公开(公告)号：US20120128392A1

公开(公告)日：2012-05-24

申请号：US13349912

申请日：2012-01-13

申请人： Ken Nakagawa ,  Kenji Kanari ,  Masaru Shimura ,  Takashi Shimada ,  Tomoo Akizuki ,  Masahiro Suzuki

发明人： Ken Nakagawa ,  Kenji Kanari ,  Masaru Shimura ,  Takashi Shimada ,  Tomoo Akizuki ,  Masahiro Suzuki

IPC分类号： G03G15/14

CPC分类号： G03G21/0047 ,  G03G21/10 ,  G03G2221/1627

摘要： A charge member charges secondary transfer remaining toner on an intermediate transfer member to a polarity opposite to a normal charge polarity. The remaining toner is moved by a transfer bias, from the intermediate transfer member onto an image bearing member. A BK station is arranged on the downstream of other stations. In a continuous BK monochromatic mode, by applying a reverse bias to transfer portions of the other stations and applying the transfer bias only to the BK station, remaining toner can be collected into the BK station (simultaneously with the transfer). In a full-color mode, remaining toner is collected into the station on the uppermost stream. Thus, the image bearing member for collecting remaining toner on the intermediate transfer member differs according to the mode, thereby suppressing the collection of remaining toner being concentrated on one image bearing member.

摘要翻译： 充电构件将中间转印构件上的二次转印剩余调色剂充电到与正常电荷极性相反的极性。 剩余的调色剂通过转印偏压从中间转印部件移动到图像承载部件上。 其他车站下游设有BK车站。 在连续的BK单色模式中，通过施加反向偏压来转移其它工位的部分并将转印偏压施加到BK工位，剩余的调色剂可以被收集到BK工位（与转印同时）。 在全色模式下，剩余碳粉被收集到最上游的车站。 因此，根据模式，用于收集中间转印部件上的剩余调色剂的图像承载部件不同，从而抑制剩余调色剂的收集集中在一个图像承载部件上。

公开(公告)号：US08158638B2

公开(公告)日：2012-04-17

申请号：US12442094

申请日：2007-09-14

申请人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

发明人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

IPC分类号： A61K31/505 ,  A61K31/415 ,  C07D491/00 ,  C07D487/02

CPC分类号： C07D495/16 ,  C07D495/20 ,  C07D495/22 ,  C07D498/22

摘要： Problem to be SolvedTo provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity.SolutionThe present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1).

摘要翻译： 要解决的问题提供抑制HSP90的作用的新型化合物，特别是抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性的新化合物。 溶液本发明提供了具有抑制HSP90的ATP酶活性且具有抗肿瘤活性的各种取代基的式（1）表示的吡唑并嘧啶化合物，包含由式（1）表示的化合物的HSP90抑制剂，包含化合物 （1）代表的抗癌剂，包含由式（1）表示的化合物的抗癌剂，包含式（1）表示的化合物的药物组合物和使用式（1）表示的化合物治疗癌症的方法 ）。

公开(公告)号：US08036574B2

公开(公告)日：2011-10-11

申请号：US12415822

申请日：2009-03-31

申请人： Masaru Shimura ,  Michio Uchida ,  Ken Nakagawa ,  Seiji Saito ,  Kenji Kanari ,  Takamitsu Soda ,  Takaaki Akamatsu ,  Kazuhiro Doda ,  Takashi Shimada ,  Shuuichi Tetsuno ,  Shigeru Hoashi ,  Tomoya Kuruma

发明人： Masaru Shimura ,  Michio Uchida ,  Ken Nakagawa ,  Seiji Saito ,  Kenji Kanari ,  Takamitsu Soda ,  Takaaki Akamatsu ,  Kazuhiro Doda ,  Takashi Shimada ,  Shuuichi Tetsuno ,  Shigeru Hoashi ,  Tomoya Kuruma

IPC分类号： G03G15/00

CPC分类号： G03G15/0131 ,  G03G15/1615 ,  G03G15/50 ,  G03G21/1647 ,  G03G21/168 ,  G03G2215/0129 ,  G03G2215/0141 ,  G03G2215/0193 ,  G03G2221/1657

摘要： An image forming apparatus for forming image on a recording medium includes a photosensitive member, a motor, a belt, and a drive member to rotate the belt, the drive member including a driven coupling. The apparatus also includes a drive coupling to rotate by a driving force generated by the motor, the drive coupling being movable in an axial direction to take an engagement position at which the driving force is transmittable to the driven coupling, and a release position. The apparatus further includes a transfer member to transfer a toner image onto the recording medium or the belt, a voltage application unit to apply a voltage to the transfer member, and a control unit to cause the voltage application unit to apply the voltage to the transfer member after the drive coupling moves to the engagement position and the driving force is transmitted to the driven coupling.

