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    Mass Spectrometer
    11.
    发明申请
    Mass Spectrometer 有权
    质谱仪

    公开(公告)号：US20090173877A1

    公开(公告)日：2009-07-09

    申请号：US12092601

    申请日：2005-11-10

    Applicant: Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    IPC: B01D59/44 ,  H01J49/00

    CPC classification number: H01J49/004 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/42

    Abstract: A mass spectrometer is disclosed comprising a first ion trap or ion guide (2), a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).

    Abstract translation: 公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器 ）。 在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。

    Mass spectrometer
    15.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US09466472B2

    公开(公告)日：2016-10-11

    申请号：US11720520

    申请日：2005-12-02

    Applicant: Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle

    Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle

    IPC: H01J49/00 ,  H01J49/06

    CPC classification number: H01J49/065

    Abstract: An ion guide is disclosed comprising one or more layers of intermediate planar, plate or mesh electrodes. A first array of first electrodes is provided on a upper surface and a second array of second electrodes is arranged on a lower surface. An ion guiding region is formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the first and second array of second electrodes in order to urge, propel, force or accelerate ions through or along the ion guide.

    Abstract translation: 公开了一种离子导向器，其包括一层或多层中间平面，板或网状电极。 第一电极阵列设置在上表面上，第二电极阵列布置在下表面上。 离子引导区域形成在离子导向器内。 优选地将一个或多个瞬态DC电压或电位施加到第一和第二第二电极阵列，以促进，推进，强迫或加速离子通过或沿着离子导向器。

    Mass spectrometer
    16.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US09281171B2

    公开(公告)日：2016-03-08

    申请号：US11721260

    申请日：2005-12-08

    Applicant: Robert Harold Bateman ,  Kevin Giles ,  Jeffery Mark Brown ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    Inventor： Robert Harold Bateman ,  Kevin Giles ,  Jeffery Mark Brown ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    IPC: H01J49/40 ,  H01J49/06 ,  H01J49/00

    CPC classification number: H01J49/062 ,  H01J49/004

    Abstract: A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyzer arranged upstream of an ion guide. Ions are scanned out of the mass selective ion trap or mass analyzer and are received in one or more axial potential wells created or formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the ion guide in order to create a plurality of axial potential wells which are translated along the length of the ion guide. Ions are released in packets from the exit of the ion guide and are orthogonally acceleration into a drift or flight region of an orthogonal acceleration Time of Flight mass analyzer with a relatively high duty cycle.

    Abstract translation: 公开了一种质谱仪，其包括布置在离子导向器上游的质量选择性离子阱或质量分析器。 离子从质量选择性离子阱或质量分析器扫描出来，并被接收在一个或多个在离子导向器内产生或形成的轴向势阱中。 优选地将一个或多个瞬态DC电压或电位施加到离子导向器，以便产生沿离子导向件的长度平移的多个轴向势阱。 离子从离子导向器的出口释放出来的离子，并且正交加速到相对较高占空比的正交加速时间飞行质量分析器的漂移或飞行区域。

    Controlling Hydrogen-Deuterium Exchange on a Spectrum by Spectrum Basis
    18.
    发明申请
    Controlling Hydrogen-Deuterium Exchange on a Spectrum by Spectrum Basis 有权
    通过光谱基础控制光谱上的氢氘交换

    公开(公告)号：US20150034813A1

    公开(公告)日：2015-02-05

    申请号：US13885913

    申请日：2011-11-16

    Applicant: Jeffery Mark Brown ,  Steven Derek Pringle ,  Keith Richardson

    Inventor： Jeffery Mark Brown ,  Steven Derek Pringle ,  Keith Richardson

    IPC: H01J49/00 ,  H01J49/26 ,  H01J49/06

    CPC classification number: H01J49/0077 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/0054 ,  H01J49/0072 ,  H01J49/06 ,  H01J49/065 ,  H01J49/26

    Abstract: A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.

    Abstract translation: 公开了一种质谱仪，其包括用于分离离子的液相色谱装置。 气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。 控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应 器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

    Glow Discharge Ion Source
    19.
    发明申请
    Glow Discharge Ion Source 有权
    辉光放电离子源

    公开(公告)号：US20110189788A1

    公开(公告)日：2011-08-04

    申请号：US13055612

    申请日：2009-07-27

    Applicant: Jeffery Mark Brown ,  Martin Raymond Green ,  Steven Derek Pringle

    Inventor： Jeffery Mark Brown ,  Martin Raymond Green ,  Steven Derek Pringle

    IPC: G01N24/00 ,  G01N21/00

    CPC classification number: H01J49/12 ,  G01N24/00 ,  H01J49/0009 ,  H01J49/0072 ,  H01J49/0495 ,  H01J49/107 ,  H01J49/165 ,  Y10T436/24

    Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.

    Abstract translation: 公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。 可以通过管状电极（14）提供试剂蒸气，然后其随后通过辉光放电电离。 所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。 考虑其他实施例，其中由辉​​光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

    Mass Spectrometer
    20.
    发明申请
    Mass Spectrometer 有权
    质谱仪

    公开(公告)号：US20100032561A1

    公开(公告)日：2010-02-11

    申请号：US12518291

    申请日：2007-12-12

    Applicant: Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    Inventor： Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    IPC: H01J49/26

    CPC classification number: G01N27/622 ,  G01N27/624 ,  H01J49/062 ,  H01J49/4235

    Abstract: A mass spectrometer is disclosed comprising a device (2) which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device (2) is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF.

    Abstract translation: 公开了一种质谱仪，其包括可在第一操作模式中操作的装置（2），其通过施加连续轴向电场根据其离子迁移率暂时分离离子。 装置（2）还可在第二操作模式中操作，其中通过脉冲施加的轴向电场ON和OFF，离子根据其质荷比逐时分离。

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