ,  Harumi Katsuyama

IPC分类号： C12Q1/42 ,  G01N31/22 ,  G01N33/52

CPC分类号： G01N33/526 ,  C12Q1/42 ,  C12Q2334/10 ,  Y10S435/805

摘要： An integral multilayer analytical element for use in the measurement of alkaline phosphatase activity, which comprises a porous spreading layer of woven fabric or knitted fabric containing an alkaline phosphatase-sensitive self-developing substrate, a buffer layer containing one or more compounds functioning as a phosphoric acid acceptor and a buffering agent and a support layer in a laminated form.

摘要翻译： 一种用于测量碱性磷酸酶活性的整体多层分析元件，其包含含有碱性磷酸酶敏感的自显影底物的机织织物或编织物的多孔扩散层，含有一种或多种用作磷酸盐的化合物的缓冲层 酸受体和缓冲剂和层叠形式的支撑层。

公开(公告)号：US08216799B2

公开(公告)日：2012-07-10

申请号：US12155890

申请日：2008-06-11

申请人： Shigeki Kageyama ,  Hideaki Tanaka

发明人： Shigeki Kageyama ,  Hideaki Tanaka

IPC分类号： C12Q1/44 ,  C12Q1/34

CPC分类号： G01N33/526 ,  C12Q1/44 ,  G01N2333/92

摘要： It is an object of the present invention to provide a dry analytical element for pancreatic lipase analysis having high selectivity with respect to pancreatic lipase, whose multianalyte correlation has been improved. The present invention provides a dry analytical element for measurement of pancreatic lipase contained in a body fluid, which comprises at least one development layer and/or reagent layer containing diglyceride or triglyceride of long-chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, wherein the development layer and/or the reagent layer comprise two or more types of anionic surfactants and at least one type of the anionic surfactant is alkylarylsulfonate.

摘要翻译： 本发明的一个目的是提供一种用于胰脂肪酶分析的干燥分析元件，该分析元件具有相对于胰腺脂肪酶具有高选择性，其胰多糖分子相关性得到改善。 本发明提供了一种用于测量包含在体液中的胰脂肪酶的干燥分析元件，其包含至少一个含有12-22个碳原子的长链烷基脂肪酸的甘油二酯或甘油三酸酯的显影层和/或试剂层，单酸甘油酯 脂肪酶和甘油测量试剂，其中显影层和/或试剂层包含两种或更多种类型的阴离子表面活性剂，并且至少一种类型的阴离子表面活性剂是烷基芳基磺酸盐。

公开(公告)号：US20090246812A1

公开(公告)日：2009-10-01

申请号：US12410046

申请日：2009-03-24

申请人： Kentaro Nakamura ,  Shigeki Kageyama

发明人： Kentaro Nakamura ,  Shigeki Kageyama

IPC分类号： C12Q1/44

CPC分类号： C12Q1/44 ,  G01N2333/92

摘要： It is an object of the present invention to provide: a dry analytical element for analyzing pancreatic lipase wherein the triglyceride is not transcribed on the support to contaminate a transportation slip or other analytical elements and wherein an additive solution of the triglyceride neither reaggregates nor precipitate, so that the dry analytical element is stable and is compatible with production. The present invention provides a dry analytical element for measuring pancreatic lipase contained in body fluid, which comprises triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerin measurement reagent, and which comprises a water-impermeable support and at least one spreading or reagent layer, wherein a hydrophilic polymer at a weight ratio of 1.8:1 or greater with respect to the triglyceride is contained.

摘要翻译： 本发明的目的是提供：用于分析胰脂肪酶的干燥分析元件，其中甘油三酯不在载体上转录以污染运输滑移或其它分析元件，并且其中甘油三酯的添加剂溶液既不再聚集也不沉淀， 使干燥分析元件稳定，与生产兼容。 本发明提供一种用于测量体液中包含的胰脂肪酶的干燥分析元件，其包含具有12-22个碳原子的长链烷基脂肪酸甘油三酯，甘油单酯脂肪酶和甘油测量试剂，并且其包含不透水的载体 和至少一个铺展剂或试剂层，其中含有相对于甘油三酯的1.8:1或更大重量比的亲水性聚合物。

公开(公告)号：US20090029481A1

公开(公告)日：2009-01-29

申请号：US11919869

申请日：2006-06-29

申请人： Masayoshi Kojima ,  Hiroyuki Hirai ,  Shigeki Kageyama ,  Yoshihiko Abe

发明人： Masayoshi Kojima ,  Hiroyuki Hirai ,  Shigeki Kageyama ,  Yoshihiko Abe

IPC分类号： G01N33/48 ,  B01J19/08

CPC分类号： G01N33/5434 ,  G01N33/92 ,  G01N2446/80

摘要： An object to be achieved by the present invention is to provide a method for determining the amount of a component contained in a specific lipoprotein fraction in a biological sample using an automatic analyzer, without the requirement of a step of fractionating a sample by centrifugation. The present invention provides a method for separating a target component in a biological sample, which comprises the steps of: (1) causing a biological sample to come into contact with independently dispersed magnetic nanoparticles having a particle size of 50 nm or less, which have anionic functional groups on their surfaces, so as to form an agglutinate of the magnetic nanoparticles and biomolecules capable of interacting with the magnetic nanoparticles; and (2) collecting the agglutinate by an external magnetic field.

