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公开(公告)号：US20110201119A1
公开(公告)日：2011-08-18
申请号：US12737791
申请日：2009-08-06
申请人： Weiguo Zhai , Jan zur Megede , Susan W. Barnett
发明人： Weiguo Zhai , Jan zur Megede , Susan W. Barnett
CPC分类号： C12N7/00 , C12N2770/36152
摘要： This invention provides alphavirus packaging cell lines useful for commercial production of recombinant alphavirus particles and structural protein expression cassettes for making the packaging cell lines.
摘要翻译： 本发明提供了可用于商业生产重组甲病毒颗粒和用于制备包装细胞系的结构蛋白表达盒的甲病毒包装细胞系。
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12.发明申请公开(公告)号：US20110052632A1
公开(公告)日：2011-03-03
申请号：US12943195
申请日：2010-11-10
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C12N2740/16122 , C12N2740/16134 , A61K2300/00
摘要： The present disclosure relates to novel polynucleotides that encode HIV Env polypeptides. In particular, the disclosure relates to sequences derived from HIV strain Botswana MJ4 encoding Env polypeptides. Compositions comprising these polynucleotides and methods of using these polynucleotides are also disclosed.
摘要翻译： 本公开涉及编码HIV Env多肽的新型多核苷酸。 特别地，本公开涉及编码Env多肽的源自HIV菌株博茨瓦纳MJ4的序列。 还公开了包含这些多核苷酸的组合物和使用这些多核苷酸的方法。
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公开(公告)号：US20100040676A1
公开(公告)日：2010-02-18
申请号：US12604335
申请日：2009-10-22
申请人： Jan zur Megede , Susan W. Barnett
发明人： Jan zur Megede , Susan W. Barnett
IPC分类号： A61K9/127 , C12P21/06 , A61K31/7088 , A61K38/00 , A61K9/16
CPC分类号： C07K14/005 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/36143
摘要： The present disclosure relates to vectors comprising polynucleotide sequences that encode HIV polypeptides. In particular, the disclosure relates polycistronic vector constructs comprising sequences that encode HIV polypeptides as a single polyprotein. Compositions comprising these vectors and sequences along with methods of using these vectors and sequences are also disclosed.
摘要翻译： 本公开涉及包含编码HIV多肽的多核苷酸序列的载体。 具体地，本公开涉及包含将HIV多肽编码为单个多蛋白的序列的多顺反子载体构建体。 还公开了包含这些载体和序列的组合以及使用这些载体和序列的方法。
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公开(公告)号：US20090208530A1
公开(公告)日：2009-08-20
申请号：US12365215
申请日：2009-02-04
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C12N2740/16122 , C12N2740/16134 , A61K2300/00
摘要： The present disclosure relates to novel polynucleotides that encode HIV Env polypeptides. In particular, the disclosure relates to sequences derived from HIV strain Botswana MJ4 encoding Env polypeptides. Compositions comprising these polynucleotides and methods of using polynucleotides are also disclosed.
摘要翻译： 本公开涉及编码HIV Env多肽的新型多核苷酸。 特别地，本公开涉及编码Env多肽的源自HIV菌株博茨瓦纳MJ4的序列。 还公开了包含这些多核苷酸的组合物和使用多核苷酸的方法。
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15.发明申请Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof 失效编码抗原性HIV C型多肽的多核苷酸，多肽及其用途公开(公告)号：US20090047339A1
公开(公告)日：2009-02-19
申请号：US12215189
申请日：2008-06-25
申请人： Susan W. Barnett , Jan zur Megede
发明人： Susan W. Barnett , Jan zur Megede
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Gag- and/or Env-containing proteins are also described.
摘要翻译： 本发明涉及编码免疫原性HIV C型Gag-和/或含Env的多肽的多核苷酸。 还描述了多核苷酸在包括DNA免疫，产生包装细胞系以及产生含Gag和/或含Env的蛋白质的应用中的用途。
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16.发明授权Fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutraliziation epitopes 有权包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和侵袭素多肽的融合蛋白公开(公告)号：US08206720B2
公开(公告)日：2012-06-26
申请号：US11597340
申请日：2005-06-08
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
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公开(公告)号：US20110257377A1
公开(公告)日：2011-10-20
申请号：US12225655
申请日：2007-03-27
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/62 , A61K2039/64 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is important to the binding properties of the complexes, and so is controlled to avoid the loss of Env's ability to bind specifically to CD4 and Tat's ability to bind specifically to anti-Tat monoclonal antibodies.
摘要翻译： HIV环境和Tat蛋白的复合物作为免疫原与Tat或Env单独相比是有利的，但当与疫苗佐剂组合时它们可能解离。 为了避免解离，Env和Tat的复合物通过使用共价交联来稳定。 交联的程度对于复合物的结合特性是重要的，因此被控制以避免Env特异性结合CD4和Tat特异性结合抗Tat单克隆抗体的能力的丧失。
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18.发明申请公开(公告)号：US20100183653A1
公开(公告)日：2010-07-22
申请号：US11597340
申请日：2005-06-08
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
IPC分类号： A61K39/02 , A61K39/21 , C12P21/06 , C12N5/10 , C12N1/21 , C12N1/19 , C12N15/63 , C07K14/24 , C07K16/00 , C07H21/04 , C07K14/155
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
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公开(公告)号：US20090238841A1
公开(公告)日：2009-09-24
申请号：US12364294
申请日：2009-02-02
申请人： John Donnelly , Susan W. Barnett , Derek O'Hagan
发明人： John Donnelly , Susan W. Barnett , Derek O'Hagan
IPC分类号： A61K39/21 , C12P21/02 , A61K31/713 , A61P31/18 , A61K31/711
CPC分类号： A61K39/21 , A61K39/12 , A61K48/0041 , A61K48/005 , A61K48/0083 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C07K14/005 , C12N15/87 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject.
摘要翻译： 本文提供包含吸附于PLG和/或HIV蛋白质的编码HIV多肽的DNA的HIV疫苗。 还提供了使用这些疫苗在受试者中产生免疫应答的方法。
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公开(公告)号：US20080300385A1
公开(公告)日：2008-12-04
申请号：US11729076
申请日：2007-03-27
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/62 , A61K2039/64 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is important to the binding properties of the complexes, and so is controlled to avoid the loss of Env's ability to bind specifically to CD4 and Tat's ability to bind specifically to anti-Tat monoclonal antibodies.
摘要翻译： HIV环境和Tat蛋白的复合物作为免疫原与Tat或Env单独相比是有利的，但当与疫苗佐剂组合时它们可能解离。 为了避免解离，Env和Tat的复合物通过使用共价交联来稳定。 交联的程度对于复合物的结合特性是重要的，因此被控制以避免Env特异性结合CD4和Tat特异性结合抗Tat单克隆抗体的能力的丧失。
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