摘要翻译： 用于在记录介质上形成图像的图像形成装置包括感光部件，马达，皮带以及用于旋转皮带的驱动部件，该驱动部件包括从动联轴器。 该装置还包括通过由电动机产生的驱动力来旋转的驱动联接器，该驱动联接器可在轴向方向上移动以采取将驱动力传递到从动联接器的接合位置和释放位置。 所述设备还包括用于将调色剂图像转印到所述记录介质或所述带上的转印部件，向所述转印部件施加电压的电压施加单元，以及使所述电压施加单元向所述转印部施加电压的控制单元 驱动联轴器移动到接合位置并且驱动力被传递到从动联轴器之后的构件。

公开(公告)号：US20100166719A1

公开(公告)日：2010-07-01

申请号：US12656139

申请日：2010-01-19

申请人： Katsutoshi Yoshizato ,  Takashi Shimada ,  Koei Toyoshima ,  Mikaru Matsunaga

发明人： Katsutoshi Yoshizato ,  Takashi Shimada ,  Koei Toyoshima ,  Mikaru Matsunaga

IPC分类号： A61K35/12 ,  A61P43/00

CPC分类号： A61L27/3869 ,  A61F2/10 ,  A61K35/12 ,  A61L27/362 ,  A61L27/3666 ,  A61L27/3813 ,  A61L2430/18 ,  C12N5/0627 ,  C12N2501/115

摘要： A method of enabling effective hair growth and furthermore, inducing hair growth closely similar to the natural hair state in the case of transplanting dermal papillae or cultured dermal papilla cells into the skin to regenerate the hair, characterized by comprising transplanting a composition containing the following components into an epidermis defect site: (a) dermal papillae or dermal papilla cells, (b) an epidermal tissue or epidermal cells and/or (c) a tissue constituting hair follicles or cells thereof.

摘要翻译： 此外，在将真皮乳头或培养的真皮乳头细胞移植到皮肤中以再生毛发的情况下，能够有效地进行毛发生长的方法，此外，诱导与天然毛发状态非常相似的毛发生长，其特征在于，包括移植含有以下成分的组合物 进入表皮缺损部位：（a）真皮乳头或真皮乳头细胞，（b）表皮组织或表皮细胞和/或（c）构成毛囊或其细胞的组织。

公开(公告)号：US20100086938A1

公开(公告)日：2010-04-08

申请号：US12516790

申请日：2007-10-02

申请人： Takashi Shimada ,  Atsuhiko Toyama ,  Taka-aki Sato

发明人： Takashi Shimada ,  Atsuhiko Toyama ,  Taka-aki Sato

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/553 ,  G01N33/552 ,  G01N33/544

CPC分类号： G01N33/6848

摘要： It is intended to provide an analysis method for a biological sample with clinical significance, which is a system being simple to such an extent that it can be applied to a clinical field, and capable of capping a molecule ionization suppression in mass spectrometry. Mass spectrometry of a biological sample using immunoprecipitation, comprising the steps of: preparing a sample containing an objective biological molecule; concentrating the biological molecule in the sample by immunoprecipitation using an antibody-bound carrier or a carrier to which a molecule capable of specifically binding to an antibody is bound; washing an immunoprecipitate of the biological molecule by using an aqueous solution containing a charge neutralizing agent as a washing liquid; and detecting the biological molecule by subjecting the washed immunoprecipitate to mass spectrometry.

摘要翻译： 旨在为具有临床意义的生物样品提供分析方法，该方法简单到能够应用于临床领域并且能够在质谱法中限制分子离子化抑制的系统。 使用免疫沉淀的生物样品的质谱法，包括以下步骤：制备含有客观生物分子的样品; 通过使用抗体结合的载体或能够与抗体特异性结合的分子结合的载体通过免疫沉淀将生物分子浓缩在样品中; 通过使用含有电荷中和剂的水溶液作为洗涤液来洗涤生物分子的免疫沉淀物; 并通过对洗涤的免疫沉淀物进行质谱检测来检测生物分子。