摘要翻译： 本发明要实现的目的是提供一种使用自动分析仪测定生物样品中特定脂蛋白部分中所含成分的量的方法，而不需要通过离心分离样品的步骤。 本发明提供一种用于分离生物样品中的目标成分的方法，其包括以下步骤：（1）使生物样品与粒径为50nm以下的独立分散的磁性纳米粒子接触， 在其表面上具有阴离子官能团，以便形成能够与磁性纳米颗粒相互作用的磁性纳米颗粒和生物分子的凝集物; 和（2）通过外部磁场收集凝集物。

公开(公告)号：US20080265688A1

公开(公告)日：2008-10-30

申请号：US11795518

申请日：2006-01-20

申请人： Katsushi Nakano ,  Shigeru Morimoto ,  Shigeki Kageyama

发明人： Katsushi Nakano ,  Shigeru Morimoto ,  Shigeki Kageyama

IPC分类号： H02K41/00

CPC分类号： G03F7/70758 ,  H02K1/02 ,  H02K1/278 ,  H02K41/031

摘要： A linear motor is equipped with a coil body (62), and a yoke (71) that supports a magnetism generating body (72) and that moves relative to the coil body (62). The yoke (71) has a first portion (73) that is formed from a magnetic material and disposed based on the saturation state of the magnetic field, which is generated by the magnetism generating body (72), in the yoke (71).

摘要翻译： 线性电动机配备有线圈体（62）和支撑磁性发生体（72）并相对于线圈体（62）移动的磁轭（71）。 磁轭（71）具有由磁性材料形成并基于由磁性发生体（72）产生的磁场的饱和状态设置在磁轭（71）中的第一部分（73）。

公开(公告)号：US06818974B2

公开(公告)日：2004-11-16

申请号：US10353950

申请日：2003-01-30

申请人： Kazuo Yokoyama ,  Shigeki Kageyama ,  Jun Otsuji

发明人： Kazuo Yokoyama ,  Shigeki Kageyama ,  Jun Otsuji

IPC分类号： H01L2348

CPC分类号： H01L23/433 ,  H01L23/04 ,  H01L23/552 ,  H01L25/165 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2924/15153 ,  H01L2924/1532 ,  H01L2924/19106 ,  H01L2924/3025 ,  H01L2924/00 ,  H01L2924/00014

摘要： A semiconductor device which has a preferable construction for downsizing, in which chip part(s) and a cap are not short-circuited, is provided. The semiconductor device includes: a substrate having a first surface with a cavity and a second surface opposite to the first surface; a semiconductor chip arranged in the cavity; a chip part mounted on the second surface of the substrate; a heat sink which is mounted on the second surface of the substrate and transfers heat liberated from the chip; a cap which is fitted to the substrate, covers the second surface of the substrate, and is joined to the heat sink; and an insulator provided between the cap and the chip part. By providing the insulator, short-circuiting of the chip part and the cap is prevented. Consequently, a distance between the cap and chip part can be shortened to downsize the size of semiconductor device.

摘要翻译： 提供了一种半导体器件，其具有芯片部分和盖子不短路的用于小型化的优选结构。 半导体器件包括：具有第一表面和第二表面的衬底，第一表面具有空腔和与第一表面相对的第二表面; 布置在空腔中的半导体芯片; 安装在基板的第二表面上的芯片部分; 散热器，其安装在所述基板的第二表面上并传递从所述芯片释放的热量; 安装到基板上的盖子覆盖基板的第二表面，并且连接到散热器; 以及设置在盖和芯片部分之间的绝缘体。 通过设置绝缘体，防止了芯片部分和盖子的短路。 因此，可以缩短盖和芯片部分之间的距离，从而缩小半导体器件的尺寸。

公开(公告)号：US5589110A

公开(公告)日：1996-12-31

申请号：US533462

申请日：1995-09-25

申请人： Takashi Motoda ,  Shoichi Karakida ,  Nobuaki Kaneno ,  Shigeki Kageyama

发明人： Takashi Motoda ,  Shoichi Karakida ,  Nobuaki Kaneno ,  Shigeki Kageyama

IPC分类号： C30B35/00 ,  C23C16/448 ,  C30B25/14 ,  H01L21/205 ,  H01L21/365 ,  B01F3/04

CPC分类号： C23C16/45561 ,  C23C16/4481 ,  C23C16/4482 ,  C23C16/4485 ,  C30B25/14 ,  H01L21/02532 ,  H01L21/02543 ,  H01L21/02546 ,  H01L21/0262

摘要： A metal organic compound container apparatus for containing a liquid metal organic compound, receiving a carrier gas, and producing a carrier gas stream saturated with vapor of the metal organic compound including a container for containing a liquid metal organic compound; an inlet pipe for introducing a carrier gas into the container, the inlet pipe having an end for immersion in the metal organic compound; a carrier gas flow rate controller for controlling carrier gas flow into the inlet pipe; a first exhaust pipe for exhausting carrier gas from the container at a first flow rate, the first exhaust pipe having an end not contacting the metal organic compound; a first gas flow rate controller for controlling one of pressure and the first flow rate of the carrier gas through the first exhaust pipe; a second exhaust pipe for exhausting carrier gas from the container at a second flow rate, the second exhaust pipe having an end not contacting the metal organic compound; and a second gas flow rate controller for controlling the second flow rate.

摘要翻译： 一种金属有机化合物容器装置，用于容纳液体金属有机化合物，接收载气，并制备包含含有液态金属有机化合物的容器的金属有机化合物饱和的载气流; 用于将载气引入容器的入口管，所述入口管具有用于浸入所述金属有机化合物的端部; 用于控制载气流入入口管的载气流量控制器; 第一排气管，其以第一流量从所述容器排出载气，所述第一排气管的端部不接触所述金属有机化合物; 第一气体流量控制器，用于控制通过第一排气管的载气的压力和第一流量之一; 第二排气管，用于以第二流量从所述容器排出载气，所述第二排气管具有不接触所述金属有机化合物的端部; 以及用于控制第二流量的第二气体流量控制器。