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公开(公告)号：US07517962B2
公开(公告)日：2009-04-14
申请号：US10862109
申请日：2004-06-04
Applicant: Steven R. Wiley
Inventor： Steven R. Wiley
IPC: C07K16/00 , C12N5/12 , A61K39/395
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
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公开(公告)号：US06958387B2
公开(公告)日：2005-10-25
申请号：US10094944
申请日：2002-03-08
Applicant: Howard R. G. Clarke , Robert F. DuBose , Steven R. Wiley
Inventor： Howard R. G. Clarke , Robert F. DuBose , Steven R. Wiley
IPC: G01N33/50 , A61K38/00 , A61K38/55 , A61P1/16 , A61P7/02 , A61P11/00 , A61P17/00 , A61P17/06 , A61P17/08 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07K14/47 , C07K14/81 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/566 , C07K1/00 , C07H21/04 , C12N1/20 , C12P21/06
CPC classification number: C07K14/8121 , A61K38/00 , C07K2317/24 , G01N2333/8121
Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.
Abstract translation: 本发明涉及Thypin，人丝氨酸蛋白酶多肽家族的新成员，制备Thypin多肽和使用这些多肽治疗各种医学病症的方法以及筛选激动或拮抗Thypin多肽活性的化合物的方法。
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公开(公告)号：US06824773B2
公开(公告)日：2004-11-30
申请号：US09742454
申请日：2000-12-19
Applicant: Steven R. Wiley
Inventor： Steven R. Wiley
IPC: A61K39395
CPC classification number: C07K14/70575 , A61K38/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Abstract translation: 本发明提供TWEAK受体和用于鉴定和使用TWEAK受体的激动剂和拮抗剂的方法。 特别地，本发明提供筛选激动剂和拮抗剂并用于治疗血管生成介导的疾病或病症的方法，例如实心瘤和心脏或外周组织的血管缺陷。
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公开(公告)号：US06727225B2
公开(公告)日：2004-04-27
申请号：US09883777
申请日：2001-06-18
Applicant: Steven R. Wiley
Inventor： Steven R. Wiley
IPC: A61K3800
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
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公开(公告)号：US20150072344A1
公开(公告)日：2015-03-12
申请号：US14481697
申请日：2014-09-09
Applicant: Steven R. Wiley
Inventor： Steven R. Wiley
IPC: C12Q1/68
CPC classification number: C12Q1/6851 , C12Q2525/161 , C12Q2525/191
Abstract: The BUMI tag is an invention which allows different species of mRNAs from different samples to be quantitatively measured at the first strand cDNA generation step, and is not affected by variations in amplification efficiency of different species of molecules, regardless of amplification method. It consists of a blend of defined nucleotides which comprise the bar-coding portion of the tag along with a set of randomly synthesized nucleotides which comprise the UMI (universal marker indicator) portion of the tag. This blend of Barcode and UMI parts comprises the BUMI tag. The two are interspersed so that the fixed nucleotides of the barcode do not form a contiguous region which might cause biases between different barcodes due to undesired complementarity between the barcode and amplification primers/adaptors.
Abstract translation: BUMI标签是允许来自不同样品的不同种类的mRNA在第一链cDNA产生步骤中定量测量的发明，并且不受扩增方法的不同种类的分子的扩增效率的变化的影响。 它由定义的核苷酸的混合物组成，其包含标签的条形编码部分以及包含标签的UMI（通用标记指示剂）部分的随机合成的核苷酸组。 条形码和UMI部件的混合包括BUMI标签。 两者是散置的，使得条形码的固定核苷酸不会形成连续区域，由于条形码和扩增引物/适配器之间的不希望的互补性，可能导致不同条形码之间的偏差。
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Patent Agency Ranking
公开(公告)号：US08361466B2
公开(公告)日：2013-01-29
申请号：US12751912
申请日：2010-03-31
Applicant: Steven R. Wiley
Inventor： Steven R. Wiley
IPC: A61K39/395
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Abstract translation: 本发明提供TWEAK受体和用于鉴定和使用TWEAK受体的激动剂和拮抗剂的方法。 特别地，本发明提供筛选激动剂和拮抗剂并用于治疗血管生成介导的疾病或病症的方法，例如实心瘤和心脏或外周组织的血管缺陷。
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公开(公告)号：US20110020267A1
公开(公告)日：2011-01-27
申请号：US12899397
申请日：2010-10-06
Applicant: Kristine M. Kim , Steven R. Wiley , Randal R. Ketchem , William C. Fanslow, III
Inventor： Kristine M. Kim , Steven R. Wiley , Randal R. Ketchem , William C. Fanslow, III
CPC classification number: A61K39/3955 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Abstract translation: 本发明提供TWEAK受体和用于鉴定和使用TWEAK受体的激动剂和拮抗剂的方法。 特别地，本发明提供筛选激动剂和拮抗剂并用于治疗血管生成介导的疾病或病症的方法，例如实心瘤和心脏或外周组织的血管缺陷。
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公开(公告)号：US20090226417A1
公开(公告)日：2009-09-10
申请号：US11890871
申请日：2007-08-08
Applicant: Peter R. Baum , Robert F. DuBose , Steven R. Wiley
Inventor： Peter R. Baum , Robert F. DuBose , Steven R. Wiley
CPC classification number: C07K14/70532 , A61K38/00 , A61K39/00
Abstract: This invention relates to B7-H1.2 and Butryophilin 2/3, new members of the human B7 polypeptide family, methods of making such polypeptides, and to methods of using them to treat immunological conditions and to identify compounds that alter the activities of these human B7 polypeptides.
Abstract translation: 本发明涉及B7-H1.2和Butryophilin2/3，人类B7多肽家族的新成员，制备这种多肽的方法，以及使用它们来治疗免疫学病症和鉴定改变这些活性的化合物的方法 人B7多肽。
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公开(公告)号：US20090118186A1
公开(公告)日：2009-05-07
申请号：US12195564
申请日：2008-08-21
Applicant: Steven R. Wiley , Raymond G. Goodwin
Inventor： Steven R. Wiley , Raymond G. Goodwin
IPC: A61K38/16
CPC classification number: C07K14/70575 , C07K16/24 , C07K16/2875 , C07K2317/34 , C07K2317/74
Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
Abstract translation: 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。
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公开(公告)号：US20080254506A1
公开(公告)日：2008-10-16
申请号：US11701883
申请日：2007-02-01
Applicant: Adel Youakim , Robert F. DuBose , Steven R. Wiley
Inventor： Adel Youakim , Robert F. DuBose , Steven R. Wiley
CPC classification number: C07K14/705 , A61K38/00 , C07K16/18 , G01N2500/02 , G01N2500/04
Abstract: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.
Abstract translation: 本发明涉及人紧密连接蛋白多肽家族的新成员，制备这种多肽的方法，以及使用它们来治疗紧密连接蛋白相关病症并鉴定改变紧密连接蛋白多肽活性的化合物的方法。
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