公开(公告)号：US20090266461A1

公开(公告)日：2009-10-29

申请号：US12439709

申请日：2007-08-02

申请人： Uchu Mukai ,  Kazuhiko Misumi ,  Takashi Shimada

发明人： Uchu Mukai ,  Kazuhiko Misumi ,  Takashi Shimada

IPC分类号： B60C5/00 ,  C08K3/22 ,  C08K5/24

CPC分类号： B60C1/00 ,  B32B25/042 ,  B32B25/12 ,  B32B25/14 ,  B32B25/16 ,  B32B2250/248 ,  B32B2307/306 ,  B32B2307/50 ,  B32B2605/00 ,  B60C2009/0021 ,  C08K3/06 ,  C08K3/22 ,  C08K5/25 ,  C08L21/00 ,  Y10T152/10495

摘要： The present invention provides a rubber composite constituted of at least two layers of members comprising a rubber composition containing a diene base rubber cross-linked by sulfur, wherein a difference in a concentration of sulfur between adjacent members in the rubber composite described above is 1.5 part by mass or more based on 100 parts by mass of a rubber component in the rubber composition described above; zinc oxide is blended in an amount satisfying a condition shown in the following equation (I) based on 100 parts by mass of a rubber component in a low sulfur concentration rubber composition among the adjacent members, and an antioxidant and/or a naphthoic hydrazide compound are blended in an amount satisfying a condition shown in the following equation (II) based on 100 parts by mass of the rubber component in the low sulfur concentration rubber composition: blending amount (parts by mass) of zinc oxide in the low sulfur concentration rubber composition>Sb×1.3+(Sa−Sb)×0.3  (I) (wherein Sa represents a blending amount (parts by mass) of sulfur in the high sulfur concentration rubber composition, and Sb represents a blending amount (parts by mass) of sulfur in the low sulfur concentration rubber composition) and blending amount (mole) of the antioxidant and/or the naphthoic hydrazide compound in the low sulfur concentration rubber composition>0.005+(Sa−Sb)/2000  (II) (wherein Sa and Sb represent the same contents as described in the equation (I)); a rubber composite improved in a problem originating in a difference in a concentration of a blending agent, particularly sulfur between adjacent rubber compositions comprising a rubber composition cross-linked by sulfur without using new raw materials and members; and a tire prepared by using the same.

摘要翻译： 本发明提供一种由至少两层构件构成的橡胶复合体，该橡胶组合物包括含有由硫交联的二烯基橡胶的橡胶组合物，其中上述橡胶复合材料中相邻构件之间的硫浓度差为1.5份 以上述橡胶组合物中的100质量份橡胶成分为基准， 氧化锌以相邻成员中的低硫浓度橡胶组合物中的橡胶成分100质量份，抗氧化剂和/或萘甲酰肼化合物为基准，以满足下述式（I）所示的条件的量进行配合 以低硫浓度橡胶组合物中的橡胶成分100质量份为基准，混合满足下述式（II）所示条件的量：低硫浓度橡胶中的氧化锌的配合量（质量份） 组成> Sbx1.3 +（Sa-Sb）x0.3（I）（其中，Sa表示高硫浓度橡胶组合物中的硫的配合量（质量份），Sb表示配合量（质量份） 低硫浓度橡胶组合物中的硫）和低硫浓度橡胶组合物> 0.005+（Sa-Sb）/ 2000（II）中的抗氧化剂和/或萘甲酰肼化合物的配合量（摩尔）（其中，Sa和 Sb 表示与等式（I）中所述相同的内容）; 橡胶复合材料改善了由于不使用新的原材料和构件而由硫交联的橡胶组合物构成的相邻橡胶组合物之间的混合剂浓度差异特别是硫的差异， 和使用该轮胎制备的轮胎。

公开(公告)号：US06429308B1

公开(公告)日：2002-08-06

申请号：US09582224

申请日：2000-07-21

申请人： Osamu Iijima ,  Takeshi Goto ,  Takashi Shimada

发明人： Osamu Iijima ,  Takeshi Goto ,  Takashi Shimada

IPC分类号： C07H2104

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315

摘要： An antisense oligonucleotide characterized in that it hybridizes specifically with chromosomal DNA and/or RNA encoding CXCR4 protein to thereby inhibit the expression of the CXCR4 protein, and a HIV infection inhibitor comprising the antisense oligonucleotide, are disclosed.

摘要翻译： 一种反义寡核苷酸，其特征在于其与编码CXCR4蛋白的染色体DNA和/或RNA特异性杂交，从而抑制CXCR4蛋白的表达，并且包含该反义寡核苷酸的HIV感染抑制剂。

公开(公告)号：US5833882A

公开(公告)日：1998-11-10

申请号：US866961

申请日：1997-06-02

申请人： Takashi Shimada ,  Youji Nawa

发明人： Takashi Shimada ,  Youji Nawa

IPC分类号： G01N31/22 ,  G01N21/77 ,  G01N21/80 ,  G08B17/117

CPC分类号： G01N31/223

摘要： A detecting agent for detecting at least one member selected from the group consisting of halogen gases and acidic gases which is contained in a gas, wherein the detecting agent comprises a discoloring component which comprises a hydroxide of a transition metal and Congo Red. Halogen gases and acidic gases which are contained in hydrogen, nitrogen, argon, or helium can be detected under a dry condition with a high sensitivity in accordance with the present invention.

摘要翻译： 一种用于检测选自由气体中包含的卤素气体和酸性气体组成的组中的至少一种的检测剂，其中所述检测剂包括包含过渡金属的氢氧化物和刚果红的变色组分。 可以在根据本发明的高灵敏度的干燥条件下检测氢，氮，氩或氦中所含的卤素气体和酸性气体。

公开(公告)号：US5769173A

公开(公告)日：1998-06-23

申请号：US539527

申请日：1995-10-06

申请人： Noritaka Egami ,  Shinichi Hattori ,  Ryosuke Taniguchi ,  Takahiro Sakamoto ,  Takashi Shimada

发明人： Noritaka Egami ,  Shinichi Hattori ,  Ryosuke Taniguchi ,  Takahiro Sakamoto ,  Takashi Shimada

IPC分类号： E02D7/18 ,  E02D11/00 ,  E21B7/24 ,  E21D20/00

CPC分类号： E02D7/18 ,  E21B7/24

摘要： A vibration exciter machine has magneto striction elements (5,6) supported by a driven pile (2), for providing a vibration of up and down direction to the driven pile (2), and a drive circuit (D1) for controlling expansion and contraction movement of the magneto striction elements (5,6) by changing a supply time period of a current supplied to the magneto striction elements (5,6). By controlling of the drive circuit (D1) the supply time period of the current which flows in the magneto striction elements (5,6) is changed to control the expansion and contraction movement of the elements (5,7). Thereby a horizontal vibration component can be eliminated and only vertical vibration component can be transmitted to the driven pile material (2).

摘要翻译： 振动激励机具有由从动桩（2）支撑的磁致动元件（5,6），用于向被驱动桩（2）提供上下方向的振动;以及驱动电路（D1），用于控制膨胀和 通过改变提供给磁致伸缩元件（5,6）的电流的供给时间段，使磁致伸缩元件（5,6）的收缩运动。 通过控制驱动电路（D1），改变在磁致伸缩元件（5,6）中流动的电流的供给时间段，以控制元件（5,7）的膨胀和收缩运动。 由此，可以消除水平振动分量，并且只有垂直振动分量可以传递到被驱动的堆料（2）。

公开(公告)号：US5665313A

公开(公告)日：1997-09-09

申请号：US511681

申请日：1995-08-07

申请人： Takashi Shimada ,  Masako Yamakawa ,  Youji Nawa

发明人： Takashi Shimada ,  Masako Yamakawa ,  Youji Nawa

IPC分类号： G01N31/22 ,  G01N33/52

CPC分类号： G01N31/224 ,  Y10T436/16 ,  Y10T436/172307

摘要： A detecting agent for hydride gases (arsine, phosphine, silane, diborane, selenium hydride etc.) which comprises at least one member selected from molybdic acid, a salt thereof, a molybdenum-containing acid (molybdophosphoric acid, etc.) and a salt thereof, and optionally a cupric salt each as a discoloring component being supported on an inorganic carrier (silica, alumina, silica-alumina, zirconia, etc.). The above detecting agent can detect the above hydride gases contained in the exhaust gas discharged from a semiconductor manufacturing process, with high accuracy, selectivity and sensitivity at a high discoloring rate without being influenced by other gases such as hydrogen gas.

摘要翻译： 含有选自钼酸，其盐，含钼酸（钼磷酸等）中的至少一种的氢化物气体（胂，膦，硅烷，乙硼烷，硒化氢等）的检测剂 和任选的作为褪色成分负载在无机载体（二氧化硅，氧化铝，二氧化硅 - 氧化铝，氧化锆等）上的铜盐）。 上述检测剂可以在高变色条件下以高精度，选择性和灵敏度从半导体制造工艺中排出的废气中所含的上述氢化物气体，而不受诸如氢气等其它气体的影响。